RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B619_LEIMU

TriTrypDb:

LmxM.34.1400

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B619

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B619

Function

Biological processes
Term	Name	Level	Count
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	1
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000966	RNA 5'-end processing	7	1
GO:0000967	rRNA 5'-end processing	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0034462	small-subunit processome assembly	7	1
GO:0034470	ncRNA processing	7	1
GO:0034471	ncRNA 5'-end processing	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0036260	RNA capping	7	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.573
CLV_NRD_NRD_1	124	126	PF00675	0.514
CLV_NRD_NRD_1	127	129	PF00675	0.505
CLV_NRD_NRD_1	135	137	PF00675	0.442
CLV_NRD_NRD_1	146	148	PF00675	0.566
CLV_NRD_NRD_1	155	157	PF00675	0.507
CLV_NRD_NRD_1	160	162	PF00675	0.542
CLV_NRD_NRD_1	229	231	PF00675	0.762
CLV_NRD_NRD_1	42	44	PF00675	0.472
CLV_NRD_NRD_1	54	56	PF00675	0.508
CLV_NRD_NRD_1	96	98	PF00675	0.454
CLV_PCSK_FUR_1	125	129	PF00082	0.489
CLV_PCSK_FUR_1	94	98	PF00082	0.477
CLV_PCSK_KEX2_1	123	125	PF00082	0.513
CLV_PCSK_KEX2_1	127	129	PF00082	0.485
CLV_PCSK_KEX2_1	135	137	PF00082	0.351
CLV_PCSK_KEX2_1	146	148	PF00082	0.566
CLV_PCSK_KEX2_1	159	161	PF00082	0.562
CLV_PCSK_KEX2_1	227	229	PF00082	0.768
CLV_PCSK_KEX2_1	42	44	PF00082	0.472
CLV_PCSK_KEX2_1	54	56	PF00082	0.508
CLV_PCSK_KEX2_1	93	95	PF00082	0.509
CLV_PCSK_KEX2_1	96	98	PF00082	0.454
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.628
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.659
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.768
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.509
CLV_PCSK_PC7_1	156	162	PF00082	0.685
CLV_PCSK_SKI1_1	14	18	PF00082	0.411
CLV_PCSK_SKI1_1	156	160	PF00082	0.602
CLV_PCSK_SKI1_1	224	228	PF00082	0.692
CLV_PCSK_SKI1_1	42	46	PF00082	0.493
DOC_MAPK_gen_1	24	33	PF00069	0.531
DOC_MAPK_gen_1	42	49	PF00069	0.291
DOC_MAPK_MEF2A_6	27	35	PF00069	0.568
DOC_MAPK_MEF2A_6	54	63	PF00069	0.579
DOC_PP1_RVXF_1	30	36	PF00149	0.573
DOC_USP7_MATH_1	137	141	PF00917	0.631
DOC_USP7_MATH_1	169	173	PF00917	0.685
DOC_USP7_MATH_1	186	190	PF00917	0.461
DOC_USP7_MATH_1	203	207	PF00917	0.662
DOC_USP7_MATH_1	215	219	PF00917	0.621
DOC_USP7_UBL2_3	205	209	PF12436	0.753
LIG_AP2alpha_1	107	111	PF02296	0.490
LIG_BIR_II_1	1	5	PF00653	0.703
LIG_deltaCOP1_diTrp_1	67	72	PF00928	0.535
LIG_FHA_1	221	227	PF00498	0.583
LIG_LIR_Apic_2	206	210	PF02991	0.470
LIG_LIR_Apic_2	5	11	PF02991	0.507
LIG_LIR_Gen_1	112	120	PF02991	0.427
LIG_LIR_Gen_1	67	75	PF02991	0.488
LIG_LIR_Nem_3	112	116	PF02991	0.409
LIG_LIR_Nem_3	67	72	PF02991	0.477
LIG_Pex14_1	103	107	PF04695	0.394
LIG_Pex14_2	107	111	PF04695	0.568
LIG_SH2_CRK	207	211	PF00017	0.475
LIG_SH2_CRK	8	12	PF00017	0.519
LIG_SH2_GRB2like	18	21	PF00017	0.577
LIG_SH2_NCK_1	8	12	PF00017	0.519
LIG_SH2_SRC	8	11	PF00017	0.512
LIG_SH2_STAT5	18	21	PF00017	0.505
LIG_SH2_STAT5	207	210	PF00017	0.471
LIG_SH3_3	53	59	PF00018	0.564
LIG_UBA3_1	60	66	PF00899	0.604
MOD_CK1_1	181	187	PF00069	0.749
MOD_CK1_1	189	195	PF00069	0.625
MOD_CK2_1	112	118	PF00069	0.494
MOD_CK2_1	137	143	PF00069	0.618
MOD_Cter_Amidation	121	124	PF01082	0.538
MOD_GlcNHglycan	171	174	PF01048	0.511
MOD_GlcNHglycan	188	191	PF01048	0.657
MOD_GlcNHglycan	213	216	PF01048	0.777
MOD_GlcNHglycan	73	76	PF01048	0.539
MOD_GSK3_1	167	174	PF00069	0.645
MOD_GSK3_1	211	218	PF00069	0.682
MOD_NEK2_1	70	75	PF00069	0.497
MOD_OFUCOSY	193	199	PF10250	0.459
MOD_PIKK_1	9	15	PF00454	0.498
MOD_Plk_1	137	143	PF00069	0.618
MOD_Plk_2-3	109	115	PF00069	0.577
MOD_Plk_4	112	118	PF00069	0.541
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.585
TRG_ENDOCYTIC_2	145	148	PF00928	0.587
TRG_ENDOCYTIC_2	38	41	PF00928	0.540
TRG_ENDOCYTIC_2	99	102	PF00928	0.509
TRG_ER_diArg_1	124	127	PF00400	0.485
TRG_ER_diArg_1	145	147	PF00400	0.565
TRG_ER_diArg_1	160	163	PF00400	0.717
TRG_ER_diArg_1	228	230	PF00400	0.684
TRG_ER_diArg_1	41	43	PF00400	0.460
TRG_ER_diArg_1	54	56	PF00400	0.494
TRG_ER_diArg_1	94	97	PF00400	0.495
TRG_ER_FFAT_2	67	77	PF00635	0.554
TRG_NLS_Bipartite_1	146	163	PF00514	0.588
TRG_NLS_MonoExtC_3	122	127	PF00514	0.549
TRG_NLS_MonoExtC_3	155	160	PF00514	0.659
TRG_NLS_MonoExtC_3	223	228	PF00514	0.776
TRG_NLS_MonoExtC_3	50	55	PF00514	0.678
TRG_NLS_MonoExtC_3	92	97	PF00514	0.488
TRG_NLS_MonoExtN_4	156	163	PF00514	0.692
TRG_NLS_MonoExtN_4	222	228	PF00514	0.773
TRG_NLS_MonoExtN_4	48	55	PF00514	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NJ36	Trypanosomatidae	52%	85%
A0A3S7X912	Leishmania donovani	94%	100%
A3LVD5	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	24%	67%
A4HMG2	Leishmania braziliensis	82%	100%
A4IB33	Leishmania infantum	94%	100%
C9ZNN2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	98%
E9AEW3	Leishmania major	92%	100%
O74362	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	69%
Q0UM32	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	29%	71%
Q2GZQ4	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	30%	70%
Q59YL9	Candida albicans (strain SC5314 / ATCC MYA-2876)	25%	72%
Q6BSS5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	77%
Q6CFT1	Yarrowia lipolytica (strain CLIB 122 / E 150)	31%	72%
Q6CSP8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	79%
Q7S8W7	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	28%	68%