C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger CCCH domain containing protein 11

Species:

Leishmania mexicana

UniProt:

E9B5Y4_LEIMU

TriTrypDb:

LmxM.34.1040

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5Y4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5Y4

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0009266	response to temperature stimulus	3	1
GO:0009408	response to heat	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050896	response to stimulus	1	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003729	mRNA binding	5	7
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	92	94	PF00675	0.589
CLV_PCSK_KEX2_1	13	15	PF00082	0.692
CLV_PCSK_KEX2_1	91	93	PF00082	0.587
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.692
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.587
CLV_PCSK_SKI1_1	27	31	PF00082	0.619
CLV_PCSK_SKI1_1	53	57	PF00082	0.478
CLV_PCSK_SKI1_1	93	97	PF00082	0.696
DOC_CDC14_PxL_1	237	245	PF14671	0.759
DOC_MAPK_gen_1	145	153	PF00069	0.750
DOC_USP7_MATH_1	264	268	PF00917	0.689
DOC_USP7_MATH_1	299	303	PF00917	0.689
LIG_14-3-3_CanoR_1	122	130	PF00244	0.639
LIG_14-3-3_CanoR_1	292	299	PF00244	0.656
LIG_14-3-3_CanoR_1	64	70	PF00244	0.541
LIG_Actin_WH2_2	48	66	PF00022	0.411
LIG_APCC_ABBA_1	204	209	PF00400	0.748
LIG_BIR_II_1	1	5	PF00653	0.565
LIG_FHA_1	3	9	PF00498	0.802
LIG_FHA_2	292	298	PF00498	0.656
LIG_FHA_2	63	69	PF00498	0.540
LIG_IBAR_NPY_1	190	192	PF08397	0.612
LIG_LIR_Apic_2	226	231	PF02991	0.681
LIG_LIR_Nem_3	245	251	PF02991	0.769
LIG_LIR_Nem_3	284	290	PF02991	0.739
LIG_PCNA_PIPBox_1	180	189	PF02747	0.649
LIG_SH2_CRK	287	291	PF00017	0.689
LIG_SH2_GRB2like	142	145	PF00017	0.557
LIG_SH2_STAT3	251	254	PF00017	0.688
LIG_SH2_STAT5	187	190	PF00017	0.558
LIG_SH2_STAT5	192	195	PF00017	0.558
LIG_SH2_STAT5	229	232	PF00017	0.672
LIG_SH2_STAT5	248	251	PF00017	0.441
LIG_SH2_STAT5	42	45	PF00017	0.513
LIG_SH3_3	157	163	PF00018	0.812
LIG_SH3_3	235	241	PF00018	0.635
LIG_SH3_3	305	311	PF00018	0.677
LIG_TRAF2_1	155	158	PF00917	0.744
LIG_TRAF2_1	223	226	PF00917	0.642
LIG_TRAF2_1	270	273	PF00917	0.790
LIG_TRFH_1	194	198	PF08558	0.724
MOD_CK1_1	2	8	PF00069	0.777
MOD_CK1_1	242	248	PF00069	0.767
MOD_CK1_1	265	271	PF00069	0.754
MOD_CK1_1	279	285	PF00069	0.575
MOD_CK2_1	267	273	PF00069	0.723
MOD_CK2_1	291	297	PF00069	0.643
MOD_CK2_1	4	10	PF00069	0.723
MOD_GlcNHglycan	180	183	PF01048	0.549
MOD_GlcNHglycan	264	267	PF01048	0.759
MOD_GlcNHglycan	269	272	PF01048	0.710
MOD_GlcNHglycan	280	284	PF01048	0.517
MOD_GSK3_1	107	114	PF00069	0.744
MOD_GSK3_1	2	9	PF00069	0.707
MOD_GSK3_1	278	285	PF00069	0.700
MOD_N-GLC_1	111	116	PF02516	0.618
MOD_N-GLC_1	117	122	PF02516	0.585
MOD_PIKK_1	242	248	PF00454	0.767
MOD_PKA_1	13	19	PF00069	0.672
MOD_PKA_2	13	19	PF00069	0.672
MOD_PKA_2	291	297	PF00069	0.658
MOD_PKA_2	63	69	PF00069	0.540
MOD_Plk_1	117	123	PF00069	0.625
MOD_Plk_4	239	245	PF00069	0.666
MOD_Plk_4	282	288	PF00069	0.549
MOD_SUMO_for_1	44	47	PF00179	0.383
MOD_SUMO_rev_2	21	29	PF00179	0.624
TRG_DiLeu_BaEn_3	24	30	PF01217	0.698
TRG_DiLeu_BaEn_4	174	180	PF01217	0.466
TRG_DiLeu_BaEn_4	25	31	PF01217	0.681
TRG_ENDOCYTIC_2	207	210	PF00928	0.753
TRG_ENDOCYTIC_2	287	290	PF00928	0.737
TRG_NES_CRM1_1	195	209	PF08389	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D6	Leptomonas seymouri	44%	100%
A0A3Q8IG28	Leishmania donovani	90%	99%
A4HMD4	Leishmania braziliensis	76%	98%
A4IB01	Leishmania infantum	90%	99%
E9AES9	Leishmania major	91%	100%