Cupin_5 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger protein family member, putative

Species:

Leishmania mexicana

UniProt:

E9B5Y3_LEIMU

TriTrypDb:

LmxM.34.1030

Length:

217

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5Y3

PDB structure(s): 3m3i_A , 3m3i_B , 3m3i_C , 3m3i_D , 3m3i_E , 3m3i_F , 3m3i_G , 3m3i_H

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.295
CLV_NRD_NRD_1	124	126	PF00675	0.367
CLV_NRD_NRD_1	48	50	PF00675	0.385
CLV_PCSK_KEX2_1	124	126	PF00082	0.367
CLV_PCSK_KEX2_1	48	50	PF00082	0.385
CLV_PCSK_SKI1_1	124	128	PF00082	0.367
CLV_Separin_Metazoa	33	37	PF03568	0.270
DOC_CKS1_1	58	63	PF01111	0.363
DOC_USP7_MATH_1	207	211	PF00917	0.384
DOC_USP7_MATH_1	51	55	PF00917	0.295
DOC_WW_Pin1_4	168	173	PF00397	0.276
DOC_WW_Pin1_4	57	62	PF00397	0.368
LIG_14-3-3_CanoR_1	49	58	PF00244	0.325
LIG_14-3-3_CanoR_1	69	78	PF00244	0.307
LIG_APCC_ABBA_1	22	27	PF00400	0.325
LIG_BIR_III_2	115	119	PF00653	0.246
LIG_BRCT_BRCA1_1	170	174	PF00533	0.291
LIG_BRCT_BRCA1_1	53	57	PF00533	0.195
LIG_FHA_1	2	8	PF00498	0.407
LIG_FHA_2	152	158	PF00498	0.186
LIG_LIR_Nem_3	175	179	PF02991	0.325
LIG_MLH1_MIPbox_1	53	57	PF16413	0.195
LIG_OCRL_FandH_1	14	26	PF00620	0.186
LIG_PDZ_Class_1	212	217	PF00595	0.554
LIG_SH2_CRK	123	127	PF00017	0.385
LIG_SH2_CRK	140	144	PF00017	0.385
LIG_SH2_CRK	163	167	PF00017	0.385
LIG_SH2_CRK	52	56	PF00017	0.291
LIG_SH2_NCK_1	140	144	PF00017	0.385
LIG_SH2_NCK_1	52	56	PF00017	0.325
LIG_SH2_STAP1	52	56	PF00017	0.359
LIG_SH2_STAT5	140	143	PF00017	0.385
LIG_SH2_STAT5	30	33	PF00017	0.335
LIG_SH2_STAT5	52	55	PF00017	0.291
LIG_SH2_STAT5	56	59	PF00017	0.291
LIG_SH3_3	101	107	PF00018	0.351
LIG_SH3_3	4	10	PF00018	0.428
LIG_SH3_3	58	64	PF00018	0.363
LIG_SH3_5	172	176	PF00018	0.303
MOD_CK1_1	151	157	PF00069	0.406
MOD_CK1_1	164	170	PF00069	0.303
MOD_CK1_1	72	78	PF00069	0.385
MOD_CK2_1	151	157	PF00069	0.202
MOD_CK2_1	90	96	PF00069	0.186
MOD_GlcNHglycan	36	39	PF01048	0.367
MOD_GSK3_1	147	154	PF00069	0.436
MOD_GSK3_1	164	171	PF00069	0.316
MOD_N-GLC_1	207	212	PF02516	0.377
MOD_NEK2_1	138	143	PF00069	0.385
MOD_NEK2_1	148	153	PF00069	0.385
MOD_NEK2_1	212	217	PF00069	0.493
MOD_NEK2_2	51	56	PF00069	0.325
MOD_PIKK_1	180	186	PF00454	0.383
MOD_PIKK_1	90	96	PF00454	0.186
MOD_Plk_1	207	213	PF00069	0.382
MOD_Plk_1	72	78	PF00069	0.385
MOD_Plk_4	161	167	PF00069	0.385
MOD_Plk_4	51	57	PF00069	0.325
MOD_Plk_4	72	78	PF00069	0.385
MOD_ProDKin_1	168	174	PF00069	0.276
MOD_ProDKin_1	57	63	PF00069	0.368
TRG_DiLeu_BaEn_1	133	138	PF01217	0.319
TRG_ENDOCYTIC_2	123	126	PF00928	0.359
TRG_ENDOCYTIC_2	163	166	PF00928	0.340
TRG_ENDOCYTIC_2	176	179	PF00928	0.234
TRG_ENDOCYTIC_2	203	206	PF00928	0.388
TRG_ENDOCYTIC_2	52	55	PF00928	0.291
TRG_ER_diArg_1	123	125	PF00400	0.367
TRG_PTS1	214	217	PF00515	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHB1	Leptomonas seymouri	72%	100%
A0A1X0NZ51	Trypanosomatidae	42%	100%
A0A3Q8IIT6	Leishmania donovani	88%	100%
A0A422P1M2	Trypanosoma rangeli	40%	100%
A4HMD3	Leishmania braziliensis	74%	100%
A4IB00	Leishmania infantum	88%	100%
E9AES8	Leishmania major	88%	100%