LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B631_LEIMU
TriTrypDb:
LmxM.34.1530
Length:
354

Annotations

LeishMANIAdb annotations

No conserved TM segments are present in this protein.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B631
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B631

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 14 18 PF00656 0.628
CLV_C14_Caspase3-7 196 200 PF00656 0.511
CLV_C14_Caspase3-7 35 39 PF00656 0.529
CLV_MEL_PAP_1 167 173 PF00089 0.499
CLV_NRD_NRD_1 130 132 PF00675 0.391
CLV_NRD_NRD_1 146 148 PF00675 0.553
CLV_NRD_NRD_1 351 353 PF00675 0.418
CLV_PCSK_KEX2_1 130 132 PF00082 0.391
CLV_PCSK_KEX2_1 146 148 PF00082 0.553
CLV_PCSK_SKI1_1 318 322 PF00082 0.472
CLV_PCSK_SKI1_1 41 45 PF00082 0.509
DEG_Nend_UBRbox_3 1 3 PF02207 0.558
DEG_SCF_TRCP1_1 127 133 PF00400 0.454
DEG_SPOP_SBC_1 171 175 PF00917 0.399
DEG_SPOP_SBC_1 226 230 PF00917 0.483
DOC_MAPK_gen_1 253 261 PF00069 0.505
DOC_USP7_MATH_1 201 205 PF00917 0.592
DOC_USP7_MATH_1 338 342 PF00917 0.517
DOC_USP7_MATH_1 90 94 PF00917 0.659
DOC_WW_Pin1_4 197 202 PF00397 0.764
DOC_WW_Pin1_4 213 218 PF00397 0.551
DOC_WW_Pin1_4 264 269 PF00397 0.556
DOC_WW_Pin1_4 272 277 PF00397 0.514
DOC_WW_Pin1_4 50 55 PF00397 0.619
DOC_WW_Pin1_4 94 99 PF00397 0.664
LIG_14-3-3_CanoR_1 12 21 PF00244 0.639
LIG_14-3-3_CanoR_1 120 124 PF00244 0.439
LIG_14-3-3_CanoR_1 130 135 PF00244 0.360
LIG_14-3-3_CanoR_1 168 176 PF00244 0.508
LIG_14-3-3_CanoR_1 178 186 PF00244 0.590
LIG_14-3-3_CanoR_1 192 201 PF00244 0.509
LIG_14-3-3_CanoR_1 318 326 PF00244 0.418
LIG_14-3-3_CanoR_1 41 48 PF00244 0.577
LIG_14-3-3_CanoR_1 84 91 PF00244 0.607
LIG_BIR_III_2 17 21 PF00653 0.484
LIG_CtBP_PxDLS_1 343 347 PF00389 0.423
LIG_FHA_1 111 117 PF00498 0.511
LIG_FHA_1 207 213 PF00498 0.625
LIG_FHA_1 315 321 PF00498 0.385
LIG_FHA_1 345 351 PF00498 0.371
LIG_FHA_2 260 266 PF00498 0.403
LIG_FHA_2 67 73 PF00498 0.635
LIG_Integrin_RGD_1 125 127 PF01839 0.422
LIG_Pex14_1 301 305 PF04695 0.378
LIG_Pex14_2 140 144 PF04695 0.389
LIG_SH2_STAP1 244 248 PF00017 0.416
LIG_SH2_STAP1 78 82 PF00017 0.636
LIG_SH2_STAT5 142 145 PF00017 0.489
LIG_SH2_STAT5 244 247 PF00017 0.443
LIG_SH2_STAT5 328 331 PF00017 0.514
LIG_SH2_STAT5 47 50 PF00017 0.758
LIG_SH3_3 45 51 PF00018 0.626
LIG_SUMO_SIM_par_1 112 118 PF11976 0.502
MOD_CK1_1 110 116 PF00069 0.485
MOD_CK1_1 150 156 PF00069 0.571
MOD_CK1_1 172 178 PF00069 0.569
MOD_CK1_1 233 239 PF00069 0.692
MOD_CK1_1 267 273 PF00069 0.563
MOD_CK1_1 52 58 PF00069 0.633
MOD_CK1_1 65 71 PF00069 0.492
