OTU domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in Ran binding protein and others/OTU-like cysteine protease, putative

Species:

Leishmania mexicana

UniProt:

E9B618_LEIMU

TriTrypDb:

LmxM.34.1390

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B618

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B618

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016579	protein deubiquitination	6	1
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	2
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003824	catalytic activity	1	2
GO:0004843	cysteine-type deubiquitinase activity	5	1
GO:0008233	peptidase activity	3	2
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	2
GO:0019783	ubiquitin-like protein peptidase activity	4	1
GO:0101005	deubiquitinase activity	5	1
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.500
CLV_NRD_NRD_1	100	102	PF00675	0.410
CLV_NRD_NRD_1	155	157	PF00675	0.633
CLV_NRD_NRD_1	161	163	PF00675	0.669
CLV_NRD_NRD_1	333	335	PF00675	0.701
CLV_NRD_NRD_1	9	11	PF00675	0.424
CLV_PCSK_FUR_1	153	157	PF00082	0.612
CLV_PCSK_FUR_1	566	570	PF00082	0.622
CLV_PCSK_KEX2_1	100	102	PF00082	0.410
CLV_PCSK_KEX2_1	155	157	PF00082	0.603
CLV_PCSK_KEX2_1	161	163	PF00082	0.629
CLV_PCSK_KEX2_1	333	335	PF00082	0.790
CLV_PCSK_KEX2_1	388	390	PF00082	0.503
CLV_PCSK_KEX2_1	565	567	PF00082	0.558
CLV_PCSK_KEX2_1	568	570	PF00082	0.578
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.525
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.600
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.638
CLV_PCSK_SKI1_1	106	110	PF00082	0.576
CLV_PCSK_SKI1_1	161	165	PF00082	0.545
CLV_PCSK_SKI1_1	180	184	PF00082	0.623
CLV_PCSK_SKI1_1	388	392	PF00082	0.514
CLV_PCSK_SKI1_1	456	460	PF00082	0.397
CLV_PCSK_SKI1_1	49	53	PF00082	0.671
CLV_PCSK_SKI1_1	565	569	PF00082	0.594
DEG_APCC_DBOX_1	220	228	PF00400	0.599
DEG_Nend_UBRbox_2	1	3	PF02207	0.593
DEG_SPOP_SBC_1	146	150	PF00917	0.624
DEG_SPOP_SBC_1	24	28	PF00917	0.745
DOC_CKS1_1	301	306	PF01111	0.474
DOC_CKS1_1	95	100	PF01111	0.434
DOC_MAPK_gen_1	478	486	PF00069	0.562
DOC_MAPK_gen_1	69	78	PF00069	0.448
DOC_MAPK_HePTP_8	68	80	PF00069	0.531
DOC_MAPK_MEF2A_6	478	486	PF00069	0.482
DOC_MAPK_MEF2A_6	71	80	PF00069	0.512
DOC_MAPK_MEF2A_6	84	92	PF00069	0.392
DOC_MIT_MIM_1	387	397	PF04212	0.543
DOC_PIKK_1	369	377	PF02985	0.608
DOC_PP1_RVXF_1	55	61	PF00149	0.560
DOC_PP2B_LxvP_1	611	614	PF13499	0.494
DOC_PP2B_LxvP_1	90	93	PF13499	0.488
DOC_PP4_FxxP_1	207	210	PF00568	0.588
DOC_PP4_FxxP_1	420	423	PF00568	0.513
DOC_USP7_MATH_1	220	224	PF00917	0.563
DOC_USP7_MATH_1	24	28	PF00917	0.706
DOC_USP7_MATH_1	33	37	PF00917	0.786
DOC_USP7_MATH_1	435	439	PF00917	0.586
DOC_USP7_MATH_1	576	580	PF00917	0.735
DOC_USP7_MATH_1	585	589	PF00917	0.694
DOC_USP7_MATH_1	598	602	PF00917	0.777
DOC_USP7_MATH_2	576	582	PF00917	0.514
DOC_USP7_UBL2_3	335	339	PF12436	0.711
DOC_USP7_UBL2_3	617	621	PF12436	0.505
DOC_WW_Pin1_4	121	126	PF00397	0.589
DOC_WW_Pin1_4	228	233	PF00397	0.689
DOC_WW_Pin1_4	300	305	PF00397	0.469
DOC_WW_Pin1_4	535	540	PF00397	0.517
DOC_WW_Pin1_4	543	548	PF00397	0.442
DOC_WW_Pin1_4	572	577	PF00397	0.732
DOC_WW_Pin1_4	580	585	PF00397	0.735
DOC_WW_Pin1_4	63	68	PF00397	0.594
DOC_WW_Pin1_4	661	666	PF00397	0.712
DOC_WW_Pin1_4	94	99	PF00397	0.420
LIG_14-3-3_CanoR_1	100	108	PF00244	0.458
LIG_14-3-3_CanoR_1	118	123	PF00244	0.501
LIG_14-3-3_CanoR_1	16	22	PF00244	0.497
LIG_14-3-3_CanoR_1	161	170	PF00244	0.571
LIG_14-3-3_CanoR_1	221	225	PF00244	0.582
LIG_14-3-3_CanoR_1	264	273	PF00244	0.587
LIG_14-3-3_CanoR_1	49	58	PF00244	0.653
LIG_14-3-3_CanoR_1	569	576	PF00244	0.693
LIG_14-3-3_CanoR_1	619	627	PF00244	0.768
LIG_14-3-3_CanoR_1	648	657	PF00244	0.728
LIG_14-3-3_CanoR_1	84	88	PF00244	0.512
LIG_deltaCOP1_diTrp_1	492	498	PF00928	0.523
LIG_eIF4E_1	527	533	PF01652	0.467
LIG_EVH1_1	611	615	PF00568	0.493
LIG_FHA_1	124	130	PF00498	0.648
LIG_FHA_1	212	218	PF00498	0.581
LIG_FHA_1	316	322	PF00498	0.405
LIG_FHA_1	504	510	PF00498	0.776
LIG_FHA_1	63	69	PF00498	0.542
LIG_FHA_2	301	307	PF00498	0.469
LIG_FHA_2	371	377	PF00498	0.540
LIG_FHA_2	43	49	PF00498	0.591
LIG_FHA_2	458	464	PF00498	0.564
LIG_FHA_2	523	529	PF00498	0.562
LIG_Integrin_RGD_1	345	347	PF01839	0.505
LIG_IRF3_LxIS_1	394	400	PF10401	0.537
LIG_LIR_Apic_2	184	189	PF02991	0.503
LIG_LIR_Gen_1	104	114	PF02991	0.532
LIG_LIR_Gen_1	442	452	PF02991	0.495
LIG_LIR_Gen_1	492	498	PF02991	0.480
LIG_LIR_Gen_1	601	611	PF02991	0.696
LIG_LIR_Gen_1	86	95	PF02991	0.497
LIG_LIR_Nem_3	104	110	PF02991	0.537
LIG_LIR_Nem_3	132	137	PF02991	0.612
LIG_LIR_Nem_3	179	185	PF02991	0.403
LIG_LIR_Nem_3	442	447	PF02991	0.471
LIG_LIR_Nem_3	453	457	PF02991	0.367
LIG_LIR_Nem_3	492	497	PF02991	0.480
LIG_LIR_Nem_3	523	527	PF02991	0.637
LIG_LIR_Nem_3	531	536	PF02991	0.456
LIG_LIR_Nem_3	601	606	PF02991	0.691
LIG_LIR_Nem_3	86	90	PF02991	0.448
LIG_NRBOX	3	9	PF00104	0.506
LIG_NRBOX	554	560	PF00104	0.573
LIG_PCNA_yPIPBox_3	180	194	PF02747	0.580
LIG_PDZ_Class_2	672	677	PF00595	0.676
LIG_Pex14_1	494	498	PF04695	0.482
LIG_Pex14_2	178	182	PF04695	0.438
LIG_PTB_Apo_2	414	421	PF02174	0.513
LIG_SH2_CRK	301	305	PF00017	0.422
LIG_SH2_CRK	444	448	PF00017	0.475
LIG_SH2_NCK_1	301	305	PF00017	0.567
