Tubulin-tyrosine ligase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9B614_LEIMU

TriTrypDb:

LmxM.34.1355

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B614

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B614

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.648
CLV_NRD_NRD_1	254	256	PF00675	0.585
CLV_PCSK_KEX2_1	254	256	PF00082	0.576
CLV_PCSK_SKI1_1	282	286	PF00082	0.622
CLV_PCSK_SKI1_1	288	292	PF00082	0.589
DEG_SCF_FBW7_1	165	171	PF00400	0.516
DEG_SPOP_SBC_1	222	226	PF00917	0.560
DOC_CKS1_1	131	136	PF01111	0.533
DOC_CKS1_1	165	170	PF01111	0.561
DOC_CKS1_1	187	192	PF01111	0.647
DOC_MAPK_RevD_3	240	255	PF00069	0.566
DOC_PP2B_LxvP_1	249	252	PF13499	0.562
DOC_PP4_FxxP_1	131	134	PF00568	0.532
DOC_PP4_FxxP_1	8	11	PF00568	0.460
DOC_USP7_MATH_1	11	15	PF00917	0.544
DOC_USP7_MATH_1	121	125	PF00917	0.588
DOC_USP7_MATH_1	163	167	PF00917	0.652
DOC_USP7_MATH_1	193	197	PF00917	0.692
DOC_USP7_MATH_1	222	226	PF00917	0.639
DOC_USP7_MATH_1	228	232	PF00917	0.576
DOC_USP7_MATH_1	280	284	PF00917	0.737
DOC_USP7_MATH_1	43	47	PF00917	0.526
DOC_USP7_MATH_1	60	64	PF00917	0.580
DOC_USP7_MATH_1	78	82	PF00917	0.564
DOC_WW_Pin1_4	12	17	PF00397	0.616
DOC_WW_Pin1_4	130	135	PF00397	0.535
DOC_WW_Pin1_4	159	164	PF00397	0.766
DOC_WW_Pin1_4	186	191	PF00397	0.647
LIG_14-3-3_CanoR_1	119	126	PF00244	0.598
LIG_BIR_II_1	1	5	PF00653	0.563
LIG_BRCT_BRCA1_1	194	198	PF00533	0.686
LIG_CtBP_PxDLS_1	105	109	PF00389	0.508
LIG_FHA_1	64	70	PF00498	0.536
LIG_FHA_2	156	162	PF00498	0.680
LIG_FHA_2	170	176	PF00498	0.633
LIG_FHA_2	187	193	PF00498	0.642
LIG_FHA_2	205	211	PF00498	0.630
LIG_LIR_Apic_2	128	134	PF02991	0.534
LIG_LIR_Apic_2	7	11	PF02991	0.462
LIG_LIR_Gen_1	27	35	PF02991	0.557
LIG_LIR_Nem_3	247	253	PF02991	0.590
LIG_LIR_Nem_3	27	31	PF02991	0.644
LIG_MYND_1	211	215	PF01753	0.659
LIG_SH2_PTP2	250	253	PF00017	0.564
LIG_SH2_STAT5	250	253	PF00017	0.564
LIG_SH3_3	10	16	PF00018	0.455
LIG_SH3_3	162	168	PF00018	0.561
LIG_SH3_3	184	190	PF00018	0.645
LIG_SH3_3	239	245	PF00018	0.568
LIG_SH3_3	42	48	PF00018	0.492
MOD_CDK_SPK_2	130	135	PF00069	0.535
MOD_CDK_SPxxK_3	130	137	PF00069	0.535
MOD_CK1_1	124	130	PF00069	0.664
MOD_CK1_1	15	21	PF00069	0.562
MOD_CK1_1	196	202	PF00069	0.707
MOD_CK1_1	216	222	PF00069	0.583
MOD_CK1_1	4	10	PF00069	0.551
MOD_CK1_1	46	52	PF00069	0.565
MOD_CK1_1	55	61	PF00069	0.752
MOD_CK1_1	63	69	PF00069	0.633
MOD_CK1_1	79	85	PF00069	0.525
MOD_CK2_1	155	161	PF00069	0.655
MOD_CK2_1	280	286	PF00069	0.726
MOD_GlcNHglycan	128	131	PF01048	0.662
MOD_GlcNHglycan	148	151	PF01048	0.669
MOD_GlcNHglycan	235	238	PF01048	0.600
MOD_GlcNHglycan	282	285	PF01048	0.699
MOD_GlcNHglycan	318	321	PF01048	0.637
MOD_GlcNHglycan	58	61	PF01048	0.636
MOD_GlcNHglycan	62	65	PF01048	0.598
MOD_GlcNHglycan	78	81	PF01048	0.520
MOD_GSK3_1	11	18	PF00069	0.536
MOD_GSK3_1	115	122	PF00069	0.567
MOD_GSK3_1	126	133	PF00069	0.705
MOD_GSK3_1	155	162	PF00069	0.743
MOD_GSK3_1	164	171	PF00069	0.571
MOD_GSK3_1	192	199	PF00069	0.796
MOD_GSK3_1	209	216	PF00069	0.620
MOD_GSK3_1	310	317	PF00069	0.704
MOD_GSK3_1	51	58	PF00069	0.773
MOD_GSK3_1	60	67	PF00069	0.539
MOD_N-GLC_1	113	118	PF02516	0.571
MOD_N-GLC_1	64	69	PF02516	0.556
MOD_NEK2_1	1	6	PF00069	0.591
MOD_NEK2_1	113	118	PF00069	0.641
MOD_NEK2_1	198	203	PF00069	0.681
MOD_NEK2_1	233	238	PF00069	0.682
MOD_NEK2_1	271	276	PF00069	0.723
MOD_NEK2_1	68	73	PF00069	0.609
MOD_PIKK_1	119	125	PF00454	0.629
MOD_PKA_2	193	199	PF00069	0.662
MOD_PKA_2	314	320	PF00069	0.675
MOD_PKA_2	43	49	PF00069	0.639
MOD_PKA_2	55	61	PF00069	0.530
MOD_PKB_1	135	143	PF00069	0.665
MOD_Plk_1	64	70	PF00069	0.560
MOD_Plk_4	121	127	PF00069	0.612
MOD_Plk_4	15	21	PF00069	0.599
MOD_Plk_4	213	219	PF00069	0.671
MOD_Plk_4	64	70	PF00069	0.570
MOD_ProDKin_1	12	18	PF00069	0.614
MOD_ProDKin_1	130	136	PF00069	0.533
MOD_ProDKin_1	159	165	PF00069	0.765
MOD_ProDKin_1	186	192	PF00069	0.650
MOD_SUMO_rev_2	140	144	PF00179	0.632
TRG_ENDOCYTIC_2	250	253	PF00928	0.564
TRG_ER_diArg_1	134	137	PF00400	0.669
TRG_ER_diArg_1	253	255	PF00400	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I411	Leptomonas seymouri	30%	87%
A0A3S7X926	Leishmania donovani	82%	100%
A4HMF7	Leishmania braziliensis	66%	100%
E9AEV8	Leishmania major	84%	100%
E9AHU5	Leishmania infantum	82%	99%