MOD_CK2_1 259 265 PF00069 0.442
MOD_CK2_1 336 342 PF00069 0.589
MOD_CK2_1 34 40 PF00069 0.583
MOD_Cter_Amidation 128 131 PF01082 0.385
MOD_GlcNHglycan 104 107 PF01048 0.520
MOD_GlcNHglycan 127 130 PF01048 0.590
MOD_GlcNHglycan 180 183 PF01048 0.662
MOD_GlcNHglycan 195 198 PF01048 0.521
MOD_GlcNHglycan 201 204 PF01048 0.579
MOD_GlcNHglycan 232 235 PF01048 0.690
MOD_GlcNHglycan 332 335 PF01048 0.616
MOD_GlcNHglycan 80 83 PF01048 0.603
MOD_GlcNHglycan 85 88 PF01048 0.648
MOD_GlcNHglycan 92 95 PF01048 0.525
MOD_GSK3_1 115 122 PF00069 0.393
MOD_GSK3_1 136 143 PF00069 0.368
MOD_GSK3_1 170 177 PF00069 0.609
MOD_GSK3_1 193 200 PF00069 0.655
MOD_GSK3_1 201 208 PF00069 0.767
MOD_GSK3_1 226 233 PF00069 0.673
MOD_GSK3_1 242 249 PF00069 0.438
MOD_GSK3_1 266 273 PF00069 0.423
MOD_GSK3_1 314 321 PF00069 0.464
MOD_GSK3_1 338 345 PF00069 0.510
MOD_GSK3_1 50 57 PF00069 0.637
MOD_GSK3_1 62 69 PF00069 0.649
MOD_GSK3_1 90 97 PF00069 0.677
MOD_LATS_1 145 151 PF00433 0.486
MOD_N-GLC_1 107 112 PF02516 0.522
MOD_N-GLC_1 147 152 PF02516 0.567
MOD_N-GLC_1 190 195 PF02516 0.560
MOD_NEK2_1 102 107 PF00069 0.581
MOD_NEK2_1 112 117 PF00069 0.505
MOD_NEK2_1 140 145 PF00069 0.430
MOD_NEK2_1 163 168 PF00069 0.383
MOD_NEK2_1 21 26 PF00069 0.672
MOD_NEK2_1 259 264 PF00069 0.488
MOD_NEK2_2 227 232 PF00069 0.488
MOD_PIKK_1 246 252 PF00454 0.395
MOD_PK_1 253 259 PF00069 0.545
MOD_PKA_1 130 136 PF00069 0.360
MOD_PKA_2 11 17 PF00069 0.627
MOD_PKA_2 119 125 PF00069 0.447
MOD_PKA_2 130 136 PF00069 0.349
MOD_PKA_2 169 175 PF00069 0.529
MOD_PKA_2 83 89 PF00069 0.656
MOD_PKB_1 168 176 PF00069 0.531
MOD_PKB_1 316 324 PF00069 0.413
MOD_Plk_1 150 156 PF00069 0.568
MOD_Plk_1 246 252 PF00069 0.474
MOD_Plk_2-3 242 248 PF00069 0.509
MOD_Plk_4 119 125 PF00069 0.481
MOD_Plk_4 130 136 PF00069 0.365
MOD_ProDKin_1 197 203 PF00069 0.763
MOD_ProDKin_1 213 219 PF00069 0.552
MOD_ProDKin_1 264 270 PF00069 0.549
MOD_ProDKin_1 272 278 PF00069 0.507
MOD_ProDKin_1 50 56 PF00069 0.621
MOD_ProDKin_1 94 100 PF00069 0.656
TRG_DiLeu_BaLyEn_6 315 320 PF01217 0.383
TRG_ER_diArg_1 167 170 PF00400 0.486
TRG_ER_diArg_1 316 319 PF00400 0.353
TRG_ER_diArg_1 9 12 PF00400 0.499
TRG_Pf-PMV_PEXEL_1 318 322 PF00026 0.392
TRG_Pf-PMV_PEXEL_1 41 45 PF00026 0.509

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4G5 Leptomonas seymouri 46% 94%
A0A3Q8II56 Leishmania donovani 84% 100%
A4HMH4 Leishmania braziliensis 64% 100%
A4IB54 Leishmania infantum 83% 71%
E9AEX5 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS