Glutaredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rdx family, putative

Species:

Leishmania mexicana

UniProt:

E9B5Z0_LEIMU

TriTrypDb:

LmxM.34.1110

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5Z0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0019725	cellular homeostasis	2	1
GO:0042592	homeostatic process	3	1
GO:0045454	cell redox homeostasis	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004791	thioredoxin-disulfide reductase activity	2	1
GO:0015035	protein-disulfide reductase activity	3	1
GO:0015036	disulfide oxidoreductase activity	4	1
GO:0016209	antioxidant activity	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	1
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	4	1
GO:0047134	protein-disulfide reductase (NAD(P)) activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.559
CLV_C14_Caspase3-7	19	23	PF00656	0.588
CLV_C14_Caspase3-7	61	65	PF00656	0.645
CLV_NRD_NRD_1	153	155	PF00675	0.564
CLV_NRD_NRD_1	191	193	PF00675	0.466
CLV_NRD_NRD_1	221	223	PF00675	0.548
CLV_NRD_NRD_1	260	262	PF00675	0.440
CLV_PCSK_FUR_1	151	155	PF00082	0.541
CLV_PCSK_FUR_1	258	262	PF00082	0.398
CLV_PCSK_KEX2_1	153	155	PF00082	0.564
CLV_PCSK_KEX2_1	221	223	PF00082	0.555
CLV_PCSK_KEX2_1	260	262	PF00082	0.440
CLV_PCSK_SKI1_1	102	106	PF00082	0.559
CLV_PCSK_SKI1_1	107	111	PF00082	0.395
CLV_PCSK_SKI1_1	221	225	PF00082	0.479
CLV_PCSK_SKI1_1	276	280	PF00082	0.463
CLV_PCSK_SKI1_1	327	331	PF00082	0.480
CLV_PCSK_SKI1_1	83	87	PF00082	0.348
DEG_COP1_1	25	34	PF00400	0.499
DOC_MAPK_gen_1	89	96	PF00069	0.423
DOC_MAPK_RevD_3	77	91	PF00069	0.471
DOC_USP7_MATH_1	147	151	PF00917	0.573
DOC_USP7_MATH_1	162	166	PF00917	0.631
DOC_USP7_MATH_1	4	8	PF00917	0.619
DOC_USP7_MATH_1	63	67	PF00917	0.736
DOC_USP7_MATH_2	6	12	PF00917	0.652
DOC_WW_Pin1_4	216	221	PF00397	0.528
DOC_WW_Pin1_4	66	71	PF00397	0.592
LIG_14-3-3_CanoR_1	261	271	PF00244	0.500
LIG_Actin_WH2_2	234	249	PF00022	0.446
LIG_APCC_ABBA_1	175	180	PF00400	0.347
LIG_APCC_ABBA_1	284	289	PF00400	0.342
LIG_BIR_II_1	1	5	PF00653	0.624
LIG_BIR_III_3	1	5	PF00653	0.624
LIG_BRCT_BRCA1_1	265	269	PF00533	0.370
LIG_FHA_1	234	240	PF00498	0.432
LIG_FHA_1	303	309	PF00498	0.424
LIG_FHA_1	69	75	PF00498	0.526
LIG_FHA_2	150	156	PF00498	0.742
LIG_FHA_2	59	65	PF00498	0.660
LIG_LIR_Gen_1	186	195	PF02991	0.592
LIG_LIR_Gen_1	282	292	PF02991	0.432
LIG_LIR_Nem_3	186	191	PF02991	0.590
LIG_LIR_Nem_3	208	212	PF02991	0.343
LIG_LIR_Nem_3	282	287	PF02991	0.363
LIG_NRBOX	308	314	PF00104	0.420
LIG_NRBOX	81	87	PF00104	0.388
LIG_PCNA_PIPBox_1	316	325	PF02747	0.284
LIG_PCNA_yPIPBox_3	316	330	PF02747	0.304
LIG_PTB_Apo_2	278	285	PF02174	0.428
LIG_PTB_Apo_2	38	45	PF02174	0.498
LIG_PTB_Phospho_1	38	44	PF10480	0.499
LIG_SH2_CRK	294	298	PF00017	0.431
LIG_SH2_NCK_1	178	182	PF00017	0.385
LIG_SH2_SRC	133	136	PF00017	0.489
LIG_SH3_2	217	222	PF14604	0.484
LIG_SH3_3	198	204	PF00018	0.436
LIG_SH3_3	214	220	PF00018	0.402
LIG_SUMO_SIM_anti_2	173	178	PF11976	0.437
LIG_SUMO_SIM_anti_2	251	258	PF11976	0.450
LIG_TRAF2_1	78	81	PF00917	0.383
LIG_TYR_ITIM	292	297	PF00017	0.421
LIG_UBA3_1	109	115	PF00899	0.463
MOD_CDC14_SPxK_1	219	222	PF00782	0.491
MOD_CDK_SPK_2	216	221	PF00069	0.477
MOD_CDK_SPxK_1	216	222	PF00069	0.478
MOD_CK1_1	66	72	PF00069	0.712
MOD_CK2_1	183	189	PF00069	0.453
MOD_CK2_1	279	285	PF00069	0.398
MOD_CK2_1	75	81	PF00069	0.393
MOD_GlcNHglycan	10	13	PF01048	0.752
MOD_GlcNHglycan	180	184	PF01048	0.300
MOD_GlcNHglycan	281	284	PF01048	0.316
MOD_GlcNHglycan	294	297	PF01048	0.442
MOD_GlcNHglycan	299	302	PF01048	0.414
MOD_GSK3_1	145	152	PF00069	0.639
MOD_GSK3_1	179	186	PF00069	0.377
MOD_GSK3_1	195	202	PF00069	0.578
MOD_GSK3_1	4	11	PF00069	0.685
MOD_GSK3_1	64	71	PF00069	0.517
MOD_N-GLC_1	297	302	PF02516	0.471
MOD_NEK2_1	233	238	PF00069	0.409
MOD_NEK2_1	263	268	PF00069	0.402
MOD_NEK2_1	279	284	PF00069	0.342
MOD_NEK2_1	292	297	PF00069	0.346
MOD_NEK2_1	314	319	PF00069	0.358
MOD_PIKK_1	135	141	PF00454	0.509
MOD_Plk_1	314	320	PF00069	0.366
MOD_Plk_2-3	75	81	PF00069	0.393
MOD_Plk_4	249	255	PF00069	0.448
MOD_Plk_4	314	320	PF00069	0.272
MOD_ProDKin_1	216	222	PF00069	0.529
MOD_ProDKin_1	66	72	PF00069	0.581
MOD_SUMO_rev_2	111	117	PF00179	0.313
MOD_SUMO_rev_2	202	212	PF00179	0.397
MOD_SUMO_rev_2	285	293	PF00179	0.270
MOD_SUMO_rev_2	75	85	PF00179	0.371
TRG_DiLeu_BaEn_1	81	86	PF01217	0.388
TRG_ENDOCYTIC_2	294	297	PF00928	0.349
TRG_ER_diArg_1	151	154	PF00400	0.541
TRG_ER_diArg_1	220	222	PF00400	0.571
TRG_ER_diArg_1	257	260	PF00400	0.429
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUE3	Leptomonas seymouri	48%	83%
A0A3Q8IP70	Leishmania donovani	90%	100%
A4IB07	Leishmania infantum	90%	100%
E9AET5	Leishmania major	88%	99%