Putative peroxisome targeting signal 1 receptor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisome targeting signal 1 receptor, putative

Species:

Leishmania mexicana

UniProt:

E9B621_LEIMU

TriTrypDb:

LmxM.34.1420

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005778	peroxisomal membrane	6	1
GO:0005829	cytosol	2	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9B621

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B621

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0016560	protein import into peroxisome matrix, docking	5	1
GO:0033036	macromolecule localization	2	2
GO:0051179	localization	1	2
GO:0051641	cellular localization	2	2
GO:0070727	cellular macromolecule localization	3	2
GO:0006810	transport	3	1
GO:0015031	protein transport	4	1
GO:0045184	establishment of protein localization	3	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000268	peroxisome targeting sequence binding	5	1
GO:0005048	signal sequence binding	4	1
GO:0005052	peroxisome matrix targeting signal-1 binding	6	1
GO:0005488	binding	1	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	387	389	PF00675	0.433
CLV_NRD_NRD_1	497	499	PF00675	0.324
CLV_PCSK_SKI1_1	218	222	PF00082	0.444
CLV_PCSK_SKI1_1	620	624	PF00082	0.316
DEG_APCC_DBOX_1	594	602	PF00400	0.305
DEG_Nend_UBRbox_2	1	3	PF02207	0.523
DOC_MAPK_DCC_7	152	161	PF00069	0.455
DOC_MAPK_MEF2A_6	152	161	PF00069	0.505
DOC_PP2B_LxvP_1	255	258	PF13499	0.471
DOC_PP4_FxxP_1	189	192	PF00568	0.637
DOC_PP4_FxxP_1	262	265	PF00568	0.508
DOC_PP4_FxxP_1	450	453	PF00568	0.411
DOC_USP7_MATH_1	118	122	PF00917	0.578
DOC_USP7_MATH_1	165	169	PF00917	0.613
DOC_USP7_MATH_1	266	270	PF00917	0.684
DOC_USP7_MATH_1	310	314	PF00917	0.386
DOC_USP7_MATH_1	414	418	PF00917	0.332
DOC_USP7_MATH_1	432	436	PF00917	0.387
DOC_USP7_MATH_1	451	455	PF00917	0.430
DOC_USP7_MATH_1	471	475	PF00917	0.207
DOC_USP7_MATH_1	568	572	PF00917	0.466
DOC_USP7_UBL2_3	509	513	PF12436	0.293
DOC_WW_Pin1_4	270	275	PF00397	0.586
LIG_14-3-3_CanoR_1	595	599	PF00244	0.328
LIG_BRCT_BRCA1_1	473	477	PF00533	0.442
LIG_FHA_1	595	601	PF00498	0.396
LIG_FHA_2	196	202	PF00498	0.477
LIG_FHA_2	270	276	PF00498	0.646
LIG_FHA_2	368	374	PF00498	0.304
LIG_FHA_2	459	465	PF00498	0.500
LIG_FHA_2	608	614	PF00498	0.414
LIG_FXI_DFP_1	326	330	PF00024	0.377
LIG_IBAR_NPY_1	322	324	PF08397	0.326
LIG_LIR_Apic_2	188	192	PF02991	0.639
LIG_LIR_Apic_2	259	265	PF02991	0.500
LIG_LIR_Apic_2	447	453	PF02991	0.476
LIG_LIR_Gen_1	180	191	PF02991	0.606
LIG_LIR_Gen_1	299	307	PF02991	0.474
LIG_LIR_Gen_1	361	372	PF02991	0.461
LIG_LIR_Gen_1	427	436	PF02991	0.514
LIG_LIR_Gen_1	474	483	PF02991	0.483
LIG_LIR_Nem_3	138	143	PF02991	0.606
LIG_LIR_Nem_3	180	186	PF02991	0.569
LIG_LIR_Nem_3	205	211	PF02991	0.430
LIG_LIR_Nem_3	361	367	PF02991	0.322
LIG_LIR_Nem_3	427	431	PF02991	0.489
LIG_LIR_Nem_3	474	480	PF02991	0.487
LIG_Pex14_1	179	183	PF04695	0.511
LIG_Pex14_1	296	300	PF04695	0.474
LIG_Pex14_1	53	57	PF04695	0.467
LIG_Pex14_2	618	622	PF04695	0.308
LIG_PTB_Apo_2	535	542	PF02174	0.234
LIG_PTB_Phospho_1	535	541	PF10480	0.234
LIG_SH2_CRK	140	144	PF00017	0.609
LIG_SH2_CRK	183	187	PF00017	0.650
LIG_SH2_GRB2like	552	555	PF00017	0.308
LIG_SH2_NCK_1	183	187	PF00017	0.539
LIG_SH2_NCK_1	558	562	PF00017	0.385
LIG_SH2_STAP1	428	432	PF00017	0.491
LIG_SH2_STAP1	463	467	PF00017	0.387
LIG_SH2_STAP1	558	562	PF00017	0.208
LIG_SH2_STAT3	611	614	PF00017	0.382
LIG_SH2_STAT5	245	248	PF00017	0.459
LIG_SH2_STAT5	282	285	PF00017	0.706
LIG_SH2_STAT5	541	544	PF00017	0.257
LIG_SH3_3	227	233	PF00018	0.469
LIG_SH3_3	234	240	PF00018	0.493
LIG_SH3_3	258	264	PF00018	0.524
LIG_SH3_3	314	320	PF00018	0.383
LIG_SH3_3	420	426	PF00018	0.443
LIG_SH3_3	431	437	PF00018	0.468
LIG_SH3_3	502	508	PF00018	0.379
LIG_SUMO_SIM_anti_2	377	383	PF11976	0.324
LIG_TRAF2_1	198	201	PF00917	0.475
LIG_TYR_ITSM	179	186	PF00017	0.646
LIG_UBA3_1	381	389	PF00899	0.423
LIG_WRC_WIRS_1	186	191	PF05994	0.635
MOD_CK1_1	144	150	PF00069	0.555
MOD_CK1_1	269	275	PF00069	0.542
MOD_CK1_1	553	559	PF00069	0.426
MOD_CK2_1	195	201	PF00069	0.483
MOD_CK2_1	269	275	PF00069	0.747
MOD_CK2_1	355	361	PF00069	0.398
MOD_CK2_1	367	373	PF00069	0.254
MOD_CK2_1	458	464	PF00069	0.443
MOD_CK2_1	607	613	PF00069	0.485
MOD_GlcNHglycan	146	149	PF01048	0.640
MOD_GlcNHglycan	167	170	PF01048	0.602
MOD_GlcNHglycan	189	192	PF01048	0.531
MOD_GlcNHglycan	26	29	PF01048	0.671
MOD_GlcNHglycan	268	271	PF01048	0.621
MOD_GlcNHglycan	38	41	PF01048	0.624
MOD_GlcNHglycan	578	581	PF01048	0.513
MOD_GlcNHglycan	90	93	PF01048	0.569
MOD_GSK3_1	177	184	PF00069	0.617
MOD_GSK3_1	24	31	PF00069	0.735
MOD_GSK3_1	266	273	PF00069	0.588
MOD_GSK3_1	32	39	PF00069	0.473
MOD_GSK3_1	399	406	PF00069	0.440
MOD_GSK3_1	471	478	PF00069	0.376
MOD_GSK3_1	576	583	PF00069	0.440
MOD_GSK3_1	84	91	PF00069	0.452
MOD_N-GLC_1	144	149	PF02516	0.660
MOD_N-GLC_1	311	316	PF02516	0.408
MOD_N-GLC_1	553	558	PF02516	0.411
MOD_NEK2_1	36	41	PF00069	0.577
MOD_NEK2_1	367	372	PF00069	0.312
MOD_NEK2_1	401	406	PF00069	0.307
MOD_NEK2_1	514	519	PF00069	0.234
MOD_NEK2_1	594	599	PF00069	0.327
MOD_NEK2_1	76	81	PF00069	0.512
MOD_NEK2_2	414	419	PF00069	0.354
MOD_PIKK_1	118	124	PF00454	0.640
MOD_PIKK_1	135	141	PF00454	0.678
MOD_PIKK_1	172	178	PF00454	0.647
MOD_PIKK_1	181	187	PF00454	0.651
MOD_PIKK_1	367	373	PF00454	0.309
MOD_PIKK_1	471	477	PF00454	0.380
MOD_PIKK_1	553	559	PF00454	0.402
MOD_PIKK_1	568	574	PF00454	0.338
MOD_PIKK_1	76	82	PF00454	0.699
MOD_PKA_2	594	600	PF00069	0.328
MOD_Plk_1	144	150	PF00069	0.697
MOD_Plk_1	181	187	PF00069	0.599
MOD_Plk_1	195	201	PF00069	0.426
MOD_Plk_1	553	559	PF00069	0.412
MOD_Plk_2-3	195	201	PF00069	0.560
MOD_Plk_2-3	458	464	PF00069	0.530
MOD_Plk_4	110	116	PF00069	0.686
MOD_Plk_4	257	263	PF00069	0.580
MOD_Plk_4	32	38	PF00069	0.395
MOD_Plk_4	444	450	PF00069	0.549
MOD_Plk_4	580	586	PF00069	0.450
MOD_ProDKin_1	270	276	PF00069	0.585
MOD_SUMO_for_1	622	625	PF00179	0.225
MOD_SUMO_rev_2	190	199	PF00179	0.614
MOD_SUMO_rev_2	506	510	PF00179	0.282
MOD_SUMO_rev_2	616	624	PF00179	0.333
TRG_DiLeu_BaEn_1	225	230	PF01217	0.540
TRG_DiLeu_BaEn_1	32	37	PF01217	0.507
TRG_DiLeu_BaEn_2	206	212	PF01217	0.483
TRG_ENDOCYTIC_2	140	143	PF00928	0.723
TRG_ENDOCYTIC_2	183	186	PF00928	0.560
TRG_ENDOCYTIC_2	209	212	PF00928	0.429
TRG_ENDOCYTIC_2	300	303	PF00928	0.501
TRG_ENDOCYTIC_2	428	431	PF00928	0.342
TRG_ENDOCYTIC_2	552	555	PF00928	0.308
TRG_NES_CRM1_1	613	625	PF08389	0.388
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT5	Leptomonas seymouri	81%	100%
A0A0S4KFV0	Bodo saltans	46%	100%
A0A1X0NH73	Trypanosomatidae	51%	96%
A0A3S7X906	Leishmania donovani	95%	100%
A0A422N9P3	Trypanosoma rangeli	58%	96%
A4HMG4	Leishmania braziliensis	85%	100%
A4IB35	Leishmania infantum	95%	100%
C9ZNN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	96%
E9AEW5	Leishmania major	93%	100%
O70525	Cavia porcellus	32%	98%
Q9FMA3	Arabidopsis thaliana	34%	86%
V5B7T1	Trypanosoma cruzi	48%	94%