Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9B5Z1_LEIMU

TriTrypDb:

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 1
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5Z1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.492
CLV_NRD_NRD_1	111	113	PF00675	0.515
CLV_NRD_NRD_1	12	14	PF00675	0.560
CLV_NRD_NRD_1	160	162	PF00675	0.740
CLV_NRD_NRD_1	9	11	PF00675	0.571
CLV_PCSK_FUR_1	10	14	PF00082	0.631
CLV_PCSK_KEX2_1	12	14	PF00082	0.543
CLV_PCSK_KEX2_1	8	10	PF00082	0.592
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.652
CLV_PCSK_SKI1_1	113	117	PF00082	0.646
CLV_PCSK_SKI1_1	12	16	PF00082	0.562
DEG_SPOP_SBC_1	134	138	PF00917	0.633
DOC_MAPK_gen_1	8	20	PF00069	0.584
DOC_MAPK_MEF2A_6	12	20	PF00069	0.505
DOC_USP7_MATH_1	179	183	PF00917	0.650
DOC_USP7_MATH_1	189	193	PF00917	0.545
DOC_USP7_MATH_1	98	102	PF00917	0.476
DOC_USP7_UBL2_3	149	153	PF12436	0.583
LIG_14-3-3_CanoR_1	12	17	PF00244	0.566
LIG_14-3-3_CanoR_1	32	42	PF00244	0.464
LIG_BIR_II_1	1	5	PF00653	0.570
LIG_FHA_1	13	19	PF00498	0.553
LIG_FHA_1	22	28	PF00498	0.503
LIG_LIR_Gen_1	49	57	PF02991	0.493
LIG_LIR_Nem_3	49	54	PF02991	0.490
LIG_NRBOX	22	28	PF00104	0.500
LIG_SH2_STAT5	222	225	PF00017	0.619
LIG_SH2_STAT5	53	56	PF00017	0.487
LIG_SUMO_SIM_anti_2	15	22	PF11976	0.610
LIG_SUMO_SIM_anti_2	2	7	PF11976	0.457
LIG_SUMO_SIM_anti_2	24	29	PF11976	0.483
LIG_SUMO_SIM_par_1	15	22	PF11976	0.570
LIG_SUMO_SIM_par_1	23	29	PF11976	0.499
LIG_TRAF2_1	145	148	PF00917	0.648
MOD_CK1_1	132	138	PF00069	0.754
MOD_CK2_1	141	147	PF00069	0.762
MOD_CK2_1	33	39	PF00069	0.693
MOD_CK2_1	98	104	PF00069	0.585
MOD_GlcNHglycan	120	123	PF01048	0.631
MOD_GlcNHglycan	126	129	PF01048	0.701
MOD_GlcNHglycan	143	146	PF01048	0.500
MOD_GlcNHglycan	190	194	PF01048	0.749
MOD_GlcNHglycan	212	215	PF01048	0.603
MOD_GlcNHglycan	28	31	PF01048	0.624
MOD_GlcNHglycan	35	38	PF01048	0.596
MOD_GlcNHglycan	76	79	PF01048	0.585
MOD_GSK3_1	114	121	PF00069	0.595
MOD_GSK3_1	129	136	PF00069	0.763
MOD_GSK3_1	206	213	PF00069	0.627
MOD_NEK2_1	1	6	PF00069	0.696
MOD_NEK2_1	26	31	PF00069	0.553
MOD_PIKK_1	179	185	PF00454	0.661
MOD_PKA_1	12	18	PF00069	0.626
MOD_PKA_2	12	18	PF00069	0.626
MOD_PKA_2	132	138	PF00069	0.754
MOD_PKA_2	206	212	PF00069	0.515
MOD_PKB_1	10	18	PF00069	0.627
MOD_Plk_1	98	104	PF00069	0.597
MOD_Plk_4	1	7	PF00069	0.693
MOD_Plk_4	12	18	PF00069	0.584
MOD_Plk_4	21	27	PF00069	0.452
MOD_SUMO_rev_2	213	221	PF00179	0.475
TRG_ENDOCYTIC_2	51	54	PF00928	0.472
TRG_ER_diArg_1	9	12	PF00400	0.568
TRG_NLS_MonoExtC_3	203	208	PF00514	0.527
TRG_NLS_MonoExtC_3	7	12	PF00514	0.649
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I116	Leptomonas seymouri	36%	100%
A0A3S7X8W8	Leishmania donovani	84%	100%