Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B639_LEIMU

TriTrypDb:

LmxM.34.1610

Length:

953

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9B639

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B639

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	907	911	PF00656	0.763
CLV_NRD_NRD_1	203	205	PF00675	0.660
CLV_NRD_NRD_1	269	271	PF00675	0.761
CLV_NRD_NRD_1	339	341	PF00675	0.724
CLV_NRD_NRD_1	522	524	PF00675	0.444
CLV_NRD_NRD_1	621	623	PF00675	0.313
CLV_NRD_NRD_1	825	827	PF00675	0.398
CLV_PCSK_KEX2_1	269	271	PF00082	0.761
CLV_PCSK_KEX2_1	339	341	PF00082	0.724
CLV_PCSK_KEX2_1	469	471	PF00082	0.386
CLV_PCSK_KEX2_1	522	524	PF00082	0.477
CLV_PCSK_KEX2_1	621	623	PF00082	0.313
CLV_PCSK_KEX2_1	645	647	PF00082	0.510
CLV_PCSK_KEX2_1	825	827	PF00082	0.366
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.386
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.510
CLV_PCSK_SKI1_1	27	31	PF00082	0.472
CLV_PCSK_SKI1_1	315	319	PF00082	0.569
CLV_PCSK_SKI1_1	505	509	PF00082	0.549
CLV_PCSK_SKI1_1	528	532	PF00082	0.510
CLV_PCSK_SKI1_1	732	736	PF00082	0.522
CLV_PCSK_SKI1_1	802	806	PF00082	0.438
CLV_PCSK_SKI1_1	851	855	PF00082	0.688
DEG_APCC_DBOX_1	26	34	PF00400	0.660
DEG_APCC_DBOX_1	504	512	PF00400	0.733
DEG_APCC_DBOX_1	570	578	PF00400	0.398
DEG_Nend_Nbox_1	1	3	PF02207	0.721
DEG_SCF_FBW7_1	256	261	PF00400	0.376
DEG_SCF_FBW7_1	891	898	PF00400	0.674
DEG_SPOP_SBC_1	341	345	PF00917	0.480
DEG_SPOP_SBC_1	378	382	PF00917	0.470
DOC_CDC14_PxL_1	155	163	PF14671	0.521
DOC_CDC14_PxL_1	552	560	PF14671	0.440
DOC_CKS1_1	892	897	PF01111	0.737
DOC_CYCLIN_RxL_1	729	736	PF00134	0.669
DOC_CYCLIN_RxL_1	799	809	PF00134	0.201
DOC_MAPK_gen_1	304	314	PF00069	0.429
DOC_MAPK_gen_1	469	477	PF00069	0.589
DOC_MAPK_gen_1	621	629	PF00069	0.641
DOC_MAPK_gen_1	825	831	PF00069	0.573
DOC_MAPK_gen_1	851	860	PF00069	0.342
DOC_MAPK_MEF2A_6	402	409	PF00069	0.491
DOC_MAPK_MEF2A_6	419	427	PF00069	0.360
DOC_MAPK_MEF2A_6	567	576	PF00069	0.503
DOC_MAPK_MEF2A_6	851	860	PF00069	0.341
DOC_PP2B_LxvP_1	142	145	PF13499	0.595
DOC_PP2B_LxvP_1	193	196	PF13499	0.548
DOC_USP7_MATH_1	187	191	PF00917	0.484
DOC_USP7_MATH_1	258	262	PF00917	0.453
DOC_USP7_MATH_1	325	329	PF00917	0.538
DOC_USP7_MATH_1	350	354	PF00917	0.479
DOC_USP7_MATH_1	378	382	PF00917	0.496
DOC_USP7_MATH_1	512	516	PF00917	0.723
DOC_USP7_MATH_1	526	530	PF00917	0.656
DOC_USP7_MATH_1	543	547	PF00917	0.246
DOC_USP7_MATH_1	791	795	PF00917	0.627
DOC_USP7_MATH_1	906	910	PF00917	0.717
DOC_WW_Pin1_4	148	153	PF00397	0.557
DOC_WW_Pin1_4	174	179	PF00397	0.512
DOC_WW_Pin1_4	185	190	PF00397	0.521
DOC_WW_Pin1_4	254	259	PF00397	0.496
DOC_WW_Pin1_4	323	328	PF00397	0.475
DOC_WW_Pin1_4	891	896	PF00397	0.686
LIG_14-3-3_CanoR_1	162	167	PF00244	0.476
LIG_14-3-3_CanoR_1	221	229	PF00244	0.464
LIG_14-3-3_CanoR_1	274	282	PF00244	0.514
LIG_14-3-3_CanoR_1	444	448	PF00244	0.682
LIG_14-3-3_CanoR_1	538	542	PF00244	0.560
LIG_14-3-3_CanoR_1	571	575	PF00244	0.398
LIG_14-3-3_CanoR_1	621	630	PF00244	0.730
LIG_14-3-3_CanoR_1	876	880	PF00244	0.721
LIG_14-3-3_CanoR_1	899	903	PF00244	0.779
LIG_14-3-3_CanoR_1	945	949	PF00244	0.710
LIG_Actin_WH2_2	188	206	PF00022	0.380
LIG_Actin_WH2_2	294	311	PF00022	0.453
LIG_BRCT_BRCA1_1	100	104	PF00533	0.438
LIG_CSL_BTD_1	745	748	PF09270	0.738
LIG_deltaCOP1_diTrp_1	769	774	PF00928	0.470
LIG_EH1_1	417	425	PF00400	0.462
LIG_EH1_1	776	784	PF00400	0.438
LIG_eIF4E_1	31	37	PF01652	0.540
LIG_EVH1_2	330	334	PF00568	0.430
LIG_EVH1_2	748	752	PF00568	0.663
LIG_FHA_1	179	185	PF00498	0.533
LIG_FHA_1	198	204	PF00498	0.554
LIG_FHA_1	230	236	PF00498	0.470
LIG_FHA_1	24	30	PF00498	0.267
LIG_FHA_1	246	252	PF00498	0.561
LIG_FHA_1	435	441	PF00498	0.389
LIG_FHA_1	537	543	PF00498	0.522
LIG_FHA_1	571	577	PF00498	0.304
LIG_FHA_1	705	711	PF00498	0.376
LIG_FHA_1	74	80	PF00498	0.455
LIG_FHA_1	779	785	PF00498	0.306
LIG_FHA_1	861	867	PF00498	0.422
LIG_FHA_2	122	128	PF00498	0.516
LIG_FHA_2	145	151	PF00498	0.534
LIG_FHA_2	331	337	PF00498	0.579
LIG_FHA_2	842	848	PF00498	0.417
LIG_FHA_2	918	924	PF00498	0.637
LIG_GBD_Chelix_1	858	866	PF00786	0.422
LIG_GBD_Chelix_1	883	891	PF00786	0.492
LIG_LIR_Apic_2	43	48	PF02991	0.394
LIG_LIR_Apic_2	745	749	PF02991	0.735
LIG_LIR_Apic_2	800	806	PF02991	0.373
LIG_LIR_Gen_1	165	172	PF02991	0.522
LIG_LIR_Gen_1	276	287	PF02991	0.533
LIG_LIR_Gen_1	651	659	PF02991	0.500
LIG_LIR_Gen_1	74	82	PF02991	0.415
LIG_LIR_Nem_3	100	105	PF02991	0.374
LIG_LIR_Nem_3	165	170	PF02991	0.521
LIG_LIR_Nem_3	276	282	PF02991	0.511
LIG_LIR_Nem_3	318	324	PF02991	0.411
LIG_LIR_Nem_3	651	655	PF02991	0.522
LIG_LIR_Nem_3	7	13	PF02991	0.529
LIG_LIR_Nem_3	74	78	PF02991	0.429
