Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B641_LEIMU

TriTrypDb:

LmxM.34.1630

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B641

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B641

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.547
CLV_NRD_NRD_1	117	119	PF00675	0.321
CLV_NRD_NRD_1	235	237	PF00675	0.683
CLV_NRD_NRD_1	244	246	PF00675	0.716
CLV_NRD_NRD_1	249	251	PF00675	0.631
CLV_NRD_NRD_1	341	343	PF00675	0.706
CLV_NRD_NRD_1	376	378	PF00675	0.652
CLV_NRD_NRD_1	424	426	PF00675	0.691
CLV_PCSK_KEX2_1	117	119	PF00082	0.321
CLV_PCSK_KEX2_1	243	245	PF00082	0.747
CLV_PCSK_KEX2_1	249	251	PF00082	0.667
CLV_PCSK_KEX2_1	340	342	PF00082	0.762
CLV_PCSK_KEX2_1	376	378	PF00082	0.652
CLV_PCSK_PC7_1	245	251	PF00082	0.750
CLV_PCSK_SKI1_1	118	122	PF00082	0.410
CLV_PCSK_SKI1_1	244	248	PF00082	0.725
DEG_APCC_DBOX_1	116	124	PF00400	0.479
DOC_CKS1_1	252	257	PF01111	0.588
DOC_CKS1_1	56	61	PF01111	0.606
DOC_MAPK_gen_1	117	124	PF00069	0.311
DOC_MAPK_MEF2A_6	117	124	PF00069	0.408
DOC_MAPK_MEF2A_6	37	45	PF00069	0.580
DOC_MAPK_NFAT4_5	117	125	PF00069	0.408
DOC_MAPK_RevD_3	328	343	PF00069	0.691
DOC_USP7_MATH_1	145	149	PF00917	0.563
DOC_USP7_MATH_1	170	174	PF00917	0.695
DOC_USP7_MATH_1	204	208	PF00917	0.647
DOC_USP7_MATH_1	280	284	PF00917	0.706
DOC_USP7_MATH_1	345	349	PF00917	0.706
DOC_USP7_MATH_1	350	354	PF00917	0.697
DOC_USP7_MATH_1	57	61	PF00917	0.529
DOC_USP7_UBL2_3	237	241	PF12436	0.738
DOC_WW_Pin1_4	172	177	PF00397	0.459
DOC_WW_Pin1_4	218	223	PF00397	0.768
DOC_WW_Pin1_4	251	256	PF00397	0.776
DOC_WW_Pin1_4	328	333	PF00397	0.657
DOC_WW_Pin1_4	405	410	PF00397	0.709
DOC_WW_Pin1_4	55	60	PF00397	0.599
LIG_14-3-3_CanoR_1	168	176	PF00244	0.471
LIG_14-3-3_CanoR_1	346	355	PF00244	0.717
LIG_14-3-3_CanoR_1	398	403	PF00244	0.609
LIG_14-3-3_CanoR_1	8	13	PF00244	0.573
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_BRCT_BRCA1_1	9	13	PF00533	0.263
LIG_Clathr_ClatBox_1	15	19	PF01394	0.523
LIG_FHA_1	210	216	PF00498	0.726
LIG_FHA_1	321	327	PF00498	0.706
LIG_FHA_1	334	340	PF00498	0.729
LIG_FHA_1	64	70	PF00498	0.549
LIG_FHA_2	130	136	PF00498	0.597
LIG_FHA_2	194	200	PF00498	0.715
LIG_FHA_2	261	267	PF00498	0.738
LIG_LIR_Gen_1	10	21	PF02991	0.489
LIG_LIR_Gen_1	119	129	PF02991	0.501
LIG_LIR_Gen_1	30	41	PF02991	0.351
LIG_LIR_Gen_1	413	424	PF02991	0.733
LIG_LIR_Nem_3	10	16	PF02991	0.482
LIG_LIR_Nem_3	119	124	PF02991	0.474
LIG_LIR_Nem_3	30	36	PF02991	0.497
LIG_LIR_Nem_3	38	43	PF02991	0.535
LIG_LIR_Nem_3	413	419	PF02991	0.739
LIG_LIR_Nem_3	78	82	PF02991	0.403
LIG_PDZ_Class_2	431	436	PF00595	0.628
LIG_SH2_NCK_1	252	256	PF00017	0.688
LIG_SH2_NCK_1	390	394	PF00017	0.732
LIG_SH2_PTP2	40	43	PF00017	0.548
LIG_SH2_SRC	40	43	PF00017	0.446
LIG_SH2_STAP1	293	297	PF00017	0.502
LIG_SH2_STAP1	390	394	PF00017	0.513
LIG_SH2_STAT5	293	296	PF00017	0.601
LIG_SH2_STAT5	307	310	PF00017	0.507
LIG_SH2_STAT5	40	43	PF00017	0.446
LIG_SH3_1	252	258	PF00018	0.801
LIG_SH3_3	227	233	PF00018	0.625
LIG_SH3_3	252	258	PF00018	0.801
LIG_SH3_3	329	335	PF00018	0.700
LIG_SH3_3	357	363	PF00018	0.647
LIG_SUMO_SIM_par_1	320	327	PF11976	0.529
LIG_TRAF2_2	230	235	PF00917	0.746
LIG_WW_3	359	363	PF00397	0.689
MOD_CAAXbox	433	436	PF01239	0.629
MOD_CDC14_SPxK_1	331	334	PF00782	0.512
MOD_CDK_SPxK_1	328	334	PF00069	0.561
MOD_CK1_1	190	196	PF00069	0.642
MOD_CK1_1	368	374	PF00069	0.574
MOD_CK1_1	403	409	PF00069	0.557
MOD_CK2_1	113	119	PF00069	0.462
MOD_CK2_1	129	135	PF00069	0.593
MOD_CK2_1	166	172	PF00069	0.453
MOD_CK2_1	193	199	PF00069	0.716
MOD_CK2_1	260	266	PF00069	0.738
MOD_CK2_1	293	299	PF00069	0.717
MOD_CK2_1	407	413	PF00069	0.718
MOD_GlcNHglycan	108	112	PF01048	0.563
MOD_GlcNHglycan	125	128	PF01048	0.427
MOD_GlcNHglycan	147	150	PF01048	0.549
MOD_GlcNHglycan	168	171	PF01048	0.493
MOD_GlcNHglycan	176	179	PF01048	0.527
MOD_GlcNHglycan	225	228	PF01048	0.787
MOD_GlcNHglycan	278	281	PF01048	0.585
MOD_GlcNHglycan	295	298	PF01048	0.571
MOD_GlcNHglycan	348	351	PF01048	0.664
MOD_GlcNHglycan	367	370	PF01048	0.814
MOD_GlcNHglycan	402	405	PF01048	0.600
MOD_GlcNHglycan	409	412	PF01048	0.589
MOD_GlcNHglycan	427	430	PF01048	0.465
MOD_GlcNHglycan	59	62	PF01048	0.482
MOD_GSK3_1	103	110	PF00069	0.592
MOD_GSK3_1	123	130	PF00069	0.340
MOD_GSK3_1	166	173	PF00069	0.588
MOD_GSK3_1	188	195	PF00069	0.615
MOD_GSK3_1	204	211	PF00069	0.714
MOD_GSK3_1	276	283	PF00069	0.670
MOD_GSK3_1	311	318	PF00069	0.659
MOD_GSK3_1	346	353	PF00069	0.713
MOD_GSK3_1	388	395	PF00069	0.734
MOD_GSK3_1	403	410	PF00069	0.538
MOD_GSK3_1	414	421	PF00069	0.662
MOD_N-GLC_1	346	351	PF02516	0.722
MOD_N-GLC_2	162	164	PF02516	0.335
MOD_NEK2_1	122	127	PF00069	0.519
MOD_NEK2_1	205	210	PF00069	0.547
MOD_NEK2_1	315	320	PF00069	0.665
MOD_NEK2_1	418	423	PF00069	0.754
MOD_NEK2_1	424	429	PF00069	0.770
MOD_NEK2_1	65	70	PF00069	0.508
MOD_PIKK_1	315	321	PF00454	0.818
MOD_PK_1	398	404	PF00069	0.608
MOD_PK_1	8	14	PF00069	0.467
MOD_PKA_1	425	431	PF00069	0.582
MOD_PKA_2	345	351	PF00069	0.606
MOD_PKA_2	36	42	PF00069	0.367
MOD_PKA_2	382	388	PF00069	0.678
MOD_PKA_2	424	430	PF00069	0.590
MOD_PKA_2	7	13	PF00069	0.279
MOD_PKB_1	166	174	PF00069	0.603
MOD_Plk_1	188	194	PF00069	0.597
MOD_Plk_1	414	420	PF00069	0.527
MOD_Plk_4	36	42	PF00069	0.390
MOD_Plk_4	8	14	PF00069	0.467
MOD_ProDKin_1	172	178	PF00069	0.463
MOD_ProDKin_1	218	224	PF00069	0.765
MOD_ProDKin_1	251	257	PF00069	0.774
MOD_ProDKin_1	328	334	PF00069	0.656
MOD_ProDKin_1	405	411	PF00069	0.710
MOD_ProDKin_1	55	61	PF00069	0.597
TRG_ENDOCYTIC_2	40	43	PF00928	0.548
TRG_ER_diArg_1	242	245	PF00400	0.660
TRG_ER_diArg_1	339	342	PF00400	0.765
TRG_ER_diArg_1	376	379	PF00400	0.540
TRG_NES_CRM1_1	152	165	PF08389	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P595	Leptomonas seymouri	37%	87%
A0A3S7X927	Leishmania donovani	73%	91%
A4HMI4	Leishmania braziliensis	47%	91%
A4IB64	Leishmania infantum	73%	91%
E9AEY5	Leishmania major	73%	99%