Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase I, putative

Species:

Leishmania mexicana

UniProt:

E9B5Y0_LEIMU

TriTrypDb:

LmxM.34.1000

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9B5Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5Y0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	17
GO:0006793	phosphorus metabolic process	3	17
GO:0006796	phosphate-containing compound metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009987	cellular process	1	17
GO:0016310	phosphorylation	5	17
GO:0019538	protein metabolic process	3	17
GO:0036211	protein modification process	4	17
GO:0043170	macromolecule metabolic process	3	17
GO:0043412	macromolecule modification	4	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0007165	signal transduction	2	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0004672	protein kinase activity	3	17
GO:0004674	protein serine/threonine kinase activity	4	17
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0016301	kinase activity	4	17
GO:0016740	transferase activity	2	17
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	17
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	17
GO:0017076	purine nucleotide binding	4	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:0140096	catalytic activity, acting on a protein	2	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.430
CLV_NRD_NRD_1	201	203	PF00675	0.338
CLV_NRD_NRD_1	283	285	PF00675	0.492
CLV_NRD_NRD_1	312	314	PF00675	0.696
CLV_PCSK_KEX2_1	19	21	PF00082	0.430
CLV_PCSK_KEX2_1	201	203	PF00082	0.338
CLV_PCSK_KEX2_1	283	285	PF00082	0.421
CLV_PCSK_KEX2_1	318	320	PF00082	0.679
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.729
CLV_PCSK_PC7_1	279	285	PF00082	0.480
CLV_PCSK_SKI1_1	136	140	PF00082	0.341
CLV_PCSK_SKI1_1	180	184	PF00082	0.338
CLV_PCSK_SKI1_1	226	230	PF00082	0.308
CLV_PCSK_SKI1_1	279	283	PF00082	0.397
DOC_CYCLIN_RxL_1	262	271	PF00134	0.415
DOC_CYCLIN_RxL_1	279	289	PF00134	0.408
DOC_MAPK_gen_1	147	156	PF00069	0.343
DOC_PP1_RVXF_1	263	270	PF00149	0.413
DOC_SPAK_OSR1_1	14	18	PF12202	0.403
DOC_USP7_MATH_1	197	201	PF00917	0.288
DOC_USP7_MATH_2	254	260	PF00917	0.408
DOC_USP7_UBL2_3	226	230	PF12436	0.313
DOC_USP7_UBL2_3	314	318	PF12436	0.638
LIG_14-3-3_CanoR_1	108	112	PF00244	0.346
LIG_14-3-3_CanoR_1	60	65	PF00244	0.329
LIG_Actin_WH2_2	204	219	PF00022	0.354
LIG_BIR_II_1	1	5	PF00653	0.513
LIG_FHA_1	112	118	PF00498	0.358
LIG_FHA_1	35	41	PF00498	0.399
LIG_FHA_2	242	248	PF00498	0.412
LIG_GBD_Chelix_1	208	216	PF00786	0.446
LIG_LIR_Gen_1	185	195	PF02991	0.338
LIG_LIR_Gen_1	231	242	PF02991	0.451
LIG_LIR_Gen_1	256	263	PF02991	0.433
LIG_LIR_Gen_1	83	94	PF02991	0.338
LIG_LIR_Nem_3	185	191	PF02991	0.354
LIG_LIR_Nem_3	219	225	PF02991	0.338
LIG_LIR_Nem_3	231	237	PF02991	0.311
LIG_LIR_Nem_3	25	29	PF02991	0.357
LIG_LIR_Nem_3	256	260	PF02991	0.353
LIG_LIR_Nem_3	274	278	PF02991	0.391
LIG_LIR_Nem_3	280	285	PF02991	0.388
LIG_LIR_Nem_3	303	308	PF02991	0.392
LIG_LIR_Nem_3	58	64	PF02991	0.343
LIG_Pex14_2	26	30	PF04695	0.373
LIG_Pex14_2	282	286	PF04695	0.401
LIG_SH2_CRK	188	192	PF00017	0.343
LIG_SH2_CRK	234	238	PF00017	0.415
LIG_SH2_CRK	275	279	PF00017	0.382
LIG_SH2_CRK	62	66	PF00017	0.327
LIG_SH2_NCK_1	234	238	PF00017	0.414
LIG_SH2_STAP1	263	267	PF00017	0.347
LIG_SH2_STAP1	297	301	PF00017	0.372
LIG_SH2_STAT5	155	158	PF00017	0.337
LIG_SH2_STAT5	188	191	PF00017	0.327
LIG_SH2_STAT5	210	213	PF00017	0.338
LIG_SH2_STAT5	214	217	PF00017	0.338
LIG_SH2_STAT5	277	280	PF00017	0.390
LIG_SH2_STAT5	295	298	PF00017	0.406
LIG_SH2_STAT5	62	65	PF00017	0.315
LIG_SUMO_SIM_par_1	113	119	PF11976	0.338
LIG_TYR_ITIM	208	213	PF00017	0.373
LIG_WRC_WIRS_1	257	262	PF05994	0.439
MOD_CK1_1	107	113	PF00069	0.349
MOD_CK1_1	190	196	PF00069	0.338
MOD_CK1_1	245	251	PF00069	0.469
MOD_CK2_1	22	28	PF00069	0.373
MOD_CK2_1	241	247	PF00069	0.403
MOD_CK2_1	300	306	PF00069	0.483
MOD_CK2_1	79	85	PF00069	0.288
MOD_Cter_Amidation	147	150	PF01082	0.354
MOD_Cter_Amidation	17	20	PF01082	0.430
MOD_Cter_Amidation	319	322	PF01082	0.728
MOD_GSK3_1	107	114	PF00069	0.341
MOD_GSK3_1	178	185	PF00069	0.359
MOD_GSK3_1	241	248	PF00069	0.400
MOD_GSK3_1	300	307	PF00069	0.414
MOD_GSK3_1	56	63	PF00069	0.371
MOD_LATS_1	102	108	PF00433	0.219
MOD_LATS_1	239	245	PF00433	0.358
MOD_N-GLC_1	261	266	PF02516	0.401
MOD_NEK2_1	111	116	PF00069	0.369
MOD_NEK2_1	127	132	PF00069	0.353
MOD_NEK2_1	182	187	PF00069	0.345
MOD_NEK2_1	216	221	PF00069	0.354
MOD_NEK2_1	261	266	PF00069	0.425
MOD_NEK2_1	304	309	PF00069	0.506
MOD_NEK2_1	56	61	PF00069	0.450
MOD_NEK2_2	277	282	PF00069	0.331
MOD_NEK2_2	297	302	PF00069	0.472
MOD_PIKK_1	63	69	PF00454	0.430
MOD_PK_1	187	193	PF00069	0.354
MOD_PKA_2	107	113	PF00069	0.373
MOD_PKA_2	216	222	PF00069	0.354
MOD_Plk_1	297	303	PF00069	0.419
MOD_Plk_4	111	117	PF00069	0.338
MOD_Plk_4	129	135	PF00069	0.189
MOD_Plk_4	256	262	PF00069	0.372
MOD_Plk_4	60	66	PF00069	0.336
MOD_Plk_4	73	79	PF00069	0.234
MOD_SUMO_for_1	138	141	PF00179	0.204
MOD_SUMO_for_1	43	46	PF00179	0.354
MOD_SUMO_rev_2	132	140	PF00179	0.343
TRG_DiLeu_BaEn_2	255	261	PF01217	0.440
TRG_ENDOCYTIC_2	188	191	PF00928	0.327
TRG_ENDOCYTIC_2	210	213	PF00928	0.338
TRG_ENDOCYTIC_2	234	237	PF00928	0.422
TRG_ENDOCYTIC_2	275	278	PF00928	0.383
TRG_ENDOCYTIC_2	305	308	PF00928	0.389
TRG_ENDOCYTIC_2	61	64	PF00928	0.339
TRG_ER_diArg_1	19	21	PF00400	0.430
TRG_ER_diArg_1	282	284	PF00400	0.495
TRG_ER_diLys_1	321	324	PF00400	0.631
TRG_NLS_MonoExtC_3	317	322	PF00514	0.579
TRG_NLS_MonoExtN_4	316	322	PF00514	0.491
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F5	Leptomonas seymouri	67%	91%
A0A0N1HU44	Leptomonas seymouri	75%	98%
A0A0N1HU45	Leptomonas seymouri	44%	84%
A0A0N1I2H3	Leptomonas seymouri	39%	88%
A0A0S4IVY6	Bodo saltans	48%	79%
A0A0S4J4X4	Bodo saltans	25%	100%
A0A0S4J7K4	Bodo saltans	24%	67%
A0A0S4JA30	Bodo saltans	51%	89%
A0A0S4JN06	Bodo saltans	63%	90%
A0A0S4JP58	Bodo saltans	49%	76%
A0A0S4JU73	Bodo saltans	28%	68%
A0A0S4JXJ0	Bodo saltans	41%	100%
A0A1X0NIT3	Trypanosomatidae	63%	98%
A0A1X0NRZ9	Trypanosomatidae	23%	88%
A0A1X0NXJ1	Trypanosomatidae	40%	88%
A0A1X0NZS9	Trypanosomatidae	50%	73%
A0A1X0P176	Trypanosomatidae	47%	84%
A0A3Q8IJ66	Leishmania donovani	68%	92%
A0A3Q8ISA0	Leishmania donovani	47%	86%
A0A3R7KRP1	Trypanosoma rangeli	25%	68%
A0A3S5IRC3	Trypanosoma rangeli	24%	87%
A0A3S7WNZ6	Leishmania donovani	37%	88%
A0A3S7X8X3	Leishmania donovani	93%	100%
A0A422MSV5	Trypanosoma rangeli	41%	89%
A0A422N5C9	Trypanosoma rangeli	66%	100%
A0A422NL83	Trypanosoma rangeli	45%	82%
A0A8I3S724	Canis lupus familiaris	26%	80%
A4H436	Leishmania braziliensis	36%	100%
A4HIT6	Leishmania braziliensis	45%	100%
A4HMD0	Leishmania braziliensis	77%	100%
A4HMD1	Leishmania braziliensis	68%	100%
A4HSC0	Leishmania infantum	37%	88%
A4I638	Leishmania infantum	47%	86%
A4IAZ7	Leishmania infantum	93%	100%
A4IAZ8	Leishmania infantum	68%	92%
A5GFW1	Sus scrofa	26%	81%
A5TY85	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	27%	75%
A7E3X2	Bos taurus	53%	71%
A8XJQ6	Caenorhabditis briggsae	27%	84%
B9VVJ6	Trypanosoma brucei brucei	64%	98%
C9ZK43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	81%
C9ZKE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	80%
C9ZNJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	98%
C9ZNJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	98%
D0A1R2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	85%
D0A8X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	88%
D7UQM5	Patiria pectinifera	23%	80%
E9AKA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B1C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	82%
E9B5Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	92%
O14965	Homo sapiens	26%	80%
O15726	Plasmodium falciparum (isolate Dd2)	56%	100%
O55099	Rattus norvegicus	24%	94%
O57252	Vaccinia virus (strain Ankara)	24%	100%
O57259	Vaccinia virus (strain Ankara)	25%	100%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	91%
O70126	Mus musculus	23%	94%
O74135	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	74%
O76324	Drosophila melanogaster	58%	74%
O80888	Arabidopsis thaliana	25%	87%
O96999	Leishmania major	35%	100%
P05986	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	81%
P06245	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	85%
P16913	Vaccinia virus (strain Western Reserve)	24%	100%
P20505	Vaccinia virus (strain Copenhagen)	24%	100%
P21098	Vaccinia virus (strain Copenhagen)	25%	100%
P24362	Vaccinia virus (strain Western Reserve)	25%	100%
P33800	Variola virus (isolate Human/India/Ind3/1967)	23%	100%
P34516	Caenorhabditis elegans	30%	94%
P35507	Bos taurus	54%	96%
P35508	Bos taurus	57%	78%
P35509	Bos taurus	52%	100%
P40233	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	73%
P40234	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	74%
P40235	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	59%	89%
P40236	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	56%	81%
P41279	Homo sapiens	26%	69%
P42158	Arabidopsis thaliana	59%	72%
P42168	Caenorhabditis elegans	55%	95%
P42169	Caenorhabditis elegans	27%	95%
P42818	Arabidopsis thaliana	25%	70%
P48729	Homo sapiens	57%	96%
P48730	Homo sapiens	57%	78%
P49674	Homo sapiens	60%	78%
P54367	Drosophila melanogaster	53%	96%
P54743	Mycobacterium leprae (strain TN)	28%	74%
P59241	Rattus norvegicus	26%	82%
P65727	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	27%	75%
P67827	Bos taurus	57%	100%
P67828	Oryctolagus cuniculus	57%	100%
P67829	Ovis aries	57%	100%
P67962	Gallus gallus	57%	96%
P67963	Xenopus laevis	57%	96%
P78368	Homo sapiens	49%	78%
P97477	Mus musculus	25%	82%
P97633	Rattus norvegicus	57%	100%
P9WI82	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	75%
P9WI83	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	75%
Q06486	Rattus norvegicus	57%	78%
Q07174	Mus musculus	25%	69%
Q09503	Caenorhabditis elegans	25%	100%
Q2TA06	Bos taurus	26%	81%
Q2YDN8	Bos taurus	24%	72%
Q32PI1	Bos taurus	27%	82%
Q39030	Arabidopsis thaliana	23%	69%
Q39050	Arabidopsis thaliana	58%	71%
Q4Q6U1	Leishmania major	48%	100%
Q4R9A9	Macaca fascicularis	52%	85%
Q54L81	Dictyostelium discoideum	23%	70%
Q556Y4	Dictyostelium discoideum	57%	76%
Q5BP74	Xenopus laevis	61%	78%
Q5PRD4	Danio rerio	52%	77%
Q5R4V3	Pongo abelii	50%	71%
Q5RC72	Pongo abelii	57%	78%
Q5XF24	Arabidopsis thaliana	60%	69%
Q5ZJS0	Gallus gallus	52%	71%
Q5ZLL1	Gallus gallus	60%	78%
Q62761	Rattus norvegicus	53%	83%
Q62762	Rattus norvegicus	48%	78%
Q62763	Rattus norvegicus	51%	72%
Q63562	Rattus norvegicus	25%	69%
Q6CWQ4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	90%
Q6K9N1	Oryza sativa subsp. japonica	60%	70%
Q6NRT0	Xenopus laevis	53%	70%
Q6P3K7	Danio rerio	57%	79%
Q6P647	Xenopus tropicalis	57%	78%
Q6QNL9	Eimeria tenella	61%	97%
Q6QNM1	Toxoplasma gondii	61%	100%
Q7JP68	Caenorhabditis elegans	27%	81%
Q7RBX5	Plasmodium yoelii yoelii	57%	100%
Q7T2E3	Danio rerio	62%	80%
Q7ZUS1	Danio rerio	26%	76%
Q80X41	Mus musculus	27%	74%
Q8BK63	Mus musculus	57%	96%
Q8BTH8	Mus musculus	53%	71%
Q8BVP5	Mus musculus	48%	78%
Q8C4X2	Mus musculus	51%	76%
Q8IHZ9	Plasmodium falciparum (isolate 3D7)	57%	100%
Q8IV63	Homo sapiens	24%	68%
Q8K3G5	Mus musculus	24%	72%
Q8LPI7	Arabidopsis thaliana	56%	78%
Q8LPJ1	Arabidopsis thaliana	59%	68%
Q8N752	Homo sapiens	57%	96%
Q8NU97	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	26%	69%
Q8QZX0	Mus musculus	26%	78%
Q8SQR2	Encephalitozoon cuniculi (strain GB-M1)	33%	100%
Q8SRL5	Encephalitozoon cuniculi (strain GB-M1)	24%	100%
Q8SS96	Encephalitozoon cuniculi (strain GB-M1)	44%	100%
Q8VYK9	Arabidopsis thaliana	57%	74%
Q8WQ99	Caenorhabditis elegans	49%	80%
Q91819	Xenopus laevis	26%	79%
Q91820	Xenopus laevis	26%	80%
Q91FD5	Invertebrate iridescent virus 6	24%	79%
Q925K9	Mus musculus	23%	100%
Q93Z18	Arabidopsis thaliana	56%	78%
Q95PZ9	Caenorhabditis elegans	31%	85%
Q96GD4	Homo sapiens	25%	94%
Q99986	Homo sapiens	29%	82%
Q9CAI5	Arabidopsis thaliana	59%	70%
Q9DC28	Mus musculus	57%	78%
Q9FFH8	Arabidopsis thaliana	60%	68%
Q9HCP0	Homo sapiens	52%	77%
Q9J509	Fowlpox virus (strain NVSL)	25%	100%
Q9J523	Fowlpox virus (strain NVSL)	26%	100%
Q9JMK2	Mus musculus	60%	78%
Q9LSX4	Arabidopsis thaliana	60%	68%
Q9LW62	Arabidopsis thaliana	59%	73%
Q9N0X0	Sus scrofa	25%	94%
Q9NHE1	Leishmania major	68%	100%
Q9NHE2	Leishmania major	91%	100%
Q9STV4	Arabidopsis thaliana	25%	73%
Q9Y6M4	Homo sapiens	50%	72%
Q9Z335	Rattus norvegicus	26%	78%
Q9ZUP4	Arabidopsis thaliana	58%	75%
Q9ZWB3	Arabidopsis thaliana	60%	69%
V5AIW9	Trypanosoma cruzi	41%	88%
V5BMQ3	Trypanosoma cruzi	46%	81%
V5BQF4	Trypanosoma cruzi	25%	87%
V5D9M1	Trypanosoma cruzi	25%	88%