Aldose 1-epimerase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldose 1-epimerase-like protein

Species:

Leishmania mexicana

UniProt:

E9B5X8_LEIMU

TriTrypDb:

LmxM.34.0980

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5X8

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	21
GO:0008152	metabolic process	1	21
GO:0044238	primary metabolic process	2	21
GO:0071704	organic substance metabolic process	2	21
GO:0005996	monosaccharide metabolic process	3	6
GO:0019318	hexose metabolic process	4	6
GO:0044281	small molecule metabolic process	2	6
GO:0006006	glucose metabolic process	5	3
GO:0006012	galactose metabolic process	5	3
GO:0009056	catabolic process	2	3
GO:0016052	carbohydrate catabolic process	4	3
GO:0019320	hexose catabolic process	5	3
GO:0019388	galactose catabolic process	6	3
GO:0033499	galactose catabolic process via UDP-galactose	7	3
GO:0044282	small molecule catabolic process	3	3
GO:0046365	monosaccharide catabolic process	4	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	21
GO:0005488	binding	1	21
GO:0016853	isomerase activity	2	21
GO:0030246	carbohydrate binding	2	21
GO:0004034	aldose 1-epimerase activity	5	15
GO:0016854	racemase and epimerase activity	3	15
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	355	357	PF00675	0.259
CLV_PCSK_KEX2_1	355	357	PF00082	0.311
CLV_PCSK_SKI1_1	281	285	PF00082	0.311
DOC_MAPK_gen_1	325	334	PF00069	0.456
DOC_MAPK_MEF2A_6	19	27	PF00069	0.471
DOC_PP2B_LxvP_1	215	218	PF13499	0.497
DOC_USP7_MATH_2	142	148	PF00917	0.509
DOC_WW_Pin1_4	170	175	PF00397	0.460
DOC_WW_Pin1_4	287	292	PF00397	0.460
LIG_14-3-3_CanoR_1	360	366	PF00244	0.474
LIG_Actin_WH2_2	11	26	PF00022	0.393
LIG_APCC_ABBA_1	282	287	PF00400	0.478
LIG_APCC_ABBAyCdc20_2	281	287	PF00400	0.478
LIG_BIR_III_2	176	180	PF00653	0.499
LIG_FHA_1	148	154	PF00498	0.489
LIG_FHA_1	18	24	PF00498	0.358
LIG_FHA_1	81	87	PF00498	0.531
LIG_FHA_2	120	126	PF00498	0.406
LIG_FHA_2	161	167	PF00498	0.539
LIG_FHA_2	239	245	PF00498	0.476
LIG_FHA_2	59	65	PF00498	0.502
LIG_LIR_Gen_1	232	243	PF02991	0.572
LIG_LIR_Nem_3	163	168	PF02991	0.519
LIG_LIR_Nem_3	232	238	PF02991	0.527
LIG_LIR_Nem_3	64	70	PF02991	0.563
LIG_OCRL_FandH_1	109	121	PF00620	0.478
LIG_Pex14_2	303	307	PF04695	0.471
LIG_PTB_Apo_2	181	188	PF02174	0.445
LIG_PTB_Phospho_1	181	187	PF10480	0.445
LIG_SH2_CRK	67	71	PF00017	0.509
LIG_SH2_GRB2like	187	190	PF00017	0.445
LIG_SH2_SRC	268	271	PF00017	0.450
LIG_SH2_STAP1	165	169	PF00017	0.511
LIG_SH2_STAT5	132	135	PF00017	0.496
LIG_SH2_STAT5	168	171	PF00017	0.547
LIG_SH2_STAT5	309	312	PF00017	0.478
LIG_SH2_STAT5	338	341	PF00017	0.466
LIG_SH3_3	344	350	PF00018	0.479
LIG_SH3_3	36	42	PF00018	0.521
LIG_SUMO_SIM_anti_2	257	262	PF11976	0.542
LIG_SUMO_SIM_par_1	269	275	PF11976	0.489
LIG_TYR_ITSM	63	70	PF00017	0.406
LIG_UBA3_1	15	19	PF00899	0.256
MOD_CK1_1	147	153	PF00069	0.518
MOD_CK1_1	290	296	PF00069	0.460
MOD_CK1_1	359	365	PF00069	0.487
MOD_CK2_1	119	125	PF00069	0.473
MOD_CK2_1	54	60	PF00069	0.498
MOD_GlcNHglycan	107	110	PF01048	0.150
MOD_GlcNHglycan	133	136	PF01048	0.325
MOD_GlcNHglycan	318	321	PF01048	0.282
MOD_GlcNHglycan	56	59	PF01048	0.385
MOD_GSK3_1	117	124	PF00069	0.499
MOD_GSK3_1	126	133	PF00069	0.448
MOD_GSK3_1	149	156	PF00069	0.518
MOD_GSK3_1	160	167	PF00069	0.489
MOD_GSK3_1	234	241	PF00069	0.524
MOD_GSK3_1	367	374	PF00069	0.486
MOD_GSK3_1	54	61	PF00069	0.492
MOD_N-GLC_1	130	135	PF02516	0.309
MOD_N-GLC_2	294	296	PF02516	0.278
MOD_NEK2_1	130	135	PF00069	0.495
MOD_NEK2_1	30	35	PF00069	0.437
MOD_NEK2_1	361	366	PF00069	0.544
MOD_NEK2_1	68	73	PF00069	0.478
MOD_NEK2_2	80	85	PF00069	0.564
MOD_NEK2_2	99	104	PF00069	0.420
MOD_PKA_2	327	333	PF00069	0.480
MOD_PKA_2	359	365	PF00069	0.515
MOD_PKA_2	99	105	PF00069	0.504
MOD_Plk_1	367	373	PF00069	0.433
MOD_Plk_2-3	234	240	PF00069	0.478
MOD_Plk_4	164	170	PF00069	0.492
MOD_Plk_4	361	367	PF00069	0.477
MOD_ProDKin_1	170	176	PF00069	0.460
MOD_ProDKin_1	287	293	PF00069	0.460
TRG_DiLeu_BaEn_1	278	283	PF01217	0.516
TRG_ENDOCYTIC_2	187	190	PF00928	0.445
TRG_ENDOCYTIC_2	300	303	PF00928	0.465
TRG_ENDOCYTIC_2	67	70	PF00928	0.406
TRG_ER_diArg_1	354	356	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.280
TRG_PTS1	374	377	PF00515	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0E0RXA9	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	27%	87%
A0A0N0P441	Leptomonas seymouri	62%	100%
A0A0N0P558	Leptomonas seymouri	35%	93%
A0A0N1PBB3	Leptomonas seymouri	52%	100%
A0A1X0NJ33	Trypanosomatidae	54%	100%
A0A1X0NX70	Trypanosomatidae	39%	99%
A0A3R7MXQ5	Trypanosoma rangeli	38%	100%
A0A3S7WXI1	Leishmania donovani	35%	92%
A0A3S7X8W5	Leishmania donovani	68%	100%
A0A3S7X8Z3	Leishmania donovani	96%	100%
A0A422N115	Trypanosoma rangeli	48%	100%
A4HCQ7	Leishmania braziliensis	36%	100%
A4I082	Leishmania infantum	35%	92%
A4IAZ4	Leishmania infantum	68%	100%
D4AMB9	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	28%	86%
E9AES2	Leishmania major	69%	99%
E9AES3	Leishmania major	95%	100%
E9AW46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B5X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	99%
P05149	Acinetobacter calcoaceticus	31%	99%
P0A9C3	Escherichia coli (strain K12)	29%	100%
P0A9C4	Shigella flexneri	29%	100%
P21955	Streptococcus thermophilus	22%	100%
P31765	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	100%
P38893	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	20%	100%
P53757	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q03PA4	Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947)	24%	100%
Q4QBD1	Leishmania major	36%	100%
Q5EA79	Bos taurus	29%	100%
Q5R8U1	Pongo abelii	29%	100%
Q66HG4	Rattus norvegicus	28%	100%
Q8K157	Mus musculus	28%	100%
Q96C23	Homo sapiens	29%	100%
Q9GKX6	Sus scrofa	28%	100%
V5B7Z0	Trypanosoma cruzi	37%	98%