Putative aldose 1-epimerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldose 1-epimerase, putative

Species:

Leishmania mexicana

UniProt:

E9B5X7_LEIMU

TriTrypDb:

LmxM.34.0970

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5X7

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	21
GO:0008152	metabolic process	1	21
GO:0044238	primary metabolic process	2	21
GO:0071704	organic substance metabolic process	2	21
GO:0005996	monosaccharide metabolic process	3	6
GO:0019318	hexose metabolic process	4	6
GO:0044281	small molecule metabolic process	2	6
GO:0006006	glucose metabolic process	5	3
GO:0006012	galactose metabolic process	5	3
GO:0009056	catabolic process	2	3
GO:0016052	carbohydrate catabolic process	4	3
GO:0019320	hexose catabolic process	5	3
GO:0019388	galactose catabolic process	6	3
GO:0033499	galactose catabolic process via UDP-galactose	7	3
GO:0044282	small molecule catabolic process	3	3
GO:0046365	monosaccharide catabolic process	4	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	21
GO:0004034	aldose 1-epimerase activity	5	16
GO:0005488	binding	1	21
GO:0016853	isomerase activity	2	21
GO:0016854	racemase and epimerase activity	3	16
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	16
GO:0030246	carbohydrate binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	353	355	PF00675	0.295
CLV_PCSK_KEX2_1	353	355	PF00082	0.350
CLV_PCSK_SKI1_1	279	283	PF00082	0.350
DOC_MAPK_gen_1	111	118	PF00069	0.485
DOC_MAPK_gen_1	323	332	PF00069	0.493
DOC_PP1_RVXF_1	12	18	PF00149	0.481
DOC_PP2B_LxvP_1	213	216	PF13499	0.525
DOC_WW_Pin1_4	169	174	PF00397	0.498
DOC_WW_Pin1_4	285	290	PF00397	0.503
LIG_14-3-3_CanoR_1	128	136	PF00244	0.611
LIG_14-3-3_CanoR_1	357	364	PF00244	0.508
LIG_Actin_WH2_2	11	26	PF00022	0.384
LIG_APCC_ABBA_1	280	285	PF00400	0.501
LIG_APCC_ABBAyCdc20_2	279	285	PF00400	0.501
LIG_BIR_III_2	175	179	PF00653	0.536
LIG_Clathr_ClatBox_1	15	19	PF01394	0.448
LIG_eIF4E_1	10	16	PF01652	0.409
LIG_FHA_1	119	125	PF00498	0.533
LIG_FHA_1	147	153	PF00498	0.532
LIG_FHA_1	18	24	PF00498	0.558
LIG_FHA_1	326	332	PF00498	0.447
LIG_FHA_2	160	166	PF00498	0.588
LIG_FHA_2	170	176	PF00498	0.572
LIG_FHA_2	237	243	PF00498	0.512
LIG_FHA_2	361	367	PF00498	0.532
LIG_FHA_2	61	67	PF00498	0.559
LIG_LIR_Apic_2	199	205	PF02991	0.556
LIG_LIR_Apic_2	59	65	PF02991	0.505
LIG_LIR_Gen_1	230	241	PF02991	0.619
LIG_LIR_Gen_1	45	55	PF02991	0.482
LIG_LIR_Nem_3	162	167	PF02991	0.558
LIG_LIR_Nem_3	230	236	PF02991	0.562
LIG_LIR_Nem_3	45	50	PF02991	0.491
LIG_Pex14_2	301	305	PF04695	0.507
LIG_SH2_CRK	12	16	PF00017	0.321
LIG_SH2_NCK_1	62	66	PF00017	0.538
LIG_SH2_SRC	266	269	PF00017	0.487
LIG_SH2_STAP1	12	16	PF00017	0.460
LIG_SH2_STAP1	164	168	PF00017	0.550
LIG_SH2_STAP1	30	34	PF00017	0.552
LIG_SH2_STAT3	91	94	PF00017	0.552
LIG_SH2_STAT5	131	134	PF00017	0.533
LIG_SH2_STAT5	147	150	PF00017	0.495
LIG_SH2_STAT5	167	170	PF00017	0.616
LIG_SH2_STAT5	307	310	PF00017	0.514
LIG_SH2_STAT5	62	65	PF00017	0.467
LIG_SH2_STAT5	92	95	PF00017	0.593
LIG_SH3_3	342	348	PF00018	0.515
