Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B643_LEIMU

TriTrypDb:

LmxM.34.1650

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

E9B643

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B643

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	11
GO:0030705	cytoskeleton-dependent intracellular transport	4	11
GO:0031503	protein-containing complex localization	2	11
GO:0035735	intraciliary transport involved in cilium assembly	4	11
GO:0042073	intraciliary transport	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0099111	microtubule-based transport	4	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.574
CLV_NRD_NRD_1	123	125	PF00675	0.649
CLV_NRD_NRD_1	142	144	PF00675	0.569
CLV_NRD_NRD_1	165	167	PF00675	0.544
CLV_NRD_NRD_1	206	208	PF00675	0.518
CLV_NRD_NRD_1	298	300	PF00675	0.640
CLV_NRD_NRD_1	331	333	PF00675	0.565
CLV_NRD_NRD_1	337	339	PF00675	0.586
CLV_NRD_NRD_1	429	431	PF00675	0.565
CLV_NRD_NRD_1	75	77	PF00675	0.617
CLV_PCSK_KEX2_1	110	112	PF00082	0.587
CLV_PCSK_KEX2_1	123	125	PF00082	0.540
CLV_PCSK_KEX2_1	167	169	PF00082	0.604
CLV_PCSK_KEX2_1	206	208	PF00082	0.518
CLV_PCSK_KEX2_1	240	242	PF00082	0.480
CLV_PCSK_KEX2_1	298	300	PF00082	0.640
CLV_PCSK_KEX2_1	331	333	PF00082	0.551
CLV_PCSK_KEX2_1	337	339	PF00082	0.559
CLV_PCSK_KEX2_1	349	351	PF00082	0.509
CLV_PCSK_KEX2_1	532	534	PF00082	0.565
CLV_PCSK_KEX2_1	75	77	PF00082	0.617
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.587
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.635
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.449
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.660
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.565
CLV_PCSK_SKI1_1	167	171	PF00082	0.528
CLV_PCSK_SKI1_1	240	244	PF00082	0.466
CLV_PCSK_SKI1_1	361	365	PF00082	0.557
CLV_PCSK_SKI1_1	397	401	PF00082	0.608
CLV_PCSK_SKI1_1	402	406	PF00082	0.601
CLV_PCSK_SKI1_1	635	639	PF00082	0.646
CLV_Separin_Metazoa	362	366	PF03568	0.649
DEG_APCC_KENBOX_2	605	609	PF00400	0.614
DEG_Nend_UBRbox_3	1	3	PF02207	0.610
DEG_SPOP_SBC_1	40	44	PF00917	0.653
DOC_MAPK_DCC_7	75	85	PF00069	0.768
DOC_MAPK_gen_1	109	117	PF00069	0.521
DOC_MAPK_gen_1	358	366	PF00069	0.670
DOC_MAPK_gen_1	397	407	PF00069	0.580
DOC_MAPK_gen_1	475	484	PF00069	0.569
DOC_MAPK_MEF2A_6	400	407	PF00069	0.590
DOC_MAPK_MEF2A_6	475	484	PF00069	0.601
DOC_MAPK_MEF2A_6	76	85	PF00069	0.773
DOC_MAPK_NFAT4_5	400	408	PF00069	0.589
DOC_USP7_MATH_1	215	219	PF00917	0.569
DOC_USP7_MATH_1	380	384	PF00917	0.508
DOC_USP7_MATH_1	40	44	PF00917	0.646
DOC_USP7_MATH_1	455	459	PF00917	0.721
DOC_USP7_MATH_1	497	501	PF00917	0.629
DOC_USP7_MATH_1	54	58	PF00917	0.734
DOC_USP7_MATH_1	74	78	PF00917	0.697
DOC_WW_Pin1_4	50	55	PF00397	0.690
DOC_WW_Pin1_4	59	64	PF00397	0.680
DOC_WW_Pin1_4	76	81	PF00397	0.758
LIG_14-3-3_CanoR_1	572	579	PF00244	0.606
