Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B637_LEIMU

TriTrypDb:

LmxM.34.1590

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B637

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B637

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.510
CLV_C14_Caspase3-7	247	251	PF00656	0.422
CLV_C14_Caspase3-7	253	257	PF00656	0.395
CLV_C14_Caspase3-7	391	395	PF00656	0.276
CLV_NRD_NRD_1	122	124	PF00675	0.740
CLV_NRD_NRD_1	431	433	PF00675	0.693
CLV_NRD_NRD_1	459	461	PF00675	0.631
CLV_PCSK_KEX2_1	110	112	PF00082	0.718
CLV_PCSK_KEX2_1	122	124	PF00082	0.672
CLV_PCSK_KEX2_1	143	145	PF00082	0.665
CLV_PCSK_KEX2_1	459	461	PF00082	0.625
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.718
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.706
CLV_PCSK_SKI1_1	10	14	PF00082	0.563
CLV_PCSK_SKI1_1	222	226	PF00082	0.576
CLV_PCSK_SKI1_1	513	517	PF00082	0.608
CLV_PCSK_SKI1_1	557	561	PF00082	0.578
CLV_PCSK_SKI1_1	59	63	PF00082	0.692
DEG_APCC_DBOX_1	496	504	PF00400	0.421
DEG_APCC_DBOX_1	9	17	PF00400	0.682
DEG_Nend_UBRbox_1	1	4	PF02207	0.725
DOC_CYCLIN_RxL_1	510	521	PF00134	0.396
DOC_CYCLIN_yCln2_LP_2	548	554	PF00134	0.216
DOC_MAPK_DCC_7	10	18	PF00069	0.706
DOC_MAPK_gen_1	143	151	PF00069	0.497
DOC_MAPK_gen_1	4	13	PF00069	0.669
DOC_MAPK_gen_1	407	415	PF00069	0.370
DOC_MAPK_MEF2A_6	144	153	PF00069	0.479
DOC_MAPK_MEF2A_6	275	283	PF00069	0.385
DOC_MAPK_MEF2A_6	407	415	PF00069	0.382
DOC_MAPK_MEF2A_6	460	469	PF00069	0.365
DOC_PP2B_LxvP_1	515	518	PF13499	0.410
DOC_SPAK_OSR1_1	347	351	PF12202	0.434
DOC_USP7_MATH_1	230	234	PF00917	0.496
DOC_USP7_MATH_1	381	385	PF00917	0.339
DOC_USP7_MATH_1	388	392	PF00917	0.353
DOC_WW_Pin1_4	182	187	PF00397	0.520
DOC_WW_Pin1_4	317	322	PF00397	0.383
DOC_WW_Pin1_4	340	345	PF00397	0.299
DOC_WW_Pin1_4	386	391	PF00397	0.425
DOC_WW_Pin1_4	461	466	PF00397	0.336
DOC_WW_Pin1_4	526	531	PF00397	0.417
DOC_WW_Pin1_4	547	552	PF00397	0.275
DOC_WW_Pin1_4	567	572	PF00397	0.199
LIG_14-3-3_CanoR_1	173	178	PF00244	0.456
LIG_14-3-3_CanoR_1	284	292	PF00244	0.419
LIG_14-3-3_CanoR_1	38	46	PF00244	0.499
LIG_14-3-3_CanoR_1	452	461	PF00244	0.446
LIG_14-3-3_CanoR_1	497	501	PF00244	0.445
LIG_14-3-3_CanoR_1	543	551	PF00244	0.387
LIG_14-3-3_CanoR_1	557	565	PF00244	0.380
LIG_14-3-3_CanoR_1	63	73	PF00244	0.457
LIG_Actin_WH2_2	44	61	PF00022	0.510
LIG_BRCT_BRCA1_1	481	485	PF00533	0.311
LIG_Clathr_ClatBox_1	134	138	PF01394	0.551
LIG_Clathr_ClatBox_1	535	539	PF01394	0.387
LIG_deltaCOP1_diTrp_1	573	578	PF00928	0.369
LIG_FHA_1	234	240	PF00498	0.479
LIG_FHA_1	284	290	PF00498	0.306
LIG_FHA_1	531	537	PF00498	0.376
LIG_FHA_1	543	549	PF00498	0.296
LIG_FHA_1	67	73	PF00498	0.490
LIG_FHA_2	155	161	PF00498	0.460
LIG_FHA_2	190	196	PF00498	0.480
