Chromo domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B608_LEIMU

TriTrypDb:

LmxM.34.1290

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B608

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B608

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.395
CLV_NRD_NRD_1	118	120	PF00675	0.712
CLV_NRD_NRD_1	195	197	PF00675	0.448
CLV_NRD_NRD_1	247	249	PF00675	0.569
CLV_NRD_NRD_1	99	101	PF00675	0.387
CLV_PCSK_KEX2_1	118	120	PF00082	0.712
CLV_PCSK_KEX2_1	195	197	PF00082	0.462
CLV_PCSK_KEX2_1	213	215	PF00082	0.562
CLV_PCSK_KEX2_1	246	248	PF00082	0.609
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.569
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.562
CLV_PCSK_PC7_1	209	215	PF00082	0.496
CLV_PCSK_PC7_1	243	249	PF00082	0.605
CLV_PCSK_SKI1_1	18	22	PF00082	0.496
DEG_SCF_TRCP1_1	232	238	PF00400	0.520
DOC_CYCLIN_RxL_1	154	167	PF00134	0.511
DOC_MAPK_gen_1	84	93	PF00069	0.432
DOC_PP2B_PxIxI_1	12	18	PF00149	0.365
DOC_USP7_MATH_1	141	145	PF00917	0.647
DOC_USP7_MATH_1	223	227	PF00917	0.471
DOC_USP7_MATH_1	67	71	PF00917	0.740
DOC_WW_Pin1_4	73	78	PF00397	0.681
DOC_WW_Pin1_4	79	84	PF00397	0.553
LIG_14-3-3_CanoR_1	140	148	PF00244	0.725
LIG_14-3-3_CanoR_1	18	23	PF00244	0.443
LIG_14-3-3_CanoR_1	37	41	PF00244	0.238
LIG_14-3-3_CanoR_1	50	54	PF00244	0.466
LIG_Actin_WH2_2	185	203	PF00022	0.457
LIG_FHA_1	12	18	PF00498	0.380
LIG_FHA_1	158	164	PF00498	0.488
LIG_FHA_1	37	43	PF00498	0.371
LIG_FHA_2	110	116	PF00498	0.541
LIG_FHA_2	55	61	PF00498	0.672
LIG_LIR_Apic_2	107	111	PF02991	0.481
LIG_MYND_1	83	87	PF01753	0.450
LIG_Pex14_2	104	108	PF04695	0.402
LIG_PTB_Apo_2	27	34	PF02174	0.389
LIG_REV1ctd_RIR_1	31	41	PF16727	0.405
LIG_SH2_STAT5	103	106	PF00017	0.346
LIG_SH2_STAT5	88	91	PF00017	0.420
LIG_SH2_STAT5	95	98	PF00017	0.420
LIG_SH3_1	84	90	PF00018	0.438
LIG_SH3_3	84	90	PF00018	0.443
LIG_SUMO_SIM_par_1	178	183	PF11976	0.299
LIG_TRAF2_1	112	115	PF00917	0.548
MOD_CDK_SPK_2	79	84	PF00069	0.574
MOD_CDK_SPxxK_3	79	86	PF00069	0.333
MOD_CK2_1	109	115	PF00069	0.505
MOD_CK2_1	21	27	PF00069	0.372
MOD_CK2_1	54	60	PF00069	0.631
MOD_Cter_Amidation	116	119	PF01082	0.441
MOD_GlcNHglycan	126	129	PF01048	0.680
MOD_GlcNHglycan	182	185	PF01048	0.477
MOD_GlcNHglycan	218	223	PF01048	0.525
MOD_GlcNHglycan	232	235	PF01048	0.700
MOD_GlcNHglycan	237	240	PF01048	0.364
MOD_GlcNHglycan	5	8	PF01048	0.568
MOD_GlcNHglycan	54	57	PF01048	0.627
MOD_GlcNHglycan	65	68	PF01048	0.657
MOD_GlcNHglycan	69	72	PF01048	0.716
MOD_GSK3_1	120	127	PF00069	0.699
MOD_GSK3_1	218	225	PF00069	0.609
MOD_GSK3_1	3	10	PF00069	0.603
MOD_GSK3_1	45	52	PF00069	0.449
MOD_GSK3_1	63	70	PF00069	0.730
MOD_NEK2_1	78	83	PF00069	0.534
MOD_PIKK_1	141	147	PF00454	0.645
MOD_PKA_2	230	236	PF00069	0.532
MOD_PKA_2	36	42	PF00069	0.561
MOD_PKA_2	49	55	PF00069	0.458
MOD_PKA_2	96	102	PF00069	0.487
MOD_Plk_1	157	163	PF00069	0.477
MOD_Plk_4	11	17	PF00069	0.363
MOD_Plk_4	187	193	PF00069	0.595
MOD_ProDKin_1	73	79	PF00069	0.680
MOD_SUMO_rev_2	55	65	PF00179	0.522
TRG_ENDOCYTIC_2	103	106	PF00928	0.361
TRG_ENDOCYTIC_2	88	91	PF00928	0.410
TRG_ER_diArg_1	245	248	PF00400	0.543
TRG_ER_diArg_1	83	86	PF00400	0.276
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5V4	Leptomonas seymouri	53%	100%
A0A1X0NIU6	Trypanosomatidae	32%	100%
A0A3R7JUY0	Trypanosoma rangeli	29%	100%
A0A3S7X907	Leishmania donovani	93%	100%
A4HMF1	Leishmania braziliensis	76%	100%
A4IB23	Leishmania infantum	92%	100%
C9ZNL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q9GN98	Leishmania major	88%	100%