LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B646_LEIMU
TriTrypDb:
LmxM.34.1680
Length:
278

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

E9B646
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B646

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 173 175 PF00675 0.538
CLV_NRD_NRD_1 227 229 PF00675 0.572
CLV_NRD_NRD_1 259 261 PF00675 0.615
CLV_NRD_NRD_1 89 91 PF00675 0.326
CLV_PCSK_KEX2_1 173 175 PF00082 0.509
CLV_PCSK_KEX2_1 227 229 PF00082 0.541
CLV_PCSK_KEX2_1 259 261 PF00082 0.615
CLV_PCSK_KEX2_1 87 89 PF00082 0.356
CLV_PCSK_PC1ET2_1 87 89 PF00082 0.374
CLV_PCSK_SKI1_1 14 18 PF00082 0.274
CLV_PCSK_SKI1_1 148 152 PF00082 0.373
CLV_PCSK_SKI1_1 167 171 PF00082 0.433
DOC_ANK_TNKS_1 89 96 PF00023 0.383
DOC_CKS1_1 218 223 PF01111 0.679
DOC_CKS1_1 39 44 PF01111 0.487
DOC_MAPK_gen_1 87 96 PF00069 0.508
DOC_MAPK_MEF2A_6 140 149 PF00069 0.516
DOC_MAPK_MEF2A_6 89 98 PF00069 0.531
DOC_PP1_RVXF_1 109 115 PF00149 0.380
DOC_PP1_RVXF_1 138 144 PF00149 0.444
DOC_PP1_RVXF_1 146 153 PF00149 0.654
DOC_PP4_FxxP_1 152 155 PF00568 0.664
DOC_PP4_FxxP_1 79 82 PF00568 0.582
DOC_USP7_MATH_1 234 238 PF00917 0.667
DOC_WW_Pin1_4 185 190 PF00397 0.750
DOC_WW_Pin1_4 217 222 PF00397 0.687
DOC_WW_Pin1_4 232 237 PF00397 0.732
DOC_WW_Pin1_4 238 243 PF00397 0.727
DOC_WW_Pin1_4 265 270 PF00397 0.693
DOC_WW_Pin1_4 38 43 PF00397 0.480
LIG_14-3-3_CanoR_1 14 19 PF00244 0.490
LIG_14-3-3_CanoR_1 211 219 PF00244 0.773
LIG_14-3-3_CanoR_1 259 267 PF00244 0.640
LIG_14-3-3_CanoR_1 45 55 PF00244 0.382
LIG_BRCT_BRCA1_1 63 67 PF00533 0.304
LIG_EH1_1 143 151 PF00400 0.485
LIG_EH1_1 53 61 PF00400 0.280
LIG_FHA_1 108 114 PF00498 0.381
LIG_FHA_1 136 142 PF00498 0.413
LIG_FHA_1 18 24 PF00498 0.340
LIG_FHA_1 195 201 PF00498 0.723
LIG_FHA_2 221 227 PF00498 0.742
LIG_GBD_Chelix_1 55 63 PF00786 0.374
LIG_LIR_Apic_2 237 242 PF02991 0.775
LIG_LIR_Gen_1 133 144 PF02991 0.356
LIG_LIR_Gen_1 28 36 PF02991 0.425
LIG_LIR_Nem_3 133 139 PF02991 0.344
LIG_LIR_Nem_3 28 33 PF02991 0.425
LIG_MAD2 111 119 PF02301 0.461
LIG_MLH1_MIPbox_1 63 67 PF16413 0.194
LIG_PDZ_Class_2 273 278 PF00595 0.746
LIG_Pex14_1 114 118 PF04695 0.354
LIG_Pex14_1 75 79 PF04695 0.553
LIG_Pex14_2 21 25 PF04695 0.369
LIG_SH2_CRK 136 140 PF00017 0.344
LIG_SH2_STAT5 127 130 PF00017 0.444
LIG_SH2_STAT5 164 167 PF00017 0.633
LIG_SH2_STAT5 219 222 PF00017 0.712
LIG_SH2_STAT5 54 57 PF00017 0.491
LIG_SH3_3 36 42 PF00018 0.465
LIG_TRAF2_2 253 258 PF00917 0.610
LIG_TYR_ITIM 134 139 PF00017 0.429
LIG_TYR_ITIM 52 57 PF00017 0.382
LIG_UBA3_1 145 151 PF00899 0.599
LIG_WRC_WIRS_1 18 23 PF05994 0.444
MOD_CDK_SPK_2 265 270 PF00069 0.663
MOD_CDK_SPxxK_3 38 45 PF00069 0.412
MOD_CK1_1 205 211 PF00069 0.693
MOD_CK1_1 241 247 PF00069 0.771
MOD_CK1_1 261 267 PF00069 0.579
MOD_CK1_1 268 274 PF00069 0.692
MOD_CK1_1 28 34 PF00069 0.427
MOD_CK1_1 44 50 PF00069 0.275
MOD_GlcNHglycan 190 193 PF01048 0.472
MOD_GlcNHglycan 212 215 PF01048 0.572
MOD_GlcNHglycan 261 264 PF01048 0.629
MOD_GlcNHglycan 270 273 PF01048 0.572
MOD_GSK3_1 10 17 PF00069 0.565
MOD_GSK3_1 130 137 PF00069 0.363
MOD_GSK3_1 184 191 PF00069 0.736
MOD_GSK3_1 234 241 PF00069 0.772
MOD_GSK3_1 261 268 PF00069 0.641
MOD_GSK3_1 34 41 PF00069 0.563
MOD_N-GLC_1 162 167 PF02516 0.502
MOD_NEK2_1 134 139 PF00069 0.366
MOD_NEK2_1 25 30 PF00069 0.374
MOD_NEK2_1 46 51 PF00069 0.378
MOD_NEK2_1 55 60 PF00069 0.330
MOD_NEK2_1 67 72 PF00069 0.344
MOD_NEK2_1 9 14 PF00069 0.582
MOD_NEK2_2 135 140 PF00069 0.194
MOD_NEK2_2 194 199 PF00069 0.720
MOD_NEK2_2 61 66 PF00069 0.194
MOD_PIKK_1 251 257 PF00454 0.736
MOD_PIKK_1 47 53 PF00454 0.376
MOD_PKA_1 259 265 PF00069 0.612
MOD_PKA_2 210 216 PF00069 0.767
MOD_PKA_2 251 257 PF00069 0.739
MOD_PKA_2 258 264 PF00069 0.685
MOD_PKA_2 44 50 PF00069 0.394
MOD_Plk_1 245 251 PF00069 0.761
MOD_Plk_4 14 20 PF00069 0.495
MOD_Plk_4 194 200 PF00069 0.746
MOD_Plk_4 25 31 PF00069 0.331
MOD_Plk_4 34 40 PF00069 0.230
MOD_Plk_4 55 61 PF00069 0.366
MOD_Plk_4 67 73 PF00069 0.344
MOD_ProDKin_1 185 191 PF00069 0.750
MOD_ProDKin_1 217 223 PF00069 0.686
MOD_ProDKin_1 232 238 PF00069 0.733
MOD_ProDKin_1 265 271 PF00069 0.692
MOD_ProDKin_1 38 44 PF00069 0.478
TRG_DiLeu_BaLyEn_6 145 150 PF01217 0.612
TRG_ENDOCYTIC_2 136 139 PF00928 0.344
TRG_ENDOCYTIC_2 54 57 PF00928 0.344
TRG_ER_diArg_1 88 90 PF00400 0.541
TRG_NLS_MonoCore_2 86 91 PF00514 0.558

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4T3 Leptomonas seymouri 47% 95%
A0A0S4KLI9 Bodo saltans 43% 100%
A0A3Q8IV65 Leishmania donovani 86% 100%
A0A3R7M240 Trypanosoma rangeli 46% 100%
A4HMI9 Leishmania braziliensis 63% 100%
A4IB69 Leishmania infantum 85% 100%
E9AEZ0 Leishmania major 83% 100%
V5B3X7 Trypanosoma cruzi 38% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS