LeishMANIAdb
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Mitochondrial carrier protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial carrier protein
Gene product:
Tripartite attachment complex protein 65
Species:
Leishmania mexicana
UniProt:
E9B5Y7_LEIMU
TriTrypDb:
LmxM.34.1080
Length:
508

Annotations

LeishMANIAdb annotations

A conserved but unique Kinetoplastid protein with 2-8 TM segments

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5Y7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5Y7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 373 377 PF00656 0.484
CLV_C14_Caspase3-7 396 400 PF00656 0.556
CLV_C14_Caspase3-7 464 468 PF00656 0.550
CLV_NRD_NRD_1 124 126 PF00675 0.483
CLV_NRD_NRD_1 223 225 PF00675 0.442
CLV_NRD_NRD_1 299 301 PF00675 0.528
CLV_NRD_NRD_1 302 304 PF00675 0.518
CLV_NRD_NRD_1 305 307 PF00675 0.508
CLV_NRD_NRD_1 308 310 PF00675 0.494
CLV_NRD_NRD_1 311 313 PF00675 0.453
CLV_NRD_NRD_1 419 421 PF00675 0.442
CLV_PCSK_FUR_1 118 122 PF00082 0.429
CLV_PCSK_FUR_1 300 304 PF00082 0.524
CLV_PCSK_FUR_1 305 309 PF00082 0.487
CLV_PCSK_KEX2_1 120 122 PF00082 0.490
CLV_PCSK_KEX2_1 123 125 PF00082 0.481
CLV_PCSK_KEX2_1 223 225 PF00082 0.442
CLV_PCSK_KEX2_1 289 291 PF00082 0.594
CLV_PCSK_KEX2_1 299 301 PF00082 0.476
CLV_PCSK_KEX2_1 302 304 PF00082 0.435
CLV_PCSK_KEX2_1 305 307 PF00082 0.399
CLV_PCSK_KEX2_1 308 310 PF00082 0.372
CLV_PCSK_KEX2_1 311 313 PF00082 0.410
CLV_PCSK_KEX2_1 32 34 PF00082 0.393
CLV_PCSK_KEX2_1 419 421 PF00082 0.442
CLV_PCSK_PC1ET2_1 120 122 PF00082 0.481
CLV_PCSK_PC1ET2_1 289 291 PF00082 0.619
CLV_PCSK_PC1ET2_1 307 309 PF00082 0.456
CLV_PCSK_PC1ET2_1 310 312 PF00082 0.604
CLV_PCSK_PC1ET2_1 32 34 PF00082 0.393
CLV_PCSK_PC7_1 303 309 PF00082 0.587
CLV_PCSK_SKI1_1 105 109 PF00082 0.391
CLV_PCSK_SKI1_1 124 128 PF00082 0.393
CLV_PCSK_SKI1_1 173 177 PF00082 0.433
CLV_PCSK_SKI1_1 208 212 PF00082 0.446
CLV_PCSK_SKI1_1 385 389 PF00082 0.523
CLV_PCSK_SKI1_1 398 402 PF00082 0.616
CLV_PCSK_SKI1_1 4 8 PF00082 0.593
CLV_PCSK_SKI1_1 423 427 PF00082 0.452
CLV_PCSK_SKI1_1 93 97 PF00082 0.329
CLV_Separin_Metazoa 351 355 PF03568 0.360
DEG_Nend_UBRbox_1 1 4 PF02207 0.542
DEG_SPOP_SBC_1 269 273 PF00917 0.481
DEG_SPOP_SBC_1 431 435 PF00917 0.394
DOC_CDC14_PxL_1 35 43 PF14671 0.379
DOC_CYCLIN_yCln2_LP_2 364 370 PF00134 0.422
DOC_MAPK_DCC_7 33 43 PF00069 0.375
DOC_MAPK_gen_1 32 40 PF00069 0.369
DOC_MAPK_gen_1 354 361 PF00069 0.360
DOC_MAPK_MEF2A_6 316 324 PF00069 0.462
DOC_MAPK_MEF2A_6 32 40 PF00069 0.242
DOC_MAPK_RevD_3 209 224 PF00069 0.423
DOC_PP1_RVXF_1 103 109 PF00149 0.493
DOC_PP1_RVXF_1 123 130 PF00149 0.405
DOC_PP1_RVXF_1 171 177 PF00149 0.412
DOC_PP1_RVXF_1 491 498 PF00149 0.369
DOC_PP2B_LxvP_1 197 200 PF13499 0.413
DOC_PP2B_LxvP_1 81 84 PF13499 0.443
DOC_USP7_MATH_1 200 204 PF00917 0.393
DOC_USP7_MATH_1 465 469 PF00917 0.430
DOC_USP7_MATH_1 98 102 PF00917 0.446
DOC_WW_Pin1_4 154 159 PF00397 0.510
DOC_WW_Pin1_4 166 171 PF00397 0.438