LIG_SH2_NCK_1	542	546	PF00017	0.430
LIG_SH2_SRC	542	545	PF00017	0.396
LIG_SH2_STAP1	444	448	PF00017	0.496
LIG_SH2_STAT5	294	297	PF00017	0.568
LIG_SH2_STAT5	3	6	PF00017	0.566
LIG_SH2_STAT5	320	323	PF00017	0.423
LIG_SH2_STAT5	427	430	PF00017	0.586
LIG_SH2_STAT5	457	460	PF00017	0.495
LIG_SH2_STAT5	536	539	PF00017	0.471
LIG_SH2_STAT5	87	90	PF00017	0.454
LIG_SH3_2	612	617	PF14604	0.595
LIG_SH3_3	134	140	PF00018	0.446
LIG_SH3_3	210	216	PF00018	0.555
LIG_SH3_3	37	43	PF00018	0.750
LIG_SH3_3	609	615	PF00018	0.717
LIG_SH3_3	639	645	PF00018	0.737
LIG_SH3_3	659	665	PF00018	0.713
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.480
LIG_SxIP_EBH_1	634	648	PF03271	0.503
LIG_TRAF2_1	125	128	PF00917	0.539
LIG_TRAF2_1	231	234	PF00917	0.544
LIG_TRAF2_1	373	376	PF00917	0.611
LIG_TRAF2_1	489	492	PF00917	0.555
LIG_TYR_ITIM	540	545	PF00017	0.412
LIG_TYR_ITSM	523	530	PF00017	0.547
LIG_WRC_WIRS_1	182	187	PF05994	0.616
LIG_WRC_WIRS_1	190	195	PF05994	0.539
MOD_CDC14_SPxK_1	66	69	PF00782	0.598
MOD_CDK_SPxK_1	63	69	PF00069	0.595
MOD_CDK_SPxK_1	94	100	PF00069	0.413
MOD_CDK_SPxxK_3	94	101	PF00069	0.414
MOD_CK1_1	121	127	PF00069	0.610
MOD_CK1_1	181	187	PF00069	0.593
MOD_CK1_1	228	234	PF00069	0.580
MOD_CK1_1	25	31	PF00069	0.634
MOD_CK1_1	277	283	PF00069	0.448
MOD_CK1_1	431	437	PF00069	0.480
MOD_CK1_1	579	585	PF00069	0.771
MOD_CK1_1	601	607	PF00069	0.770
MOD_CK1_1	664	670	PF00069	0.711
MOD_CK1_1	86	92	PF00069	0.444
MOD_CK2_1	121	127	PF00069	0.409
MOD_CK2_1	227	233	PF00069	0.650
MOD_CK2_1	370	376	PF00069	0.513
MOD_CK2_1	457	463	PF00069	0.289
MOD_CK2_1	486	492	PF00069	0.436
MOD_CK2_1	522	528	PF00069	0.586
MOD_CK2_1	572	578	PF00069	0.469
MOD_CK2_1	626	632	PF00069	0.731
MOD_GlcNHglycan	164	167	PF01048	0.729
MOD_GlcNHglycan	17	20	PF01048	0.592
MOD_GlcNHglycan	171	174	PF01048	0.676
MOD_GlcNHglycan	27	30	PF01048	0.711
MOD_GlcNHglycan	328	331	PF01048	0.696
MOD_GlcNHglycan	35	38	PF01048	0.546
MOD_GlcNHglycan	412	415	PF01048	0.303
MOD_GlcNHglycan	52	55	PF01048	0.665
MOD_GlcNHglycan	559	562	PF01048	0.531
MOD_GlcNHglycan	578	581	PF01048	0.540
MOD_GlcNHglycan	585	588	PF01048	0.701
MOD_GlcNHglycan	591	594	PF01048	0.640
MOD_GSK3_1	141	148	PF00069	0.572
MOD_GSK3_1	174	181	PF00069	0.613
MOD_GSK3_1	235	242	PF00069	0.677
MOD_GSK3_1	24	31	PF00069	0.673
MOD_GSK3_1	431	438	PF00069	0.480
MOD_GSK3_1	516	523	PF00069	0.425
MOD_GSK3_1	570	577	PF00069	0.710
MOD_GSK3_1	579	586	PF00069	0.759
MOD_GSK3_1	601	608	PF00069	0.776
MOD_GSK3_1	626	633	PF00069	0.653
MOD_GSK3_1	644	651	PF00069	0.759
MOD_GSK3_1	657	664	PF00069	0.722
MOD_LATS_1	343	349	PF00433	0.619
MOD_N-GLC_1	397	402	PF02516	0.388
MOD_N-GLC_1	569	574	PF02516	0.669
MOD_N-GLC_1	601	606	PF02516	0.691
MOD_N-GLC_1	62	67	PF02516	0.508
MOD_NEK2_1	129	134	PF00069	0.716
MOD_NEK2_1	145	150	PF00069	0.604
MOD_NEK2_1	164	169	PF00069	0.709
MOD_NEK2_1	178	183	PF00069	0.648
MOD_NEK2_1	226	231	PF00069	0.487
MOD_NEK2_1	397	402	PF00069	0.516
MOD_NEK2_1	428	433	PF00069	0.422
MOD_NEK2_1	503	508	PF00069	0.606
MOD_NEK2_1	520	525	PF00069	0.543
MOD_NEK2_1	631	636	PF00069	0.602
MOD_NEK2_1	78	83	PF00069	0.398
MOD_NEK2_2	457	462	PF00069	0.289
MOD_PIKK_1	164	170	PF00454	0.641
MOD_PIKK_1	274	280	PF00454	0.479
MOD_PKA_1	100	106	PF00069	0.457
MOD_PKA_2	100	106	PF00069	0.457
MOD_PKA_2	15	21	PF00069	0.525
MOD_PKA_2	220	226	PF00069	0.568
MOD_PKA_2	263	269	PF00069	0.580
MOD_PKA_2	515	521	PF00069	0.434
MOD_PKA_2	83	89	PF00069	0.477
MOD_PKB_1	646	654	PF00069	0.759
MOD_Plk_1	516	522	PF00069	0.477
MOD_Plk_1	601	607	PF00069	0.759
MOD_Plk_1	631	637	PF00069	0.537
MOD_Plk_2-3	370	376	PF00069	0.537
MOD_Plk_2-3	463	469	PF00069	0.447
MOD_Plk_4	129	135	PF00069	0.619
MOD_Plk_4	141	147	PF00069	0.547
MOD_Plk_4	181	187	PF00069	0.573
MOD_Plk_4	189	195	PF00069	0.518
MOD_Plk_4	528	534	PF00069	0.497
MOD_Plk_4	83	89	PF00069	0.504
MOD_ProDKin_1	121	127	PF00069	0.589
MOD_ProDKin_1	228	234	PF00069	0.691
MOD_ProDKin_1	300	306	PF00069	0.469
MOD_ProDKin_1	535	541	PF00069	0.515
MOD_ProDKin_1	543	549	PF00069	0.457
MOD_ProDKin_1	572	578	PF00069	0.741
MOD_ProDKin_1	580	586	PF00069	0.734
MOD_ProDKin_1	63	69	PF00069	0.595
MOD_ProDKin_1	661	667	PF00069	0.712
MOD_ProDKin_1	94	100	PF00069	0.413
MOD_SUMO_rev_2	315	321	PF00179	0.478
TRG_DiLeu_BaEn_1	159	164	PF01217	0.643
TRG_DiLeu_BaEn_2	202	208	PF01217	0.600
TRG_DiLeu_BaEn_4	159	165	PF01217	0.684
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.548
TRG_DiLeu_LyEn_5	159	164	PF01217	0.643
TRG_ENDOCYTIC_2	134	137	PF00928	0.579
TRG_ENDOCYTIC_2	320	323	PF00928	0.617
TRG_ENDOCYTIC_2	444	447	PF00928	0.325
TRG_ENDOCYTIC_2	527	530	PF00928	0.493
TRG_ENDOCYTIC_2	542	545	PF00928	0.317
TRG_ENDOCYTIC_2	87	90	PF00928	0.480
TRG_ER_diArg_1	152	155	PF00400	0.573
TRG_ER_diArg_1	161	163	PF00400	0.613
TRG_ER_diArg_1	645	648	PF00400	0.729
TRG_NLS_MonoExtC_3	564	569	PF00514	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5V7	Leptomonas seymouri	56%	100%
A0A1X0NIV4	Trypanosomatidae	32%	86%
A0A3Q8IJ90	Leishmania donovani	90%	100%
A0A3R7MGK1	Trypanosoma rangeli	39%	98%
A4HMG1	Leishmania braziliensis	67%	100%
A4IB32	Leishmania infantum	90%	100%
C9ZNN0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	74%
E9AEW2	Leishmania major	87%	100%
V5BC93	Trypanosoma cruzi	39%	100%