WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B615_LEIMU

TriTrypDb:

LmxM.34.1360

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B615

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B615

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.690
CLV_C14_Caspase3-7	184	188	PF00656	0.752
CLV_C14_Caspase3-7	370	374	PF00656	0.529
CLV_C14_Caspase3-7	381	385	PF00656	0.505
CLV_NRD_NRD_1	298	300	PF00675	0.705
CLV_NRD_NRD_1	387	389	PF00675	0.521
CLV_NRD_NRD_1	394	396	PF00675	0.477
CLV_NRD_NRD_1	417	419	PF00675	0.460
CLV_PCSK_FUR_1	426	430	PF00082	0.500
CLV_PCSK_KEX2_1	298	300	PF00082	0.661
CLV_PCSK_KEX2_1	389	391	PF00082	0.522
CLV_PCSK_KEX2_1	396	398	PF00082	0.483
CLV_PCSK_KEX2_1	417	419	PF00082	0.532
CLV_PCSK_KEX2_1	428	430	PF00082	0.454
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.656
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.522
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.483
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.499
CLV_PCSK_SKI1_1	310	314	PF00082	0.675
CLV_PCSK_SKI1_1	397	401	PF00082	0.645
CLV_PCSK_SKI1_1	55	59	PF00082	0.700
CLV_PCSK_SKI1_1	82	86	PF00082	0.527
DEG_Nend_UBRbox_3	1	3	PF02207	0.589
DEG_SCF_FBW7_1	361	367	PF00400	0.656
DEG_SPOP_SBC_1	201	205	PF00917	0.728
DOC_CKS1_1	245	250	PF01111	0.663
DOC_CKS1_1	361	366	PF01111	0.658
DOC_USP7_MATH_1	113	117	PF00917	0.639
DOC_USP7_MATH_1	201	205	PF00917	0.810
DOC_USP7_MATH_1	226	230	PF00917	0.627
DOC_USP7_MATH_1	294	298	PF00917	0.611
DOC_USP7_MATH_1	315	319	PF00917	0.690
DOC_USP7_MATH_1	336	340	PF00917	0.650
DOC_USP7_MATH_1	364	368	PF00917	0.699
DOC_USP7_UBL2_3	310	314	PF12436	0.630
DOC_USP7_UBL2_3	396	400	PF12436	0.526
DOC_USP7_UBL2_3	60	64	PF12436	0.688
DOC_WW_Pin1_4	244	249	PF00397	0.654
DOC_WW_Pin1_4	257	262	PF00397	0.610
DOC_WW_Pin1_4	298	303	PF00397	0.646
DOC_WW_Pin1_4	334	339	PF00397	0.514
DOC_WW_Pin1_4	360	365	PF00397	0.698
LIG_14-3-3_CanoR_1	19	24	PF00244	0.593
LIG_14-3-3_CanoR_1	365	371	PF00244	0.648
LIG_14-3-3_CanoR_1	49	58	PF00244	0.607
LIG_14-3-3_CanoR_1	82	91	PF00244	0.554
LIG_BRCT_BRCA1_1	336	340	PF00533	0.563
LIG_BRCT_BRCA1_1	429	433	PF00533	0.364
LIG_eIF4E_1	323	329	PF01652	0.599
LIG_FHA_1	113	119	PF00498	0.682
LIG_FHA_1	245	251	PF00498	0.562
LIG_FHA_1	273	279	PF00498	0.634
LIG_FHA_1	319	325	PF00498	0.652
LIG_FHA_2	258	264	PF00498	0.642
LIG_FHA_2	341	347	PF00498	0.656
LIG_FHA_2	9	15	PF00498	0.533
LIG_LIR_Gen_1	377	385	PF02991	0.512
LIG_LIR_Nem_3	165	171	PF02991	0.641
LIG_LIR_Nem_3	177	182	PF02991	0.595
LIG_LIR_Nem_3	241	246	PF02991	0.748
LIG_LIR_Nem_3	377	382	PF02991	0.525
LIG_Pex14_2	58	62	PF04695	0.656
LIG_SH2_GRB2like	323	326	PF00017	0.659
LIG_SH2_STAT5	169	172	PF00017	0.634
LIG_SH2_STAT5	181	184	PF00017	0.546
LIG_SH2_STAT5	230	233	PF00017	0.655
LIG_SH2_STAT5	234	237	PF00017	0.640
LIG_SH2_STAT5	24	27	PF00017	0.418