DOC_WW_Pin1_4 270 275 PF00397 0.481
DOC_WW_Pin1_4 46 51 PF00397 0.590
DOC_WW_Pin1_4 477 482 PF00397 0.380
DOC_WW_Pin1_4 59 64 PF00397 0.440
LIG_14-3-3_CanoR_1 132 141 PF00244 0.377
LIG_14-3-3_CanoR_1 173 179 PF00244 0.419
LIG_14-3-3_CanoR_1 208 214 PF00244 0.496
LIG_14-3-3_CanoR_1 248 252 PF00244 0.764
LIG_14-3-3_CanoR_1 260 266 PF00244 0.694
LIG_14-3-3_CanoR_1 33 39 PF00244 0.367
LIG_14-3-3_CanoR_1 331 337 PF00244 0.401
LIG_14-3-3_CanoR_1 354 360 PF00244 0.357
LIG_14-3-3_CanoR_1 452 458 PF00244 0.428
LIG_14-3-3_CanoR_1 474 480 PF00244 0.458
LIG_AP2alpha_2 140 142 PF02296 0.358
LIG_BRCT_BRCA1_1 103 107 PF00533 0.298
LIG_BRCT_BRCA1_1 467 471 PF00533 0.461
LIG_CaM_IQ_9 291 307 PF13499 0.494
LIG_CSL_BTD_1 70 73 PF09270 0.459
LIG_EVH1_1 167 171 PF00568 0.510
LIG_EVH1_2 171 175 PF00568 0.333
LIG_FHA_1 280 286 PF00498 0.560
LIG_FHA_1 35 41 PF00498 0.342
LIG_FHA_1 356 362 PF00498 0.363
LIG_FHA_1 392 398 PF00498 0.521
LIG_FHA_1 424 430 PF00498 0.516
LIG_FHA_1 441 447 PF00498 0.284
LIG_FHA_2 135 141 PF00498 0.343
LIG_FHA_2 155 161 PF00498 0.369
LIG_FHA_2 210 216 PF00498 0.398
LIG_FHA_2 394 400 PF00498 0.544
LIG_FHA_2 487 493 PF00498 0.387
LIG_IRF3_LxIS_1 182 188 PF10401 0.370
LIG_LIR_Gen_1 212 222 PF02991 0.449
LIG_LIR_Gen_1 379 388 PF02991 0.464
LIG_LIR_Gen_1 496 505 PF02991 0.475
LIG_LIR_Gen_1 75 86 PF02991 0.540
LIG_LIR_LC3C_4 109 114 PF02991 0.463
LIG_LIR_Nem_3 137 142 PF02991 0.508
LIG_LIR_Nem_3 212 217 PF02991 0.444
LIG_LIR_Nem_3 379 383 PF02991 0.463
LIG_LIR_Nem_3 480 486 PF02991 0.347
LIG_LIR_Nem_3 496 501 PF02991 0.337
LIG_LIR_Nem_3 75 81 PF02991 0.543
LIG_NRBOX 348 354 PF00104 0.371
LIG_NRBOX 360 366 PF00104 0.411
LIG_PALB2_WD40_1 73 81 PF16756 0.445
LIG_SH2_CRK 330 334 PF00017 0.391
LIG_SH2_STAP1 386 390 PF00017 0.438
LIG_SH2_STAT3 386 389 PF00017 0.439
LIG_SH2_STAT3 484 487 PF00017 0.383
LIG_SH2_STAT5 102 105 PF00017 0.395
LIG_SH2_STAT5 11 14 PF00017 0.425
LIG_SH2_STAT5 219 222 PF00017 0.380
LIG_SH2_STAT5 27 30 PF00017 0.253
LIG_SH3_2 168 173 PF14604 0.493
LIG_SH3_3 135 141 PF00018 0.465
LIG_SH3_3 165 171 PF00018 0.538
LIG_SH3_3 33 39 PF00018 0.240
LIG_SH3_CIN85_PxpxPR_1 168 173 PF14604 0.493
LIG_SUMO_SIM_anti_2 428 435 PF11976 0.481
LIG_SUMO_SIM_par_1 148 153 PF11976 0.578
LIG_SUMO_SIM_par_1 209 215 PF11976 0.397
LIG_SUMO_SIM_par_1 428 435 PF11976 0.432
LIG_TRFH_1 44 48 PF08558 0.350
LIG_TYR_ITIM 328 333 PF00017 0.406
LIG_WRC_WIRS_1 494 499 PF05994 0.492
LIG_WW_3 170 174 PF00397 0.473
MOD_CDK_SPK_2 154 159 PF00069 0.375
MOD_CDK_SPxxK_3 166 173 PF00069 0.505
MOD_CK1_1 101 107 PF00069 0.555
MOD_CK1_1 119 125 PF00069 0.367
MOD_CK1_1 250 256 PF00069 0.649
MOD_CK1_1 261 267 PF00069 0.564
MOD_CK1_1 268 274 PF00069 0.499
MOD_CK1_1 435 441 PF00069 0.436
MOD_CK1_1 477 483 PF00069 0.449
MOD_CK1_1 49 55 PF00069 0.629
MOD_CK2_1 209 215 PF00069 0.397
MOD_CK2_1 398 404 PF00069 0.593
MOD_GlcNHglycan 187 190 PF01048 0.396
MOD_GlcNHglycan 252 255 PF01048 0.789
MOD_GlcNHglycan 274 277 PF01048 0.679