LIG_14-3-3_CanoR_1	611	620	PF00244	0.571
LIG_14-3-3_CanoR_1	75	83	PF00244	0.764
LIG_Actin_WH2_2	144	161	PF00022	0.636
LIG_deltaCOP1_diTrp_1	538	548	PF00928	0.443
LIG_FHA_1	187	193	PF00498	0.492
LIG_FHA_1	380	386	PF00498	0.650
LIG_FHA_1	387	393	PF00498	0.632
LIG_FHA_1	40	46	PF00498	0.665
LIG_FHA_1	440	446	PF00498	0.592
LIG_FHA_1	548	554	PF00498	0.553
LIG_FHA_1	565	571	PF00498	0.380
LIG_FHA_2	17	23	PF00498	0.645
LIG_FHA_2	491	497	PF00498	0.582
LIG_FHA_2	602	608	PF00498	0.576
LIG_HCF-1_HBM_1	342	345	PF13415	0.639
LIG_LIR_Gen_1	33	41	PF02991	0.613
LIG_LIR_Gen_1	468	476	PF02991	0.569
LIG_LIR_Nem_3	104	108	PF02991	0.567
LIG_LIR_Nem_3	33	38	PF02991	0.615
LIG_LIR_Nem_3	468	473	PF02991	0.651
LIG_PDZ_Class_2	634	639	PF00595	0.602
LIG_RPA_C_Fungi	255	267	PF08784	0.484
LIG_RPA_C_Fungi	494	506	PF08784	0.629
LIG_SH2_GRB2like	272	275	PF00017	0.586
LIG_SH2_PTP2	470	473	PF00017	0.679
LIG_SH2_SRC	12	15	PF00017	0.550
LIG_SH2_STAP1	272	276	PF00017	0.586
LIG_SH2_STAP1	530	534	PF00017	0.580
LIG_SH2_STAT3	345	348	PF00017	0.630
LIG_SH2_STAT5	105	108	PF00017	0.591
LIG_SH2_STAT5	12	15	PF00017	0.507
LIG_SH2_STAT5	421	424	PF00017	0.553
LIG_SH2_STAT5	470	473	PF00017	0.603
LIG_SH2_STAT5	530	533	PF00017	0.613
LIG_SUMO_SIM_anti_2	253	259	PF11976	0.487
LIG_SUMO_SIM_anti_2	483	489	PF11976	0.550
LIG_SUMO_SIM_par_1	599	604	PF11976	0.473
LIG_SUMO_SIM_par_1	614	622	PF11976	0.435
LIG_TRAF2_1	179	182	PF00917	0.602
LIG_TRAF2_1	224	227	PF00917	0.558
LIG_TRAF2_1	289	292	PF00917	0.495
LIG_TRAF2_1	414	417	PF00917	0.561
LIG_TRAF2_1	566	569	PF00917	0.611
LIG_TRAF2_1	619	622	PF00917	0.590
LIG_WW_3	72	76	PF00397	0.599
MOD_CDK_SPxxK_3	63	70	PF00069	0.721
MOD_CK1_1	218	224	PF00069	0.588
MOD_CK1_1	34	40	PF00069	0.679
MOD_CK1_1	368	374	PF00069	0.633
MOD_CK1_1	528	534	PF00069	0.616
MOD_CK1_1	79	85	PF00069	0.677
MOD_CK1_1	86	92	PF00069	0.589
MOD_CK2_1	16	22	PF00069	0.640
MOD_CK2_1	286	292	PF00069	0.522
MOD_CK2_1	373	379	PF00069	0.614
MOD_CK2_1	490	496	PF00069	0.537
MOD_CK2_1	497	503	PF00069	0.551
MOD_CK2_1	517	523	PF00069	0.295
MOD_CK2_1	572	578	PF00069	0.558
MOD_CK2_1	601	607	PF00069	0.520
MOD_CK2_1	616	622	PF00069	0.589
MOD_CK2_1	93	99	PF00069	0.461
MOD_DYRK1A_RPxSP_1	76	80	PF00069	0.789
MOD_GlcNHglycan	14	17	PF01048	0.642
MOD_GlcNHglycan	457	460	PF01048	0.760
MOD_GlcNHglycan	519	522	PF01048	0.622
MOD_GlcNHglycan	76	79	PF01048	0.644
MOD_GlcNHglycan	85	88	PF01048	0.568
MOD_GlcNHglycan	95	98	PF01048	0.550
MOD_GlcNHglycan	99	102	PF01048	0.657
MOD_GSK3_1	214	221	PF00069	0.526
MOD_GSK3_1	242	249	PF00069	0.505
MOD_GSK3_1	27	34	PF00069	0.691
MOD_GSK3_1	365	372	PF00069	0.627
MOD_GSK3_1	455	462	PF00069	0.689
MOD_GSK3_1	50	57	PF00069	0.694
MOD_GSK3_1	528	535	PF00069	0.581
MOD_GSK3_1	59	66	PF00069	0.700
MOD_GSK3_1	79	86	PF00069	0.621
MOD_GSK3_1	8	15	PF00069	0.607
MOD_GSK3_1	93	100	PF00069	0.589
MOD_N-GLC_1	497	502	PF02516	0.600
MOD_N-GLC_1	512	517	PF02516	0.574
MOD_N-GLC_1	59	64	PF02516	0.777
MOD_NEK2_1	158	163	PF00069	0.586
MOD_NEK2_1	208	213	PF00069	0.543
MOD_NEK2_1	31	36	PF00069	0.706
MOD_NEK2_1	41	46	PF00069	0.601
MOD_NEK2_2	215	220	PF00069	0.573
MOD_PIKK_1	16	22	PF00454	0.625
MOD_PIKK_1	547	553	PF00454	0.558
MOD_PIKK_1	564	570	PF00454	0.573
MOD_PIKK_1	590	596	PF00454	0.576
MOD_PK_1	286	292	PF00069	0.568
MOD_PK_1	532	538	PF00069	0.604
MOD_PKA_1	532	538	PF00069	0.604
MOD_PKA_2	158	164	PF00069	0.566
MOD_PKA_2	386	392	PF00069	0.634
MOD_PKA_2	459	465	PF00069	0.664
MOD_PKA_2	532	538	PF00069	0.604
MOD_PKA_2	74	80	PF00069	0.793
MOD_PKB_1	315	323	PF00069	0.659
MOD_Plk_1	243	249	PF00069	0.483
MOD_Plk_1	27	33	PF00069	0.663
MOD_Plk_1	286	292	PF00069	0.522
MOD_Plk_1	590	596	PF00069	0.483
MOD_Plk_1	606	612	PF00069	0.487
MOD_Plk_2-3	22	28	PF00069	0.663
MOD_Plk_2-3	373	379	PF00069	0.614
MOD_Plk_2-3	580	586	PF00069	0.523
MOD_Plk_2-3	622	628	PF00069	0.586
MOD_Plk_4	101	107	PF00069	0.631
MOD_Plk_4	34	40	PF00069	0.687
MOD_Plk_4	41	47	PF00069	0.723
MOD_Plk_4	532	538	PF00069	0.604
MOD_Plk_4	8	14	PF00069	0.510
MOD_Plk_4	88	94	PF00069	0.691
MOD_ProDKin_1	50	56	PF00069	0.688
MOD_ProDKin_1	59	65	PF00069	0.681
MOD_ProDKin_1	76	82	PF00069	0.756
MOD_SUMO_for_1	169	172	PF00179	0.591
MOD_SUMO_for_1	179	182	PF00179	0.586
MOD_SUMO_rev_2	160	169	PF00179	0.617
MOD_SUMO_rev_2	232	242	PF00179	0.425
MOD_SUMO_rev_2	287	295	PF00179	0.494
MOD_SUMO_rev_2	342	351	PF00179	0.590
MOD_SUMO_rev_2	520	526	PF00179	0.621
MOD_SUMO_rev_2	575	584	PF00179	0.588
TRG_DiLeu_BaEn_1	300	305	PF01217	0.637
TRG_DiLeu_BaEn_4	328	334	PF01217	0.613
TRG_ENDOCYTIC_2	105	108	PF00928	0.534
TRG_ENDOCYTIC_2	470	473	PF00928	0.607
TRG_ER_diArg_1	122	124	PF00400	0.654
TRG_ER_diArg_1	129	132	PF00400	0.577
TRG_ER_diArg_1	166	169	PF00400	0.542
TRG_ER_diArg_1	192	195	PF00400	0.578
TRG_ER_diArg_1	205	207	PF00400	0.503
TRG_ER_diArg_1	276	279	PF00400	0.498
TRG_ER_diArg_1	297	299	PF00400	0.615
TRG_ER_diArg_1	331	333	PF00400	0.636
TRG_ER_diArg_1	74	76	PF00400	0.790
TRG_NES_CRM1_1	181	196	PF08389	0.564
TRG_NES_CRM1_1	394	406	PF08389	0.586
TRG_NES_CRM1_1	615	630	PF08389	0.547
TRG_NLS_MonoExtC_3	166	172	PF00514	0.621
TRG_NLS_MonoExtN_4	166	171	PF00514	0.627
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	350	355	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	543	547	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Z0	Leptomonas seymouri	71%	95%
A0A0S4J233	Bodo saltans	30%	78%
A0A1X0P6M5	Trypanosomatidae	46%	100%
A0A3Q8IHW5	Leishmania donovani	96%	100%
A4HMI6	Leishmania braziliensis	90%	100%
A4IB66	Leishmania infantum	96%	100%
C9ZZH6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	97%
E9AEY7	Leishmania major	96%	100%
V5BTK9	Trypanosoma cruzi	45%	96%