Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5X9_LEIMU

TriTrypDb:

LmxM.34.0990

Length:

859

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5X9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.632
CLV_C14_Caspase3-7	328	332	PF00656	0.689
CLV_C14_Caspase3-7	81	85	PF00656	0.646
CLV_NRD_NRD_1	581	583	PF00675	0.464
CLV_NRD_NRD_1	675	677	PF00675	0.613
CLV_NRD_NRD_1	785	787	PF00675	0.632
CLV_NRD_NRD_1	809	811	PF00675	0.749
CLV_NRD_NRD_1	822	824	PF00675	0.632
CLV_NRD_NRD_1	855	857	PF00675	0.523
CLV_PCSK_FUR_1	673	677	PF00082	0.483
CLV_PCSK_FUR_1	783	787	PF00082	0.617
CLV_PCSK_KEX2_1	581	583	PF00082	0.458
CLV_PCSK_KEX2_1	675	677	PF00082	0.613
CLV_PCSK_KEX2_1	757	759	PF00082	0.668
CLV_PCSK_KEX2_1	785	787	PF00082	0.632
CLV_PCSK_KEX2_1	809	811	PF00082	0.749
CLV_PCSK_KEX2_1	822	824	PF00082	0.632
CLV_PCSK_PC1ET2_1	757	759	PF00082	0.624
CLV_PCSK_SKI1_1	152	156	PF00082	0.383
CLV_PCSK_SKI1_1	632	636	PF00082	0.633
CLV_PCSK_SKI1_1	67	71	PF00082	0.460
DEG_COP1_1	130	140	PF00400	0.496
DEG_Nend_Nbox_1	1	3	PF02207	0.494
DEG_SPOP_SBC_1	524	528	PF00917	0.483
DEG_SPOP_SBC_1	661	665	PF00917	0.541
DOC_ANK_TNKS_1	301	308	PF00023	0.568
DOC_CKS1_1	191	196	PF01111	0.522
DOC_CKS1_1	220	225	PF01111	0.376
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.423
DOC_MAPK_gen_1	4	14	PF00069	0.386
DOC_MAPK_MEF2A_6	152	159	PF00069	0.432
DOC_MAPK_MEF2A_6	442	450	PF00069	0.469
DOC_MAPK_MEF2A_6	7	16	PF00069	0.347
DOC_PP1_RVXF_1	376	383	PF00149	0.496
DOC_PP4_FxxP_1	204	207	PF00568	0.447
DOC_USP7_MATH_1	100	104	PF00917	0.674
DOC_USP7_MATH_1	119	123	PF00917	0.368
DOC_USP7_MATH_1	244	248	PF00917	0.654
DOC_USP7_MATH_1	615	619	PF00917	0.658
DOC_USP7_MATH_1	638	642	PF00917	0.593
DOC_USP7_MATH_1	660	664	PF00917	0.547
DOC_USP7_MATH_1	846	850	PF00917	0.660
DOC_USP7_UBL2_3	403	407	PF12436	0.589
DOC_WW_Pin1_4	174	179	PF00397	0.465
DOC_WW_Pin1_4	190	195	PF00397	0.576
DOC_WW_Pin1_4	209	214	PF00397	0.423
DOC_WW_Pin1_4	219	224	PF00397	0.386
DOC_WW_Pin1_4	276	281	PF00397	0.589
DOC_WW_Pin1_4	397	402	PF00397	0.629
DOC_WW_Pin1_4	467	472	PF00397	0.648
DOC_WW_Pin1_4	490	495	PF00397	0.629
DOC_WW_Pin1_4	611	616	PF00397	0.640
DOC_WW_Pin1_4	762	767	PF00397	0.613
DOC_WW_Pin1_4	837	842	PF00397	0.716
LIG_14-3-3_CanoR_1	240	244	PF00244	0.457
LIG_14-3-3_CanoR_1	274	281	PF00244	0.583
LIG_14-3-3_CanoR_1	302	310	PF00244	0.609
LIG_14-3-3_CanoR_1	442	446	PF00244	0.518
LIG_14-3-3_CanoR_1	532	538	PF00244	0.471
LIG_14-3-3_CanoR_1	59	63	PF00244	0.484
LIG_14-3-3_CanoR_1	600	607	PF00244	0.463
LIG_14-3-3_CanoR_1	673	679	PF00244	0.577
LIG_14-3-3_CanoR_1	693	700	PF00244	0.452
LIG_Actin_WH2_2	589	607	PF00022	0.424
LIG_APCC_ABBA_1	446	451	PF00400	0.518
LIG_BIR_III_2	827	831	PF00653	0.639
LIG_BIR_III_4	565	569	PF00653	0.469
LIG_BRCT_BRCA1_1	737	741	PF00533	0.664
LIG_BRCT_BRCA1_1	75	79	PF00533	0.703
LIG_FHA_1	210	216	PF00498	0.489
LIG_FHA_1	248	254	PF00498	0.578
LIG_FHA_1	311	317	PF00498	0.694
LIG_FHA_1	407	413	PF00498	0.499
LIG_FHA_1	44	50	PF00498	0.546
LIG_FHA_1	468	474	PF00498	0.644
LIG_FHA_1	526	532	PF00498	0.539
LIG_FHA_1	540	546	PF00498	0.409
LIG_FHA_1	737	743	PF00498	0.657
LIG_FHA_2	156	162	PF00498	0.440
LIG_FHA_2	301	307	PF00498	0.677
LIG_FHA_2	415	421	PF00498	0.649
LIG_FHA_2	426	432	PF00498	0.554
LIG_FHA_2	693	699	PF00498	0.577
LIG_FHA_2	89	95	PF00498	0.662
LIG_GBD_Chelix_1	156	164	PF00786	0.442
LIG_LIR_Gen_1	177	188	PF02991	0.503
LIG_LIR_Gen_1	225	235	PF02991	0.468
LIG_LIR_Gen_1	570	580	PF02991	0.455
LIG_LIR_Gen_1	677	686	PF02991	0.616
LIG_LIR_Nem_3	17	23	PF02991	0.440
LIG_LIR_Nem_3	177	183	PF02991	0.486
LIG_LIR_Nem_3	225	230	PF02991	0.564
LIG_LIR_Nem_3	371	376	PF02991	0.444
LIG_LIR_Nem_3	570	575	PF02991	0.423
LIG_LIR_Nem_3	812	817	PF02991	0.641
LIG_LYPXL_yS_3	20	23	PF13949	0.401
LIG_MLH1_MIPbox_1	75	79	PF16413	0.636
LIG_MYND_1	471	475	PF01753	0.476
LIG_PTB_Apo_2	568	575	PF02174	0.381
LIG_Rb_pABgroove_1	21	29	PF01858	0.244
LIG_RPA_C_Fungi	158	170	PF08784	0.438
LIG_SH2_CRK	227	231	PF00017	0.445
LIG_SH2_CRK	27	31	PF00017	0.282
LIG_SH2_CRK	60	64	PF00017	0.491
LIG_SH2_GRB2like	569	572	PF00017	0.446
LIG_SH2_NCK_1	227	231	PF00017	0.445
LIG_SH2_NCK_1	5	9	PF00017	0.497
LIG_SH2_STAP1	569	573	PF00017	0.439
LIG_SH2_STAP1	583	587	PF00017	0.486
LIG_SH2_STAT5	106	109	PF00017	0.509
LIG_SH2_STAT5	478	481	PF00017	0.503
LIG_SH2_STAT5	733	736	PF00017	0.616
LIG_SH3_1	502	508	PF00018	0.498
LIG_SH3_3	135	141	PF00018	0.465
LIG_SH3_3	185	191	PF00018	0.552
LIG_SH3_3	314	320	PF00018	0.676
LIG_SH3_3	398	404	PF00018	0.559
LIG_SH3_3	450	456	PF00018	0.588
LIG_SH3_3	457	463	PF00018	0.592
LIG_SH3_3	502	508	PF00018	0.785
LIG_SH3_3	840	846	PF00018	0.680
LIG_SH3_4	403	410	PF00018	0.555
LIG_SUMO_SIM_anti_2	132	139	PF11976	0.486
LIG_SUMO_SIM_anti_2	166	171	PF11976	0.379
LIG_SUMO_SIM_par_1	212	217	PF11976	0.467
LIG_SUMO_SIM_par_1	22	28	PF11976	0.394
LIG_SUMO_SIM_par_1	605	610	PF11976	0.508
LIG_TRAF2_1	428	431	PF00917	0.460
LIG_TRAF2_1	687	690	PF00917	0.606
LIG_TYR_ITIM	18	23	PF00017	0.429
LIG_UBA3_1	22	29	PF00899	0.404
LIG_WRC_WIRS_1	156	161	PF05994	0.441
LIG_WRC_WIRS_1	253	258	PF05994	0.522
LIG_WRC_WIRS_1	30	35	PF05994	0.520
LIG_WW_3	578	582	PF00397	0.510
MOD_CDK_SPxK_1	397	403	PF00069	0.577
MOD_CDK_SPxxK_3	467	474	PF00069	0.496
MOD_CK1_1	219	225	PF00069	0.394
MOD_CK1_1	242	248	PF00069	0.614
MOD_CK1_1	255	261	PF00069	0.523
MOD_CK1_1	279	285	PF00069	0.620
MOD_CK1_1	347	353	PF00069	0.650
MOD_CK1_1	365	371	PF00069	0.595
MOD_CK1_1	415	421	PF00069	0.662
MOD_CK1_1	44	50	PF00069	0.721
MOD_CK1_1	551	557	PF00069	0.486
MOD_CK1_1	665	671	PF00069	0.638
MOD_CK1_1	68	74	PF00069	0.625
MOD_CK1_1	711	717	PF00069	0.690
MOD_CK1_1	832	838	PF00069	0.699
MOD_CK1_1	85	91	PF00069	0.725
MOD_CK2_1	155	161	PF00069	0.438
MOD_CK2_1	414	420	PF00069	0.655
MOD_CK2_1	425	431	PF00069	0.510
MOD_CK2_1	677	683	PF00069	0.570
MOD_CK2_1	692	698	PF00069	0.593
MOD_Cter_Amidation	726	729	PF01082	0.681
MOD_Cter_Amidation	755	758	PF01082	0.709
MOD_Cter_Amidation	820	823	PF01082	0.682
MOD_GlcNHglycan	207	210	PF01048	0.556
MOD_GlcNHglycan	216	219	PF01048	0.422
MOD_GlcNHglycan	246	249	PF01048	0.593
MOD_GlcNHglycan	261	264	PF01048	0.541
MOD_GlcNHglycan	276	279	PF01048	0.621
MOD_GlcNHglycan	283	287	PF01048	0.598
MOD_GlcNHglycan	350	353	PF01048	0.584
MOD_GlcNHglycan	43	46	PF01048	0.741
MOD_GlcNHglycan	511	514	PF01048	0.649
MOD_GlcNHglycan	53	56	PF01048	0.658
MOD_GlcNHglycan	601	604	PF01048	0.620
MOD_GlcNHglycan	610	614	PF01048	0.625
MOD_GlcNHglycan	831	834	PF01048	0.697
MOD_GlcNHglycan	848	851	PF01048	0.528
MOD_GSK3_1	155	162	PF00069	0.391
MOD_GSK3_1	205	212	PF00069	0.329
MOD_GSK3_1	238	245	PF00069	0.593
MOD_GSK3_1	252	259	PF00069	0.608
MOD_GSK3_1	297	304	PF00069	0.566
MOD_GSK3_1	344	351	PF00069	0.562
MOD_GSK3_1	353	360	PF00069	0.542
MOD_GSK3_1	361	368	PF00069	0.494
MOD_GSK3_1	408	415	PF00069	0.434
MOD_GSK3_1	462	469	PF00069	0.552
MOD_GSK3_1	515	522	PF00069	0.625
MOD_GSK3_1	523	530	PF00069	0.509
MOD_GSK3_1	58	65	PF00069	0.711
MOD_GSK3_1	605	612	PF00069	0.517
MOD_GSK3_1	661	668	PF00069	0.595
MOD_GSK3_1	67	74	PF00069	0.728
MOD_GSK3_1	708	715	PF00069	0.616
MOD_GSK3_1	82	89	PF00069	0.733
MOD_GSK3_1	829	836	PF00069	0.689
MOD_GSK3_1	842	849	PF00069	0.708
MOD_GSK3_1	96	103	PF00069	0.449
MOD_LATS_1	272	278	PF00433	0.449
MOD_N-GLC_1	100	105	PF02516	0.578
MOD_N-GLC_1	111	116	PF02516	0.465
MOD_N-GLC_1	119	124	PF02516	0.385
MOD_N-GLC_1	74	79	PF02516	0.536
MOD_N-GLC_1	751	756	PF02516	0.544
MOD_NEK2_1	155	160	PF00069	0.386
MOD_NEK2_1	216	221	PF00069	0.423
MOD_NEK2_1	256	261	PF00069	0.545
MOD_NEK2_1	346	351	PF00069	0.585
MOD_NEK2_1	533	538	PF00069	0.458
MOD_NEK2_1	598	603	PF00069	0.435
MOD_NEK2_1	609	614	PF00069	0.552
MOD_NEK2_1	709	714	PF00069	0.576
MOD_PIKK_1	473	479	PF00454	0.555
MOD_PIKK_1	668	674	PF00454	0.629
MOD_PIKK_1	702	708	PF00454	0.458
MOD_PK_1	163	169	PF00069	0.385
MOD_PK_1	581	587	PF00069	0.446
MOD_PKA_1	581	587	PF00069	0.484
MOD_PKA_1	785	791	PF00069	0.649
MOD_PKA_2	239	245	PF00069	0.448
MOD_PKA_2	301	307	PF00069	0.728
MOD_PKA_2	41	47	PF00069	0.600
MOD_PKA_2	441	447	PF00069	0.511
MOD_PKA_2	473	479	PF00069	0.538
MOD_PKA_2	533	539	PF00069	0.464
MOD_PKA_2	58	64	PF00069	0.474
MOD_PKA_2	581	587	PF00069	0.425
MOD_PKA_2	599	605	PF00069	0.435
MOD_PKA_2	668	674	PF00069	0.675
MOD_PKA_2	692	698	PF00069	0.707
MOD_PKA_2	785	791	PF00069	0.649
MOD_PKB_1	783	791	PF00069	0.637
MOD_Plk_1	100	106	PF00069	0.605
MOD_Plk_1	119	125	PF00069	0.369
MOD_Plk_1	419	425	PF00069	0.509
MOD_Plk_1	661	667	PF00069	0.521
MOD_Plk_1	74	80	PF00069	0.683
MOD_Plk_2-3	662	668	PF00069	0.521
MOD_Plk_4	119	125	PF00069	0.626
MOD_Plk_4	155	161	PF00069	0.432
MOD_Plk_4	165	171	PF00069	0.329
MOD_Plk_4	216	222	PF00069	0.434
MOD_Plk_4	252	258	PF00069	0.592
MOD_Plk_4	29	35	PF00069	0.513
MOD_Plk_4	357	363	PF00069	0.514
MOD_Plk_4	368	374	PF00069	0.463
MOD_Plk_4	441	447	PF00069	0.452
MOD_Plk_4	58	64	PF00069	0.620
MOD_Plk_4	638	644	PF00069	0.536
MOD_Plk_4	74	80	PF00069	0.612
MOD_ProDKin_1	174	180	PF00069	0.464
MOD_ProDKin_1	190	196	PF00069	0.574
MOD_ProDKin_1	209	215	PF00069	0.420
MOD_ProDKin_1	219	225	PF00069	0.382
MOD_ProDKin_1	276	282	PF00069	0.593
MOD_ProDKin_1	397	403	PF00069	0.629
MOD_ProDKin_1	467	473	PF00069	0.644
MOD_ProDKin_1	490	496	PF00069	0.631
MOD_ProDKin_1	611	617	PF00069	0.645
MOD_ProDKin_1	762	768	PF00069	0.608
MOD_ProDKin_1	837	843	PF00069	0.710
MOD_SUMO_for_1	508	511	PF00179	0.622
MOD_SUMO_rev_2	749	759	PF00179	0.648
TRG_DiLeu_BaEn_1	132	137	PF01217	0.480
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.364
TRG_ENDOCYTIC_2	180	183	PF00928	0.485
TRG_ENDOCYTIC_2	20	23	PF00928	0.401
TRG_ENDOCYTIC_2	227	230	PF00928	0.439
TRG_ENDOCYTIC_2	27	30	PF00928	0.434
TRG_ENDOCYTIC_2	5	8	PF00928	0.497
TRG_ENDOCYTIC_2	569	572	PF00928	0.446
TRG_ENDOCYTIC_2	60	63	PF00928	0.500
TRG_ENDOCYTIC_2	814	817	PF00928	0.641
TRG_ER_diArg_1	531	534	PF00400	0.428
TRG_ER_diArg_1	580	582	PF00400	0.495
TRG_ER_diArg_1	673	676	PF00400	0.513
TRG_ER_diArg_1	783	786	PF00400	0.613
TRG_ER_diArg_1	809	811	PF00400	0.749
TRG_ER_diArg_1	822	824	PF00400	0.632
TRG_NES_CRM1_1	6	19	PF08389	0.477
TRG_Pf-PMV_PEXEL_1	822	827	PF00026	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P319	Leptomonas seymouri	50%	95%
A0A1X0NIZ7	Trypanosomatidae	28%	100%
A0A3S7X8X6	Leishmania donovani	88%	100%
A4HMC9	Leishmania braziliensis	75%	99%
A4IAZ6	Leishmania infantum	88%	100%
E9AES4	Leishmania major	87%	100%