AAA domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase family associated with various cellular activities (AAA), putative

Species:

Leishmania mexicana

UniProt:

E9B605_LEIMU

TriTrypDb:

LmxM.34.1260

Length:

361

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	2
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9B605

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B605

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0016887	ATP hydrolysis activity	7	10
GO:0017076	purine nucleotide binding	4	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.590
CLV_C14_Caspase3-7	201	205	PF00656	0.462
CLV_C14_Caspase3-7	211	215	PF00656	0.462
CLV_MEL_PAP_1	18	24	PF00089	0.628
CLV_NRD_NRD_1	248	250	PF00675	0.291
CLV_NRD_NRD_1	258	260	PF00675	0.234
CLV_NRD_NRD_1	67	69	PF00675	0.439
CLV_PCSK_KEX2_1	248	250	PF00082	0.287
CLV_PCSK_KEX2_1	257	259	PF00082	0.238
CLV_PCSK_KEX2_1	67	69	PF00082	0.466

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5V2	Leptomonas seymouri	84%	100%
A0A0N0P643	Leptomonas seymouri	30%	67%
A0A0N1HRH8	Leptomonas seymouri	32%	66%
A0A0N1IM81	Leptomonas seymouri	32%	82%
A0A0N1P9H6	Leptomonas seymouri	33%	81%
A0A0S4IPV5	Bodo saltans	34%	82%
A0A0S4IR32	Bodo saltans	39%	68%
A0A0S4IY28	Bodo saltans	33%	100%
A0A0S4JKQ6	Bodo saltans	26%	100%
A0A0S4KLG9	Bodo saltans	36%	72%

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