MOD_GlcNHglycan 285 288 PF01048 0.430
MOD_GlcNHglycan 439 442 PF01048 0.497
MOD_GlcNHglycan 463 466 PF01048 0.462
MOD_GlcNHglycan 467 470 PF01048 0.450
MOD_GlcNHglycan 8 11 PF01048 0.440
MOD_GlcNHglycan 81 84 PF01048 0.602
MOD_GSK3_1 150 157 PF00069 0.606
MOD_GSK3_1 162 169 PF00069 0.622
MOD_GSK3_1 261 268 PF00069 0.681
MOD_GSK3_1 279 286 PF00069 0.678
MOD_GSK3_1 355 362 PF00069 0.453
MOD_GSK3_1 372 379 PF00069 0.384
MOD_GSK3_1 431 438 PF00069 0.429
MOD_GSK3_1 461 468 PF00069 0.430
MOD_GSK3_1 52 59 PF00069 0.648
MOD_N-GLC_1 4 9 PF02516 0.479
MOD_N-GLC_1 79 84 PF02516 0.500
MOD_NEK2_1 108 113 PF00069 0.443
MOD_NEK2_1 142 147 PF00069 0.424
MOD_NEK2_1 150 155 PF00069 0.455
MOD_NEK2_1 185 190 PF00069 0.365
MOD_NEK2_1 359 364 PF00069 0.341
MOD_NEK2_1 378 383 PF00069 0.363
MOD_NEK2_1 432 437 PF00069 0.365
MOD_NEK2_1 472 477 PF00069 0.404
MOD_NEK2_1 6 11 PF00069 0.403
MOD_NEK2_2 209 214 PF00069 0.393
MOD_NEK2_2 355 360 PF00069 0.461
MOD_NEK2_2 393 398 PF00069 0.402
MOD_PIKK_1 258 264 PF00454 0.603
MOD_PKA_2 247 253 PF00069 0.646
MOD_PKA_2 355 361 PF00069 0.361
MOD_Plk_1 108 114 PF00069 0.574
MOD_Plk_1 161 167 PF00069 0.572
MOD_Plk_4 108 114 PF00069 0.413
MOD_Plk_4 134 140 PF00069 0.416
MOD_Plk_4 142 148 PF00069 0.338
MOD_Plk_4 162 168 PF00069 0.398
MOD_Plk_4 209 215 PF00069 0.515
MOD_Plk_4 332 338 PF00069 0.394
MOD_Plk_4 344 350 PF00069 0.369
MOD_Plk_4 413 419 PF00069 0.618
MOD_Plk_4 432 438 PF00069 0.425
MOD_Plk_4 493 499 PF00069 0.453
MOD_Plk_4 98 104 PF00069 0.459
MOD_ProDKin_1 154 160 PF00069 0.518
MOD_ProDKin_1 166 172 PF00069 0.427
MOD_ProDKin_1 270 276 PF00069 0.482
MOD_ProDKin_1 46 52 PF00069 0.600
MOD_ProDKin_1 477 483 PF00069 0.382
MOD_ProDKin_1 59 65 PF00069 0.434
TRG_DiLeu_BaLyEn_6 122 127 PF01217 0.545
TRG_DiLeu_BaLyEn_6 146 151 PF01217 0.537
TRG_DiLeu_BaLyEn_6 36 41 PF01217 0.413
TRG_ENDOCYTIC_2 219 222 PF00928 0.385
TRG_ENDOCYTIC_2 330 333 PF00928 0.400
TRG_ENDOCYTIC_2 368 371 PF00928 0.476
TRG_ENDOCYTIC_2 483 486 PF00928 0.468
TRG_ENDOCYTIC_2 498 501 PF00928 0.286
TRG_ER_diArg_1 121 124 PF00400 0.475
TRG_ER_diArg_1 222 224 PF00400 0.428
TRG_ER_diArg_1 298 300 PF00400 0.541
TRG_ER_diArg_1 305 308 PF00400 0.476
TRG_ER_diArg_1 309 312 PF00400 0.452
TRG_ER_diArg_1 353 356 PF00400 0.461
TRG_ER_diArg_1 418 420 PF00400 0.456
TRG_NLS_Bipartite_1 289 311 PF00514 0.373
TRG_NLS_MonoCore_2 305 310 PF00514 0.385
TRG_NLS_MonoExtC_3 119 124 PF00514 0.449
TRG_NLS_MonoExtC_3 305 310 PF00514 0.385
TRG_NLS_MonoExtN_4 118 124 PF00514 0.456
TRG_NLS_MonoExtN_4 303 310 PF00514 0.381
TRG_Pf-PMV_PEXEL_1 296 301 PF00026 0.556

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JMW3 Bodo saltans 21% 100%
A0A3S5H7Y7 Leishmania donovani 90% 100%
A0A422N586 Trypanosoma rangeli 33% 85%
A4IB04 Leishmania infantum 90% 100%
C9ZNK4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 85%
E9AET2 Leishmania major 89% 100%
V5D9L8 Trypanosoma cruzi 32% 84%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS