Kri1_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 111, putative

Species:

Leishmania mexicana

UniProt:

E9B5Y8_LEIMU

TriTrypDb:

LmxM.34.1090

Length:

1048

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030686	90S preribosome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B5Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5Y8

Function

Biological processes
Term	Name	Level	Count
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	1
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1006	1010	PF00656	0.745
CLV_C14_Caspase3-7	101	105	PF00656	0.693
CLV_C14_Caspase3-7	110	114	PF00656	0.700
CLV_C14_Caspase3-7	26	30	PF00656	0.665
CLV_C14_Caspase3-7	489	493	PF00656	0.445
CLV_C14_Caspase3-7	529	533	PF00656	0.816
CLV_C14_Caspase3-7	614	618	PF00656	0.583
CLV_C14_Caspase3-7	831	835	PF00656	0.661
CLV_C14_Caspase3-7	980	984	PF00656	0.665
CLV_NRD_NRD_1	157	159	PF00675	0.772
CLV_NRD_NRD_1	168	170	PF00675	0.640
CLV_NRD_NRD_1	205	207	PF00675	0.500
CLV_NRD_NRD_1	271	273	PF00675	0.508
CLV_NRD_NRD_1	343	345	PF00675	0.598
CLV_NRD_NRD_1	391	393	PF00675	0.595
CLV_NRD_NRD_1	476	478	PF00675	0.700
CLV_NRD_NRD_1	511	513	PF00675	0.657
CLV_NRD_NRD_1	52	54	PF00675	0.626
CLV_NRD_NRD_1	608	610	PF00675	0.560
CLV_NRD_NRD_1	614	616	PF00675	0.526
CLV_NRD_NRD_1	622	624	PF00675	0.510
CLV_NRD_NRD_1	644	646	PF00675	0.367
CLV_NRD_NRD_1	701	703	PF00675	0.451
CLV_NRD_NRD_1	923	925	PF00675	0.396
CLV_NRD_NRD_1	928	930	PF00675	0.322
CLV_NRD_NRD_1	943	945	PF00675	0.541
CLV_PCSK_FUR_1	619	623	PF00082	0.551
CLV_PCSK_FUR_1	920	924	PF00082	0.449
CLV_PCSK_KEX2_1	157	159	PF00082	0.782
CLV_PCSK_KEX2_1	167	169	PF00082	0.698
CLV_PCSK_KEX2_1	205	207	PF00082	0.497
CLV_PCSK_KEX2_1	343	345	PF00082	0.546
CLV_PCSK_KEX2_1	348	350	PF00082	0.515
CLV_PCSK_KEX2_1	365	367	PF00082	0.522
CLV_PCSK_KEX2_1	457	459	PF00082	0.467
CLV_PCSK_KEX2_1	621	623	PF00082	0.519
CLV_PCSK_KEX2_1	638	640	PF00082	0.333
CLV_PCSK_KEX2_1	644	646	PF00082	0.328
CLV_PCSK_KEX2_1	922	924	PF00082	0.393
CLV_PCSK_KEX2_1	927	929	PF00082	0.405
CLV_PCSK_KEX2_1	943	945	PF00082	0.537
CLV_PCSK_KEX2_1	973	975	PF00082	0.524
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.701
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.497
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.540
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.522
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.496
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.365
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.306
CLV_PCSK_PC1ET2_1	973	975	PF00082	0.603
CLV_PCSK_PC7_1	344	350	PF00082	0.660
CLV_PCSK_PC7_1	923	929	PF00082	0.388
CLV_PCSK_SKI1_1	169	173	PF00082	0.726
CLV_PCSK_SKI1_1	17	21	PF00082	0.663
CLV_PCSK_SKI1_1	266	270	PF00082	0.440
CLV_PCSK_SKI1_1	272	276	PF00082	0.460
CLV_PCSK_SKI1_1	282	286	PF00082	0.626
CLV_PCSK_SKI1_1	365	369	PF00082	0.593
CLV_PCSK_SKI1_1	405	409	PF00082	0.535
CLV_PCSK_SKI1_1	423	427	PF00082	0.540
CLV_PCSK_SKI1_1	457	461	PF00082	0.485
CLV_PCSK_SKI1_1	498	502	PF00082	0.501
CLV_PCSK_SKI1_1	638	642	PF00082	0.342
CLV_PCSK_SKI1_1	662	666	PF00082	0.475
CLV_Separin_Metazoa	420	424	PF03568	0.730
DEG_APCC_DBOX_1	387	395	PF00400	0.701
DEG_APCC_DBOX_1	816	824	PF00400	0.629
DEG_Kelch_Keap1_1	521	526	PF01344	0.735
DEG_Kelch_Keap1_1	731	736	PF01344	0.398
DEG_SCF_FBW7_1	2	9	PF00400	0.481
DEG_SCF_TRCP1_1	523	528	PF00400	0.518
DEG_SPOP_SBC_1	79	83	PF00917	0.651
DOC_ANK_TNKS_1	137	144	PF00023	0.704
DOC_CKS1_1	3	8	PF01111	0.482
DOC_CYCLIN_yCln2_LP_2	691	697	PF00134	0.449
DOC_MAPK_gen_1	220	229	PF00069	0.740
DOC_MAPK_gen_1	272	280	PF00069	0.621
DOC_MAPK_gen_1	775	785	PF00069	0.693
DOC_MAPK_MEF2A_6	272	280	PF00069	0.648
DOC_PP1_RVXF_1	15	21	PF00149	0.751
DOC_PP2B_LxvP_1	691	694	PF13499	0.449
DOC_PP2B_LxvP_1	986	989	PF13499	0.687
DOC_PP4_FxxP_1	326	329	PF00568	0.477
DOC_PP4_FxxP_1	596	599	PF00568	0.597
DOC_USP7_MATH_1	1003	1007	PF00917	0.720
DOC_USP7_MATH_1	141	145	PF00917	0.593
DOC_USP7_MATH_1	291	295	PF00917	0.778
DOC_USP7_MATH_1	305	309	PF00917	0.698
DOC_USP7_MATH_1	353	357	PF00917	0.613
DOC_USP7_MATH_1	433	437	PF00917	0.743
DOC_USP7_MATH_1	473	477	PF00917	0.658
DOC_USP7_MATH_1	490	494	PF00917	0.523
DOC_USP7_MATH_1	6	10	PF00917	0.770
DOC_USP7_MATH_1	755	759	PF00917	0.626
DOC_USP7_MATH_1	767	771	PF00917	0.682
DOC_USP7_MATH_1	861	865	PF00917	0.475
DOC_USP7_MATH_1	869	873	PF00917	0.343
DOC_USP7_UBL2_3	216	220	PF12436	0.620
DOC_USP7_UBL2_3	351	355	PF12436	0.683
DOC_USP7_UBL2_3	474	478	PF12436	0.721
DOC_USP7_UBL2_3	773	777	PF12436	0.717
DOC_WW_Pin1_4	113	118	PF00397	0.817
DOC_WW_Pin1_4	2	7	PF00397	0.475
DOC_WW_Pin1_4	298	303	PF00397	0.798
LIG_14-3-3_CanoR_1	1023	1033	PF00244	0.701
LIG_14-3-3_CanoR_1	272	277	PF00244	0.517
LIG_14-3-3_CanoR_1	423	433	PF00244	0.688
LIG_14-3-3_CanoR_1	450	459	PF00244	0.654
LIG_14-3-3_CanoR_1	840	846	PF00244	0.573
LIG_Actin_WH2_2	264	281	PF00022	0.621
LIG_AP2alpha_1	785	789	PF02296	0.749
LIG_BRCT_BRCA1_1	492	496	PF00533	0.662
LIG_BRCT_BRCA1_1	871	875	PF00533	0.398
LIG_FHA_1	146	152	PF00498	0.774
LIG_FHA_1	273	279	PF00498	0.618
LIG_FHA_1	603	609	PF00498	0.702
LIG_FHA_1	739	745	PF00498	0.712
LIG_FHA_1	74	80	PF00498	0.540
LIG_FHA_1	796	802	PF00498	0.603
LIG_FHA_1	884	890	PF00498	0.344
LIG_FHA_1	949	955	PF00498	0.537
LIG_FHA_2	105	111	PF00498	0.743
LIG_FHA_2	116	122	PF00498	0.732
LIG_FHA_2	210	216	PF00498	0.659
LIG_FHA_2	357	363	PF00498	0.525
LIG_FHA_2	489	495	PF00498	0.617
LIG_FHA_2	612	618	PF00498	0.588
LIG_FHA_2	831	837	PF00498	0.644
LIG_GBD_Chelix_1	967	975	PF00786	0.595
LIG_GSK3_LRP6_1	2	8	PF00069	0.477
LIG_IRF3_LxIS_1	276	281	PF10401	0.411
LIG_LIR_Apic_2	595	599	PF02991	0.617
LIG_LIR_Gen_1	416	425	PF02991	0.711
LIG_LIR_Gen_1	541	550	PF02991	0.567
LIG_LIR_Nem_3	155	159	PF02991	0.726
LIG_LIR_Nem_3	416	422	PF02991	0.700
LIG_LIR_Nem_3	541	546	PF02991	0.603
LIG_LIR_Nem_3	849	855	PF02991	0.329
LIG_LIR_Nem_3	942	948	PF02991	0.487
LIG_LYPXL_L_2	804	813	PF13949	0.613
LIG_NRP_CendR_1	1047	1048	PF00754	0.752
LIG_Pex14_1	565	569	PF04695	0.491
LIG_Pex14_2	496	500	PF04695	0.493
LIG_Pex14_2	785	789	PF04695	0.749
LIG_Rb_pABgroove_1	702	710	PF01858	0.475
LIG_SH2_CRK	543	547	PF00017	0.550
LIG_SH2_CRK	945	949	PF00017	0.606
LIG_SH2_GRB2like	542	545	PF00017	0.632
LIG_SH2_NCK_1	429	433	PF00017	0.703
LIG_SH2_STAP1	197	201	PF00017	0.511
LIG_SH2_STAP1	909	913	PF00017	0.328
LIG_SH2_STAT3	201	204	PF00017	0.613
LIG_SH2_STAT3	574	577	PF00017	0.584
LIG_SH2_STAT5	725	728	PF00017	0.449
LIG_SH2_STAT5	912	915	PF00017	0.328
LIG_SH2_STAT5	991	994	PF00017	0.496
LIG_SH3_1	67	73	PF00018	0.762
LIG_SH3_3	299	305	PF00018	0.770
LIG_SH3_3	67	73	PF00018	0.742
LIG_SH3_3	691	697	PF00018	0.449
LIG_SH3_3	979	985	PF00018	0.685
LIG_SUMO_SIM_anti_2	798	805	PF11976	0.552
LIG_SUMO_SIM_par_1	883	891	PF11976	0.346
LIG_TRAF2_1	107	110	PF00917	0.762
LIG_TRAF2_1	185	188	PF00917	0.619
LIG_TRAF2_1	317	320	PF00917	0.583
LIG_TRAF2_1	329	332	PF00917	0.444
LIG_TRAF2_1	550	553	PF00917	0.567
LIG_TRAF2_1	579	582	PF00917	0.680
LIG_TRAF2_1	758	761	PF00917	0.572
LIG_TRAF2_1	888	891	PF00917	0.344
LIG_TRAF2_2	956	961	PF00917	0.688
LIG_UBA3_1	837	846	PF00899	0.581
MOD_CK1_1	123	129	PF00069	0.711
MOD_CK1_1	22	28	PF00069	0.604
MOD_CK1_1	301	307	PF00069	0.769
MOD_CK1_1	356	362	PF00069	0.576
MOD_CK1_1	415	421	PF00069	0.592
MOD_CK1_1	469	475	PF00069	0.515
MOD_CK1_1	521	527	PF00069	0.738
MOD_CK1_1	528	534	PF00069	0.729
MOD_CK1_1	538	544	PF00069	0.622
MOD_CK1_1	74	80	PF00069	0.712
MOD_CK1_1	8	14	PF00069	0.750
MOD_CK1_1	938	944	PF00069	0.591
MOD_CK1_1	98	104	PF00069	0.693
MOD_CK2_1	100	106	PF00069	0.752
MOD_CK2_1	115	121	PF00069	0.685
MOD_CK2_1	181	187	PF00069	0.760
MOD_CK2_1	209	215	PF00069	0.640
MOD_CK2_1	239	245	PF00069	0.746
MOD_CK2_1	25	31	PF00069	0.764
MOD_CK2_1	291	297	PF00069	0.518
MOD_CK2_1	439	445	PF00069	0.739
MOD_CK2_1	450	456	PF00069	0.551
MOD_CK2_1	488	494	PF00069	0.699
MOD_CK2_1	755	761	PF00069	0.588
MOD_CK2_1	830	836	PF00069	0.652
MOD_CK2_1	885	891	PF00069	0.344
MOD_Cter_Amidation	1045	1048	PF01082	0.623
MOD_Cter_Amidation	165	168	PF01082	0.771
MOD_GlcNHglycan	142	146	PF01048	0.522
MOD_GlcNHglycan	282	285	PF01048	0.709
MOD_GlcNHglycan	293	296	PF01048	0.780
MOD_GlcNHglycan	430	433	PF01048	0.777
MOD_GlcNHglycan	440	444	PF01048	0.784
MOD_GlcNHglycan	468	471	PF01048	0.596
MOD_GlcNHglycan	520	523	PF01048	0.739
MOD_GlcNHglycan	535	540	PF01048	0.766
MOD_GlcNHglycan	59	62	PF01048	0.721
MOD_GlcNHglycan	73	76	PF01048	0.673
MOD_GlcNHglycan	733	736	PF01048	0.398
MOD_GlcNHglycan	769	772	PF01048	0.717
MOD_GlcNHglycan	8	11	PF01048	0.789
MOD_GlcNHglycan	871	874	PF01048	0.405
MOD_GSK3_1	1	8	PF00069	0.780
MOD_GSK3_1	1004	1011	PF00069	0.764
MOD_GSK3_1	115	122	PF00069	0.472
MOD_GSK3_1	124	131	PF00069	0.736
MOD_GSK3_1	141	148	PF00069	0.701
MOD_GSK3_1	19	26	PF00069	0.551
MOD_GSK3_1	301	308	PF00069	0.752
MOD_GSK3_1	424	431	PF00069	0.754
MOD_GSK3_1	435	442	PF00069	0.757
MOD_GSK3_1	469	476	PF00069	0.559
MOD_GSK3_1	508	515	PF00069	0.710
MOD_GSK3_1	521	528	PF00069	0.682
MOD_GSK3_1	71	78	PF00069	0.697
MOD_GSK3_1	795	802	PF00069	0.650
MOD_GSK3_1	824	831	PF00069	0.672
MOD_GSK3_1	935	942	PF00069	0.562
MOD_GSK3_1	95	102	PF00069	0.726
MOD_N-GLC_1	182	187	PF02516	0.640
MOD_N-GLC_1	260	265	PF02516	0.574
MOD_N-GLC_1	969	974	PF02516	0.603
MOD_NEK2_1	124	129	PF00069	0.754
MOD_NEK2_1	278	283	PF00069	0.698
MOD_NEK2_1	368	373	PF00069	0.607
MOD_NEK2_1	464	469	PF00069	0.625
MOD_NEK2_1	654	659	PF00069	0.344
MOD_NEK2_1	823	828	PF00069	0.671
MOD_NEK2_1	841	846	PF00069	0.533
MOD_NEK2_2	1024	1029	PF00069	0.484
MOD_NEK2_2	75	80	PF00069	0.621
MOD_PKA_1	272	278	PF00069	0.538
MOD_PKA_1	512	518	PF00069	0.681
MOD_PKA_2	1024	1030	PF00069	0.735
MOD_PKA_2	278	284	PF00069	0.702
MOD_PKA_2	939	945	PF00069	0.516
MOD_Plk_1	1008	1014	PF00069	0.492
MOD_Plk_1	120	126	PF00069	0.546
MOD_Plk_1	260	266	PF00069	0.578
MOD_Plk_1	883	889	PF00069	0.344
MOD_Plk_2-3	104	110	PF00069	0.738
MOD_Plk_2-3	182	188	PF00069	0.722
MOD_Plk_2-3	209	215	PF00069	0.629
MOD_Plk_2-3	239	245	PF00069	0.686
MOD_Plk_2-3	488	494	PF00069	0.609
MOD_Plk_4	538	544	PF00069	0.681
MOD_Plk_4	761	767	PF00069	0.603
MOD_Plk_4	799	805	PF00069	0.645
MOD_ProDKin_1	113	119	PF00069	0.818
MOD_ProDKin_1	2	8	PF00069	0.477
MOD_ProDKin_1	298	304	PF00069	0.797
MOD_SUMO_for_1	317	320	PF00179	0.636
MOD_SUMO_rev_2	104	114	PF00179	0.783
MOD_SUMO_rev_2	362	367	PF00179	0.638
MOD_SUMO_rev_2	400	404	PF00179	0.525
MOD_SUMO_rev_2	453	459	PF00179	0.542
MOD_SUMO_rev_2	635	640	PF00179	0.413
MOD_SUMO_rev_2	696	705	PF00179	0.335
MOD_SUMO_rev_2	709	718	PF00179	0.335
TRG_DiLeu_BaEn_3	760	766	PF01217	0.573
TRG_DiLeu_BaEn_3	962	968	PF01217	0.365
TRG_DiLeu_BaEn_4	461	467	PF01217	0.585
TRG_DiLeu_BaEn_4	635	641	PF01217	0.413
TRG_DiLeu_BaEn_4	850	856	PF01217	0.449
TRG_DiLeu_BaEn_4	890	896	PF01217	0.449
TRG_DiLeu_BaLyEn_6	455	460	PF01217	0.397
TRG_ENDOCYTIC_2	543	546	PF00928	0.563
TRG_ENDOCYTIC_2	852	855	PF00928	0.328
TRG_ENDOCYTIC_2	877	880	PF00928	0.344
TRG_ENDOCYTIC_2	945	948	PF00928	0.483
TRG_ER_diArg_1	156	158	PF00400	0.719
TRG_ER_diArg_1	168	170	PF00400	0.561
TRG_ER_diArg_1	343	345	PF00400	0.653
TRG_ER_diArg_1	619	622	PF00400	0.532
TRG_ER_diArg_1	62	65	PF00400	0.745
TRG_ER_diArg_1	817	820	PF00400	0.382
TRG_ER_diArg_1	922	924	PF00400	0.375
TRG_ER_diArg_1	927	929	PF00400	0.353
TRG_ER_diArg_1	943	945	PF00400	0.527
TRG_ER_diArg_1	992	995	PF00400	0.616
TRG_NLS_Bipartite_1	157	171	PF00514	0.599
TRG_NLS_Bipartite_1	272	289	PF00514	0.626
TRG_NLS_Bipartite_1	457	478	PF00514	0.493
TRG_NLS_Bipartite_1	621	642	PF00514	0.415
TRG_NLS_MonoExtC_3	391	396	PF00514	0.654
TRG_NLS_MonoExtC_3	473	478	PF00514	0.454
TRG_NLS_MonoExtC_3	511	516	PF00514	0.752
TRG_NLS_MonoExtC_3	774	779	PF00514	0.743
TRG_NLS_MonoExtN_4	282	289	PF00514	0.609
TRG_NLS_MonoExtN_4	474	481	PF00514	0.592
TRG_NLS_MonoExtN_4	512	517	PF00514	0.701
TRG_NLS_MonoExtN_4	773	780	PF00514	0.740
TRG_Pf-PMV_PEXEL_1	392	397	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	598	602	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	973	977	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZY8	Leptomonas seymouri	61%	99%
A0A0S4JTV9	Bodo saltans	34%	100%
A0A1X0NGP0	Trypanosomatidae	39%	100%
A0A3R7NCJ6	Trypanosoma rangeli	41%	100%
A0A3S7X904	Leishmania donovani	90%	100%
A4HFF6	Leishmania braziliensis	78%	100%
A4IB05	Leishmania infantum	90%	100%
C9ZNK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AET3	Leishmania major	91%	100%
V5ATL2	Trypanosoma cruzi	36%	100%