Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B603_LEIMU

TriTrypDb:

LmxM.34.1240

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B603

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B603

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.502
CLV_NRD_NRD_1	260	262	PF00675	0.384
CLV_NRD_NRD_1	302	304	PF00675	0.574
CLV_NRD_NRD_1	316	318	PF00675	0.447
CLV_NRD_NRD_1	339	341	PF00675	0.518
CLV_NRD_NRD_1	383	385	PF00675	0.579
CLV_NRD_NRD_1	401	403	PF00675	0.512
CLV_NRD_NRD_1	438	440	PF00675	0.562
CLV_NRD_NRD_1	505	507	PF00675	0.584
CLV_NRD_NRD_1	621	623	PF00675	0.457
CLV_NRD_NRD_1	679	681	PF00675	0.531
CLV_NRD_NRD_1	833	835	PF00675	0.525
CLV_NRD_NRD_1	89	91	PF00675	0.470
CLV_PCSK_FUR_1	258	262	PF00082	0.335
CLV_PCSK_FUR_1	381	385	PF00082	0.337
CLV_PCSK_FUR_1	817	821	PF00082	0.515
CLV_PCSK_KEX2_1	15	17	PF00082	0.501
CLV_PCSK_KEX2_1	260	262	PF00082	0.447
CLV_PCSK_KEX2_1	273	275	PF00082	0.530
CLV_PCSK_KEX2_1	302	304	PF00082	0.551
CLV_PCSK_KEX2_1	31	33	PF00082	0.378
CLV_PCSK_KEX2_1	316	318	PF00082	0.396
CLV_PCSK_KEX2_1	329	331	PF00082	0.316
CLV_PCSK_KEX2_1	339	341	PF00082	0.425
CLV_PCSK_KEX2_1	383	385	PF00082	0.348
CLV_PCSK_KEX2_1	401	403	PF00082	0.431
CLV_PCSK_KEX2_1	679	681	PF00082	0.531
CLV_PCSK_KEX2_1	819	821	PF00082	0.562
CLV_PCSK_KEX2_1	89	91	PF00082	0.469
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.612
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.511
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.373
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.623
CLV_PCSK_PC1ET2_1	819	821	PF00082	0.570
CLV_PCSK_SKI1_1	15	19	PF00082	0.554
CLV_PCSK_SKI1_1	173	177	PF00082	0.500
CLV_PCSK_SKI1_1	265	269	PF00082	0.650
CLV_PCSK_SKI1_1	330	334	PF00082	0.620
CLV_PCSK_SKI1_1	340	344	PF00082	0.554
CLV_PCSK_SKI1_1	39	43	PF00082	0.409
CLV_PCSK_SKI1_1	448	452	PF00082	0.500
CLV_PCSK_SKI1_1	764	768	PF00082	0.572
DEG_APCC_DBOX_1	315	323	PF00400	0.495
DEG_APCC_DBOX_1	38	46	PF00400	0.365
DEG_APCC_DBOX_1	477	485	PF00400	0.471
DEG_APCC_DBOX_1	621	629	PF00400	0.473
DEG_APCC_DBOX_1	777	785	PF00400	0.428
DEG_APCC_DBOX_1	798	806	PF00400	0.564
DOC_ANK_TNKS_1	708	715	PF00023	0.357
DOC_CYCLIN_RxL_1	75	85	PF00134	0.452
DOC_CYCLIN_RxL_1	761	771	PF00134	0.488
DOC_MAPK_gen_1	316	324	PF00069	0.494
DOC_MAPK_gen_1	413	420	PF00069	0.535
DOC_MAPK_gen_1	620	630	PF00069	0.526
DOC_MAPK_gen_1	832	842	PF00069	0.489
DOC_MAPK_MEF2A_6	20	28	PF00069	0.650
DOC_MAPK_MEF2A_6	690	698	PF00069	0.536
DOC_USP7_MATH_1	107	111	PF00917	0.375
DOC_USP7_MATH_1	635	639	PF00917	0.507
DOC_USP7_MATH_1	738	742	PF00917	0.627
DOC_USP7_MATH_1	770	774	PF00917	0.496
DOC_USP7_MATH_1	789	793	PF00917	0.527
DOC_USP7_MATH_1	91	95	PF00917	0.547
DOC_USP7_UBL2_3	413	417	PF12436	0.450
DOC_WW_Pin1_4	357	362	PF00397	0.628
DOC_WW_Pin1_4	665	670	PF00397	0.583
DOC_WW_Pin1_4	755	760	PF00397	0.686
LIG_14-3-3_CanoR_1	16	24	PF00244	0.553
LIG_14-3-3_CanoR_1	32	36	PF00244	0.461
LIG_14-3-3_CanoR_1	381	389	PF00244	0.420
LIG_14-3-3_CanoR_1	4	10	PF00244	0.620
LIG_14-3-3_CanoR_1	466	471	PF00244	0.568
LIG_14-3-3_CanoR_1	499	503	PF00244	0.568
LIG_14-3-3_CanoR_1	506	510	PF00244	0.583
LIG_14-3-3_CanoR_1	679	683	PF00244	0.526
LIG_14-3-3_CanoR_1	806	810	PF00244	0.436
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_BRCT_BRCA1_1	402	406	PF00533	0.340
LIG_BRCT_BRCA1_1	772	776	PF00533	0.327
LIG_CaM_IQ_9	809	824	PF13499	0.564
LIG_Clathr_ClatBox_1	698	702	PF01394	0.462
LIG_eIF4E_1	682	688	PF01652	0.632
LIG_eIF4E_1	693	699	PF01652	0.321
LIG_FHA_1	16	22	PF00498	0.522
LIG_FHA_1	174	180	PF00498	0.582
LIG_FHA_1	219	225	PF00498	0.463
LIG_FHA_1	23	29	PF00498	0.537
LIG_FHA_1	267	273	PF00498	0.459
LIG_FHA_1	388	394	PF00498	0.540
LIG_FHA_1	493	499	PF00498	0.525
LIG_FHA_1	703	709	PF00498	0.440
LIG_FHA_2	393	399	PF00498	0.486
LIG_FHA_2	506	512	PF00498	0.585
LIG_FHA_2	538	544	PF00498	0.457
LIG_FHA_2	806	812	PF00498	0.543
LIG_LIR_Gen_1	159	168	PF02991	0.566
LIG_LIR_Nem_3	113	119	PF02991	0.336
LIG_LIR_Nem_3	159	165	PF02991	0.571
LIG_NRP_CendR_1	843	846	PF00754	0.560
LIG_PCNA_yPIPBox_3	31	45	PF02747	0.519
LIG_PTAP_UEV_1	751	756	PF05743	0.543
LIG_Rb_LxCxE_1	320	341	PF01857	0.434
LIG_SH2_CRK	116	120	PF00017	0.330
LIG_SH2_SRC	632	635	PF00017	0.505
LIG_SH2_STAP1	277	281	PF00017	0.556
LIG_SH2_STAP1	632	636	PF00017	0.572
LIG_SH2_STAT3	277	280	PF00017	0.559
LIG_SH2_STAT5	218	221	PF00017	0.595
LIG_SH2_STAT5	581	584	PF00017	0.480
LIG_SH2_STAT5	693	696	PF00017	0.531
LIG_SH3_3	749	755	PF00018	0.570
LIG_SUMO_SIM_anti_2	320	328	PF11976	0.571
LIG_SUMO_SIM_par_1	24	30	PF11976	0.571
LIG_SUMO_SIM_par_1	320	328	PF11976	0.545
LIG_SUMO_SIM_par_1	366	372	PF11976	0.485
LIG_SUMO_SIM_par_1	697	702	PF11976	0.462
LIG_TRAF2_1	422	425	PF00917	0.603
LIG_TRAF2_1	508	511	PF00917	0.696
