NLI interacting factor-like phosphatase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase/Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania mexicana

UniProt:

E9B629_LEIMU

TriTrypDb:

LmxM.34.1510

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B629

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B629

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	581	585	PF00656	0.683
CLV_NRD_NRD_1	19	21	PF00675	0.590
CLV_NRD_NRD_1	237	239	PF00675	0.577
CLV_NRD_NRD_1	336	338	PF00675	0.605
CLV_NRD_NRD_1	361	363	PF00675	0.593
CLV_NRD_NRD_1	364	366	PF00675	0.599
CLV_NRD_NRD_1	400	402	PF00675	0.725
CLV_NRD_NRD_1	433	435	PF00675	0.744
CLV_NRD_NRD_1	543	545	PF00675	0.786
CLV_NRD_NRD_1	565	567	PF00675	0.779
CLV_NRD_NRD_1	71	73	PF00675	0.435
CLV_PCSK_KEX2_1	19	21	PF00082	0.590
CLV_PCSK_KEX2_1	237	239	PF00082	0.577
CLV_PCSK_KEX2_1	361	363	PF00082	0.609
CLV_PCSK_KEX2_1	399	401	PF00082	0.724
CLV_PCSK_KEX2_1	432	434	PF00082	0.743
CLV_PCSK_KEX2_1	543	545	PF00082	0.786
CLV_PCSK_KEX2_1	565	567	PF00082	0.779
CLV_PCSK_KEX2_1	71	73	PF00082	0.457
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.532
CLV_PCSK_PC7_1	395	401	PF00082	0.721
CLV_PCSK_SKI1_1	103	107	PF00082	0.412
CLV_PCSK_SKI1_1	134	138	PF00082	0.412
CLV_PCSK_SKI1_1	220	224	PF00082	0.514
CLV_PCSK_SKI1_1	71	75	PF00082	0.443
DEG_APCC_DBOX_1	71	79	PF00400	0.412
DEG_Nend_UBRbox_3	1	3	PF02207	0.567
DEG_SPOP_SBC_1	492	496	PF00917	0.679
DOC_CKS1_1	265	270	PF01111	0.726
DOC_MAPK_gen_1	347	357	PF00069	0.746
DOC_MAPK_gen_1	571	578	PF00069	0.529
DOC_MAPK_gen_1	71	78	PF00069	0.434
DOC_MAPK_MEF2A_6	187	195	PF00069	0.412
DOC_MAPK_MEF2A_6	71	80	PF00069	0.412
DOC_PP4_FxxP_1	200	203	PF00568	0.387
DOC_SPAK_OSR1_1	22	26	PF12202	0.504
DOC_USP7_MATH_1	148	152	PF00917	0.481
DOC_USP7_MATH_1	270	274	PF00917	0.805
DOC_USP7_MATH_1	276	280	PF00917	0.702
DOC_USP7_MATH_1	284	288	PF00917	0.568
DOC_USP7_MATH_1	390	394	PF00917	0.769
DOC_USP7_MATH_1	492	496	PF00917	0.663
DOC_USP7_MATH_1	512	516	PF00917	0.488
DOC_USP7_MATH_1	569	573	PF00917	0.770
DOC_USP7_MATH_1	96	100	PF00917	0.514
DOC_WW_Pin1_4	181	186	PF00397	0.353
DOC_WW_Pin1_4	264	269	PF00397	0.720
DOC_WW_Pin1_4	6	11	PF00397	0.585
LIG_14-3-3_CanoR_1	168	174	PF00244	0.412
LIG_14-3-3_CanoR_1	30	40	PF00244	0.434
LIG_14-3-3_CanoR_1	433	438	PF00244	0.782
LIG_14-3-3_CanoR_1	52	56	PF00244	0.559
LIG_14-3-3_CanoR_1	95	105	PF00244	0.397
LIG_APCC_ABBA_1	139	144	PF00400	0.412
LIG_BRCT_BRCA1_1	485	489	PF00533	0.699
LIG_Clathr_ClatBox_1	75	79	PF01394	0.412
