C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B5Y2_LEIMU

TriTrypDb:

LmxM.34.1020

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5Y2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5Y2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	6
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.810
CLV_NRD_NRD_1	25	27	PF00675	0.738
CLV_PCSK_KEX2_1	135	137	PF00082	0.411
CLV_PCSK_KEX2_1	25	27	PF00082	0.738
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.411
CLV_PCSK_SKI1_1	151	155	PF00082	0.411
CLV_PCSK_SKI1_1	361	365	PF00082	0.689
DEG_APCC_DBOX_1	360	368	PF00400	0.688
DEG_Nend_UBRbox_3	1	3	PF02207	0.606
DEG_SPOP_SBC_1	17	21	PF00917	0.726
DEG_SPOP_SBC_1	338	342	PF00917	0.705
DOC_CKS1_1	1	6	PF01111	0.686
DOC_CYCLIN_yCln2_LP_2	277	283	PF00134	0.492
DOC_PP2B_LxvP_1	277	280	PF13499	0.482
DOC_PP4_FxxP_1	365	368	PF00568	0.642
DOC_USP7_MATH_1	104	108	PF00917	0.806
DOC_USP7_MATH_1	17	21	PF00917	0.726
DOC_USP7_MATH_1	181	185	PF00917	0.676
DOC_USP7_MATH_1	207	211	PF00917	0.519
DOC_USP7_MATH_1	214	218	PF00917	0.548
DOC_USP7_MATH_1	288	292	PF00917	0.714
DOC_USP7_MATH_1	330	334	PF00917	0.622
DOC_USP7_MATH_1	353	357	PF00917	0.649
DOC_USP7_MATH_1	90	94	PF00917	0.678
DOC_USP7_MATH_1	96	100	PF00917	0.695
DOC_WW_Pin1_4	108	113	PF00397	0.803
DOC_WW_Pin1_4	247	252	PF00397	0.837
DOC_WW_Pin1_4	339	344	PF00397	0.604
DOC_WW_Pin1_4	35	40	PF00397	0.658
DOC_WW_Pin1_4	51	56	PF00397	0.709
DOC_WW_Pin1_4	83	88	PF00397	0.553
LIG_BRCT_BRCA1_1	361	365	PF00533	0.689
LIG_DLG_GKlike_1	25	33	PF00625	0.724
LIG_FHA_1	1	7	PF00498	0.684
LIG_FHA_1	240	246	PF00498	0.739
LIG_FHA_1	414	420	PF00498	0.453
LIG_FHA_2	17	23	PF00498	0.744
LIG_LIR_Apic_2	362	368	PF02991	0.686
LIG_LIR_Gen_1	33	40	PF02991	0.704
LIG_LIR_Gen_1	333	343	PF02991	0.679
LIG_LIR_Gen_1	392	398	PF02991	0.759
LIG_LIR_Gen_1	69	78	PF02991	0.704
LIG_LIR_Nem_3	143	148	PF02991	0.411
LIG_LIR_Nem_3	158	164	PF02991	0.555
LIG_LIR_Nem_3	33	37	PF02991	0.710
LIG_LIR_Nem_3	333	338	PF02991	0.784
LIG_LIR_Nem_3	62	68	PF02991	0.701
LIG_LIR_Nem_3	69	74	PF02991	0.692
LIG_LYPXL_yS_3	65	68	PF13949	0.774
LIG_SH2_STAP1	202	206	PF00017	0.546
LIG_SH2_STAT3	164	167	PF00017	0.691
LIG_SH2_STAT5	164	167	PF00017	0.568
LIG_SH2_STAT5	386	389	PF00017	0.677
LIG_SH3_1	81	87	PF00018	0.605
LIG_SH3_3	112	118	PF00018	0.793
LIG_SH3_3	238	244	PF00018	0.755
LIG_SH3_3	248	254	PF00018	0.818
LIG_SH3_3	400	406	PF00018	0.672
LIG_SH3_3	81	87	PF00018	0.667
LIG_SUMO_SIM_par_1	319	325	PF11976	0.783
LIG_TRAF2_1	75	78	PF00917	0.734
LIG_TYR_ITIM	63	68	PF00017	0.564
MOD_CK1_1	100	106	PF00069	0.702
MOD_CK1_1	108	114	PF00069	0.781
MOD_CK1_1	21	27	PF00069	0.703
MOD_CK1_1	259	265	PF00069	0.710
MOD_CK1_1	70	76	PF00069	0.681
MOD_CK2_1	16	22	PF00069	0.692
MOD_CK2_1	7	13	PF00069	0.789
MOD_CK2_1	72	78	PF00069	0.731
MOD_GlcNHglycan	102	105	PF01048	0.562
MOD_GlcNHglycan	121	124	PF01048	0.667
MOD_GlcNHglycan	141	145	PF01048	0.279
MOD_GlcNHglycan	208	212	PF01048	0.568
MOD_GlcNHglycan	258	261	PF01048	0.724
MOD_GlcNHglycan	413	416	PF01048	0.571
MOD_GlcNHglycan	7	10	PF01048	0.640
MOD_GlcNHglycan	94	97	PF01048	0.634
MOD_GSK3_1	100	107	PF00069	0.661
MOD_GSK3_1	119	126	PF00069	0.681
MOD_GSK3_1	127	134	PF00069	0.557
MOD_GSK3_1	17	24	PF00069	0.732
MOD_GSK3_1	235	242	PF00069	0.723
MOD_GSK3_1	72	79	PF00069	0.695
MOD_GSK3_1	92	99	PF00069	0.649
MOD_N-GLC_1	100	105	PF02516	0.728
MOD_N-GLC_1	235	240	PF02516	0.746
MOD_N-GLC_1	247	252	PF02516	0.663
MOD_N-GLC_1	394	399	PF02516	0.554
MOD_NEK2_1	140	145	PF00069	0.411
MOD_NEK2_1	258	263	PF00069	0.694
MOD_NEK2_1	272	277	PF00069	0.667
MOD_NEK2_1	321	326	PF00069	0.752
MOD_NEK2_1	7	12	PF00069	0.579
MOD_NEK2_1	97	102	PF00069	0.587
MOD_PIKK_1	181	187	PF00454	0.461
MOD_PIKK_1	249	255	PF00454	0.706
MOD_PIKK_1	27	33	PF00454	0.601
MOD_PIKK_1	43	49	PF00454	0.704
MOD_PKA_1	25	31	PF00069	0.726
MOD_PKA_2	25	31	PF00069	0.715
MOD_Plk_4	30	36	PF00069	0.760
MOD_ProDKin_1	108	114	PF00069	0.804
MOD_ProDKin_1	247	253	PF00069	0.836
MOD_ProDKin_1	339	345	PF00069	0.605
MOD_ProDKin_1	35	41	PF00069	0.659
MOD_ProDKin_1	51	57	PF00069	0.709
MOD_ProDKin_1	83	89	PF00069	0.554
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.503
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.524
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.705
TRG_ENDOCYTIC_2	393	396	PF00928	0.765
TRG_ENDOCYTIC_2	65	68	PF00928	0.774
TRG_NLS_MonoExtN_4	133	139	PF00514	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P318	Leptomonas seymouri	38%	74%
A0A3S7X8W6	Leishmania donovani	89%	99%
A4HMD2	Leishmania braziliensis	55%	99%
A4IAZ9	Leishmania infantum	87%	99%
E9AES7	Leishmania major	87%	100%