LeishMANIAdb
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Thioredoxin domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Thioredoxin domain-containing protein
Gene product:
thioredoxin, putative
Species:
Leishmania mexicana
UniProt:
E9B612_LEIMU
TriTrypDb:
LmxM.34.1330
Length:
563

Annotations

LeishMANIAdb annotations

Contains a thioredoxin domain. Homologous to ER-associated disulphide isomerases in other Eukaryotes.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 0
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9B612
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B612

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 1
GO:0006950 response to stress 2 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
Molecular functions
Term Name Level Count
GO:0003756 protein disulfide isomerase activity 3 9
GO:0003824 catalytic activity 1 9
GO:0016853 isomerase activity 2 9
GO:0016860 intramolecular oxidoreductase activity 3 9
GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4 9
GO:0140096 catalytic activity, acting on a protein 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 276 280 PF00656 0.238
CLV_PCSK_KEX2_1 442 444 PF00082 0.502
CLV_PCSK_KEX2_1 561 563 PF00082 0.489
CLV_PCSK_KEX2_1 76 78 PF00082 0.566
CLV_PCSK_PC1ET2_1 442 444 PF00082 0.589
CLV_PCSK_PC1ET2_1 561 563 PF00082 0.516
CLV_PCSK_PC1ET2_1 76 78 PF00082 0.546
CLV_PCSK_SKI1_1 445 449 PF00082 0.510
CLV_PCSK_SKI1_1 81 85 PF00082 0.465
CLV_PCSK_SKI1_1 96 100 PF00082 0.381
DEG_APCC_DBOX_1 10 18 PF00400 0.529
DEG_Nend_UBRbox_1 1 4 PF02207 0.416
DEG_SCF_FBW7_1 404 410 PF00400 0.307
DOC_CDC14_PxL_1 373 381 PF14671 0.312
DOC_CKS1_1 10 15 PF01111 0.394
DOC_CKS1_1 213 218 PF01111 0.322
DOC_CKS1_1 404 409 PF01111 0.311
DOC_CKS1_1 461 466 PF01111 0.414
DOC_MAPK_gen_1 423 430 PF00069 0.345
DOC_MAPK_MEF2A_6 11 20 PF00069 0.520
DOC_MAPK_MEF2A_6 356 363 PF00069 0.370
DOC_MAPK_RevD_3 428 443 PF00069 0.312
DOC_PP1_RVXF_1 406 412 PF00149 0.371
DOC_SPAK_OSR1_1 238 242 PF12202 0.265
DOC_USP7_MATH_1 232 236 PF00917 0.309
DOC_USP7_MATH_1 307 311 PF00917 0.506
DOC_USP7_MATH_1 407 411 PF00917 0.379
DOC_USP7_UBL2_3 555 559 PF12436 0.660
DOC_WW_Pin1_4 209 214 PF00397 0.405
DOC_WW_Pin1_4 403 408 PF00397 0.323
DOC_WW_Pin1_4 460 465 PF00397 0.399
DOC_WW_Pin1_4 86 91 PF00397 0.281
DOC_WW_Pin1_4 9 14 PF00397 0.517
LIG_14-3-3_CanoR_1 126 134 PF00244 0.280
LIG_14-3-3_CanoR_1 408 414 PF00244 0.286
LIG_APCC_ABBA_1 283 288 PF00400 0.308
LIG_BRCT_BRCA1_1 130 134 PF00533 0.295
LIG_BRCT_BRCA1_1 69 73 PF00533 0.296
LIG_CaM_NSCaTE_8 224 231 PF13499 0.379
LIG_eIF4E_1 505 511 PF01652 0.374
LIG_FHA_1 10 16 PF00498 0.523
LIG_FHA_1 116 122 PF00498 0.196
LIG_FHA_1 197 203 PF00498 0.441
LIG_FHA_1 21 27 PF00498 0.519
LIG_FHA_1 404 410 PF00498 0.355
LIG_FHA_1 51 57 PF00498 0.393
LIG_FHA_2 324 330 PF00498 0.338
LIG_FHA_2 439 445 PF00498 0.374
LIG_GBD_Chelix_1 16 24 PF00786 0.563
LIG_LIR_Apic_2 287 293 PF02991 0.300
LIG_LIR_Apic_2 51 57 PF02991 0.396
LIG_LIR_Apic_2 69 74 PF02991 0.212
LIG_LIR_Gen_1 117 124 PF02991 0.291
LIG_LIR_Gen_1 188 197 PF02991 0.332
LIG_LIR_Gen_1 329 339 PF02991 0.387
LIG_LIR_Gen_1 410 421 PF02991 0.376
LIG_LIR_Gen_1 519 529 PF02991 0.267
LIG_LIR_Gen_1 533 542 PF02991 0.353
LIG_LIR_LC3C_4 12 17 PF02991 0.354
LIG_LIR_LC3C_4 281 285 PF02991 0.378
LIG_LIR_Nem_3 117 122 PF02991 0.383
LIG_LIR_Nem_3 131 136 PF02991 0.256
LIG_LIR_Nem_3 137 142 PF02991 0.255
LIG_LIR_Nem_3 188 193 PF02991 0.328
LIG_LIR_Nem_3 256 262 PF02991 0.311
LIG_LIR_Nem_3 329 334 PF02991 0.368
LIG_LIR_Nem_3 372 378 PF02991 0.397
LIG_LIR_Nem_3 410 416 PF02991 0.354
LIG_LIR_Nem_3 503 508 PF02991 0.348
LIG_LIR_Nem_3 519 525 PF02991 0.242
LIG_LIR_Nem_3 533 537 PF02991 0.299
LIG_MLH1_MIPbox_1 130 134 PF16413 0.295
LIG_OCRL_FandH_1 330 342 PF00620 0.371
LIG_PCNA_yPIPBox_3 126 134 PF02747 0.339
LIG_PCNA_yPIPBox_3 480 491 PF02747 0.286
LIG_Pex14_1 422 426 PF04695 0.295
LIG_PTB_Apo_2 233 240 PF02174 0.306
LIG_PTB_Apo_2 62 69 PF02174 0.339
LIG_REV1ctd_RIR_1 444 453 PF16727 0.325
LIG_SH2_CRK 259 263 PF00017 0.347
LIG_SH2_GRB2like 189 192 PF00017 0.232
LIG_SH2_PTP2 205 208 PF00017 0.323
LIG_SH2_PTP2 413 416 PF00017 0.319
LIG_SH2_SRC 205 208 PF00017 0.294
LIG_SH2_SRC 413 416 PF00017 0.367
LIG_SH2_STAP1 426 430 PF00017 0.389
LIG_SH2_STAP1 517 521 PF00017 0.313
LIG_SH2_STAT3 487 490 PF00017 0.339
LIG_SH2_STAT5 133 136 PF00017 0.276
LIG_SH2_STAT5 144 147 PF00017 0.207
LIG_SH2_STAT5 170 173 PF00017 0.317
LIG_SH2_STAT5 189 192 PF00017 0.291
LIG_SH2_STAT5 205 208 PF00017 0.287
LIG_SH2_STAT5 358 361 PF00017 0.283
LIG_SH2_STAT5 413 416 PF00017 0.367
LIG_SH2_STAT5 501 504 PF00017 0.333
LIG_SH2_STAT5 71 74 PF00017 0.296
LIG_SH3_3 203 209 PF00018 0.302
LIG_SH3_3 210 216 PF00018 0.349
LIG_SH3_3 538 544 PF00018 0.289
LIG_SH3_3 87 93 PF00018 0.327
LIG_SUMO_SIM_anti_2 12 18 PF11976 0.538
LIG_SUMO_SIM_anti_2 40 48 PF11976 0.319
LIG_SUMO_SIM_anti_2 412 418 PF11976 0.332
LIG_SUMO_SIM_anti_2 523 528 PF11976 0.417
LIG_SUMO_SIM_par_1 40 48 PF11976 0.413
LIG_TRAF2_1 399 402 PF00917 0.382
LIG_TYR_ITIM 510 515 PF00017 0.403
LIG_UBA3_1 347 356 PF00899 0.405
LIG_WRC_WIRS_1 531 536 PF05994 0.417
MOD_CDK_SPK_2 403 408 PF00069 0.316
MOD_CDK_SPxK_1 460 466 PF00069 0.409
MOD_CK1_1 176 182 PF00069 0.384
MOD_CK1_1 212 218 PF00069 0.317
MOD_CK1_1 47 53 PF00069 0.390
MOD_CK2_1 176 182 PF00069 0.345
MOD_CK2_1 211 217 PF00069 0.389
MOD_CK2_1 243 249 PF00069 0.407
MOD_CK2_1 323 329 PF00069 0.430
MOD_CK2_1 396 402 PF00069 0.466
MOD_GlcNHglycan 167 170 PF01048 0.496
MOD_GlcNHglycan 275 278 PF01048 0.569
MOD_GlcNHglycan 296 299 PF01048 0.624
MOD_GlcNHglycan 344 347 PF01048 0.580
MOD_GSK3_1 138 145 PF00069 0.274
MOD_GSK3_1 174 181 PF00069 0.373
MOD_GSK3_1 20 27 PF00069 0.600
MOD_GSK3_1 208 215 PF00069 0.377
MOD_GSK3_1 302 309 PF00069 0.456
MOD_GSK3_1 318 325 PF00069 0.302
MOD_GSK3_1 403 410 PF00069 0.374
MOD_GSK3_1 44 51 PF00069 0.393
MOD_N-GLC_1 103 108 PF02516 0.448
MOD_NEK2_1 103 108 PF00069 0.316
MOD_NEK2_1 165 170 PF00069 0.381
MOD_NEK2_1 20 25 PF00069 0.559
MOD_NEK2_1 322 327 PF00069 0.401
MOD_NEK2_1 347 352 PF00069 0.361
MOD_PIKK_1 157 163 PF00454 0.322
MOD_PIKK_1 243 249 PF00454 0.399
MOD_PIKK_1 476 482 PF00454 0.204
MOD_PKA_2 125 131 PF00069 0.390
MOD_PKA_2 307 313 PF00069 0.452
MOD_PKA_2 407 413 PF00069 0.289
MOD_Plk_1 103 109 PF00069 0.280
MOD_Plk_1 185 191 PF00069 0.331
MOD_Plk_1 302 308 PF00069 0.444
MOD_Plk_1 396 402 PF00069 0.406
MOD_Plk_4 138 144 PF00069 0.258
MOD_Plk_4 185 191 PF00069 0.241
MOD_Plk_4 56 62 PF00069 0.341
MOD_Plk_4 67 73 PF00069 0.235
MOD_Plk_4 94 100 PF00069 0.258
MOD_ProDKin_1 209 215 PF00069 0.405
MOD_ProDKin_1 403 409 PF00069 0.318
MOD_ProDKin_1 460 466 PF00069 0.401
MOD_ProDKin_1 86 92 PF00069 0.281
MOD_ProDKin_1 9 15 PF00069 0.517
MOD_SUMO_rev_2 188 197 PF00179 0.287
TRG_DiLeu_BaEn_1 41 46 PF01217 0.396
TRG_DiLeu_BaEn_1 470 475 PF01217 0.378
TRG_DiLeu_BaLyEn_6 10 15 PF01217 0.572
TRG_ENDOCYTIC_2 133 136 PF00928 0.265
TRG_ENDOCYTIC_2 205 208 PF00928 0.345
TRG_ENDOCYTIC_2 259 262 PF00928 0.308
TRG_ENDOCYTIC_2 358 361 PF00928 0.275
TRG_ENDOCYTIC_2 413 416 PF00928 0.319
TRG_ENDOCYTIC_2 505 508 PF00928 0.359
TRG_ENDOCYTIC_2 512 515 PF00928 0.327
TRG_ENDOCYTIC_2 517 520 PF00928 0.320
TRG_ER_diArg_1 422 425 PF00400 0.390
TRG_ER_diLys_1 559 563 PF00400 0.639
TRG_Pf-PMV_PEXEL_1 366 370 PF00026 0.614
TRG_Pf-PMV_PEXEL_1 380 384 PF00026 0.439

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYT4 Leptomonas seymouri 66% 100%
A0A0S4KJA1 Bodo saltans 27% 98%
A0A1X0NH48 Trypanosomatidae 37% 100%
A0A3S7X8Z9 Leishmania donovani 91% 100%
A0A422N9H3 Trypanosoma rangeli 37% 100%
A4HMF5 Leishmania braziliensis 84% 100%
A4IB27 Leishmania infantum 91% 100%
C9ZNM3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 96%
Q9GRP8 Leishmania major 90% 100%
V5ASA4 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS