Dolichyl-diphosphooligosaccharide--protein glycotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligosaccharyl transferase-like protein

Species:

Leishmania mexicana

UniProt:

E9B5Z3_LEIMU

TriTrypDb:

LmxM.34.1150

Length:

838

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	27
GO:0110165	cellular anatomical entity	1	27
GO:0005635	nuclear envelope	4	4
GO:0005783	endoplasmic reticulum	5	4
GO:0031967	organelle envelope	3	4
GO:0031975	envelope	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4

Expansion

Sequence features

E9B5Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5Z3

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	27
GO:0006807	nitrogen compound metabolic process	2	27
GO:0008152	metabolic process	1	27
GO:0019538	protein metabolic process	3	27
GO:0036211	protein modification process	4	27
GO:0043170	macromolecule metabolic process	3	27
GO:0043412	macromolecule modification	4	27
GO:0043413	macromolecule glycosylation	3	27
GO:0044238	primary metabolic process	2	27
GO:0070085	glycosylation	2	27
GO:0071704	organic substance metabolic process	2	27
GO:1901564	organonitrogen compound metabolic process	3	27

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	27
GO:0004576	oligosaccharyl transferase activity	5	27
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	6	27
GO:0005488	binding	1	27
GO:0016740	transferase activity	2	27
GO:0016757	glycosyltransferase activity	3	27
GO:0016758	hexosyltransferase activity	4	27
GO:0043167	ion binding	2	27
GO:0043169	cation binding	3	27
GO:0046872	metal ion binding	4	27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	500	504	PF00656	0.568
CLV_C14_Caspase3-7	636	640	PF00656	0.314
CLV_MEL_PAP_1	545	551	PF00089	0.254
CLV_MEL_PAP_1	805	811	PF00089	0.474
CLV_NRD_NRD_1	400	402	PF00675	0.382
CLV_NRD_NRD_1	434	436	PF00675	0.297
CLV_NRD_NRD_1	819	821	PF00675	0.605
CLV_PCSK_KEX2_1	522	524	PF00082	0.461
CLV_PCSK_KEX2_1	819	821	PF00082	0.598
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.458
CLV_PCSK_PC1ET2_1	819	821	PF00082	0.559
CLV_PCSK_SKI1_1	380	384	PF00082	0.447
CLV_PCSK_SKI1_1	48	52	PF00082	0.224
CLV_PCSK_SKI1_1	534	538	PF00082	0.447
CLV_PCSK_SKI1_1	54	58	PF00082	0.266
CLV_PCSK_SKI1_1	583	587	PF00082	0.575
CLV_PCSK_SKI1_1	653	657	PF00082	0.500
CLV_PCSK_SKI1_1	760	764	PF00082	0.601
CLV_PCSK_SKI1_1	820	824	PF00082	0.546
CLV_PCSK_SKI1_1	830	834	PF00082	0.500
CLV_Separin_Metazoa	329	333	PF03568	0.285
DEG_SCF_FBW7_1	560	566	PF00400	0.213
DEG_SPOP_SBC_1	123	127	PF00917	0.474
DOC_AGCK_PIF_1	411	416	PF00069	0.225
DOC_AGCK_PIF_2	108	113	PF00069	0.294
DOC_CKS1_1	560	565	PF01111	0.225
DOC_CYCLIN_RxL_1	377	387	PF00134	0.255
DOC_CYCLIN_yCln2_LP_2	462	468	PF00134	0.255
DOC_MAPK_gen_1	228	237	PF00069	0.359
DOC_MAPK_gen_1	332	339	PF00069	0.485
DOC_MAPK_gen_1	435	444	PF00069	0.403
DOC_MAPK_MEF2A_6	542	551	PF00069	0.611
DOC_PP1_RVXF_1	581	587	PF00149	0.395
DOC_PP1_RVXF_1	615	622	PF00149	0.303
DOC_PP1_RVXF_1	806	812	PF00149	0.288
DOC_PP2B_LxvP_1	365	368	PF13499	0.207
DOC_PP4_FxxP_1	579	582	PF00568	0.385
DOC_USP7_MATH_1	122	126	PF00917	0.339
DOC_USP7_MATH_1	177	181	PF00917	0.267
DOC_USP7_MATH_1	306	310	PF00917	0.280
DOC_USP7_MATH_1	33	37	PF00917	0.627
DOC_USP7_MATH_1	431	435	PF00917	0.450
DOC_USP7_MATH_1	490	494	PF00917	0.592
DOC_USP7_MATH_1	496	500	PF00917	0.648
DOC_USP7_MATH_1	532	536	PF00917	0.564
DOC_USP7_MATH_1	563	567	PF00917	0.387
DOC_USP7_MATH_1	677	681	PF00917	0.364
DOC_USP7_UBL2_3	402	406	PF12436	0.156
DOC_USP7_UBL2_3	830	834	PF12436	0.299
DOC_WW_Pin1_4	302	307	PF00397	0.280
DOC_WW_Pin1_4	401	406	PF00397	0.233
DOC_WW_Pin1_4	488	493	PF00397	0.509
DOC_WW_Pin1_4	559	564	PF00397	0.474
DOC_WW_Pin1_4	609	614	PF00397	0.327
DOC_WW_Pin1_4	654	659	PF00397	0.307
DOC_WW_Pin1_4	683	688	PF00397	0.345
DOC_WW_Pin1_4	718	723	PF00397	0.325
LIG_14-3-3_CanoR_1	228	234	PF00244	0.303
LIG_14-3-3_CanoR_1	23	28	PF00244	0.580
LIG_14-3-3_CanoR_1	274	278	PF00244	0.532
LIG_14-3-3_CanoR_1	283	288	PF00244	0.406
LIG_14-3-3_CanoR_1	401	405	PF00244	0.258
LIG_14-3-3_CanoR_1	523	533	PF00244	0.590
LIG_14-3-3_CanoR_1	571	579	PF00244	0.359
LIG_14-3-3_CanoR_1	634	638	PF00244	0.334
LIG_14-3-3_CanoR_1	691	697	PF00244	0.320
LIG_14-3-3_CanoR_1	725	729	PF00244	0.370
LIG_14-3-3_CanoR_1	73	78	PF00244	0.280
LIG_14-3-3_CanoR_1	808	812	PF00244	0.420
LIG_14-3-3_CanoR_1	820	825	PF00244	0.387
LIG_Actin_WH2_2	51	69	PF00022	0.202
LIG_Actin_WH2_2	533	550	PF00022	0.494
LIG_Actin_WH2_2	595	611	PF00022	0.268
LIG_AP2alpha_2	88	90	PF02296	0.280
LIG_BRCT_BRCA1_1	104	108	PF00533	0.381
LIG_BRCT_BRCA1_1	46	50	PF00533	0.565
LIG_CSL_BTD_1	418	421	PF09270	0.160
LIG_deltaCOP1_diTrp_1	480	489	PF00928	0.584
LIG_FHA_1	165	171	PF00498	0.367
LIG_FHA_1	469	475	PF00498	0.307
LIG_FHA_1	560	566	PF00498	0.492
LIG_FHA_1	654	660	PF00498	0.313
LIG_FHA_1	736	742	PF00498	0.392
LIG_FHA_2	590	596	PF00498	0.248
LIG_FHA_2	821	827	PF00498	0.345
LIG_LIR_Apic_2	487	492	PF02991	0.553
LIG_LIR_Apic_2	578	582	PF02991	0.390
LIG_LIR_Apic_2	716	720	PF02991	0.378
LIG_LIR_Apic_2	788	792	PF02991	0.457
LIG_LIR_Gen_1	101	111	PF02991	0.341
LIG_LIR_Gen_1	190	199	PF02991	0.433
LIG_LIR_Gen_1	219	227	PF02991	0.333
LIG_LIR_Gen_1	480	490	PF02991	0.555
LIG_LIR_Gen_1	603	613	PF02991	0.304
LIG_LIR_Gen_1	671	677	PF02991	0.352
LIG_LIR_Gen_1	695	705	PF02991	0.403
LIG_LIR_Gen_1	746	756	PF02991	0.412
LIG_LIR_Gen_1	810	817	PF02991	0.339
LIG_LIR_Nem_3	101	107	PF02991	0.278
LIG_LIR_Nem_3	109	113	PF02991	0.282
LIG_LIR_Nem_3	115	119	PF02991	0.263
LIG_LIR_Nem_3	125	131	PF02991	0.251
LIG_LIR_Nem_3	190	194	PF02991	0.380
LIG_LIR_Nem_3	219	224	PF02991	0.318
LIG_LIR_Nem_3	286	291	PF02991	0.301
LIG_LIR_Nem_3	305	310	PF02991	0.274
LIG_LIR_Nem_3	47	53	PF02991	0.530
LIG_LIR_Nem_3	480	486	PF02991	0.496
LIG_LIR_Nem_3	603	608	PF02991	0.311
LIG_LIR_Nem_3	671	675	PF02991	0.285
LIG_LIR_Nem_3	695	700	PF02991	0.324
LIG_LIR_Nem_3	746	751	PF02991	0.355
LIG_LIR_Nem_3	753	759	PF02991	0.303
LIG_LIR_Nem_3	79	83	PF02991	0.283
LIG_LIR_Nem_3	810	814	PF02991	0.351
LIG_LIR_Nem_3	88	93	PF02991	0.280
LIG_LYPXL_yS_3	128	131	PF13949	0.376
LIG_MLH1_MIPbox_1	104	108	PF16413	0.381
LIG_NRBOX	312	318	PF00104	0.378
LIG_PDZ_Class_1	833	838	PF00595	0.320
LIG_Pex14_1	104	108	PF04695	0.280
LIG_Pex14_1	564	568	PF04695	0.276
LIG_Pex14_1	622	626	PF04695	0.292
LIG_Pex14_2	107	111	PF04695	0.216
LIG_Pex14_2	410	414	PF04695	0.386
LIG_Pex14_2	87	91	PF04695	0.259
LIG_PTB_Apo_2	691	698	PF02174	0.324
LIG_PTB_Phospho_1	691	697	PF10480	0.320
LIG_SH2_CRK	717	721	PF00017	0.379
LIG_SH2_CRK	756	760	PF00017	0.293
LIG_SH2_CRK	80	84	PF00017	0.294
LIG_SH2_NCK_1	445	449	PF00017	0.195
LIG_SH2_PTP2	253	256	PF00017	0.352
LIG_SH2_PTP2	672	675	PF00017	0.284
LIG_SH2_SRC	601	604	PF00017	0.300
LIG_SH2_SRC	82	85	PF00017	0.313
LIG_SH2_STAP1	285	289	PF00017	0.352
LIG_SH2_STAP1	408	412	PF00017	0.203
LIG_SH2_STAP1	416	420	PF00017	0.194
LIG_SH2_STAP1	479	483	PF00017	0.445
LIG_SH2_STAP1	70	74	PF00017	0.237
LIG_SH2_STAP1	752	756	PF00017	0.362
LIG_SH2_STAT3	624	627	PF00017	0.284
LIG_SH2_STAT5	221	224	PF00017	0.376
LIG_SH2_STAT5	253	256	PF00017	0.352
LIG_SH2_STAT5	285	288	PF00017	0.453
LIG_SH2_STAT5	289	292	PF00017	0.436
LIG_SH2_STAT5	371	374	PF00017	0.267
LIG_SH2_STAT5	451	454	PF00017	0.324
LIG_SH2_STAT5	601	604	PF00017	0.324
LIG_SH2_STAT5	672	675	PF00017	0.284
LIG_SH2_STAT5	82	85	PF00017	0.346
LIG_SH2_STAT5	828	831	PF00017	0.284
LIG_SH3_3	153	159	PF00018	0.376
LIG_SH3_3	294	300	PF00018	0.415
LIG_SH3_3	557	563	PF00018	0.478
LIG_SH3_3	699	705	PF00018	0.412
LIG_SH3_3	772	778	PF00018	0.359
LIG_SH3_3	779	785	PF00018	0.363
LIG_SUMO_SIM_anti_2	457	463	PF11976	0.209
LIG_SUMO_SIM_par_1	167	174	PF11976	0.260
LIG_SUMO_SIM_par_1	55	61	PF11976	0.218
LIG_SUMO_SIM_par_1	554	559	PF11976	0.390
LIG_SUMO_SIM_par_1	73	79	PF11976	0.314
LIG_SxIP_EBH_1	187	200	PF03271	0.350
LIG_TRAF2_1	592	595	PF00917	0.250
LIG_TYR_ITSM	217	224	PF00017	0.317
LIG_UBA3_1	59	67	PF00899	0.299
LIG_UBA3_1	728	737	PF00899	0.394
LIG_WRC_WIRS_1	217	222	PF05994	0.317
LIG_WRC_WIRS_1	59	64	PF05994	0.483
MOD_CDC14_SPxK_1	305	308	PF00782	0.381
MOD_CDK_SPK_2	401	406	PF00069	0.178
MOD_CDK_SPK_2	609	614	PF00069	0.245
MOD_CDK_SPxK_1	302	308	PF00069	0.280
MOD_CDK_SPxxK_3	718	725	PF00069	0.373
MOD_CK1_1	178	184	PF00069	0.298
MOD_CK1_1	226	232	PF00069	0.352
MOD_CK1_1	3	9	PF00069	0.720
MOD_CK1_1	34	40	PF00069	0.662
MOD_CK1_1	446	452	PF00069	0.225
MOD_CK1_1	499	505	PF00069	0.709
MOD_CK1_1	535	541	PF00069	0.668
MOD_CK1_1	575	581	PF00069	0.348
MOD_CK1_1	76	82	PF00069	0.284
MOD_CK1_1	768	774	PF00069	0.332
MOD_CK2_1	38	44	PF00069	0.541
MOD_CK2_1	393	399	PF00069	0.247
MOD_CK2_1	431	437	PF00069	0.403
MOD_CK2_1	505	511	PF00069	0.699
MOD_CK2_1	589	595	PF00069	0.318
MOD_CK2_1	820	826	PF00069	0.391
MOD_GlcNHglycan	104	107	PF01048	0.570
MOD_GlcNHglycan	176	180	PF01048	0.498
MOD_GlcNHglycan	352	355	PF01048	0.349
MOD_GlcNHglycan	375	378	PF01048	0.505
MOD_GlcNHglycan	494	497	PF01048	0.379
MOD_GlcNHglycan	506	510	PF01048	0.568
MOD_GlcNHglycan	574	577	PF01048	0.575
MOD_GlcNHglycan	614	617	PF01048	0.421
MOD_GlcNHglycan	679	682	PF01048	0.585
MOD_GlcNHglycan	767	770	PF01048	0.566
MOD_GlcNHglycan	835	838	PF01048	0.528
MOD_GSK3_1	171	178	PF00069	0.343
MOD_GSK3_1	22	29	PF00069	0.699
MOD_GSK3_1	273	280	PF00069	0.522
MOD_GSK3_1	302	309	PF00069	0.298
MOD_GSK3_1	33	40	PF00069	0.643
MOD_GSK3_1	44	51	PF00069	0.590
MOD_GSK3_1	446	453	PF00069	0.274
MOD_GSK3_1	484	491	PF00069	0.628
MOD_GSK3_1	492	499	PF00069	0.640
MOD_GSK3_1	511	518	PF00069	0.747
MOD_GSK3_1	559	566	PF00069	0.283
MOD_GSK3_1	58	65	PF00069	0.331
MOD_GSK3_1	608	615	PF00069	0.277
MOD_GSK3_1	98	105	PF00069	0.344
MOD_N-GLC_1	632	637	PF02516	0.508
MOD_N-GLC_1	765	770	PF02516	0.527
MOD_N-GLC_2	208	210	PF02516	0.280
MOD_NEK2_1	131	136	PF00069	0.333
MOD_NEK2_1	189	194	PF00069	0.363
MOD_NEK2_1	198	203	PF00069	0.356
MOD_NEK2_1	216	221	PF00069	0.214
MOD_NEK2_1	393	398	PF00069	0.250
MOD_NEK2_1	412	417	PF00069	0.310
MOD_NEK2_1	505	510	PF00069	0.661
MOD_NEK2_1	556	561	PF00069	0.330
MOD_NEK2_1	58	63	PF00069	0.341
MOD_NEK2_1	608	613	PF00069	0.289
MOD_NEK2_1	724	729	PF00069	0.319
MOD_NEK2_2	223	228	PF00069	0.317
MOD_NEK2_2	38	43	PF00069	0.531
MOD_NEK2_2	532	537	PF00069	0.522
MOD_NMyristoyl	1	7	PF02799	0.569
MOD_PIKK_1	511	517	PF00454	0.799
MOD_PIKK_1	563	569	PF00454	0.333
MOD_PK_1	73	79	PF00069	0.315
MOD_PKA_1	820	826	PF00069	0.323
MOD_PKA_2	22	28	PF00069	0.579
MOD_PKA_2	229	235	PF00069	0.316
MOD_PKA_2	273	279	PF00069	0.532
MOD_PKA_2	400	406	PF00069	0.247
MOD_PKA_2	454	460	PF00069	0.478
MOD_PKA_2	608	614	PF00069	0.294
MOD_PKA_2	633	639	PF00069	0.313
MOD_PKA_2	724	730	PF00069	0.365
MOD_PKA_2	807	813	PF00069	0.318
MOD_PKB_1	348	356	PF00069	0.513
MOD_Plk_1	412	418	PF00069	0.232
MOD_Plk_1	632	638	PF00069	0.319
MOD_Plk_4	112	118	PF00069	0.280
MOD_Plk_4	216	222	PF00069	0.317
MOD_Plk_4	265	271	PF00069	0.424
MOD_Plk_4	277	283	PF00069	0.424
MOD_Plk_4	414	420	PF00069	0.317
MOD_Plk_4	446	452	PF00069	0.321
MOD_Plk_4	661	667	PF00069	0.364
MOD_Plk_4	692	698	PF00069	0.310
MOD_Plk_4	724	730	PF00069	0.358
MOD_Plk_4	743	749	PF00069	0.269
MOD_Plk_4	785	791	PF00069	0.365
MOD_ProDKin_1	302	308	PF00069	0.280
MOD_ProDKin_1	401	407	PF00069	0.233
MOD_ProDKin_1	488	494	PF00069	0.511
MOD_ProDKin_1	559	565	PF00069	0.474
MOD_ProDKin_1	609	615	PF00069	0.328
MOD_ProDKin_1	654	660	PF00069	0.313
MOD_ProDKin_1	683	689	PF00069	0.341
MOD_ProDKin_1	718	724	PF00069	0.320
MOD_SUMO_rev_2	826	835	PF00179	0.297
TRG_DiLeu_BaEn_1	661	666	PF01217	0.322
TRG_DiLeu_BaEn_2	436	442	PF01217	0.403
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.267
TRG_ENDOCYTIC_2	128	131	PF00928	0.420
TRG_ENDOCYTIC_2	221	224	PF00928	0.317
TRG_ENDOCYTIC_2	243	246	PF00928	0.317
TRG_ENDOCYTIC_2	253	256	PF00928	0.317
TRG_ENDOCYTIC_2	285	288	PF00928	0.317
TRG_ENDOCYTIC_2	408	411	PF00928	0.237
TRG_ENDOCYTIC_2	605	608	PF00928	0.306
TRG_ENDOCYTIC_2	672	675	PF00928	0.284
TRG_ENDOCYTIC_2	697	700	PF00928	0.335
TRG_ENDOCYTIC_2	756	759	PF00928	0.288
TRG_ENDOCYTIC_2	80	83	PF00928	0.294
TRG_ER_diArg_1	227	230	PF00400	0.377
TRG_ER_diArg_1	331	334	PF00400	0.498
TRG_ER_diArg_1	339	342	PF00400	0.468
TRG_ER_diArg_1	347	350	PF00400	0.412
TRG_NES_CRM1_1	311	326	PF08389	0.381
TRG_NLS_MonoExtN_4	816	823	PF00514	0.333
TRG_Pf-PMV_PEXEL_1	380	385	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ72	Bodo saltans	52%	100%
A0A1X0NFU7	Trypanosomatidae	55%	99%
A0A3Q8IHT0	Leishmania donovani	70%	97%
A0A3Q8II34	Leishmania donovani	57%	100%
A0A3Q8ILY7	Leishmania donovani	88%	100%
A0A3Q8IV37	Leishmania donovani	74%	100%
A0A422MX14	Trypanosoma rangeli	57%	100%
A4HFF9	Leishmania braziliensis	69%	100%
A4HMD5	Leishmania braziliensis	80%	100%
A4HMD6	Leishmania braziliensis	55%	100%
A4HMD7	Leishmania braziliensis	71%	100%
A4IB08	Leishmania infantum	71%	97%
A4IB09	Leishmania infantum	88%	100%
A4IB10	Leishmania infantum	57%	100%
C9ZNL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
C9ZQ40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E2RG47	Canis lupus familiaris	30%	100%
E9AET6	Leishmania major	75%	100%
E9AET7	Leishmania major	89%	100%
E9AET8	Leishmania major	57%	100%
E9AET9	Leishmania major	74%	100%
E9AHU4	Leishmania infantum	74%	100%
E9B5Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9B5Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9B5Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	98%
F1PJP5	Canis lupus familiaris	29%	100%
O94335	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P39007	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P46975	Caenorhabditis elegans	30%	100%
P46977	Homo sapiens	30%	100%
P46978	Mus musculus	30%	100%
Q2KJI2	Bos taurus	29%	100%
Q3TDQ1	Mus musculus	30%	100%
Q54NM9	Dictyostelium discoideum	30%	100%
Q5RCE2	Pongo abelii	30%	100%
Q7XQ88	Oryza sativa subsp. japonica	32%	100%
Q8TCJ2	Homo sapiens	30%	100%
Q93ZY3	Arabidopsis thaliana	32%	100%
Q9FX21	Arabidopsis thaliana	32%	100%
V5BDM6	Trypanosoma cruzi	57%	100%