Putative choline/ethanolamine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

choline/ethanolamine kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B626_LEIMU

TriTrypDb:

LmxM.34.1470

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B626

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B626

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0044237	cellular metabolic process	2	13
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006646	phosphatidylethanolamine biosynthetic process	6	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046337	phosphatidylethanolamine metabolic process	6	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0004305	ethanolamine kinase activity	5	3
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	3
GO:0004103	choline kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.557
CLV_C14_Caspase3-7	583	587	PF00656	0.577
CLV_C14_Caspase3-7	65	69	PF00656	0.663
CLV_NRD_NRD_1	275	277	PF00675	0.238
CLV_NRD_NRD_1	413	415	PF00675	0.304
CLV_NRD_NRD_1	446	448	PF00675	0.302
CLV_PCSK_KEX2_1	392	394	PF00082	0.324
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.362
CLV_PCSK_SKI1_1	201	205	PF00082	0.271
CLV_PCSK_SKI1_1	27	31	PF00082	0.555
CLV_PCSK_SKI1_1	297	301	PF00082	0.344
CLV_PCSK_SKI1_1	325	329	PF00082	0.358
CLV_PCSK_SKI1_1	35	39	PF00082	0.600
CLV_PCSK_SKI1_1	387	391	PF00082	0.348
CLV_PCSK_SKI1_1	447	451	PF00082	0.307
CLV_PCSK_SKI1_1	585	589	PF00082	0.559
CLV_Separin_Metazoa	24	28	PF03568	0.594
DEG_APCC_DBOX_1	296	304	PF00400	0.369
DEG_APCC_DBOX_1	592	600	PF00400	0.521
DOC_AGCK_PIF_2	467	472	PF00069	0.480
DOC_ANK_TNKS_1	494	501	PF00023	0.644
DOC_CKS1_1	309	314	PF01111	0.548
DOC_CKS1_1	43	48	PF01111	0.693
DOC_CYCLIN_RxL_1	153	164	PF00134	0.514
DOC_CYCLIN_RxL_1	354	364	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	299	305	PF00134	0.577
DOC_MAPK_gen_1	105	114	PF00069	0.733
DOC_MAPK_gen_1	358	368	PF00069	0.562
DOC_MAPK_gen_1	392	399	PF00069	0.539
DOC_MAPK_JIP1_4	156	162	PF00069	0.729
DOC_MAPK_MEF2A_6	392	399	PF00069	0.520
DOC_MAPK_MEF2A_6	463	470	PF00069	0.483
DOC_PP1_RVXF_1	461	468	PF00149	0.562
DOC_USP7_MATH_1	254	258	PF00917	0.548
DOC_USP7_MATH_1	282	286	PF00917	0.577
DOC_USP7_MATH_1	329	333	PF00917	0.572
DOC_USP7_MATH_1	347	351	PF00917	0.497
DOC_USP7_MATH_1	436	440	PF00917	0.519
DOC_USP7_MATH_1	556	560	PF00917	0.616
DOC_USP7_MATH_1	634	638	PF00917	0.509
DOC_USP7_UBL2_3	448	452	PF12436	0.511
DOC_USP7_UBL2_3	96	100	PF12436	0.598
DOC_WW_Pin1_4	143	148	PF00397	0.713
DOC_WW_Pin1_4	231	236	PF00397	0.491
DOC_WW_Pin1_4	261	266	PF00397	0.480
DOC_WW_Pin1_4	308	313	PF00397	0.528
DOC_WW_Pin1_4	42	47	PF00397	0.640
DOC_WW_Pin1_4	586	591	PF00397	0.599
LIG_14-3-3_CanoR_1	108	113	PF00244	0.701
LIG_14-3-3_CanoR_1	156	161	PF00244	0.713
LIG_14-3-3_CanoR_1	276	282	PF00244	0.438
LIG_14-3-3_CanoR_1	361	368	PF00244	0.484
LIG_14-3-3_CanoR_1	372	376	PF00244	0.469
LIG_APCC_ABBAyCdc20_2	463	469	PF00400	0.504
LIG_BIR_III_2	346	350	PF00653	0.522
LIG_BRCT_BRCA1_1	373	377	PF00533	0.369
LIG_BRCT_BRCA1_1	441	445	PF00533	0.562
LIG_CtBP_PxDLS_1	46	50	PF00389	0.715
LIG_deltaCOP1_diTrp_1	127	135	PF00928	0.476
LIG_FHA_1	200	206	PF00498	0.405
LIG_FHA_1	256	262	PF00498	0.471
LIG_FHA_1	361	367	PF00498	0.556
LIG_FHA_1	586	592	PF00498	0.460
LIG_FHA_1	80	86	PF00498	0.612
LIG_FHA_2	150	156	PF00498	0.600
LIG_FHA_2	309	315	PF00498	0.531
LIG_FHA_2	483	489	PF00498	0.480
LIG_FHA_2	534	540	PF00498	0.248
LIG_FHA_2	581	587	PF00498	0.619
LIG_FHA_2	590	596	PF00498	0.502
LIG_FXI_DFP_1	195	199	PF00024	0.600
LIG_KLC1_Yacidic_2	333	337	PF13176	0.522
LIG_LIR_Gen_1	270	278	PF02991	0.563
LIG_LIR_Gen_1	28	37	PF02991	0.535
LIG_LIR_Gen_1	280	291	PF02991	0.564
LIG_LIR_Gen_1	313	323	PF02991	0.522
LIG_LIR_Gen_1	374	383	PF02991	0.561
LIG_LIR_Gen_1	469	480	PF02991	0.546
LIG_LIR_Gen_1	61	70	PF02991	0.723
LIG_LIR_Gen_1	611	621	PF02991	0.403
LIG_LIR_Gen_1	652	660	PF02991	0.350
LIG_LIR_Nem_3	127	131	PF02991	0.504
LIG_LIR_Nem_3	139	143	PF02991	0.517
LIG_LIR_Nem_3	217	222	PF02991	0.577
LIG_LIR_Nem_3	240	246	PF02991	0.472
LIG_LIR_Nem_3	270	275	PF02991	0.481
LIG_LIR_Nem_3	28	34	PF02991	0.527
LIG_LIR_Nem_3	280	286	PF02991	0.481
LIG_LIR_Nem_3	313	318	PF02991	0.522
LIG_LIR_Nem_3	355	360	PF02991	0.505
LIG_LIR_Nem_3	374	378	PF02991	0.555
LIG_LIR_Nem_3	469	475	PF02991	0.493
LIG_LIR_Nem_3	501	507	PF02991	0.525
LIG_LIR_Nem_3	518	523	PF02991	0.355
LIG_LIR_Nem_3	6	12	PF02991	0.655
LIG_LIR_Nem_3	611	616	PF02991	0.362
LIG_LIR_Nem_3	641	645	PF02991	0.361
LIG_LIR_Nem_3	652	656	PF02991	0.348
LIG_NRBOX	385	391	PF00104	0.562
LIG_PCNA_yPIPBox_3	10	18	PF02747	0.583
LIG_PCNA_yPIPBox_3	647	661	PF02747	0.479
LIG_Pex14_2	445	449	PF04695	0.562
LIG_Rb_pABgroove_1	129	137	PF01858	0.470
LIG_SH2_CRK	509	513	PF00017	0.556
LIG_SH2_NCK_1	309	313	PF00017	0.577
LIG_SH2_NCK_1	472	476	PF00017	0.480
LIG_SH2_PTP2	653	656	PF00017	0.397
LIG_SH2_SRC	31	34	PF00017	0.567
LIG_SH2_STAP1	283	287	PF00017	0.562
LIG_SH2_STAT3	516	519	PF00017	0.571
LIG_SH2_STAT5	315	318	PF00017	0.562
LIG_SH2_STAT5	33	36	PF00017	0.571
LIG_SH2_STAT5	335	338	PF00017	0.577
LIG_SH2_STAT5	472	475	PF00017	0.505
LIG_SH2_STAT5	493	496	PF00017	0.480
LIG_SH2_STAT5	509	512	PF00017	0.478
LIG_SH2_STAT5	535	538	PF00017	0.526
LIG_SH2_STAT5	574	577	PF00017	0.386
LIG_SH2_STAT5	642	645	PF00017	0.400
LIG_SH2_STAT5	653	656	PF00017	0.322
LIG_SH3_2	196	201	PF14604	0.607
LIG_SH3_3	193	199	PF00018	0.585
LIG_SH3_3	550	556	PF00018	0.572
LIG_SUMO_SIM_anti_2	382	388	PF11976	0.562
LIG_SUMO_SIM_par_1	44	54	PF11976	0.714
LIG_TRAF2_1	311	314	PF00917	0.536
LIG_TRAF2_1	512	515	PF00917	0.550
LIG_UBA3_1	173	181	PF00899	0.604
LIG_UBA3_1	385	392	PF00899	0.562
LIG_WRC_WIRS_1	238	243	PF05994	0.480
LIG_WRC_WIRS_1	283	288	PF05994	0.573
LIG_WRC_WIRS_1	612	617	PF05994	0.458
LIG_WW_3	24	28	PF00397	0.594
MOD_CDK_SPxxK_3	586	593	PF00069	0.609
MOD_CK1_1	210	216	PF00069	0.562
MOD_CK1_1	36	42	PF00069	0.604
MOD_CK1_1	439	445	PF00069	0.552
MOD_CK1_1	48	54	PF00069	0.552
MOD_CK1_1	606	612	PF00069	0.451
MOD_CK2_1	149	155	PF00069	0.593
MOD_CK2_1	308	314	PF00069	0.505
MOD_CK2_1	347	353	PF00069	0.480
MOD_CK2_1	482	488	PF00069	0.480
MOD_CK2_1	533	539	PF00069	0.235
MOD_CK2_1	589	595	PF00069	0.539
MOD_CMANNOS	610	613	PF00535	0.339
MOD_GlcNHglycan	182	185	PF01048	0.509
MOD_GlcNHglycan	209	212	PF01048	0.354
MOD_GlcNHglycan	27	30	PF01048	0.511
MOD_GlcNHglycan	379	382	PF01048	0.377
MOD_GlcNHglycan	637	640	PF01048	0.413
MOD_GSK3_1	146	153	PF00069	0.739
MOD_GSK3_1	180	187	PF00069	0.483
MOD_GSK3_1	348	355	PF00069	0.494
MOD_GSK3_1	367	374	PF00069	0.562
MOD_GSK3_1	41	48	PF00069	0.694
MOD_GSK3_1	435	442	PF00069	0.514
MOD_GSK3_1	51	58	PF00069	0.649
MOD_GSK3_1	534	541	PF00069	0.324
MOD_GSK3_1	585	592	PF00069	0.501
MOD_GSK3_1	622	629	PF00069	0.486
MOD_LATS_1	118	124	PF00433	0.661
MOD_N-GLC_1	120	125	PF02516	0.614
MOD_N-GLC_1	337	342	PF02516	0.349
MOD_N-GLC_1	626	631	PF02516	0.373
MOD_N-GLC_1	68	73	PF02516	0.655
MOD_NEK2_1	318	323	PF00069	0.385
MOD_NEK2_1	336	341	PF00069	0.561
MOD_NEK2_1	352	357	PF00069	0.416
MOD_NEK2_1	360	365	PF00069	0.486
MOD_NEK2_1	397	402	PF00069	0.545
MOD_NEK2_1	482	487	PF00069	0.476
MOD_NEK2_1	533	538	PF00069	0.519
MOD_NEK2_1	55	60	PF00069	0.594
MOD_NEK2_1	600	605	PF00069	0.356
MOD_NEK2_1	608	613	PF00069	0.308
MOD_NEK2_1	62	67	PF00069	0.549
MOD_NEK2_1	89	94	PF00069	0.466
MOD_NEK2_2	33	38	PF00069	0.577
MOD_PIKK_1	167	173	PF00454	0.499
MOD_PIKK_1	337	343	PF00454	0.571
MOD_PK_1	108	114	PF00069	0.700
MOD_PKA_2	360	366	PF00069	0.495
MOD_PKA_2	371	377	PF00069	0.444
MOD_PKA_2	494	500	PF00069	0.464
MOD_Plk_1	120	126	PF00069	0.613
MOD_Plk_1	167	173	PF00069	0.531
MOD_Plk_1	352	358	PF00069	0.543
MOD_Plk_1	4	10	PF00069	0.360
MOD_Plk_1	51	57	PF00069	0.722
MOD_Plk_4	136	142	PF00069	0.560
MOD_Plk_4	199	205	PF00069	0.418
MOD_Plk_4	263	269	PF00069	0.520
MOD_Plk_4	282	288	PF00069	0.577
MOD_Plk_4	371	377	PF00069	0.495
MOD_Plk_4	4	10	PF00069	0.553
MOD_Plk_4	58	64	PF00069	0.500
MOD_ProDKin_1	143	149	PF00069	0.716
MOD_ProDKin_1	231	237	PF00069	0.491
MOD_ProDKin_1	261	267	PF00069	0.480
MOD_ProDKin_1	308	314	PF00069	0.528
MOD_ProDKin_1	42	48	PF00069	0.636
MOD_ProDKin_1	586	592	PF00069	0.595
MOD_SUMO_for_1	37	40	PF00179	0.588
TRG_DiLeu_BaEn_1	168	173	PF01217	0.600
TRG_DiLeu_BaEn_1	270	275	PF01217	0.562
TRG_DiLeu_BaEn_1	314	319	PF01217	0.369
TRG_DiLeu_BaEn_1	81	86	PF01217	0.509
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.562
TRG_ENDOCYTIC_2	283	286	PF00928	0.516
TRG_ENDOCYTIC_2	31	34	PF00928	0.567
TRG_ENDOCYTIC_2	315	318	PF00928	0.522
TRG_ENDOCYTIC_2	472	475	PF00928	0.491
TRG_ENDOCYTIC_2	477	480	PF00928	0.483
TRG_ENDOCYTIC_2	63	66	PF00928	0.739
TRG_ENDOCYTIC_2	653	656	PF00928	0.350
TRG_ER_diArg_1	230	233	PF00400	0.577
TRG_NES_CRM1_1	214	227	PF08389	0.577
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZI3	Leptomonas seymouri	69%	100%
A0A0S4JCZ4	Bodo saltans	23%	100%
A0A1X0NH78	Trypanosomatidae	42%	100%
A0A1X0NIW4	Trypanosomatidae	42%	100%
A0A3Q8IPA3	Leishmania donovani	95%	100%
A0A422N9U8	Trypanosoma rangeli	43%	100%
A4HMG9	Leishmania braziliensis	87%	99%
A4IB50	Leishmania infantum	94%	100%
C9ZNP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AEX0	Leishmania major	93%	100%
V5BC85	Trypanosoma cruzi	45%	100%