LIG_SH2_STAT5	244	247	PF00017	0.623
LIG_SH2_STAT5	323	326	PF00017	0.659
LIG_SH3_3	20	26	PF00018	0.599
LIG_SH3_3	309	315	PF00018	0.630
LIG_SH3_3	346	352	PF00018	0.678
LIG_SH3_3	90	96	PF00018	0.660
LIG_SUMO_SIM_anti_2	377	384	PF11976	0.517
LIG_TRAF2_1	260	263	PF00917	0.565
LIG_UBA3_1	398	407	PF00899	0.409
MOD_CDK_SPK_2	360	365	PF00069	0.657
MOD_CDK_SPxK_1	298	304	PF00069	0.511
MOD_CK1_1	126	132	PF00069	0.674
MOD_CK1_1	136	142	PF00069	0.568
MOD_CK1_1	270	276	PF00069	0.652
MOD_CK1_1	318	324	PF00069	0.673
MOD_CK1_1	367	373	PF00069	0.583
MOD_CK1_1	48	54	PF00069	0.655
MOD_CK2_1	126	132	PF00069	0.681
MOD_CK2_1	221	227	PF00069	0.661
MOD_CK2_1	257	263	PF00069	0.562
MOD_CK2_1	342	348	PF00069	0.662
MOD_GlcNHglycan	128	131	PF01048	0.714
MOD_GlcNHglycan	135	138	PF01048	0.732
MOD_GlcNHglycan	150	154	PF01048	0.620
MOD_GlcNHglycan	275	278	PF01048	0.639
MOD_GlcNHglycan	39	42	PF01048	0.701
MOD_GlcNHglycan	51	54	PF01048	0.577
MOD_GSK3_1	15	22	PF00069	0.597
MOD_GSK3_1	209	216	PF00069	0.586
MOD_GSK3_1	250	257	PF00069	0.635
MOD_GSK3_1	266	273	PF00069	0.651
MOD_GSK3_1	280	287	PF00069	0.623
MOD_GSK3_1	294	301	PF00069	0.568
MOD_GSK3_1	336	343	PF00069	0.700
MOD_GSK3_1	355	362	PF00069	0.509
MOD_GSK3_1	43	50	PF00069	0.651
MOD_LATS_1	47	53	PF00433	0.659
MOD_N-GLC_1	267	272	PF02516	0.563
MOD_N-GLC_1	6	11	PF02516	0.426
MOD_NEK2_1	1	6	PF00069	0.755
MOD_NEK2_1	185	190	PF00069	0.713
MOD_NEK2_1	357	362	PF00069	0.533
MOD_NEK2_1	37	42	PF00069	0.692
MOD_PIKK_1	202	208	PF00454	0.691
MOD_PIKK_1	211	217	PF00454	0.573
MOD_PIKK_1	250	256	PF00454	0.636
MOD_PIKK_1	261	267	PF00454	0.702
MOD_PK_1	19	25	PF00069	0.584
MOD_PKA_2	133	139	PF00069	0.602
MOD_PKA_2	18	24	PF00069	0.591
MOD_PKA_2	318	324	PF00069	0.692
MOD_PKA_2	364	370	PF00069	0.653
MOD_PKA_2	43	49	PF00069	0.665
MOD_Plk_1	113	119	PF00069	0.610
MOD_Plk_1	367	373	PF00069	0.600
MOD_Plk_4	1	7	PF00069	0.633
MOD_Plk_4	175	181	PF00069	0.608
MOD_Plk_4	19	25	PF00069	0.495
MOD_Plk_4	226	232	PF00069	0.474
MOD_Plk_4	238	244	PF00069	0.538
MOD_Plk_4	336	342	PF00069	0.599
MOD_Plk_4	352	358	PF00069	0.531
MOD_ProDKin_1	244	250	PF00069	0.660
MOD_ProDKin_1	257	263	PF00069	0.610
MOD_ProDKin_1	298	304	PF00069	0.644
MOD_ProDKin_1	334	340	PF00069	0.517
MOD_ProDKin_1	360	366	PF00069	0.698
MOD_SUMO_rev_2	381	391	PF00179	0.549
TRG_DiLeu_BaEn_1	394	399	PF01217	0.364
TRG_DiLeu_BaEn_2	386	392	PF01217	0.440
TRG_DiLeu_BaEn_3	377	383	PF01217	0.472
TRG_DiLeu_LyEn_5	394	399	PF01217	0.403
TRG_ENDOCYTIC_2	179	182	PF00928	0.604
TRG_ER_diArg_1	388	391	PF00400	0.520
TRG_ER_diArg_1	395	398	PF00400	0.484
TRG_NLS_MonoExtC_3	297	302	PF00514	0.650
TRG_NLS_MonoExtN_4	296	302	PF00514	0.653
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IV47	Leishmania donovani	83%	100%
A4HMF8	Leishmania braziliensis	54%	100%
A4IB29	Leishmania infantum	83%	100%
E9AEV9	Leishmania major	81%	100%