Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B630_LEIMU

TriTrypDb:

LmxM.34.1520

Length:

728

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 5
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9B630

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B630

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.470
CLV_NRD_NRD_1	153	155	PF00675	0.547
CLV_NRD_NRD_1	255	257	PF00675	0.527
CLV_NRD_NRD_1	354	356	PF00675	0.559
CLV_NRD_NRD_1	603	605	PF00675	0.479
CLV_PCSK_FUR_1	11	15	PF00082	0.407
CLV_PCSK_KEX2_1	11	13	PF00082	0.471
CLV_PCSK_KEX2_1	153	155	PF00082	0.547
CLV_PCSK_KEX2_1	179	181	PF00082	0.498
CLV_PCSK_KEX2_1	255	257	PF00082	0.494
CLV_PCSK_KEX2_1	353	355	PF00082	0.559
CLV_PCSK_KEX2_1	602	604	PF00082	0.483
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.498
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.416
CLV_PCSK_PC7_1	598	604	PF00082	0.394
CLV_PCSK_SKI1_1	248	252	PF00082	0.543
CLV_PCSK_SKI1_1	34	38	PF00082	0.332
CLV_PCSK_SKI1_1	534	538	PF00082	0.570
CLV_PCSK_SKI1_1	587	591	PF00082	0.433
CLV_PCSK_SKI1_1	635	639	PF00082	0.445
DEG_APCC_DBOX_1	33	41	PF00400	0.240
DEG_Nend_UBRbox_3	1	3	PF02207	0.626
DEG_SCF_FBW7_1	658	663	PF00400	0.629
DEG_SCF_FBW7_2	622	628	PF00400	0.625
DOC_CDC14_PxL_1	433	441	PF14671	0.635
DOC_CKS1_1	541	546	PF01111	0.686
DOC_CKS1_1	622	627	PF01111	0.627
DOC_CYCLIN_yClb5_NLxxxL_5	205	214	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	214	217	PF00134	0.751
DOC_CYCLIN_yCln2_LP_2	700	706	PF00134	0.342
DOC_MAPK_DCC_7	702	710	PF00069	0.342
DOC_MAPK_MEF2A_6	34	42	PF00069	0.280
DOC_MAPK_MEF2A_6	702	710	PF00069	0.348
DOC_PP1_RVXF_1	633	640	PF00149	0.651
DOC_PP2B_LxvP_1	214	217	PF13499	0.751
DOC_PP2B_PxIxI_1	366	372	PF00149	0.730
DOC_PP4_MxPP_1	190	193	PF00568	0.753
DOC_USP7_MATH_1	140	144	PF00917	0.701
DOC_USP7_MATH_1	301	305	PF00917	0.704
DOC_USP7_MATH_1	357	361	PF00917	0.744
DOC_USP7_MATH_1	447	451	PF00917	0.739
DOC_USP7_MATH_1	561	565	PF00917	0.607
DOC_USP7_MATH_1	58	62	PF00917	0.392
DOC_USP7_MATH_1	674	678	PF00917	0.694
DOC_USP7_MATH_1	81	85	PF00917	0.404
DOC_WW_Pin1_4	2	7	PF00397	0.621
DOC_WW_Pin1_4	22	27	PF00397	0.574
DOC_WW_Pin1_4	262	267	PF00397	0.763
DOC_WW_Pin1_4	355	360	PF00397	0.755
DOC_WW_Pin1_4	374	379	PF00397	0.547
DOC_WW_Pin1_4	382	387	PF00397	0.631
DOC_WW_Pin1_4	417	422	PF00397	0.684
DOC_WW_Pin1_4	452	457	PF00397	0.599
DOC_WW_Pin1_4	540	545	PF00397	0.749
DOC_WW_Pin1_4	618	623	PF00397	0.763
DOC_WW_Pin1_4	656	661	PF00397	0.670
LIG_14-3-3_CanoR_1	118	123	PF00244	0.722
LIG_14-3-3_CanoR_1	14	24	PF00244	0.599
LIG_14-3-3_CanoR_1	183	189	PF00244	0.625
LIG_14-3-3_CanoR_1	462	469	PF00244	0.634
LIG_14-3-3_CanoR_1	517	522	PF00244	0.765
LIG_14-3-3_CanoR_1	550	558	PF00244	0.726
LIG_14-3-3_CanoR_1	80	90	PF00244	0.517
LIG_Actin_WH2_2	474	492	PF00022	0.673
LIG_APCC_ABBA_1	215	220	PF00400	0.647
LIG_BH_BH3_1	191	207	PF00452	0.745
LIG_BRCT_BRCA1_1	301	305	PF00533	0.705
LIG_BRCT_BRCA1_1	361	365	PF00533	0.752
LIG_BRCT_BRCA1_1	384	388	PF00533	0.736
LIG_deltaCOP1_diTrp_1	666	673	PF00928	0.715
LIG_eIF4E_1	281	287	PF01652	0.705
LIG_FHA_1	209	215	PF00498	0.683
LIG_FHA_1	338	344	PF00498	0.782
LIG_FHA_1	456	462	PF00498	0.616
LIG_FHA_1	712	718	PF00498	0.409
LIG_FHA_1	73	79	PF00498	0.395
LIG_FHA_2	127	133	PF00498	0.717
LIG_FHA_2	554	560	PF00498	0.670
LIG_FHA_2	636	642	PF00498	0.632
LIG_FHA_2	661	667	PF00498	0.662
LIG_GBD_Chelix_1	202	210	PF00786	0.458
LIG_LIR_Gen_1	170	178	PF02991	0.655
LIG_LIR_Gen_1	430	440	PF02991	0.630
LIG_LIR_Gen_1	467	477	PF02991	0.624
LIG_LIR_Gen_1	543	552	PF02991	0.673
LIG_LIR_Gen_1	563	574	PF02991	0.568
LIG_LIR_Gen_1	630	639	PF02991	0.665
LIG_LIR_Nem_3	170	174	PF02991	0.657
LIG_LIR_Nem_3	362	368	PF02991	0.737
LIG_LIR_Nem_3	430	436	PF02991	0.662
LIG_LIR_Nem_3	438	443	PF02991	0.639
LIG_LIR_Nem_3	467	472	PF02991	0.657
LIG_LIR_Nem_3	476	481	PF02991	0.559
LIG_LIR_Nem_3	515	521	PF02991	0.727
LIG_LIR_Nem_3	543	549	PF02991	0.645
LIG_LIR_Nem_3	563	569	PF02991	0.560
LIG_LIR_Nem_3	630	636	PF02991	0.670
LIG_LIR_Nem_3	638	642	PF02991	0.604
LIG_LIR_Nem_3	653	658	PF02991	0.678
LIG_LIR_Nem_3	677	682	PF02991	0.389
LIG_MLH1_MIPbox_1	384	388	PF16413	0.736
LIG_PCNA_yPIPBox_3	397	411	PF02747	0.790
LIG_Pex14_2	100	104	PF04695	0.201
LIG_Pex14_2	709	713	PF04695	0.415
LIG_REV1ctd_RIR_1	385	391	PF16727	0.683
LIG_SH2_CRK	478	482	PF00017	0.632
LIG_SH2_CRK	633	637	PF00017	0.676
LIG_SH2_GRB2like	165	168	PF00017	0.677
LIG_SH2_NCK_1	165	169	PF00017	0.674
LIG_SH2_NCK_1	429	433	PF00017	0.674
LIG_SH2_PTP2	546	549	PF00017	0.658
LIG_SH2_SRC	165	168	PF00017	0.673
LIG_SH2_STAP1	165	169	PF00017	0.673
LIG_SH2_STAP1	429	433	PF00017	0.674
LIG_SH2_STAP1	478	482	PF00017	0.666
LIG_SH2_STAP1	483	487	PF00017	0.694
LIG_SH2_STAT5	105	108	PF00017	0.269
LIG_SH2_STAT5	41	44	PF00017	0.416
LIG_SH2_STAT5	546	549	PF00017	0.658
LIG_SH2_STAT5	650	653	PF00017	0.659
LIG_SH2_STAT5	89	92	PF00017	0.396
LIG_SH3_2	392	397	PF14604	0.822
LIG_SH3_3	361	367	PF00018	0.722
LIG_SH3_3	389	395	PF00018	0.828
LIG_SH3_3	619	625	PF00018	0.791
LIG_SH3_3	700	706	PF00018	0.371
LIG_SH3_3	95	101	PF00018	0.279
LIG_TRAF2_1	557	560	PF00917	0.623
LIG_TRAF2_1	663	666	PF00917	0.666
LIG_TRFH_1	433	437	PF08558	0.540
LIG_TRFH_1	469	473	PF08558	0.615
LIG_TYR_ITIM	39	44	PF00017	0.220
LIG_UBA3_1	435	441	PF00899	0.595
LIG_WRC_WIRS_1	636	641	PF05994	0.592
LIG_WW_1	192	195	PF00397	0.721
MOD_CK1_1	121	127	PF00069	0.674
MOD_CK1_1	143	149	PF00069	0.610
MOD_CK1_1	19	25	PF00069	0.476
MOD_CK1_1	271	277	PF00069	0.572
MOD_CK1_1	29	35	PF00069	0.567
MOD_CK1_1	299	305	PF00069	0.582
MOD_CK1_1	399	405	PF00069	0.718
MOD_CK1_1	422	428	PF00069	0.644
MOD_CK1_1	450	456	PF00069	0.496
MOD_CK1_1	500	506	PF00069	0.730
MOD_CK1_1	520	526	PF00069	0.707
MOD_CK1_1	553	559	PF00069	0.671
MOD_CK1_1	61	67	PF00069	0.762
MOD_CK1_1	621	627	PF00069	0.634
MOD_CK1_1	661	667	PF00069	0.720
MOD_CK2_1	553	559	PF00069	0.574
MOD_CK2_1	660	666	PF00069	0.663
MOD_DYRK1A_RPxSP_1	355	359	PF00069	0.598
MOD_DYRK1A_RPxSP_1	382	386	PF00069	0.486
MOD_GlcNHglycan	142	145	PF01048	0.734
MOD_GlcNHglycan	298	301	PF01048	0.631
MOD_GlcNHglycan	355	358	PF01048	0.703
MOD_GlcNHglycan	398	401	PF01048	0.703
MOD_GlcNHglycan	466	469	PF01048	0.561
MOD_GlcNHglycan	499	502	PF01048	0.668
MOD_GlcNHglycan	58	61	PF01048	0.614
MOD_GlcNHglycan	66	69	PF01048	0.660
MOD_GlcNHglycan	83	86	PF01048	0.442
MOD_GSK3_1	118	125	PF00069	0.604
MOD_GSK3_1	139	146	PF00069	0.711
MOD_GSK3_1	15	22	PF00069	0.466
MOD_GSK3_1	258	265	PF00069	0.722
MOD_GSK3_1	349	356	PF00069	0.674
MOD_GSK3_1	460	467	PF00069	0.660
MOD_GSK3_1	520	527	PF00069	0.678
MOD_GSK3_1	550	557	PF00069	0.582
MOD_GSK3_1	58	65	PF00069	0.702
MOD_GSK3_1	617	624	PF00069	0.738
MOD_GSK3_1	646	653	PF00069	0.569
MOD_GSK3_1	656	663	PF00069	0.699
MOD_GSK3_1	68	75	PF00069	0.626
MOD_N-GLC_1	184	189	PF02516	0.531
MOD_N-GLC_1	208	213	PF02516	0.635
MOD_N-GLC_1	258	263	PF02516	0.621
MOD_N-GLC_1	346	351	PF02516	0.772
MOD_N-GLC_1	611	616	PF02516	0.706
MOD_N-GLC_1	81	86	PF02516	0.498
MOD_NEK2_1	286	291	PF00069	0.626