LIG_deltaCOP1_diTrp_1	409	417	PF00928	0.712
LIG_EH1_1	173	181	PF00400	0.412
LIG_eIF4E_1	133	139	PF01652	0.412
LIG_FHA_1	113	119	PF00498	0.499
LIG_FHA_1	176	182	PF00498	0.390
LIG_FHA_1	213	219	PF00498	0.405
LIG_FHA_1	505	511	PF00498	0.722
LIG_FHA_1	515	521	PF00498	0.813
LIG_FHA_1	584	590	PF00498	0.731
LIG_FHA_1	65	71	PF00498	0.487
LIG_FHA_2	255	261	PF00498	0.513
LIG_FHA_2	349	355	PF00498	0.646
LIG_FHA_2	42	48	PF00498	0.501
LIG_GBD_Chelix_1	588	596	PF00786	0.657
LIG_GBD_Chelix_1	76	84	PF00786	0.412
LIG_IBAR_NPY_1	154	156	PF08397	0.412
LIG_Integrin_RGD_1	460	462	PF01839	0.540
LIG_LIR_Gen_1	172	181	PF02991	0.412
LIG_LIR_Gen_1	26	33	PF02991	0.567
LIG_LIR_Gen_1	422	429	PF02991	0.716
LIG_LIR_Gen_1	99	109	PF02991	0.353
LIG_LIR_Nem_3	127	133	PF02991	0.412
LIG_LIR_Nem_3	172	176	PF02991	0.448
LIG_LIR_Nem_3	26	31	PF02991	0.560
LIG_LIR_Nem_3	99	104	PF02991	0.353
LIG_MLH1_MIPbox_1	485	489	PF16413	0.699
LIG_MYND_1	500	504	PF01753	0.813
LIG_PCNA_yPIPBox_3	120	130	PF02747	0.385
LIG_RPA_C_Fungi	532	544	PF08784	0.540
LIG_SH2_GRB2like	425	428	PF00017	0.720
LIG_SH2_PTP2	28	31	PF00017	0.446
LIG_SH2_STAP1	425	429	PF00017	0.719
LIG_SH2_STAP1	61	65	PF00017	0.498
LIG_SH2_STAT5	28	31	PF00017	0.428
LIG_SH3_2	386	391	PF14604	0.702
LIG_SH3_3	262	268	PF00018	0.716
LIG_SH3_3	383	389	PF00018	0.741
LIG_SH3_3	498	504	PF00018	0.801
LIG_SH3_3	506	512	PF00018	0.658
LIG_SH3_3	60	66	PF00018	0.506
LIG_SH3_3	90	96	PF00018	0.318
LIG_SH3_4	388	395	PF00018	0.722
LIG_SUMO_SIM_anti_2	221	227	PF11976	0.593
LIG_SUMO_SIM_par_1	109	116	PF11976	0.412
LIG_SUMO_SIM_par_1	177	184	PF11976	0.390
LIG_SUMO_SIM_par_1	221	227	PF11976	0.491
LIG_SUMO_SIM_par_1	74	79	PF11976	0.412
LIG_TRAF2_1	257	260	PF00917	0.566
LIG_TRAF2_1	351	354	PF00917	0.635
LIG_TRFH_1	92	96	PF08558	0.412
LIG_UBA3_1	212	220	PF00899	0.514
LIG_WW_3	388	392	PF00397	0.713
MOD_CDC14_SPxK_1	184	187	PF00782	0.412
MOD_CDK_SPxK_1	181	187	PF00069	0.412
MOD_CK1_1	172	178	PF00069	0.514
MOD_CK1_1	263	269	PF00069	0.730
MOD_CK1_1	3	9	PF00069	0.506
MOD_CK1_1	336	342	PF00069	0.626
MOD_CK1_1	463	469	PF00069	0.819
MOD_CK1_1	476	482	PF00069	0.786
MOD_CK1_1	483	489	PF00069	0.731
MOD_CK1_1	572	578	PF00069	0.772
MOD_CK2_1	254	260	PF00069	0.595
MOD_CK2_1	293	299	PF00069	0.648
MOD_CK2_1	348	354	PF00069	0.649
MOD_CK2_1	6	12	PF00069	0.521
MOD_GlcNHglycan	115	118	PF01048	0.373
MOD_GlcNHglycan	150	153	PF01048	0.440
MOD_GlcNHglycan	2	5	PF01048	0.608
MOD_GlcNHglycan	226	229	PF01048	0.470
MOD_GlcNHglycan	272	275	PF01048	0.684
MOD_GlcNHglycan	278	281	PF01048	0.670
MOD_GlcNHglycan	285	289	PF01048	0.674
MOD_GlcNHglycan	338	341	PF01048	0.738
MOD_GlcNHglycan	435	438	PF01048	0.730
MOD_GlcNHglycan	495	498	PF01048	0.726
MOD_GlcNHglycan	534	537	PF01048	0.762
MOD_GlcNHglycan	67	70	PF01048	0.469
MOD_GSK3_1	2	9	PF00069	0.682
MOD_GSK3_1	259	266	PF00069	0.766
MOD_GSK3_1	270	277	PF00069	0.689
MOD_GSK3_1	284	291	PF00069	0.537
MOD_GSK3_1	390	397	PF00069	0.810
MOD_GSK3_1	411	418	PF00069	0.718
MOD_GSK3_1	475	482	PF00069	0.781
MOD_GSK3_1	488	495	PF00069	0.619
MOD_GSK3_1	514	521	PF00069	0.706
MOD_GSK3_1	528	535	PF00069	0.690
MOD_GSK3_1	572	579	PF00069	0.682
MOD_GSK3_1	61	68	PF00069	0.495
MOD_N-GLC_1	96	101	PF02516	0.454
MOD_NEK2_1	104	109	PF00069	0.412
MOD_NEK2_1	118	123	PF00069	0.412
MOD_NEK2_1	137	142	PF00069	0.501
MOD_NEK2_1	224	229	PF00069	0.469
MOD_NEK2_1	303	308	PF00069	0.391
MOD_NEK2_1	488	493	PF00069	0.709
MOD_NEK2_1	532	537	PF00069	0.654
MOD_PIKK_1	3	9	PF00454	0.514
MOD_PIKK_1	372	378	PF00454	0.617
MOD_PIKK_1	473	479	PF00454	0.781
MOD_PIKK_1	518	524	PF00454	0.648
MOD_PKA_1	433	439	PF00069	0.716
MOD_PKA_2	119	125	PF00069	0.412
MOD_PKA_2	260	266	PF00069	0.691
MOD_PKA_2	31	37	PF00069	0.502
MOD_PKA_2	336	342	PF00069	0.626
MOD_PKA_2	390	396	PF00069	0.804
MOD_PKA_2	433	439	PF00069	0.716
MOD_PKA_2	51	57	PF00069	0.558
MOD_PKA_2	572	578	PF00069	0.658
MOD_PKA_2	88	94	PF00069	0.340
MOD_Plk_1	284	290	PF00069	0.536
MOD_Plk_1	461	467	PF00069	0.705
MOD_Plk_1	583	589	PF00069	0.782
MOD_Plk_1	61	67	PF00069	0.493
MOD_Plk_2-3	293	299	PF00069	0.648
MOD_Plk_2-3	51	57	PF00069	0.497
MOD_Plk_4	175	181	PF00069	0.507
MOD_Plk_4	443	449	PF00069	0.524
MOD_Plk_4	483	489	PF00069	0.798
MOD_Plk_4	528	534	PF00069	0.569
MOD_Plk_4	88	94	PF00069	0.379
MOD_ProDKin_1	181	187	PF00069	0.353
MOD_ProDKin_1	264	270	PF00069	0.719
MOD_ProDKin_1	6	12	PF00069	0.587
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.487
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.518
TRG_ENDOCYTIC_2	133	136	PF00928	0.412
TRG_ENDOCYTIC_2	28	31	PF00928	0.446
TRG_ENDOCYTIC_2	425	428	PF00928	0.720
TRG_ER_diArg_1	18	20	PF00400	0.623
TRG_ER_diArg_1	237	239	PF00400	0.637
TRG_ER_diArg_1	29	32	PF00400	0.382
TRG_ER_diArg_1	368	371	PF00400	0.633
TRG_ER_diArg_1	399	401	PF00400	0.724
TRG_ER_diArg_1	70	72	PF00400	0.459
TRG_NES_CRM1_1	214	226	PF08389	0.412
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P590	Leptomonas seymouri	49%	90%
A0A3Q8IM24	Leishmania donovani	91%	100%
A4HMH2	Leishmania braziliensis	77%	100%
A4IB52	Leishmania infantum	91%	100%
E9AEX3	Leishmania major	89%	100%