Nuclear pore complex protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP82

Species:

Leishmania mexicana

UniProt:

E9B638_LEIMU

TriTrypDb:

LmxM.34.1600

Length:

775

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0031080	nuclear pore outer ring	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9B638

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B638

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.590
CLV_C14_Caspase3-7	174	178	PF00656	0.391
CLV_C14_Caspase3-7	226	230	PF00656	0.435
CLV_C14_Caspase3-7	243	247	PF00656	0.578
CLV_C14_Caspase3-7	251	255	PF00656	0.495
CLV_C14_Caspase3-7	327	331	PF00656	0.513
CLV_C14_Caspase3-7	550	554	PF00656	0.347
CLV_C14_Caspase3-7	593	597	PF00656	0.436
CLV_C14_Caspase3-7	643	647	PF00656	0.399
CLV_C14_Caspase3-7	81	85	PF00656	0.522
CLV_C14_Caspase3-7	9	13	PF00656	0.471
CLV_NRD_NRD_1	184	186	PF00675	0.485
CLV_NRD_NRD_1	414	416	PF00675	0.381
CLV_NRD_NRD_1	589	591	PF00675	0.479
CLV_NRD_NRD_1	662	664	PF00675	0.459
CLV_PCSK_KEX2_1	184	186	PF00082	0.485
CLV_PCSK_KEX2_1	203	205	PF00082	0.485
CLV_PCSK_KEX2_1	282	284	PF00082	0.518
CLV_PCSK_KEX2_1	414	416	PF00082	0.381
CLV_PCSK_KEX2_1	589	591	PF00082	0.479
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.429
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.518
CLV_PCSK_SKI1_1	203	207	PF00082	0.373
CLV_PCSK_SKI1_1	23	27	PF00082	0.487
CLV_PCSK_SKI1_1	231	235	PF00082	0.351
CLV_PCSK_SKI1_1	279	283	PF00082	0.439
CLV_PCSK_SKI1_1	293	297	PF00082	0.248
CLV_PCSK_SKI1_1	415	419	PF00082	0.393
CLV_PCSK_SKI1_1	505	509	PF00082	0.466
CLV_PCSK_SKI1_1	590	594	PF00082	0.510
CLV_PCSK_SKI1_1	595	599	PF00082	0.524
DEG_APCC_DBOX_1	414	422	PF00400	0.353
DEG_Nend_UBRbox_3	1	3	PF02207	0.699
DEG_SPOP_SBC_1	371	375	PF00917	0.505
DEG_SPOP_SBC_1	433	437	PF00917	0.315
DOC_CYCLIN_yCln2_LP_2	477	483	PF00134	0.380
DOC_MAPK_gen_1	203	210	PF00069	0.439
DOC_MAPK_gen_1	663	671	PF00069	0.294
DOC_MAPK_MEF2A_6	203	210	PF00069	0.439
DOC_PP2B_LxvP_1	428	431	PF13499	0.393
DOC_PP4_FxxP_1	210	213	PF00568	0.464
DOC_USP7_MATH_1	105	109	PF00917	0.308
DOC_USP7_MATH_1	171	175	PF00917	0.393
DOC_USP7_MATH_1	370	374	PF00917	0.683
DOC_USP7_MATH_1	645	649	PF00917	0.426
DOC_USP7_MATH_1	657	661	PF00917	0.351
DOC_USP7_MATH_1	682	686	PF00917	0.426
DOC_USP7_MATH_1	728	732	PF00917	0.582
DOC_USP7_MATH_1	757	761	PF00917	0.550
DOC_WW_Pin1_4	472	477	PF00397	0.320
LIG_14-3-3_CanoR_1	204	209	PF00244	0.460
LIG_14-3-3_CanoR_1	293	302	PF00244	0.383
LIG_14-3-3_CanoR_1	314	319	PF00244	0.524
LIG_14-3-3_CanoR_1	589	598	PF00244	0.408
LIG_14-3-3_CanoR_1	639	649	PF00244	0.460
LIG_14-3-3_CanoR_1	659	667	PF00244	0.585
LIG_Actin_WH2_2	86	101	PF00022	0.337
LIG_BRCT_BRCA1_1	21	25	PF00533	0.413
LIG_BRCT_BRCA1_1	661	665	PF00533	0.466
LIG_BRCT_BRCA1_1	695	699	PF00533	0.466
LIG_deltaCOP1_diTrp_1	117	122	PF00928	0.414
LIG_FHA_1	190	196	PF00498	0.539
LIG_FHA_1	294	300	PF00498	0.431
LIG_FHA_1	393	399	PF00498	0.663
LIG_FHA_1	420	426	PF00498	0.422
LIG_FHA_1	462	468	PF00498	0.424
LIG_FHA_1	50	56	PF00498	0.644
LIG_FHA_1	579	585	PF00498	0.432
LIG_FHA_1	704	710	PF00498	0.413
LIG_FHA_2	112	118	PF00498	0.352
LIG_FHA_2	207	213	PF00498	0.552
LIG_FHA_2	255	261	PF00498	0.591
LIG_FHA_2	292	298	PF00498	0.473
LIG_FHA_2	512	518	PF00498	0.426
LIG_FHA_2	591	597	PF00498	0.317
LIG_FHA_2	641	647	PF00498	0.481
LIG_FHA_2	698	704	PF00498	0.466
LIG_LIR_Apic_2	207	213	PF02991	0.466
LIG_LIR_Gen_1	42	50	PF02991	0.705
LIG_LIR_Gen_1	452	462	PF02991	0.421
LIG_LIR_Gen_1	69	79	PF02991	0.377
LIG_LIR_Gen_1	696	703	PF02991	0.415
LIG_LIR_Nem_3	22	28	PF02991	0.355
LIG_LIR_Nem_3	307	312	PF02991	0.450
LIG_LIR_Nem_3	317	322	PF02991	0.467
LIG_LIR_Nem_3	42	48	PF02991	0.710
LIG_LIR_Nem_3	452	457	PF02991	0.421
LIG_LIR_Nem_3	498	504	PF02991	0.350
LIG_LIR_Nem_3	69	74	PF02991	0.375
LIG_LIR_Nem_3	696	702	PF02991	0.412
LIG_LIR_Nem_3	89	94	PF02991	0.345
LIG_NRBOX	270	276	PF00104	0.331
LIG_PDZ_Class_1	770	775	PF00595	0.512
LIG_Pex14_1	118	122	PF04695	0.433
LIG_Pex14_1	71	75	PF04695	0.417
LIG_Pex14_2	508	512	PF04695	0.477
LIG_RPA_C_Fungi	756	768	PF08784	0.486
LIG_SH2_CRK	309	313	PF00017	0.381
LIG_SH2_CRK	336	340	PF00017	0.204
LIG_SH2_CRK	454	458	PF00017	0.354
LIG_SH2_CRK	474	478	PF00017	0.189
LIG_SH2_CRK	501	505	PF00017	0.367
LIG_SH2_NCK_1	742	746	PF00017	0.453
LIG_SH2_STAP1	316	320	PF00017	0.356
LIG_SH2_STAP1	336	340	PF00017	0.513
LIG_SH2_STAP1	454	458	PF00017	0.439
LIG_SH2_STAP1	547	551	PF00017	0.404
LIG_SH2_STAT5	182	185	PF00017	0.372
LIG_SH2_STAT5	322	325	PF00017	0.507
LIG_SH2_STAT5	557	560	PF00017	0.387
LIG_SH2_STAT5	604	607	PF00017	0.435
LIG_SH2_STAT5	628	631	PF00017	0.466
LIG_SH3_4	23	30	PF00018	0.387
LIG_SUMO_SIM_anti_2	229	236	PF11976	0.418
LIG_SUMO_SIM_anti_2	270	275	PF11976	0.320
LIG_SUMO_SIM_anti_2	648	653	PF11976	0.305
LIG_SUMO_SIM_par_1	204	209	PF11976	0.443
LIG_SUMO_SIM_par_1	272	278	PF11976	0.335
LIG_SUMO_SIM_par_1	393	400	PF11976	0.654
LIG_SUMO_SIM_par_1	735	741	PF11976	0.493
LIG_TRAF2_1	377	380	PF00917	0.757
LIG_UBA3_1	273	282	PF00899	0.468
MOD_CK1_1	238	244	PF00069	0.453
MOD_CK1_1	249	255	PF00069	0.702
MOD_CK1_1	291	297	PF00069	0.466
MOD_CK1_1	374	380	PF00069	0.632
MOD_CK1_1	397	403	PF00069	0.452
MOD_CK1_1	409	415	PF00069	0.519
MOD_CK1_1	513	519	PF00069	0.497
MOD_CK1_1	658	664	PF00069	0.523
MOD_CK1_1	69	75	PF00069	0.392
MOD_CK1_1	724	730	PF00069	0.542
MOD_CK2_1	111	117	PF00069	0.358
MOD_CK2_1	374	380	PF00069	0.554
MOD_CK2_1	434	440	PF00069	0.538
MOD_CK2_1	538	544	PF00069	0.483
MOD_CK2_1	682	688	PF00069	0.567
MOD_CK2_1	697	703	PF00069	0.353
MOD_CMANNOS	118	121	PF00535	0.379
MOD_GlcNHglycan	111	114	PF01048	0.363
MOD_GlcNHglycan	187	190	PF01048	0.441
MOD_GlcNHglycan	242	245	PF01048	0.686
MOD_GlcNHglycan	248	251	PF01048	0.720
MOD_GlcNHglycan	408	411	PF01048	0.565
MOD_GlcNHglycan	436	439	PF01048	0.609