MOD_NEK2_1	312	317	PF00069	0.545
MOD_NEK2_1	396	401	PF00069	0.807
MOD_NEK2_1	460	465	PF00069	0.537
MOD_NEK2_1	497	502	PF00069	0.674
MOD_NEK2_1	646	651	PF00069	0.540
MOD_NEK2_1	711	716	PF00069	0.474
MOD_NEK2_2	561	566	PF00069	0.502
MOD_PIKK_1	357	363	PF00454	0.646
MOD_PIKK_1	461	467	PF00454	0.621
MOD_PIKK_1	580	586	PF00454	0.601
MOD_PIKK_1	661	667	PF00454	0.741
MOD_PKA_1	353	359	PF00069	0.597
MOD_PKA_2	134	140	PF00069	0.675
MOD_PKA_2	353	359	PF00069	0.578
MOD_PKA_2	396	402	PF00069	0.683
MOD_PKA_2	461	467	PF00069	0.561
MOD_PKA_2	56	62	PF00069	0.560
MOD_Plk_1	159	165	PF00069	0.640
MOD_Plk_1	184	190	PF00069	0.596
MOD_Plk_1	258	264	PF00069	0.624
MOD_Plk_1	271	277	PF00069	0.579
MOD_Plk_2-3	554	560	PF00069	0.660
MOD_Plk_4	126	132	PF00069	0.635
MOD_Plk_4	143	149	PF00069	0.662
MOD_Plk_4	159	165	PF00069	0.502
MOD_Plk_4	19	25	PF00069	0.490
MOD_Plk_4	286	292	PF00069	0.592
MOD_Plk_4	435	441	PF00069	0.553
MOD_Plk_4	447	453	PF00069	0.484
MOD_Plk_4	455	461	PF00069	0.438
MOD_Plk_4	561	567	PF00069	0.513
MOD_Plk_4	646	652	PF00069	0.594
MOD_Plk_4	675	681	PF00069	0.410
MOD_ProDKin_1	2	8	PF00069	0.526
MOD_ProDKin_1	22	28	PF00069	0.456
MOD_ProDKin_1	262	268	PF00069	0.720
MOD_ProDKin_1	355	361	PF00069	0.704
MOD_ProDKin_1	374	380	PF00069	0.426
MOD_ProDKin_1	382	388	PF00069	0.541
MOD_ProDKin_1	417	423	PF00069	0.610
MOD_ProDKin_1	452	458	PF00069	0.491
MOD_ProDKin_1	540	546	PF00069	0.702
MOD_ProDKin_1	618	624	PF00069	0.719
MOD_ProDKin_1	656	662	PF00069	0.597
MOD_SUMO_rev_2	175	181	PF00179	0.626
TRG_DiLeu_BaEn_2	176	182	PF01217	0.635
TRG_ENDOCYTIC_2	195	198	PF00928	0.597
TRG_ENDOCYTIC_2	295	298	PF00928	0.656
TRG_ENDOCYTIC_2	41	44	PF00928	0.220
TRG_ENDOCYTIC_2	478	481	PF00928	0.584
TRG_ENDOCYTIC_2	546	549	PF00928	0.577
TRG_ENDOCYTIC_2	633	636	PF00928	0.606
TRG_ER_diArg_1	11	14	PF00400	0.595
TRG_ER_diArg_1	152	154	PF00400	0.694
TRG_ER_diArg_1	254	256	PF00400	0.696
TRG_ER_diArg_1	403	406	PF00400	0.637
TRG_ER_diArg_1	602	604	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.705

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N3	Leptomonas seymouri	37%	99%
A0A3S7X910	Leishmania donovani	95%	100%
A4HMH3	Leishmania braziliensis	79%	100%
A4IB53	Leishmania infantum	95%	100%
C9ZZG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AEX4	Leishmania major	94%	100%
V5B3W1	Trypanosoma cruzi	24%	100%