Mitochondrial processing peptidase, beta subunit,putative,metallo-peptidase, Clan ME, Family M16

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial processing peptidase, beta subunit, putative

Species:

Leishmania mexicana

UniProt:

E9B617_LEIMU

TriTrypDb:

LmxM.34.1380

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B617

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B617

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0003824	catalytic activity	1	6
GO:0016491	oxidoreductase activity	2	5
GO:0004175	endopeptidase activity	4	1
GO:0004222	metalloendopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008237	metallopeptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	432	434	PF00675	0.361
CLV_NRD_NRD_1	461	463	PF00675	0.382
CLV_PCSK_KEX2_1	432	434	PF00082	0.361
CLV_PCSK_SKI1_1	176	180	PF00082	0.340
CLV_PCSK_SKI1_1	198	202	PF00082	0.416
CLV_PCSK_SKI1_1	25	29	PF00082	0.522
CLV_PCSK_SKI1_1	316	320	PF00082	0.295
CLV_PCSK_SKI1_1	425	429	PF00082	0.368
CLV_PCSK_SKI1_1	54	58	PF00082	0.354
DEG_APCC_DBOX_1	24	32	PF00400	0.524
DEG_APCC_DBOX_1	432	440	PF00400	0.370
DEG_APCC_KENBOX_2	123	127	PF00400	0.440
DOC_CKS1_1	186	191	PF01111	0.389
DOC_CKS1_1	243	248	PF01111	0.195
DOC_MAPK_JIP1_4	165	171	PF00069	0.316
DOC_MAPK_MEF2A_6	54	62	PF00069	0.354
DOC_PIKK_1	167	174	PF02985	0.310
DOC_USP7_MATH_1	178	182	PF00917	0.295
DOC_USP7_MATH_1	234	238	PF00917	0.308
DOC_USP7_UBL2_3	244	248	PF12436	0.300
DOC_USP7_UBL2_3	402	406	PF12436	0.368
DOC_WW_Pin1_4	179	184	PF00397	0.340
DOC_WW_Pin1_4	185	190	PF00397	0.359
DOC_WW_Pin1_4	242	247	PF00397	0.195
DOC_WW_Pin1_4	325	330	PF00397	0.306
LIG_14-3-3_CanoR_1	209	214	PF00244	0.389
LIG_14-3-3_CanoR_1	269	274	PF00244	0.295
LIG_14-3-3_CanoR_1	316	322	PF00244	0.295
LIG_14-3-3_CanoR_1	433	443	PF00244	0.465
LIG_APCC_ABBAyCdc20_2	152	158	PF00400	0.422
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BRCT_BRCA1_1	1	5	PF00533	0.568
LIG_BRCT_BRCA1_1	20	24	PF00533	0.469
LIG_Clathr_ClatBox_1	410	414	PF01394	0.409
LIG_deltaCOP1_diTrp_1	479	484	PF00928	0.369
LIG_EH_1	342	346	PF12763	0.310
LIG_FHA_1	248	254	PF00498	0.285
LIG_FHA_1	270	276	PF00498	0.295
LIG_FHA_1	55	61	PF00498	0.312
LIG_FHA_1	74	80	PF00498	0.215
LIG_FHA_2	227	233	PF00498	0.295
LIG_FHA_2	379	385	PF00498	0.310
LIG_LIR_Gen_1	114	122	PF02991	0.333
LIG_LIR_Gen_1	2	12	PF02991	0.575
LIG_LIR_Gen_1	320	329	PF02991	0.295
LIG_LIR_Gen_1	384	393	PF02991	0.295
LIG_LIR_Gen_1	437	448	PF02991	0.387
LIG_LIR_Nem_3	116	122	PF02991	0.331
LIG_LIR_Nem_3	2	8	PF02991	0.570
LIG_LIR_Nem_3	21	27	PF02991	0.466
LIG_LIR_Nem_3	237	242	PF02991	0.312
LIG_LIR_Nem_3	320	324	PF02991	0.295
LIG_LIR_Nem_3	348	352	PF02991	0.469
LIG_LIR_Nem_3	384	388	PF02991	0.295
LIG_LIR_Nem_3	437	443	PF02991	0.376
LIG_LIR_Nem_3	467	471	PF02991	0.322
LIG_LIR_Nem_3	66	71	PF02991	0.445
LIG_PCNA_PIPBox_1	452	461	PF02747	0.362
LIG_PCNA_yPIPBox_3	304	318	PF02747	0.295
LIG_PCNA_yPIPBox_3	452	463	PF02747	0.364
LIG_Pex14_1	266	270	PF04695	0.310
LIG_Pex14_1	484	488	PF04695	0.382
LIG_PTB_Apo_2	264	271	PF02174	0.310
LIG_PTB_Phospho_1	264	270	PF10480	0.310
LIG_Rb_pABgroove_1	434	442	PF01858	0.522
LIG_SH2_CRK	119	123	PF00017	0.354
LIG_SH2_CRK	270	274	PF00017	0.310
LIG_SH2_CRK	466	470	PF00017	0.327
LIG_SH2_NCK_1	380	384	PF00017	0.310
LIG_SH2_NCK_1	440	444	PF00017	0.383
LIG_SH2_NCK_1	68	72	PF00017	0.440
LIG_SH2_SRC	68	71	PF00017	0.440
LIG_SH2_STAT5	117	120	PF00017	0.389
LIG_SH2_STAT5	238	241	PF00017	0.354
LIG_SH2_STAT5	258	261	PF00017	0.329
LIG_SH2_STAT5	358	361	PF00017	0.317
LIG_SH2_STAT5	380	383	PF00017	0.310
LIG_SH2_STAT5	458	461	PF00017	0.366
LIG_SH2_STAT5	468	471	PF00017	0.318
LIG_SH3_2	243	248	PF14604	0.316
LIG_SH3_3	183	189	PF00018	0.485
LIG_SH3_3	240	246	PF00018	0.382
LIG_SUMO_SIM_par_1	217	223	PF11976	0.312
LIG_TRAF2_1	46	49	PF00917	0.329
LIG_TRAF2_1	99	102	PF00917	0.422
LIG_TYR_ITIM	268	273	PF00017	0.310
LIG_WRC_WIRS_1	318	323	PF05994	0.295
MOD_CDK_SPxK_1	242	248	PF00069	0.195
MOD_CK1_1	327	333	PF00069	0.303
MOD_CK1_1	338	344	PF00069	0.281
MOD_CK1_1	4	10	PF00069	0.624
MOD_CK1_1	416	422	PF00069	0.355
MOD_CK2_1	226	232	PF00069	0.295
MOD_CK2_1	302	308	PF00069	0.295
MOD_CK2_1	378	384	PF00069	0.295
MOD_CK2_1	63	69	PF00069	0.310
MOD_Cter_Amidation	430	433	PF01082	0.382
MOD_Cter_Amidation	460	463	PF01082	0.441
MOD_GlcNHglycan	20	23	PF01048	0.592
MOD_GlcNHglycan	222	225	PF01048	0.340
MOD_GlcNHglycan	414	418	PF01048	0.401
MOD_GSK3_1	120	127	PF00069	0.440
MOD_GSK3_1	13	20	PF00069	0.543
MOD_GSK3_1	298	305	PF00069	0.440
MOD_GSK3_1	31	38	PF00069	0.401
MOD_GSK3_1	320	327	PF00069	0.298
MOD_GSK3_1	478	485	PF00069	0.363
MOD_GSK3_1	50	57	PF00069	0.393
MOD_GSK3_1	85	92	PF00069	0.362
MOD_N-GLC_1	34	39	PF02516	0.468
MOD_N-GLC_1	89	94	PF02516	0.329
MOD_NEK2_1	1	6	PF00069	0.627
MOD_NEK2_1	302	307	PF00069	0.295
MOD_NEK2_1	324	329	PF00069	0.310
MOD_NEK2_1	345	350	PF00069	0.459
MOD_NEK2_1	378	383	PF00069	0.295
MOD_NEK2_1	413	418	PF00069	0.400
MOD_NEK2_1	85	90	PF00069	0.366
MOD_PIKK_1	302	308	PF00454	0.301
MOD_PIKK_1	478	484	PF00454	0.379
MOD_PKA_1	198	204	PF00069	0.416
MOD_PKA_2	208	214	PF00069	0.319
MOD_PKB_1	11	19	PF00069	0.565
MOD_Plk_1	113	119	PF00069	0.292
MOD_Plk_1	226	232	PF00069	0.307
MOD_Plk_1	335	341	PF00069	0.410
MOD_Plk_1	34	40	PF00069	0.455
MOD_Plk_4	113	119	PF00069	0.380
MOD_Plk_4	234	240	PF00069	0.445
MOD_Plk_4	4	10	PF00069	0.575
MOD_Plk_4	464	470	PF00069	0.326
MOD_ProDKin_1	179	185	PF00069	0.340
MOD_ProDKin_1	242	248	PF00069	0.195
MOD_ProDKin_1	325	331	PF00069	0.306
TRG_DiLeu_BaEn_2	80	86	PF01217	0.389
TRG_ENDOCYTIC_2	117	120	PF00928	0.333
TRG_ENDOCYTIC_2	270	273	PF00928	0.310
TRG_ENDOCYTIC_2	349	352	PF00928	0.451
TRG_ENDOCYTIC_2	440	443	PF00928	0.372
TRG_ENDOCYTIC_2	466	469	PF00928	0.325
TRG_ENDOCYTIC_2	68	71	PF00928	0.441
TRG_ER_diArg_1	11	14	PF00400	0.613
TRG_ER_diArg_1	432	434	PF00400	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P575	Leptomonas seymouri	29%	99%
A0A0N1PEB5	Leptomonas seymouri	89%	100%
A0A0S4IUJ1	Bodo saltans	31%	95%
A0A0S4KFV6	Bodo saltans	66%	98%
A0A1X0NHX2	Trypanosomatidae	68%	95%
A0A1X0P2L6	Trypanosomatidae	29%	96%
A0A3S7X938	Leishmania donovani	97%	100%
A0A422N9N5	Trypanosoma rangeli	74%	100%
A0A422NGW3	Trypanosoma rangeli	29%	100%
A0A451EJB9	Leishmania donovani	31%	99%
A4HMG0	Leishmania braziliensis	93%	100%
A4HRI8	Leishmania infantum	31%	99%
A4IB31	Leishmania infantum	97%	100%
C9ZNM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
C9ZXM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AC56	Leishmania major	31%	100%
E9AEW1	Leishmania major	97%	100%
E9AJF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
O04308	Arabidopsis thaliana	25%	98%
O25656	Helicobacter pylori (strain ATCC 700392 / 26695)	21%	100%
O32965	Mycobacterium leprae (strain TN)	26%	100%
O60044	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	100%
O75439	Homo sapiens	31%	100%
O86835	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	24%	100%
O94745	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	98%
P07256	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P0A5S9	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	25%	100%
P10507	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P11913	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	28%	100%
P11914	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P20069	Rattus norvegicus	27%	94%
P22695	Homo sapiens	25%	100%
P23004	Bos taurus	25%	100%
P29677	Solanum tuberosum	27%	97%
P31800	Bos taurus	31%	100%
P31930	Homo sapiens	30%	100%
P32551	Rattus norvegicus	26%	100%
P43264	Euglena gracilis	32%	99%
P55679	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	24%	96%
P97997	Blastocladiella emersonii	25%	100%
P98080	Caenorhabditis elegans	27%	100%
P9WHT4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	24%	100%
P9WHT5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	100%
Q00302	Blastocladiella emersonii	30%	100%
Q03346	Rattus norvegicus	31%	100%
Q0P5M8	Bos taurus	27%	93%
Q10713	Homo sapiens	26%	93%
Q1RJ61	Rickettsia bellii (strain RML369-C)	22%	100%
Q23295	Caenorhabditis elegans	30%	100%
Q3SZ71	Bos taurus	31%	100%
Q42290	Arabidopsis thaliana	32%	92%
Q4UML9	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	23%	100%
Q4W6B5	Dictyostelium discoideum	28%	100%
Q5R513	Pongo abelii	26%	93%
Q5REK3	Pongo abelii	31%	100%
Q68FY0	Rattus norvegicus	30%	100%
Q6C2E3	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	100%
Q95XN2	Caenorhabditis elegans	24%	95%
Q9CXT8	Mus musculus	31%	100%
Q9CZ13	Mus musculus	30%	100%
Q9DB77	Mus musculus	25%	100%
Q9DC61	Mus musculus	27%	94%
Q9P7X1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q9Y8B5	Lentinula edodes	30%	100%
Q9ZU25	Arabidopsis thaliana	24%	97%
V5BGV2	Trypanosoma cruzi	76%	100%
V5BH27	Trypanosoma cruzi	30%	100%