Non-specific serine/threonine protein kinase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B5Y1_LEIMU

TriTrypDb:

LmxM.34.1010

Length:

354

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: najma.rachidi@pasteur.fr
Publication title: Identification of the Host Substratome of Leishmania-Secreted Casein Kinase 1 Using a SILAC-Based Quantitative Mass Spectrometry Assay
Publication 1st author(s): Despina Smirlis
Publication Identifier(s): 35047509
Host organism: -1
Interaction detection method(s): MI:0423
Interaction type: MI:0414
Identification method participant A: autoradiography
Identification method participant B: predetermined participant
ID(s) interactor A: Q15545
ID(s) interactor B: Q9NHE1
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme target
Biological role(s) interactor B: enzyme
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9B5Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5Y1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0007165	signal transduction	2	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004672	protein kinase activity	3	13
GO:0004674	protein serine/threonine kinase activity	4	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	3	9	PF00089	0.476
CLV_NRD_NRD_1	103	105	PF00675	0.308
CLV_NRD_NRD_1	197	199	PF00675	0.346
CLV_NRD_NRD_1	235	237	PF00675	0.461
CLV_PCSK_KEX2_1	103	105	PF00082	0.341
CLV_PCSK_KEX2_1	197	199	PF00082	0.346
CLV_PCSK_KEX2_1	275	277	PF00082	0.415
CLV_PCSK_KEX2_1	298	300	PF00082	0.418
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.382
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.425
CLV_PCSK_SKI1_1	127	131	PF00082	0.358
CLV_PCSK_SKI1_1	132	136	PF00082	0.335
CLV_PCSK_SKI1_1	176	180	PF00082	0.346
CLV_PCSK_SKI1_1	275	279	PF00082	0.407
DEG_Nend_UBRbox_3	1	3	PF02207	0.663
DOC_CKS1_1	238	243	PF01111	0.437
DOC_CYCLIN_RxL_1	100	110	PF00134	0.366
DOC_CYCLIN_RxL_1	258	267	PF00134	0.432
DOC_MAPK_gen_1	145	152	PF00069	0.344
DOC_MAPK_gen_1	236	244	PF00069	0.519
DOC_MAPK_gen_1	275	283	PF00069	0.363
DOC_PP1_RVXF_1	118	124	PF00149	0.306
DOC_PP1_RVXF_1	259	266	PF00149	0.430
DOC_USP7_MATH_1	311	315	PF00917	0.670
DOC_USP7_UBL2_3	222	226	PF12436	0.328
DOC_WW_Pin1_4	237	242	PF00397	0.426
DOC_WW_Pin1_4	321	326	PF00397	0.764
LIG_14-3-3_CanoR_1	103	108	PF00244	0.344
LIG_14-3-3_CanoR_1	236	241	PF00244	0.429
LIG_Actin_WH2_2	200	215	PF00022	0.346
LIG_Actin_WH2_2	285	300	PF00022	0.383
LIG_AP2alpha_1	278	282	PF02296	0.447
LIG_APCC_ABBAyCdc20_2	127	133	PF00400	0.306
LIG_BRCT_BRCA1_1	18	22	PF00533	0.321
LIG_FHA_1	108	114	PF00498	0.347
LIG_FHA_1	237	243	PF00498	0.456
LIG_FHA_2	223	229	PF00498	0.329
LIG_FHA_2	238	244	PF00498	0.474
LIG_LIR_Gen_1	181	191	PF02991	0.346
LIG_LIR_Gen_1	228	235	PF02991	0.466
LIG_LIR_Gen_1	270	278	PF02991	0.367
LIG_LIR_Gen_1	79	90	PF02991	0.347
LIG_LIR_Nem_3	181	187	PF02991	0.362
LIG_LIR_Nem_3	19	25	PF02991	0.358
LIG_LIR_Nem_3	215	221	PF02991	0.346
LIG_LIR_Nem_3	228	233	PF02991	0.467
LIG_LIR_Nem_3	251	256	PF02991	0.386
LIG_LIR_Nem_3	270	274	PF02991	0.422
LIG_LIR_Nem_3	54	60	PF02991	0.381
LIG_Pex14_2	22	26	PF04695	0.381
LIG_Pex14_2	249	253	PF04695	0.369
LIG_Pex14_2	278	282	PF04695	0.409
LIG_SH2_CRK	184	188	PF00017	0.362
LIG_SH2_CRK	230	234	PF00017	0.459
LIG_SH2_CRK	271	275	PF00017	0.399
LIG_SH2_CRK	58	62	PF00017	0.362
LIG_SH2_GRB2like	256	259	PF00017	0.368
LIG_SH2_NCK_1	230	234	PF00017	0.461
LIG_SH2_STAP1	53	57	PF00017	0.400
LIG_SH2_STAT5	151	154	PF00017	0.332
LIG_SH2_STAT5	184	187	PF00017	0.346
LIG_SH2_STAT5	206	209	PF00017	0.346
LIG_SH2_STAT5	210	213	PF00017	0.346
LIG_SH2_STAT5	259	262	PF00017	0.399
LIG_SH2_STAT5	273	276	PF00017	0.502
LIG_SH2_STAT5	291	294	PF00017	0.414
LIG_SH3_3	333	339	PF00018	0.670
LIG_SH3_3	65	71	PF00018	0.306
LIG_SUMO_SIM_anti_2	239	246	PF11976	0.532
LIG_SUMO_SIM_par_1	109	115	PF11976	0.346
LIG_TRAF2_1	225	228	PF00917	0.341
LIG_TRAF2_1	303	306	PF00917	0.511
LIG_WRC_WIRS_1	97	102	PF05994	0.321
MOD_CK1_1	106	112	PF00069	0.350
MOD_CK1_1	186	192	PF00069	0.346
MOD_CK2_1	116	122	PF00069	0.400
MOD_CK2_1	18	24	PF00069	0.405
MOD_CK2_1	222	228	PF00069	0.343
MOD_CK2_1	237	243	PF00069	0.437
MOD_CK2_1	300	306	PF00069	0.487
MOD_Cter_Amidation	101	104	PF01082	0.341
MOD_Cter_Amidation	143	146	PF01082	0.346
MOD_Cter_Amidation	195	198	PF01082	0.382
MOD_GlcNHglycan	18	21	PF01048	0.321
MOD_GlcNHglycan	340	343	PF01048	0.781
MOD_GlcNHglycan	347	350	PF01048	0.717
MOD_GlcNHglycan	62	65	PF01048	0.382
MOD_GSK3_1	103	110	PF00069	0.349
MOD_GSK3_1	174	181	PF00069	0.362
MOD_GSK3_1	26	33	PF00069	0.321
MOD_N-GLC_1	321	326	PF02516	0.709
MOD_NEK2_1	107	112	PF00069	0.358
MOD_NEK2_1	123	128	PF00069	0.302
MOD_NEK2_1	140	145	PF00069	0.346
MOD_NEK2_1	178	183	PF00069	0.346
MOD_NEK2_1	212	217	PF00069	0.346
MOD_NEK2_1	26	31	PF00069	0.341
MOD_NEK2_1	293	298	PF00069	0.396
MOD_PK_1	183	189	PF00069	0.362
MOD_PKA_1	103	109	PF00069	0.306
MOD_PKA_1	236	242	PF00069	0.445
MOD_PKA_2	103	109	PF00069	0.381
MOD_PKA_2	212	218	PF00069	0.346
MOD_PKA_2	231	237	PF00069	0.458
MOD_PKA_2	26	32	PF00069	0.341
MOD_Plk_1	269	275	PF00069	0.362
MOD_Plk_1	293	299	PF00069	0.417
MOD_Plk_4	107	113	PF00069	0.346
MOD_Plk_4	125	131	PF00069	0.346
MOD_Plk_4	269	275	PF00069	0.397
MOD_ProDKin_1	237	243	PF00069	0.431
MOD_ProDKin_1	321	327	PF00069	0.764
MOD_SUMO_for_1	39	42	PF00179	0.362
MOD_SUMO_rev_2	128	136	PF00179	0.362
MOD_SUMO_rev_2	234	239	PF00179	0.448
TRG_ENDOCYTIC_2	184	187	PF00928	0.346
TRG_ENDOCYTIC_2	206	209	PF00928	0.346
TRG_ENDOCYTIC_2	230	233	PF00928	0.466
TRG_ENDOCYTIC_2	271	274	PF00928	0.403
TRG_ENDOCYTIC_2	58	61	PF00928	0.344
TRG_ENDOCYTIC_2	75	78	PF00928	0.306
TRG_ER_diArg_1	103	105	PF00400	0.341
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F5	Leptomonas seymouri	90%	99%
A0A0N1HU44	Leptomonas seymouri	63%	100%
A0A0N1HU45	Leptomonas seymouri	43%	92%
A0A0N1I2H3	Leptomonas seymouri	36%	96%
A0A0S4IHW4	Bodo saltans	25%	79%
A0A0S4IVY6	Bodo saltans	51%	86%
A0A0S4JA30	Bodo saltans	55%	97%
A0A0S4JMF5	Bodo saltans	24%	94%
A0A0S4JN06	Bodo saltans	78%	98%
A0A0S4JP58	Bodo saltans	50%	83%
A0A0S4JTJ8	Bodo saltans	26%	77%
A0A0S4JXJ0	Bodo saltans	41%	100%
A0A1X0NIT3	Trypanosomatidae	85%	100%
A0A1X0NRZ9	Trypanosomatidae	25%	96%
A0A1X0NXJ1	Trypanosomatidae	40%	96%
A0A1X0NZS9	Trypanosomatidae	46%	80%
A0A1X0P176	Trypanosomatidae	49%	91%
A0A1X0P3K5	Trypanosomatidae	25%	77%
A0A3Q8IC87	Leishmania donovani	23%	95%
A0A3Q8IJ66	Leishmania donovani	99%	100%
A0A3Q8ISA0	Leishmania donovani	48%	94%
A0A3R7K5P9	Trypanosoma rangeli	23%	95%
A0A3R7KRP1	Trypanosoma rangeli	22%	74%
A0A3S7WNZ6	Leishmania donovani	35%	96%
A0A3S7WZA2	Leishmania donovani	46%	68%
A0A3S7X8X3	Leishmania donovani	66%	100%
A0A422MSV5	Trypanosoma rangeli	41%	97%
A0A422N5C9	Trypanosoma rangeli	86%	100%
A0A422NFN4	Trypanosoma rangeli	25%	70%
A0A422NL83	Trypanosoma rangeli	51%	89%
A0A8I3S724	Canis lupus familiaris	29%	87%
A2QN07	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	89%
A4H436	Leishmania braziliensis	34%	100%
A4HCD7	Leishmania braziliensis	23%	83%
A4HEI6	Leishmania braziliensis	45%	69%
A4HIT6	Leishmania braziliensis	46%	100%
A4HMD0	Leishmania braziliensis	64%	100%
A4HMD1	Leishmania braziliensis	98%	100%
A4HSC0	Leishmania infantum	35%	96%
A4HZV1	Leishmania infantum	23%	95%
A4I1K4	Leishmania infantum	46%	68%
A4I638	Leishmania infantum	48%	94%
A4IAZ7	Leishmania infantum	66%	100%
A4IAZ8	Leishmania infantum	99%	100%
A5GFW1	Sus scrofa	27%	88%
A5TY85	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	26%	82%
A7E3X2	Bos taurus	59%	77%
B9VVJ6	Trypanosoma brucei brucei	88%	100%
C9ZK43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	88%
C9ZNJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
C9ZNJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	88%	100%
C9ZXP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	90%
D0A1R2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	93%
E9AKA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ASL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	73%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	95%
E9AXN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	68%
E9B1C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	90%
E9B5Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
O01427	Caenorhabditis elegans	24%	100%
O14965	Homo sapiens	27%	88%
O15726	Plasmodium falciparum (isolate Dd2)	61%	100%
O35832	Rattus norvegicus	25%	78%
O57252	Vaccinia virus (strain Ankara)	24%	100%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
O74135	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	81%
O76324	Drosophila melanogaster	61%	80%
O96999	Leishmania major	35%	100%
P16913	Vaccinia virus (strain Western Reserve)	24%	100%
P20505	Vaccinia virus (strain Copenhagen)	24%	100%
P29295	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	60%	72%
P33800	Variola virus (isolate Human/India/Ind3/1967)	24%	100%
P34516	Caenorhabditis elegans	29%	100%
P34556	Caenorhabditis elegans	25%	100%
P35507	Bos taurus	53%	100%
P35508	Bos taurus	69%	85%
P35509	Bos taurus	60%	100%
P39962	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	68%
P40230	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	53%	66%
P40233	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	79%
P40234	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	81%
P40235	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	68%	97%
P40236	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	62%	88%
P42158	Arabidopsis thaliana	68%	79%
P42168	Caenorhabditis elegans	58%	100%
P47811	Mus musculus	27%	98%
P48729	Homo sapiens	58%	100%
P48730	Homo sapiens	69%	85%
P49674	Homo sapiens	69%	85%
P53683	Oryza sativa subsp. japonica	24%	66%
P54367	Drosophila melanogaster	60%	100%
P59241	Rattus norvegicus	28%	89%
P65727	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	26%	82%
P67827	Bos taurus	60%	100%
P67828	Oryctolagus cuniculus	60%	100%
P67829	Ovis aries	60%	100%
P67962	Gallus gallus	58%	100%
P67963	Xenopus laevis	58%	100%
P70618	Rattus norvegicus	27%	98%
P78368	Homo sapiens	51%	85%
P97477	Mus musculus	27%	90%
P97633	Rattus norvegicus	59%	100%
P9WI62	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	24%	89%
P9WI63	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	24%	89%
P9WI82	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	82%
P9WI83	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	82%
Q04899	Mus musculus	25%	78%
Q06486	Rattus norvegicus	69%	85%
Q09503	Caenorhabditis elegans	27%	100%
Q09892	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q0CIC7	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	27%	96%
Q20471	Caenorhabditis elegans	63%	71%
Q2QY53	Oryza sativa subsp. japonica	27%	81%
Q2RAX3	Oryza sativa subsp. japonica	27%	78%
Q2TA06	Bos taurus	27%	88%
Q2U469	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	26%	100%
Q32PI1	Bos taurus	28%	89%
Q39050	Arabidopsis thaliana	65%	77%
Q4Q6U1	Leishmania major	48%	100%
Q4Q9T3	Leishmania major	47%	70%
Q4QBR6	Leishmania major	23%	95%
Q4R9A9	Macaca fascicularis	52%	93%
Q54C18	Dictyostelium discoideum	24%	69%
Q54DF7	Dictyostelium discoideum	36%	72%
Q556Y4	Dictyostelium discoideum	63%	83%
Q5BP74	Xenopus laevis	69%	85%
Q5JLD8	Oryza sativa subsp. japonica	27%	79%
Q5PRD4	Danio rerio	59%	84%
Q5R4V3	Pongo abelii	55%	78%
Q5R7I7	Pongo abelii	24%	100%
Q5RC72	Pongo abelii	69%	85%
Q5SUV5	Mus musculus	24%	92%
Q5XF24	Arabidopsis thaliana	68%	76%
Q5ZJS0	Gallus gallus	58%	78%
Q5ZLL1	Gallus gallus	69%	85%
Q62761	Rattus norvegicus	58%	91%
Q62762	Rattus norvegicus	57%	85%
Q62763	Rattus norvegicus	55%	79%
Q6DE87	Xenopus laevis	23%	75%
Q6K9N1	Oryza sativa subsp. japonica	68%	76%
Q6NRT0	Xenopus laevis	57%	77%
Q6NU47	Xenopus laevis	22%	100%
Q6P3K7	Danio rerio	69%	87%
Q6P647	Xenopus tropicalis	69%	85%
Q6QNL9	Eimeria tenella	65%	100%
Q6QNM1	Toxoplasma gondii	69%	100%
Q7RBX5	Plasmodium yoelii yoelii	62%	100%
Q7T2E3	Danio rerio	69%	88%
Q7TYY6	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	24%	89%
Q7X996	Oryza sativa subsp. japonica	25%	80%
Q7ZUS1	Danio rerio	23%	83%
Q80X41	Mus musculus	28%	80%
Q84VQ3	Arabidopsis thaliana	25%	81%
Q86AD7	Dictyostelium discoideum	29%	90%
Q86Y07	Homo sapiens	30%	70%
Q8BK63	Mus musculus	58%	100%
Q8BN21	Mus musculus	30%	70%
Q8BTH8	Mus musculus	59%	77%
Q8BVP5	Mus musculus	57%	85%
Q8C4X2	Mus musculus	55%	83%
Q8IHZ9	Plasmodium falciparum (isolate 3D7)	62%	100%
Q8IZL9	Homo sapiens	26%	100%
Q8LPI7	Arabidopsis thaliana	57%	86%
Q8LPJ1	Arabidopsis thaliana	62%	74%
Q8MYQ1	Caenorhabditis elegans	26%	80%
Q8N752	Homo sapiens	60%	100%
Q8NU97	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	25%	75%
Q8SQR2	Encephalitozoon cuniculi (strain GB-M1)	33%	100%
Q8SRL5	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
Q8SS96	Encephalitozoon cuniculi (strain GB-M1)	45%	100%
Q8VDF3	Mus musculus	26%	96%
Q8VYK9	Arabidopsis thaliana	68%	81%
Q8WQ99	Caenorhabditis elegans	54%	87%
Q91819	Xenopus laevis	26%	87%
Q91820	Xenopus laevis	26%	87%
Q91FD5	Invertebrate iridescent virus 6	28%	86%
Q93VK0	Arabidopsis thaliana	24%	100%
Q93Z18	Arabidopsis thaliana	58%	85%
Q95NE7	Pan troglodytes	25%	98%
Q95PZ9	Caenorhabditis elegans	27%	93%
Q965G5	Caenorhabditis elegans	24%	97%
Q99986	Homo sapiens	28%	89%
Q9C562	Arabidopsis thaliana	22%	74%
Q9CAI5	Arabidopsis thaliana	64%	76%
Q9DC28	Mus musculus	69%	85%
Q9FFH8	Arabidopsis thaliana	66%	74%
Q9H3Y6	Homo sapiens	26%	73%
Q9HCP0	Homo sapiens	58%	84%
Q9I958	Cyprinus carpio	24%	98%
Q9J509	Fowlpox virus (strain NVSL)	26%	100%
Q9J523	Fowlpox virus (strain NVSL)	28%	100%
Q9JMK2	Mus musculus	69%	85%
Q9LDI3	Arabidopsis thaliana	27%	79%
Q9LSX4	Arabidopsis thaliana	67%	74%
Q9LW62	Arabidopsis thaliana	61%	80%
Q9LWM4	Oryza sativa subsp. japonica	25%	77%
Q9MAM1	Arabidopsis thaliana	28%	79%
Q9NHE1	Leishmania major	99%	100%
Q9NHE2	Leishmania major	70%	100%
Q9STV4	Arabidopsis thaliana	26%	80%
Q9U6D2	Ancylostoma caninum	28%	94%
Q9UIK4	Homo sapiens	26%	96%
Q9UV50	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	91%
Q9Y6M4	Homo sapiens	55%	79%
Q9ZUP4	Arabidopsis thaliana	62%	82%
Q9ZWB3	Arabidopsis thaliana	67%	75%
V5AIW9	Trypanosoma cruzi	43%	96%
V5B8S3	Trypanosoma cruzi	25%	77%
V5BMQ3	Trypanosoma cruzi	47%	89%
V5DMJ4	Trypanosoma cruzi	24%	100%