LIG_TRAF2_1	540	543	PF00917	0.527
LIG_TRAF2_1	648	651	PF00917	0.432
LIG_WRC_WIRS_1	393	398	PF05994	0.484
MOD_CK1_1	298	304	PF00069	0.613
MOD_CK1_1	419	425	PF00069	0.449
MOD_CK1_1	718	724	PF00069	0.466
MOD_CK1_1	753	759	PF00069	0.643
MOD_CK2_1	103	109	PF00069	0.588
MOD_CK2_1	31	37	PF00069	0.534
MOD_CK2_1	419	425	PF00069	0.588
MOD_CK2_1	441	447	PF00069	0.430
MOD_CK2_1	505	511	PF00069	0.572
MOD_CK2_1	537	543	PF00069	0.495
MOD_CK2_1	645	651	PF00069	0.569
MOD_CK2_1	745	751	PF00069	0.482
MOD_CK2_1	765	771	PF00069	0.548
MOD_CK2_1	805	811	PF00069	0.541
MOD_Cter_Amidation	399	402	PF01082	0.543
MOD_GlcNHglycan	105	108	PF01048	0.645
MOD_GlcNHglycan	119	122	PF01048	0.453
MOD_GlcNHglycan	137	140	PF01048	0.484
MOD_GlcNHglycan	569	572	PF01048	0.400
MOD_GlcNHglycan	721	724	PF01048	0.625
MOD_GlcNHglycan	751	755	PF01048	0.670
MOD_GlcNHglycan	768	771	PF01048	0.393
MOD_GSK3_1	135	142	PF00069	0.672
MOD_GSK3_1	157	164	PF00069	0.663
MOD_GSK3_1	27	34	PF00069	0.521
MOD_GSK3_1	353	360	PF00069	0.636
MOD_GSK3_1	494	501	PF00069	0.668
MOD_GSK3_1	659	666	PF00069	0.574
MOD_GSK3_1	714	721	PF00069	0.564
MOD_GSK3_1	753	760	PF00069	0.552
MOD_GSK3_1	766	773	PF00069	0.572
MOD_GSK3_1	826	833	PF00069	0.530
MOD_GSK3_1	838	845	PF00069	0.586
MOD_GSK3_1	99	106	PF00069	0.523
MOD_N-GLC_1	10	15	PF02516	0.524
MOD_N-GLC_1	744	749	PF02516	0.667
MOD_NEK2_1	10	15	PF00069	0.579
MOD_NEK2_1	157	162	PF00069	0.539
MOD_NEK2_1	284	289	PF00069	0.392
MOD_NEK2_1	441	446	PF00069	0.440
MOD_NEK2_1	451	456	PF00069	0.429
MOD_NEK2_1	477	482	PF00069	0.481
MOD_NEK2_1	492	497	PF00069	0.454
MOD_NEK2_1	498	503	PF00069	0.512
MOD_NEK2_1	715	720	PF00069	0.570
MOD_NEK2_1	731	736	PF00069	0.524
MOD_NEK2_1	784	789	PF00069	0.445
MOD_NEK2_1	805	810	PF00069	0.540
MOD_NEK2_1	826	831	PF00069	0.457
MOD_NEK2_2	494	499	PF00069	0.502
MOD_NEK2_2	739	744	PF00069	0.582
MOD_PIKK_1	173	179	PF00454	0.350
MOD_PIKK_1	219	225	PF00454	0.398
MOD_PIKK_1	512	518	PF00454	0.630
MOD_PIKK_1	715	721	PF00454	0.419
MOD_PIKK_1	745	751	PF00454	0.748
MOD_PIKK_1	789	795	PF00454	0.511
MOD_PIKK_1	96	102	PF00454	0.651
MOD_PK_1	31	37	PF00069	0.482
MOD_PKA_1	15	21	PF00069	0.555
MOD_PKA_1	31	37	PF00069	0.534
MOD_PKA_2	15	21	PF00069	0.514
MOD_PKA_2	31	37	PF00069	0.423
MOD_PKA_2	382	388	PF00069	0.375
MOD_PKA_2	400	406	PF00069	0.462
MOD_PKA_2	477	483	PF00069	0.446
MOD_PKA_2	498	504	PF00069	0.578
MOD_PKA_2	505	511	PF00069	0.639
MOD_PKA_2	678	684	PF00069	0.532
MOD_PKA_2	702	708	PF00069	0.452
MOD_PKA_2	715	721	PF00069	0.593
MOD_PKA_2	805	811	PF00069	0.453
MOD_PKA_2	826	832	PF00069	0.478
MOD_PKA_2	91	97	PF00069	0.467
MOD_PKB_1	115	123	PF00069	0.457
MOD_Plk_1	108	114	PF00069	0.485
MOD_Plk_1	295	301	PF00069	0.490
MOD_Plk_1	441	447	PF00069	0.433
MOD_Plk_1	703	709	PF00069	0.554
MOD_Plk_1	784	790	PF00069	0.516
MOD_Plk_1	795	801	PF00069	0.560
MOD_Plk_2-3	22	28	PF00069	0.547
MOD_Plk_4	157	163	PF00069	0.515
MOD_Plk_4	295	301	PF00069	0.490
MOD_Plk_4	392	398	PF00069	0.587
MOD_Plk_4	416	422	PF00069	0.446
MOD_Plk_4	466	472	PF00069	0.474
MOD_Plk_4	477	483	PF00069	0.470
MOD_Plk_4	5	11	PF00069	0.524
MOD_Plk_4	557	563	PF00069	0.551
MOD_Plk_4	757	763	PF00069	0.529
MOD_ProDKin_1	357	363	PF00069	0.622
MOD_ProDKin_1	665	671	PF00069	0.577
MOD_ProDKin_1	755	761	PF00069	0.684
MOD_SUMO_for_1	272	275	PF00179	0.646
MOD_SUMO_for_1	762	765	PF00179	0.440
MOD_SUMO_rev_2	128	136	PF00179	0.474
MOD_SUMO_rev_2	71	77	PF00179	0.498
TRG_DiLeu_BaEn_1	132	137	PF01217	0.584
TRG_DiLeu_BaEn_1	320	325	PF01217	0.576
TRG_DiLeu_BaEn_1	328	333	PF01217	0.487
TRG_DiLeu_BaEn_1	40	45	PF01217	0.450
TRG_DiLeu_BaEn_1	683	688	PF01217	0.488
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.510
TRG_DiLeu_BaLyEn_6	544	549	PF01217	0.519
TRG_DiLeu_BaLyEn_6	655	660	PF01217	0.565
TRG_ENDOCYTIC_2	116	119	PF00928	0.333
TRG_ENDOCYTIC_2	693	696	PF00928	0.531
TRG_ER_diArg_1	143	146	PF00400	0.647
TRG_ER_diArg_1	258	261	PF00400	0.510
TRG_ER_diArg_1	381	384	PF00400	0.336
TRG_ER_diArg_1	628	631	PF00400	0.436
TRG_ER_diArg_1	678	680	PF00400	0.535
TRG_ER_diArg_1	799	802	PF00400	0.470
TRG_ER_diArg_1	89	92	PF00400	0.492
TRG_NES_CRM1_1	209	223	PF08389	0.465
TRG_NES_CRM1_1	449	461	PF08389	0.492
TRG_NES_CRM1_1	596	610	PF08389	0.470
TRG_NLS_MonoExtN_4	620	626	PF00514	0.520
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	330	335	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	547	552	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX59	Leptomonas seymouri	52%	99%
A0A1X0NHD9	Trypanosomatidae	25%	100%
A0A3R7K5V9	Trypanosoma rangeli	27%	100%
A0A3S5H7Y8	Leishmania donovani	90%	100%
A4HME6	Leishmania braziliensis	79%	100%
A4IB18	Leishmania infantum	90%	100%
C9ZNP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	98%
E9AEU7	Leishmania major	90%	100%