LIG_LIR_Nem_3	769	775	PF02991	0.432
LIG_LIR_Nem_3	847	853	PF02991	0.407
LIG_LIR_Nem_3	93	99	PF02991	0.678
LIG_MAD2	136	144	PF02301	0.536
LIG_MYND_1	140	144	PF01753	0.539
LIG_NRBOX	852	858	PF00104	0.368
LIG_NRBOX	865	871	PF00104	0.422
LIG_PCNA_yPIPBox_3	621	633	PF02747	0.718
LIG_PCNA_yPIPBox_3	842	854	PF02747	0.450
LIG_Pex14_1	566	570	PF04695	0.448
LIG_Pex14_2	560	564	PF04695	0.323
LIG_Pex14_2	584	588	PF04695	0.279
LIG_Pex14_2	813	817	PF04695	0.391
LIG_SH2_CRK	10	14	PF00017	0.410
LIG_SH2_CRK	279	283	PF00017	0.516
LIG_SH2_CRK	45	49	PF00017	0.394
LIG_SH2_CRK	850	854	PF00017	0.452
LIG_SH2_GRB2like	167	170	PF00017	0.361
LIG_SH2_NCK_1	447	451	PF00017	0.593
LIG_SH2_SRC	167	170	PF00017	0.426
LIG_SH2_STAP1	105	109	PF00017	0.492
LIG_SH2_STAP1	247	251	PF00017	0.500
LIG_SH2_STAP1	562	566	PF00017	0.488
LIG_SH2_STAP1	650	654	PF00017	0.541
LIG_SH2_STAP1	797	801	PF00017	0.366
LIG_SH2_STAT5	247	250	PF00017	0.592
LIG_SH2_STAT5	279	282	PF00017	0.514
LIG_SH2_STAT5	416	419	PF00017	0.476
LIG_SH2_STAT5	45	48	PF00017	0.369
LIG_SH2_STAT5	632	635	PF00017	0.643
LIG_SH2_STAT5	773	776	PF00017	0.350
LIG_SH2_STAT5	803	806	PF00017	0.335
LIG_SH2_STAT5	812	815	PF00017	0.335
LIG_SH2_STAT5	830	833	PF00017	0.412
LIG_SH3_1	324	330	PF00018	0.372
LIG_SH3_3	109	115	PF00018	0.465
LIG_SH3_3	134	140	PF00018	0.540
LIG_SH3_3	153	159	PF00018	0.572
LIG_SH3_3	186	192	PF00018	0.550
LIG_SH3_3	250	256	PF00018	0.387
LIG_SH3_3	286	292	PF00018	0.561
LIG_SH3_3	324	330	PF00018	0.372
LIG_SH3_3	428	434	PF00018	0.438
LIG_SH3_3	508	514	PF00018	0.550
LIG_SH3_3	605	611	PF00018	0.673
LIG_SH3_3	943	949	PF00018	0.603
LIG_Sin3_3	596	603	PF02671	0.613
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.492
LIG_SUMO_SIM_anti_2	422	429	PF11976	0.209
LIG_SUMO_SIM_anti_2	436	443	PF11976	0.306
LIG_SUMO_SIM_anti_2	550	556	PF11976	0.377
LIG_SUMO_SIM_anti_2	781	786	PF11976	0.339
LIG_SUMO_SIM_par_1	422	429	PF11976	0.198
LIG_SUMO_SIM_par_1	436	443	PF11976	0.244
LIG_SUMO_SIM_par_1	74	81	PF11976	0.441
LIG_TYR_ITIM	771	776	PF00017	0.560
LIG_TYR_ITIM	8	13	PF00017	0.390
LIG_Vh1_VBS_1	58	76	PF01044	0.201
LIG_WRC_WIRS_1	658	663	PF05994	0.463
LIG_WRC_WIRS_1	91	96	PF05994	0.717
LIG_WRC_WIRS_1	99	104	PF05994	0.426
LIG_WW_3	143	147	PF00397	0.546
MOD_CK1_1	151	157	PF00069	0.536
MOD_CK1_1	245	251	PF00069	0.555
MOD_CK1_1	326	332	PF00069	0.527
MOD_CK1_1	343	349	PF00069	0.414
MOD_CK1_1	360	366	PF00069	0.382
MOD_CK1_1	443	449	PF00069	0.528
MOD_CK1_1	742	748	PF00069	0.735
MOD_CK1_1	90	96	PF00069	0.736
MOD_CK2_1	121	127	PF00069	0.573
MOD_CK2_1	144	150	PF00069	0.535
MOD_CK2_1	162	168	PF00069	0.333
MOD_CK2_1	330	336	PF00069	0.527
MOD_CK2_1	360	366	PF00069	0.422
MOD_CK2_1	379	385	PF00069	0.460
MOD_CK2_1	906	912	PF00069	0.749
MOD_CK2_1	917	923	PF00069	0.638
MOD_CMANNOS	408	411	PF00535	0.719
MOD_Cter_Amidation	267	270	PF01082	0.770
MOD_GlcNHglycan	127	131	PF01048	0.770
MOD_GlcNHglycan	173	177	PF01048	0.736
MOD_GlcNHglycan	237	240	PF01048	0.706
MOD_GlcNHglycan	345	348	PF01048	0.769
MOD_GlcNHglycan	450	453	PF01048	0.358
MOD_GlcNHglycan	486	489	PF01048	0.471
MOD_GlcNHglycan	528	531	PF01048	0.545
MOD_GlcNHglycan	545	548	PF01048	0.217
MOD_GlcNHglycan	577	580	PF01048	0.201
MOD_GlcNHglycan	69	72	PF01048	0.447
MOD_GSK3_1	144	151	PF00069	0.505
MOD_GSK3_1	174	181	PF00069	0.575
MOD_GSK3_1	235	242	PF00069	0.486
MOD_GSK3_1	254	261	PF00069	0.349
MOD_GSK3_1	292	299	PF00069	0.522
MOD_GSK3_1	326	333	PF00069	0.499
MOD_GSK3_1	67	74	PF00069	0.432
MOD_GSK3_1	700	707	PF00069	0.462
MOD_GSK3_1	738	745	PF00069	0.725
MOD_GSK3_1	887	894	PF00069	0.662
MOD_GSK3_1	898	905	PF00069	0.668
MOD_GSK3_1	906	913	PF00069	0.596
MOD_N-GLC_1	121	126	PF02516	0.719
MOD_N-GLC_1	209	214	PF02516	0.801
MOD_N-GLC_1	315	320	PF02516	0.605
MOD_N-GLC_1	67	72	PF02516	0.415
MOD_N-GLC_1	691	696	PF02516	0.542
MOD_NEK2_1	126	131	PF00069	0.540
MOD_NEK2_1	179	184	PF00069	0.536
MOD_NEK2_1	23	28	PF00069	0.396
MOD_NEK2_1	308	313	PF00069	0.361
MOD_NEK2_1	425	430	PF00069	0.489
MOD_NEK2_1	440	445	PF00069	0.449
MOD_NEK2_1	483	488	PF00069	0.742
MOD_NEK2_1	50	55	PF00069	0.452
MOD_NEK2_1	657	662	PF00069	0.403
MOD_NEK2_1	700	705	PF00069	0.346
MOD_NEK2_1	73	78	PF00069	0.417
MOD_NEK2_1	841	846	PF00069	0.513
MOD_NEK2_1	87	92	PF00069	0.677
MOD_NEK2_2	209	214	PF00069	0.510
MOD_NEK2_2	350	355	PF00069	0.493
MOD_NEK2_2	4	9	PF00069	0.540
MOD_NEK2_2	797	802	PF00069	0.301
MOD_PIKK_1	220	226	PF00454	0.609
MOD_PIKK_1	239	245	PF00454	0.570
MOD_PIKK_1	622	628	PF00454	0.727
MOD_PIKK_1	944	950	PF00454	0.607
MOD_PKA_2	220	226	PF00069	0.576
MOD_PKA_2	273	279	PF00069	0.513
MOD_PKA_2	308	314	PF00069	0.353
MOD_PKA_2	443	449	PF00069	0.680
MOD_PKA_2	537	543	PF00069	0.560
MOD_PKA_2	570	576	PF00069	0.398
MOD_PKA_2	875	881	PF00069	0.722
MOD_PKA_2	898	904	PF00069	0.796
MOD_PKA_2	944	950	PF00069	0.607
MOD_Plk_1	121	127	PF00069	0.548
MOD_Plk_1	239	245	PF00069	0.528
MOD_Plk_1	315	321	PF00069	0.406
MOD_Plk_1	360	366	PF00069	0.459
MOD_Plk_1	4	10	PF00069	0.707
MOD_Plk_1	50	56	PF00069	0.386
MOD_Plk_1	67	73	PF00069	0.228
MOD_Plk_1	691	697	PF00069	0.342
MOD_Plk_1	928	934	PF00069	0.814
MOD_Plk_2-3	917	923	PF00069	0.620
MOD_Plk_4	162	168	PF00069	0.496
MOD_Plk_4	296	302	PF00069	0.559
MOD_Plk_4	308	314	PF00069	0.400
MOD_Plk_4	379	385	PF00069	0.436
MOD_Plk_4	395	401	PF00069	0.448
MOD_Plk_4	4	10	PF00069	0.684
MOD_Plk_4	434	440	PF00069	0.238
MOD_Plk_4	537	543	PF00069	0.558
MOD_Plk_4	570	576	PF00069	0.299
MOD_Plk_4	657	663	PF00069	0.463
MOD_Plk_4	683	689	PF00069	0.445
MOD_Plk_4	700	706	PF00069	0.242
MOD_Plk_4	742	748	PF00069	0.684
MOD_Plk_4	778	784	PF00069	0.372
MOD_Plk_4	785	791	PF00069	0.363
MOD_Plk_4	836	842	PF00069	0.393
MOD_Plk_4	98	104	PF00069	0.357
MOD_ProDKin_1	148	154	PF00069	0.556
MOD_ProDKin_1	174	180	PF00069	0.514
MOD_ProDKin_1	185	191	PF00069	0.522
MOD_ProDKin_1	254	260	PF00069	0.493
MOD_ProDKin_1	323	329	PF00069	0.479
MOD_ProDKin_1	891	897	PF00069	0.689
MOD_SUMO_for_1	170	173	PF00179	0.518
MOD_SUMO_rev_2	907	916	PF00179	0.651
TRG_DiLeu_BaEn_1	127	132	PF01217	0.534
TRG_DiLeu_BaEn_2	716	722	PF01217	0.682
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.453
TRG_DiLeu_BaLyEn_6	594	599	PF01217	0.653
TRG_ENDOCYTIC_2	10	13	PF00928	0.435
TRG_ENDOCYTIC_2	167	170	PF00928	0.504
TRG_ENDOCYTIC_2	279	282	PF00928	0.514
TRG_ENDOCYTIC_2	773	776	PF00928	0.433
TRG_ENDOCYTIC_2	850	853	PF00928	0.452
TRG_ER_diArg_1	306	309	PF00400	0.430
TRG_ER_diArg_1	521	523	PF00400	0.653
TRG_ER_diArg_1	620	622	PF00400	0.518
TRG_ER_diArg_1	824	826	PF00400	0.712
TRG_ER_diArg_1	949	952	PF00400	0.610
TRG_Pf-PMV_PEXEL_1	622	626	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	851	855	PF00026	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N6	Leptomonas seymouri	39%	99%
A0A1X0P5S8	Trypanosomatidae	22%	100%
A0A3S5H7Z0	Leishmania donovani	86%	100%
A4HMI2	Leishmania braziliensis	68%	99%
A4IB62	Leishmania infantum	85%	100%
C9ZZH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AEY3	Leishmania major	85%	100%