Iron-sulfur assembly protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iron-sulfur assembly protein 2, putative

Species:

Leishmania mexicana

UniProt:

E9B613_LEIMU

TriTrypDb:

LmxM.34.1350

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B613

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B613

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016226	iron-sulfur cluster assembly	4	1
GO:0019538	protein metabolic process	3	1
GO:0022607	cellular component assembly	4	1
GO:0031163	metallo-sulfur cluster assembly	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	1
GO:0106035	protein maturation by [4Fe-4S] cluster transfer	6	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005506	iron ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051537	2 iron, 2 sulfur cluster binding	4	1
GO:0051539	4 iron, 4 sulfur cluster binding	4	1
GO:0051540	metal cluster binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	165	167	PF00675	0.593
CLV_NRD_NRD_1	189	191	PF00675	0.484
CLV_NRD_NRD_1	213	215	PF00675	0.758
CLV_NRD_NRD_1	50	52	PF00675	0.519
CLV_PCSK_KEX2_1	167	169	PF00082	0.441
CLV_PCSK_KEX2_1	189	191	PF00082	0.484
CLV_PCSK_KEX2_1	213	215	PF00082	0.758
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.441
CLV_PCSK_PC7_1	209	215	PF00082	0.756
DEG_Nend_Nbox_1	1	3	PF02207	0.558
DEG_SPOP_SBC_1	173	177	PF00917	0.753
DOC_USP7_MATH_1	12	16	PF00917	0.667
DOC_USP7_MATH_1	171	175	PF00917	0.698
DOC_USP7_MATH_1	199	203	PF00917	0.698
DOC_USP7_MATH_1	68	72	PF00917	0.452
DOC_WW_Pin1_4	101	106	PF00397	0.601
DOC_WW_Pin1_4	113	118	PF00397	0.517
DOC_WW_Pin1_4	212	217	PF00397	0.464
DOC_WW_Pin1_4	22	27	PF00397	0.674
DOC_WW_Pin1_4	39	44	PF00397	0.501
LIG_14-3-3_CanoR_1	3	7	PF00244	0.537
LIG_14-3-3_CanoR_1	51	58	PF00244	0.599
LIG_14-3-3_CterR_2	218	221	PF00244	0.712
LIG_DCNL_PONY_1	1	4	PF03556	0.694
LIG_FHA_2	28	34	PF00498	0.647
LIG_LIR_Gen_1	143	153	PF02991	0.462
LIG_LIR_Gen_1	61	69	PF02991	0.423
LIG_LIR_Nem_3	143	148	PF02991	0.458
LIG_LIR_Nem_3	61	67	PF02991	0.452
LIG_SH2_STAT5	64	67	PF00017	0.447
LIG_SH2_STAT5	77	80	PF00017	0.477
MOD_CDC14_SPxK_1	215	218	PF00782	0.463
MOD_CDK_SPK_2	113	118	PF00069	0.517
MOD_CDK_SPK_2	39	44	PF00069	0.525
MOD_CDK_SPxK_1	212	218	PF00069	0.468
MOD_CK1_1	15	21	PF00069	0.714
MOD_CK1_1	172	178	PF00069	0.752
MOD_CK1_1	203	209	PF00069	0.757
MOD_CK2_1	124	130	PF00069	0.599
MOD_Cter_Amidation	187	190	PF01082	0.483
MOD_GlcNHglycan	124	127	PF01048	0.554
MOD_GlcNHglycan	14	17	PF01048	0.714
MOD_GlcNHglycan	142	145	PF01048	0.259
MOD_GlcNHglycan	171	174	PF01048	0.708
MOD_GlcNHglycan	192	195	PF01048	0.649
MOD_GlcNHglycan	70	73	PF01048	0.455
MOD_GSK3_1	120	127	PF00069	0.533
MOD_GSK3_1	169	176	PF00069	0.651
MOD_GSK3_1	18	25	PF00069	0.699
MOD_GSK3_1	199	206	PF00069	0.620
MOD_GSK3_1	214	221	PF00069	0.674
MOD_GSK3_1	35	42	PF00069	0.541
MOD_GSK3_1	47	54	PF00069	0.581
MOD_GSK3_1	8	15	PF00069	0.690
MOD_N-GLC_1	130	135	PF02516	0.502
MOD_NEK2_1	124	129	PF00069	0.544
MOD_NEK2_1	140	145	PF00069	0.345
MOD_NEK2_1	161	166	PF00069	0.453
MOD_NEK2_1	2	7	PF00069	0.540
MOD_PIKK_1	176	182	PF00454	0.479
MOD_PK_1	37	43	PF00069	0.540
MOD_PKA_1	166	172	PF00069	0.639
MOD_PKA_1	51	57	PF00069	0.532
MOD_PKA_2	169	175	PF00069	0.721
MOD_PKA_2	2	8	PF00069	0.541
MOD_Plk_1	130	136	PF00069	0.497
MOD_Plk_2-3	130	136	PF00069	0.486
MOD_ProDKin_1	101	107	PF00069	0.601
MOD_ProDKin_1	113	119	PF00069	0.511
MOD_ProDKin_1	212	218	PF00069	0.468
MOD_ProDKin_1	22	28	PF00069	0.672
MOD_ProDKin_1	39	45	PF00069	0.496
MOD_SUMO_rev_2	135	143	PF00179	0.466
TRG_ENDOCYTIC_2	64	67	PF00928	0.447
TRG_ER_diArg_1	165	168	PF00400	0.376
TRG_ER_diArg_1	212	214	PF00400	0.474
TRG_NLS_MonoExtC_3	165	170	PF00514	0.629
TRG_NLS_MonoExtN_4	166	171	PF00514	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD94	Leptomonas seymouri	63%	98%
A0A1X0NHC3	Trypanosomatidae	53%	100%
A0A3R7LRU0	Trypanosoma rangeli	56%	100%
A0A3S7X981	Leishmania donovani	86%	100%
A4HMF6	Leishmania braziliensis	76%	100%
A4IB28	Leishmania infantum	86%	100%
C9ZNM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
Q9GRP9	Leishmania major	89%	100%