LIG_SH3_3	36	42	PF00018	0.560
LIG_SH3_3	52	58	PF00018	0.552
LIG_SUMO_SIM_anti_2	255	260	PF11976	0.583
LIG_SUMO_SIM_par_1	267	273	PF11976	0.526
LIG_WRC_WIRS_1	147	152	PF05994	0.552
MOD_CK1_1	166	172	PF00069	0.593
MOD_CK1_1	183	189	PF00069	0.535
MOD_CK1_1	288	294	PF00069	0.506
MOD_CK1_1	33	39	PF00069	0.507
MOD_CK1_1	360	366	PF00069	0.509
MOD_CK2_1	360	366	PF00069	0.520
MOD_GlcNHglycan	132	135	PF01048	0.382
MOD_GlcNHglycan	137	140	PF01048	0.367
MOD_GlcNHglycan	316	319	PF01048	0.319
MOD_GSK3_1	148	155	PF00069	0.567
MOD_GSK3_1	159	166	PF00069	0.607
MOD_GSK3_1	232	239	PF00069	0.563
MOD_N-GLC_1	129	134	PF02516	0.347
MOD_N-GLC_1	335	340	PF02516	0.352
MOD_N-GLC_2	100	102	PF02516	0.352
MOD_N-GLC_2	146	148	PF02516	0.352
MOD_N-GLC_2	292	294	PF02516	0.301
MOD_NEK2_1	118	123	PF00069	0.519
MOD_NEK2_1	129	134	PF00069	0.532
MOD_NEK2_1	182	187	PF00069	0.550
MOD_NEK2_1	68	73	PF00069	0.510
MOD_NEK2_2	159	164	PF00069	0.552
MOD_NEK2_2	98	103	PF00069	0.493
MOD_PIKK_1	90	96	PF00454	0.552
MOD_PKA_2	325	331	PF00069	0.516
MOD_Plk_1	360	366	PF00069	0.521
MOD_Plk_2-3	232	238	PF00069	0.501
MOD_Plk_2-3	60	66	PF00069	0.398
MOD_Plk_4	159	165	PF00069	0.546
MOD_ProDKin_1	169	175	PF00069	0.498
MOD_ProDKin_1	285	291	PF00069	0.503
MOD_SUMO_for_1	5	8	PF00179	0.428
TRG_DiLeu_BaEn_1	276	281	PF01217	0.554
TRG_ENDOCYTIC_2	12	15	PF00928	0.330
TRG_ENDOCYTIC_2	147	150	PF00928	0.506
TRG_ENDOCYTIC_2	298	301	PF00928	0.502
TRG_ER_diArg_1	352	354	PF00400	0.550
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0E0RXA9	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	25%	85%
A0A0N0P441	Leptomonas seymouri	82%	100%
A0A0N0P558	Leptomonas seymouri	35%	91%
A0A0N1PBB3	Leptomonas seymouri	47%	99%
A0A1X0NJ33	Trypanosomatidae	47%	98%
A0A1X0NX70	Trypanosomatidae	38%	97%
A0A3R7MXQ5	Trypanosoma rangeli	36%	98%
A0A3S7WXI1	Leishmania donovani	33%	91%
A0A3S7X8W5	Leishmania donovani	94%	100%
A0A3S7X8Z3	Leishmania donovani	70%	98%
A0A422N115	Trypanosoma rangeli	44%	98%
A4HCQ7	Leishmania braziliensis	34%	100%
A4I082	Leishmania infantum	33%	91%
A4IAZ4	Leishmania infantum	94%	100%
D4AMB9	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	28%	84%
E9AES2	Leishmania major	96%	100%
E9AES3	Leishmania major	70%	100%
E9AW46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B5X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	98%
P05149	Acinetobacter calcoaceticus	28%	97%
P0A9C3	Escherichia coli (strain K12)	29%	100%
P0A9C4	Shigella flexneri	29%	100%
P21955	Streptococcus thermophilus	20%	100%
P31765	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	100%
P38893	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P53757	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q03PA4	Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947)	25%	100%
Q4QBD1	Leishmania major	35%	100%
Q5EA79	Bos taurus	27%	100%
Q5R8U1	Pongo abelii	26%	100%
Q66HG4	Rattus norvegicus	28%	100%
Q8K157	Mus musculus	28%	100%
Q96C23	Homo sapiens	26%	100%
Q9GKX6	Sus scrofa	27%	100%
V5B7Z0	Trypanosoma cruzi	36%	96%