Protein phosphatase 1 regulatory subunit 22

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B647_LEIMU

TriTrypDb:

LmxM.34.1690

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9B647

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B647

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.731
CLV_C14_Caspase3-7	452	456	PF00656	0.419
CLV_NRD_NRD_1	289	291	PF00675	0.743
CLV_NRD_NRD_1	331	333	PF00675	0.705
CLV_NRD_NRD_1	409	411	PF00675	0.566
CLV_PCSK_FUR_1	423	427	PF00082	0.629
CLV_PCSK_KEX2_1	289	291	PF00082	0.743
CLV_PCSK_KEX2_1	409	411	PF00082	0.544
CLV_PCSK_KEX2_1	425	427	PF00082	0.441
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.592
CLV_PCSK_SKI1_1	100	104	PF00082	0.528
CLV_PCSK_SKI1_1	112	116	PF00082	0.522
CLV_PCSK_SKI1_1	158	162	PF00082	0.543
CLV_PCSK_SKI1_1	409	413	PF00082	0.566
CLV_PCSK_SKI1_1	425	429	PF00082	0.417
CLV_PCSK_SKI1_1	89	93	PF00082	0.524
DEG_APCC_DBOX_1	261	269	PF00400	0.555
DEG_SCF_FBW7_1	240	245	PF00400	0.279
DEG_SPOP_SBC_1	114	118	PF00917	0.757
DOC_CKS1_1	75	80	PF01111	0.506
DOC_CYCLIN_RxL_1	136	147	PF00134	0.430
DOC_CYCLIN_RxL_1	404	417	PF00134	0.577
DOC_CYCLIN_RxL_1	421	431	PF00134	0.590
DOC_MAPK_gen_1	421	430	PF00069	0.540
DOC_MAPK_MEF2A_6	390	398	PF00069	0.623
DOC_MAPK_MEF2A_6	74	82	PF00069	0.561
DOC_PP2B_LxvP_1	108	111	PF13499	0.491
DOC_USP7_MATH_1	16	20	PF00917	0.457
DOC_USP7_MATH_1	242	246	PF00917	0.478
DOC_USP7_MATH_1	270	274	PF00917	0.554
DOC_USP7_MATH_1	346	350	PF00917	0.678
DOC_USP7_MATH_1	471	475	PF00917	0.568
DOC_USP7_UBL2_3	329	333	PF12436	0.442
DOC_USP7_UBL2_3	421	425	PF12436	0.614
DOC_USP7_UBL2_3	434	438	PF12436	0.529
DOC_WW_Pin1_4	199	204	PF00397	0.478
DOC_WW_Pin1_4	238	243	PF00397	0.484
DOC_WW_Pin1_4	40	45	PF00397	0.482
DOC_WW_Pin1_4	74	79	PF00397	0.591
LIG_14-3-3_CanoR_1	269	275	PF00244	0.568
LIG_14-3-3_CanoR_1	449	457	PF00244	0.420
LIG_14-3-3_CanoR_1	48	56	PF00244	0.443
LIG_Actin_WH2_2	443	460	PF00022	0.524
LIG_BIR_II_1	1	5	PF00653	0.450
LIG_BIR_III_4	124	128	PF00653	0.637
LIG_BIR_III_4	355	359	PF00653	0.717
LIG_BIR_III_4	417	421	PF00653	0.528
LIG_BRCT_BRCA1_1	1	5	PF00533	0.450
LIG_BRCT_BRCA1_1	340	344	PF00533	0.553
LIG_Clathr_ClatBox_1	91	95	PF01394	0.469
LIG_eIF4E_1	145	151	PF01652	0.508
LIG_FHA_1	200	206	PF00498	0.540
LIG_FHA_1	215	221	PF00498	0.394
LIG_FHA_1	298	304	PF00498	0.605
LIG_FHA_1	434	440	PF00498	0.547
LIG_FHA_1	75	81	PF00498	0.720
LIG_FHA_2	116	122	PF00498	0.643
LIG_FHA_2	150	156	PF00498	0.505
LIG_FHA_2	159	165	PF00498	0.440
LIG_FHA_2	443	449	PF00498	0.529
LIG_HP1_1	270	274	PF01393	0.570
LIG_LIR_Gen_1	144	151	PF02991	0.467
LIG_LIR_Gen_1	2	10	PF02991	0.456
LIG_LIR_Gen_1	341	352	PF02991	0.569
LIG_LIR_Gen_1	472	483	PF02991	0.568
LIG_LIR_Nem_3	144	148	PF02991	0.460
LIG_LIR_Nem_3	2	8	PF02991	0.584
LIG_LIR_Nem_3	341	347	PF02991	0.559
LIG_LIR_Nem_3	472	478	PF02991	0.570
LIG_NRBOX	407	413	PF00104	0.508
LIG_PTB_Apo_2	139	146	PF02174	0.554
LIG_PTB_Apo_2	279	286	PF02174	0.421
LIG_PTB_Phospho_1	139	145	PF10480	0.502
LIG_PTB_Phospho_1	279	285	PF10480	0.411
LIG_RPA_C_Fungi	345	357	PF08784	0.788
LIG_SH2_CRK	145	149	PF00017	0.508
LIG_SH2_NCK_1	61	65	PF00017	0.365
LIG_SH2_STAT5	201	204	PF00017	0.573
LIG_SUMO_SIM_par_1	161	166	PF11976	0.408
LIG_TRAF2_1	441	444	PF00917	0.426
LIG_TYR_ITIM	143	148	PF00017	0.489
MOD_CDK_SPK_2	199	204	PF00069	0.454
MOD_CK1_1	116	122	PF00069	0.761
MOD_CK1_1	144	150	PF00069	0.459
MOD_CK1_1	261	267	PF00069	0.528
MOD_CK1_1	374	380	PF00069	0.655
MOD_CK1_1	456	462	PF00069	0.565
MOD_CK2_1	149	155	PF00069	0.529
MOD_CK2_1	289	295	PF00069	0.734
MOD_CK2_1	442	448	PF00069	0.537
MOD_Cter_Amidation	287	290	PF01082	0.722
MOD_GlcNHglycan	100	103	PF01048	0.536
MOD_GlcNHglycan	132	135	PF01048	0.658
MOD_GlcNHglycan	217	220	PF01048	0.511
MOD_GlcNHglycan	344	347	PF01048	0.691
MOD_GlcNHglycan	359	362	PF01048	0.618
MOD_GlcNHglycan	369	374	PF01048	0.729
MOD_GlcNHglycan	489	492	PF01048	0.573
MOD_GSK3_1	110	117	PF00069	0.688
MOD_GSK3_1	168	175	PF00069	0.343
MOD_GSK3_1	238	245	PF00069	0.312
MOD_GSK3_1	284	291	PF00069	0.633
MOD_GSK3_1	31	38	PF00069	0.698
MOD_GSK3_1	338	345	PF00069	0.585
MOD_GSK3_1	346	353	PF00069	0.584
MOD_GSK3_1	369	376	PF00069	0.767
MOD_GSK3_1	449	456	PF00069	0.552
MOD_GSK3_1	478	485	PF00069	0.498
MOD_N-GLC_1	141	146	PF02516	0.430
MOD_N-GLC_1	233	238	PF02516	0.539
MOD_NEK2_1	115	120	PF00069	0.749
MOD_NEK2_1	141	146	PF00069	0.374
MOD_NEK2_1	163	168	PF00069	0.392
MOD_NEK2_1	215	220	PF00069	0.448
MOD_NEK2_1	247	252	PF00069	0.516
MOD_NEK2_1	284	289	PF00069	0.649
MOD_NEK2_1	35	40	PF00069	0.652
MOD_NEK2_1	380	385	PF00069	0.733
MOD_NEK2_1	464	469	PF00069	0.542
MOD_NEK2_1	482	487	PF00069	0.336
MOD_NEK2_1	84	89	PF00069	0.403
MOD_NEK2_2	270	275	PF00069	0.508
MOD_NEK2_2	31	36	PF00069	0.442
MOD_PIKK_1	168	174	PF00454	0.534
MOD_PIKK_1	297	303	PF00454	0.616
MOD_PIKK_1	316	322	PF00454	0.373
MOD_PIKK_1	381	387	PF00454	0.727
MOD_PIKK_1	412	418	PF00454	0.533
MOD_PKA_1	289	295	PF00069	0.752
MOD_PKA_2	183	189	PF00069	0.542
MOD_PKA_2	261	267	PF00069	0.525
MOD_PKA_2	288	294	PF00069	0.752
MOD_PKA_2	308	314	PF00069	0.571
MOD_Plk_1	104	110	PF00069	0.501
MOD_Plk_1	141	147	PF00069	0.406
MOD_Plk_1	233	239	PF00069	0.564
MOD_Plk_1	471	477	PF00069	0.503
MOD_Plk_2-3	233	239	PF00069	0.531
MOD_Plk_4	158	164	PF00069	0.461
MOD_Plk_4	178	184	PF00069	0.359
MOD_Plk_4	242	248	PF00069	0.434
MOD_Plk_4	31	37	PF00069	0.640
MOD_Plk_4	376	382	PF00069	0.734
MOD_Plk_4	478	484	PF00069	0.481
MOD_ProDKin_1	199	205	PF00069	0.470
MOD_ProDKin_1	238	244	PF00069	0.485
MOD_ProDKin_1	40	46	PF00069	0.482
MOD_ProDKin_1	74	80	PF00069	0.591
MOD_SUMO_rev_2	415	422	PF00179	0.585
TRG_DiLeu_BaEn_1	407	412	PF01217	0.483
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.547
TRG_DiLeu_LyEn_5	407	412	PF01217	0.507
TRG_ENDOCYTIC_2	145	148	PF00928	0.461
TRG_ER_diArg_1	408	410	PF00400	0.581
TRG_Pf-PMV_PEXEL_1	426	431	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E0	Leptomonas seymouri	52%	100%
A0A0S4KH47	Bodo saltans	28%	100%
A0A1X0P5U4	Trypanosomatidae	33%	100%
A0A3Q8IF21	Leishmania donovani	93%	100%
A0A422NQ71	Trypanosoma rangeli	36%	100%
A4HMJ0	Leishmania braziliensis	83%	100%
C9ZZH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AEZ1	Leishmania major	89%	97%