LIG_FHA_2	202	208	PF00498	0.523
LIG_FHA_2	242	248	PF00498	0.432
LIG_FHA_2	251	257	PF00498	0.468
LIG_FHA_2	285	291	PF00498	0.388
LIG_FHA_2	519	525	PF00498	0.462
LIG_FHA_2	568	574	PF00498	0.229
LIG_HCF-1_HBM_1	486	489	PF13415	0.418
LIG_LIR_Apic_2	264	269	PF02991	0.410
LIG_LIR_Gen_1	160	171	PF02991	0.320
LIG_LIR_Gen_1	418	429	PF02991	0.374
LIG_LIR_Gen_1	482	493	PF02991	0.318
LIG_LIR_Gen_1	529	540	PF02991	0.386
LIG_LIR_Nem_3	101	107	PF02991	0.443
LIG_LIR_Nem_3	290	295	PF02991	0.374
LIG_LIR_Nem_3	311	316	PF02991	0.333
LIG_LIR_Nem_3	394	400	PF02991	0.407
LIG_LIR_Nem_3	418	424	PF02991	0.381
LIG_LIR_Nem_3	482	488	PF02991	0.310
LIG_LIR_Nem_3	529	535	PF02991	0.395
LIG_LYPXL_yS_3	445	448	PF13949	0.464
LIG_MYND_1	514	518	PF01753	0.442
LIG_NRBOX	499	505	PF00104	0.450
LIG_PCNA_yPIPBox_3	77	87	PF02747	0.512
LIG_Pex14_1	357	361	PF04695	0.454
LIG_Pex14_2	177	181	PF04695	0.455
LIG_Pex14_2	309	313	PF04695	0.355
LIG_PTB_Apo_2	223	230	PF02174	0.479
LIG_PTB_Apo_2	301	308	PF02174	0.408
LIG_REV1ctd_RIR_1	258	267	PF16727	0.417
LIG_SH2_CRK	266	270	PF00017	0.357
LIG_SH2_CRK	421	425	PF00017	0.486
LIG_SH2_CRK	438	442	PF00017	0.402
LIG_SH2_GRB2like	178	181	PF00017	0.450
LIG_SH2_GRB2like	520	523	PF00017	0.440
LIG_SH2_NCK_1	520	524	PF00017	0.444
LIG_SH2_STAT3	300	303	PF00017	0.247
LIG_SH2_STAT5	163	166	PF00017	0.373
LIG_SH2_STAT5	315	318	PF00017	0.400
LIG_SH2_STAT5	336	339	PF00017	0.427
LIG_SH2_STAT5	440	443	PF00017	0.337
LIG_SH2_STAT5	473	476	PF00017	0.399
LIG_SH2_STAT5	483	486	PF00017	0.322
LIG_SH2_STAT5	489	492	PF00017	0.310
LIG_SH2_STAT5	520	523	PF00017	0.463
LIG_SH2_STAT5	558	561	PF00017	0.309
LIG_SH3_1	2	8	PF00018	0.577
LIG_SH3_2	279	284	PF14604	0.341
LIG_SH3_2	5	10	PF14604	0.565
LIG_SH3_3	2	8	PF00018	0.577
LIG_SH3_3	276	282	PF00018	0.370
LIG_SH3_3	338	344	PF00018	0.316
LIG_SH3_3	548	554	PF00018	0.208
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.383
LIG_SUMO_SIM_par_1	501	508	PF11976	0.422
LIG_SUMO_SIM_par_1	533	539	PF11976	0.326
LIG_TRAF2_1	321	324	PF00917	0.476
LIG_TYR_ITIM	419	424	PF00017	0.491
LIG_TYR_ITIM	436	441	PF00017	0.394
LIG_UBA3_1	470	476	PF00899	0.293
LIG_WRC_WIRS_1	174	179	PF05994	0.451
LIG_WW_3	44	48	PF00397	0.325
MOD_CDK_SPxxK_3	340	347	PF00069	0.410
MOD_CDK_SPxxK_3	386	393	PF00069	0.366
MOD_CK1_1	176	182	PF00069	0.481
MOD_CK1_1	233	239	PF00069	0.382
MOD_CK1_1	317	323	PF00069	0.375
MOD_CK2_1	154	160	PF00069	0.459
MOD_CK2_1	189	195	PF00069	0.503
MOD_CK2_1	201	207	PF00069	0.409
MOD_CK2_1	241	247	PF00069	0.410
MOD_CK2_1	284	290	PF00069	0.365
MOD_CK2_1	488	494	PF00069	0.397
MOD_CK2_1	495	501	PF00069	0.381
MOD_CK2_1	518	524	PF00069	0.438
MOD_GlcNHglycan	232	235	PF01048	0.711
MOD_GlcNHglycan	353	356	PF01048	0.632
MOD_GSK3_1	176	183	PF00069	0.452
MOD_GSK3_1	225	232	PF00069	0.493
MOD_GSK3_1	351	358	PF00069	0.349
MOD_GSK3_1	369	376	PF00069	0.398
MOD_GSK3_1	495	502	PF00069	0.415
MOD_GSK3_1	526	533	PF00069	0.449
MOD_GSK3_1	553	560	PF00069	0.303
MOD_N-GLC_1	112	117	PF02516	0.717
MOD_N-GLC_1	130	135	PF02516	0.544
MOD_N-GLC_1	225	230	PF02516	0.726
MOD_N-GLC_1	234	239	PF02516	0.684
MOD_N-GLC_1	261	266	PF02516	0.650
MOD_N-GLC_1	305	310	PF02516	0.553
MOD_N-GLC_1	446	451	PF02516	0.637
MOD_N-GLC_2	180	182	PF02516	0.648
MOD_NEK2_1	149	154	PF00069	0.426
MOD_NEK2_1	261	266	PF00069	0.356
MOD_NEK2_1	283	288	PF00069	0.400
MOD_NEK2_1	316	321	PF00069	0.434
MOD_NEK2_1	415	420	PF00069	0.348
MOD_PIKK_1	507	513	PF00454	0.458
MOD_PIKK_1	66	72	PF00454	0.514
MOD_PKA_2	283	289	PF00069	0.376
MOD_PKA_2	290	296	PF00069	0.380
MOD_PKA_2	37	43	PF00069	0.523
MOD_PKA_2	496	502	PF00069	0.445
MOD_PKA_2	542	548	PF00069	0.358
MOD_PKB_1	367	375	PF00069	0.407
MOD_Plk_1	130	136	PF00069	0.540
MOD_Plk_1	225	231	PF00069	0.533
MOD_Plk_1	261	267	PF00069	0.451
MOD_Plk_1	305	311	PF00069	0.349
MOD_Plk_1	507	513	PF00069	0.477
MOD_Plk_2-3	250	256	PF00069	0.508
MOD_Plk_2-3	96	102	PF00069	0.489
MOD_Plk_4	130	136	PF00069	0.494
MOD_Plk_4	17	23	PF00069	0.330
MOD_Plk_4	479	485	PF00069	0.392
MOD_Plk_4	499	505	PF00069	0.429
MOD_ProDKin_1	182	188	PF00069	0.518
MOD_ProDKin_1	317	323	PF00069	0.392
MOD_ProDKin_1	340	346	PF00069	0.300
MOD_ProDKin_1	386	392	PF00069	0.421
MOD_ProDKin_1	461	467	PF00069	0.335
MOD_ProDKin_1	526	532	PF00069	0.414
MOD_ProDKin_1	547	553	PF00069	0.276
MOD_ProDKin_1	567	573	PF00069	0.202
MOD_SUMO_for_1	109	112	PF00179	0.518
MOD_SUMO_rev_2	311	316	PF00179	0.388
MOD_SUMO_rev_2	55	61	PF00179	0.498
TRG_DiLeu_BaEn_1	130	135	PF01217	0.545
TRG_DiLeu_BaEn_1	68	73	PF01217	0.518
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.305
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.353
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.451
TRG_ENDOCYTIC_2	104	107	PF00928	0.497
TRG_ENDOCYTIC_2	163	166	PF00928	0.425
TRG_ENDOCYTIC_2	421	424	PF00928	0.436
TRG_ENDOCYTIC_2	438	441	PF00928	0.364
TRG_ENDOCYTIC_2	445	448	PF00928	0.413
TRG_ENDOCYTIC_2	489	492	PF00928	0.316
TRG_ER_diArg_1	121	123	PF00400	0.506
TRG_ER_diArg_1	459	461	PF00400	0.342
TRG_NES_CRM1_1	140	154	PF08389	0.496
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.718
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJZ6	Leptomonas seymouri	44%	100%
A0A0S4J8J1	Bodo saltans	26%	100%
A0A1X0P5Y1	Trypanosomatidae	28%	100%
A0A3R7KJC8	Trypanosoma rangeli	29%	100%
A0A3S7X958	Leishmania donovani	89%	100%
A4HMI0	Leishmania braziliensis	71%	99%
A4IB60	Leishmania infantum	88%	100%
E9AEY1	Leishmania major	85%	100%
V5BJE1	Trypanosoma cruzi	29%	100%