MOD_GlcNHglycan	540	543	PF01048	0.455
MOD_GlcNHglycan	564	567	PF01048	0.450
MOD_GlcNHglycan	607	610	PF01048	0.526
MOD_GlcNHglycan	635	638	PF01048	0.382
MOD_GlcNHglycan	68	71	PF01048	0.471
MOD_GlcNHglycan	726	729	PF01048	0.609
MOD_GlcNHglycan	94	97	PF01048	0.428
MOD_GSK3_1	105	112	PF00069	0.345
MOD_GSK3_1	185	192	PF00069	0.494
MOD_GSK3_1	2	9	PF00069	0.599
MOD_GSK3_1	370	377	PF00069	0.595
MOD_GSK3_1	390	397	PF00069	0.626
MOD_GSK3_1	406	413	PF00069	0.618
MOD_GSK3_1	429	436	PF00069	0.402
MOD_GSK3_1	496	503	PF00069	0.392
MOD_GSK3_1	507	514	PF00069	0.354
MOD_GSK3_1	558	565	PF00069	0.469
MOD_GSK3_1	655	662	PF00069	0.604
MOD_GSK3_1	671	678	PF00069	0.427
MOD_GSK3_1	693	700	PF00069	0.473
MOD_GSK3_1	704	711	PF00069	0.478
MOD_GSK3_1	718	725	PF00069	0.579
MOD_N-GLC_1	109	114	PF02516	0.420
MOD_N-GLC_1	246	251	PF02516	0.636
MOD_NEK2_1	1	6	PF00069	0.606
MOD_NEK2_1	206	211	PF00069	0.454
MOD_NEK2_1	227	232	PF00069	0.510
MOD_NEK2_1	235	240	PF00069	0.556
MOD_NEK2_1	507	512	PF00069	0.353
MOD_NEK2_1	61	66	PF00069	0.578
MOD_NEK2_1	708	713	PF00069	0.495
MOD_NEK2_1	74	79	PF00069	0.296
MOD_PIKK_1	238	244	PF00454	0.507
MOD_PIKK_1	558	564	PF00454	0.363
MOD_PK_1	314	320	PF00069	0.224
MOD_PKA_2	238	244	PF00069	0.543
MOD_PKA_2	658	664	PF00069	0.504
MOD_Plk_1	496	502	PF00069	0.418
MOD_Plk_1	61	67	PF00069	0.622
MOD_Plk_1	645	651	PF00069	0.459
MOD_Plk_2-3	117	123	PF00069	0.386
MOD_Plk_2-3	254	260	PF00069	0.530
MOD_Plk_2-3	394	400	PF00069	0.594
MOD_Plk_4	111	117	PF00069	0.400
MOD_Plk_4	171	177	PF00069	0.352
MOD_Plk_4	254	260	PF00069	0.607
MOD_Plk_4	314	320	PF00069	0.512
MOD_Plk_4	429	435	PF00069	0.416
MOD_Plk_4	44	50	PF00069	0.674
MOD_Plk_4	496	502	PF00069	0.376
MOD_Plk_4	682	688	PF00069	0.420
MOD_Plk_4	694	700	PF00069	0.332
MOD_Plk_4	704	710	PF00069	0.354
MOD_ProDKin_1	472	478	PF00069	0.321
MOD_SUMO_for_1	524	527	PF00179	0.464
MOD_SUMO_rev_2	81	90	PF00179	0.312
TRG_DiLeu_BaEn_1	89	94	PF01217	0.375
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.413
TRG_DiLeu_BaLyEn_6	733	738	PF01217	0.412
TRG_ENDOCYTIC_2	309	312	PF00928	0.359
TRG_ENDOCYTIC_2	316	319	PF00928	0.370
TRG_ENDOCYTIC_2	336	339	PF00928	0.328
TRG_ENDOCYTIC_2	454	457	PF00928	0.430
TRG_ENDOCYTIC_2	474	477	PF00928	0.188
TRG_ENDOCYTIC_2	501	504	PF00928	0.346
TRG_ENDOCYTIC_2	557	560	PF00928	0.311
TRG_ER_diArg_1	183	185	PF00400	0.383
TRG_ER_diArg_1	414	416	PF00400	0.386
TRG_ER_diArg_1	588	590	PF00400	0.464
TRG_NES_CRM1_1	89	102	PF08389	0.443
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	761	765	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P593	Leptomonas seymouri	51%	97%
A0A0S4J4X2	Bodo saltans	25%	100%
A0A3S7X934	Leishmania donovani	92%	99%
A0A422NQA4	Trypanosoma rangeli	31%	100%
A4HMI1	Leishmania braziliensis	80%	100%
A4IB61	Leishmania infantum	92%	99%
C9ZZH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AEY2	Leishmania major	91%	100%
V5B3W9	Trypanosoma cruzi	30%	100%