Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5X6_LEIMU

TriTrypDb:

LmxM.34.0960

Length:

795

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5X6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.482
CLV_C14_Caspase3-7	471	475	PF00656	0.476
CLV_NRD_NRD_1	11	13	PF00675	0.445
CLV_NRD_NRD_1	134	136	PF00675	0.656
CLV_NRD_NRD_1	188	190	PF00675	0.425
CLV_NRD_NRD_1	312	314	PF00675	0.442
CLV_NRD_NRD_1	580	582	PF00675	0.562
CLV_NRD_NRD_1	608	610	PF00675	0.578
CLV_NRD_NRD_1	689	691	PF00675	0.698
CLV_PCSK_FUR_1	578	582	PF00082	0.486
CLV_PCSK_KEX2_1	10	12	PF00082	0.446
CLV_PCSK_KEX2_1	134	136	PF00082	0.656
CLV_PCSK_KEX2_1	188	190	PF00082	0.445
CLV_PCSK_KEX2_1	214	216	PF00082	0.508
CLV_PCSK_KEX2_1	312	314	PF00082	0.442
CLV_PCSK_KEX2_1	580	582	PF00082	0.494
CLV_PCSK_KEX2_1	608	610	PF00082	0.578
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.508
CLV_PCSK_SKI1_1	104	108	PF00082	0.652
CLV_PCSK_SKI1_1	229	233	PF00082	0.488
CLV_PCSK_SKI1_1	270	274	PF00082	0.509
CLV_PCSK_SKI1_1	410	414	PF00082	0.439
CLV_PCSK_SKI1_1	555	559	PF00082	0.368
DEG_APCC_DBOX_1	554	562	PF00400	0.465
DEG_Nend_Nbox_1	1	3	PF02207	0.506
DEG_SCF_FBW7_1	411	417	PF00400	0.484
DEG_SCF_TRCP1_1	471	477	PF00400	0.465
DEG_SPOP_SBC_1	151	155	PF00917	0.755
DOC_CDC14_PxL_1	755	763	PF14671	0.358
DOC_CKS1_1	24	29	PF01111	0.527
DOC_CKS1_1	411	416	PF01111	0.470
DOC_CKS1_1	492	497	PF01111	0.420
DOC_CYCLIN_RxL_1	267	275	PF00134	0.405
DOC_CYCLIN_RxL_1	552	560	PF00134	0.344
DOC_CYCLIN_yCln2_LP_2	281	287	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	492	498	PF00134	0.424
DOC_MAPK_gen_1	134	141	PF00069	0.654
DOC_MAPK_gen_1	578	585	PF00069	0.563
DOC_MAPK_gen_1	59	68	PF00069	0.384
DOC_MAPK_gen_1	690	701	PF00069	0.731
DOC_MAPK_MEF2A_6	325	333	PF00069	0.356
DOC_MAPK_MEF2A_6	484	492	PF00069	0.480
DOC_MAPK_MEF2A_6	555	563	PF00069	0.466
DOC_PP1_RVXF_1	63	69	PF00149	0.367
DOC_PP1_RVXF_1	696	702	PF00149	0.538
DOC_PP2B_LxvP_1	139	142	PF13499	0.713
DOC_PP2B_LxvP_1	281	284	PF13499	0.446
DOC_PP2B_LxvP_1	561	564	PF13499	0.472
DOC_USP7_MATH_1	140	144	PF00917	0.817
DOC_USP7_MATH_1	151	155	PF00917	0.718
DOC_USP7_MATH_1	159	163	PF00917	0.655
DOC_USP7_MATH_1	177	181	PF00917	0.610
DOC_USP7_MATH_1	255	259	PF00917	0.575
DOC_USP7_MATH_1	285	289	PF00917	0.715
DOC_USP7_MATH_1	402	406	PF00917	0.471
DOC_USP7_MATH_1	454	458	PF00917	0.585
DOC_USP7_MATH_1	507	511	PF00917	0.612
DOC_USP7_MATH_1	591	595	PF00917	0.622
DOC_USP7_MATH_1	641	645	PF00917	0.705
DOC_USP7_MATH_1	722	726	PF00917	0.833
DOC_WW_Pin1_4	147	152	PF00397	0.631
DOC_WW_Pin1_4	193	198	PF00397	0.653
DOC_WW_Pin1_4	202	207	PF00397	0.666
DOC_WW_Pin1_4	23	28	PF00397	0.473
DOC_WW_Pin1_4	272	277	PF00397	0.484
DOC_WW_Pin1_4	338	343	PF00397	0.527
DOC_WW_Pin1_4	410	415	PF00397	0.485
DOC_WW_Pin1_4	420	425	PF00397	0.564
DOC_WW_Pin1_4	474	479	PF00397	0.609
DOC_WW_Pin1_4	491	496	PF00397	0.646
DOC_WW_Pin1_4	634	639	PF00397	0.622
LIG_14-3-3_CanoR_1	189	197	PF00244	0.611
LIG_14-3-3_CanoR_1	300	306	PF00244	0.567
LIG_14-3-3_CanoR_1	312	322	PF00244	0.372
LIG_14-3-3_CanoR_1	441	446	PF00244	0.438
LIG_14-3-3_CanoR_1	651	655	PF00244	0.573
LIG_14-3-3_CanoR_1	785	791	PF00244	0.383
LIG_14-3-3_CanoR_1	94	103	PF00244	0.507
LIG_CSL_BTD_1	281	284	PF09270	0.446
LIG_EH1_1	671	679	PF00400	0.340
LIG_FHA_1	105	111	PF00498	0.570
LIG_FHA_1	12	18	PF00498	0.523
LIG_FHA_1	124	130	PF00498	0.628
LIG_FHA_1	170	176	PF00498	0.726
LIG_FHA_1	249	255	PF00498	0.602
LIG_FHA_1	26	32	PF00498	0.539
LIG_FHA_1	328	334	PF00498	0.599
LIG_FHA_1	358	364	PF00498	0.457
LIG_FHA_1	460	466	PF00498	0.583
LIG_FHA_1	530	536	PF00498	0.608
LIG_FHA_1	547	553	PF00498	0.323
LIG_FHA_1	558	564	PF00498	0.353
LIG_FHA_1	634	640	PF00498	0.638
LIG_FHA_1	678	684	PF00498	0.499
LIG_FHA_1	736	742	PF00498	0.578
LIG_FHA_1	96	102	PF00498	0.544
LIG_FHA_2	293	299	PF00498	0.714
LIG_FHA_2	498	504	PF00498	0.439
LIG_FHA_2	543	549	PF00498	0.425
LIG_FHA_2	563	569	PF00498	0.263
LIG_FHA_2	650	656	PF00498	0.461
LIG_FHA_2	742	748	PF00498	0.419
LIG_GBD_Chelix_1	392	400	PF00786	0.379
LIG_Integrin_isoDGR_2	514	516	PF01839	0.595
LIG_LIR_Apic_2	548	553	PF02991	0.330
LIG_LIR_Gen_1	180	187	PF02991	0.598
LIG_LIR_Gen_1	426	435	PF02991	0.477
LIG_LIR_Nem_3	180	184	PF02991	0.574
LIG_LIR_Nem_3	426	432	PF02991	0.468
LIG_LIR_Nem_3	789	794	PF02991	0.442
LIG_LYPXL_yS_3	758	761	PF13949	0.336
LIG_SH2_CRK	82	86	PF00017	0.328
LIG_SH2_GRB2like	614	617	PF00017	0.560
LIG_SH2_PTP2	54	57	PF00017	0.449
LIG_SH2_PTP2	550	553	PF00017	0.387
LIG_SH2_SRC	20	23	PF00017	0.548
LIG_SH2_SRC	54	57	PF00017	0.470
LIG_SH2_SRC	540	543	PF00017	0.431
LIG_SH2_SRC	774	777	PF00017	0.426
LIG_SH2_STAP1	614	618	PF00017	0.638
LIG_SH2_STAP1	654	658	PF00017	0.368
LIG_SH2_STAT5	191	194	PF00017	0.614
LIG_SH2_STAT5	20	23	PF00017	0.467
LIG_SH2_STAT5	350	353	PF00017	0.393
LIG_SH2_STAT5	371	374	PF00017	0.552
LIG_SH2_STAT5	54	57	PF00017	0.353
LIG_SH2_STAT5	540	543	PF00017	0.392
LIG_SH2_STAT5	550	553	PF00017	0.299
LIG_SH2_STAT5	665	668	PF00017	0.463
LIG_SH2_STAT5	67	70	PF00017	0.328
LIG_SH2_STAT5	769	772	PF00017	0.372
LIG_SH2_STAT5	774	777	PF00017	0.387
LIG_SH3_1	376	382	PF00018	0.487
LIG_SH3_2	719	724	PF14604	0.635
LIG_SH3_3	125	131	PF00018	0.701
LIG_SH3_3	145	151	PF00018	0.484
LIG_SH3_3	21	27	PF00018	0.535
LIG_SH3_3	336	342	PF00018	0.698
LIG_SH3_3	358	364	PF00018	0.471
LIG_SH3_3	376	382	PF00018	0.487
LIG_SH3_3	405	411	PF00018	0.376
LIG_SH3_3	503	509	PF00018	0.583
LIG_SH3_3	640	646	PF00018	0.718
LIG_SH3_3	661	667	PF00018	0.320
LIG_SH3_3	68	74	PF00018	0.411
LIG_SH3_3	716	722	PF00018	0.628
LIG_SUMO_SIM_par_1	137	144	PF11976	0.656
LIG_SUMO_SIM_par_1	644	650	PF11976	0.476
LIG_TRAF2_1	295	298	PF00917	0.685
LIG_TYR_ITIM	80	85	PF00017	0.393
LIG_UBA3_1	100	105	PF00899	0.372
LIG_WRC_WIRS_1	403	408	PF05994	0.364
MOD_CDK_SPK_2	193	198	PF00069	0.543
MOD_CDK_SPxK_1	23	29	PF00069	0.529
MOD_CK1_1	150	156	PF00069	0.670
MOD_CK1_1	162	168	PF00069	0.770
MOD_CK1_1	193	199	PF00069	0.599
MOD_CK1_1	299	305	PF00069	0.628
MOD_CK1_1	307	313	PF00069	0.474
MOD_CK1_1	457	463	PF00069	0.618
MOD_CK1_1	472	478	PF00069	0.656
MOD_CK1_1	510	516	PF00069	0.626
MOD_CK1_1	650	656	PF00069	0.437
MOD_CK1_1	723	729	PF00069	0.678
MOD_CK1_1	737	743	PF00069	0.582
MOD_CK2_1	292	298	PF00069	0.696
MOD_CK2_1	497	503	PF00069	0.427
MOD_CK2_1	542	548	PF00069	0.481
MOD_CK2_1	562	568	PF00069	0.253
MOD_CK2_1	616	622	PF00069	0.468
MOD_CK2_1	649	655	PF00069	0.510
MOD_CK2_1	714	720	PF00069	0.652
MOD_CK2_1	741	747	PF00069	0.417
MOD_Cter_Amidation	688	691	PF01082	0.552
MOD_DYRK1A_RPxSP_1	410	414	PF00069	0.439
MOD_GlcNHglycan	164	167	PF01048	0.796
MOD_GlcNHglycan	192	195	PF01048	0.667
MOD_GlcNHglycan	215	218	PF01048	0.529
MOD_GlcNHglycan	255	258	PF01048	0.700
MOD_GlcNHglycan	259	262	PF01048	0.547
MOD_GlcNHglycan	285	288	PF01048	0.531
MOD_GlcNHglycan	357	360	PF01048	0.442
MOD_GlcNHglycan	41	44	PF01048	0.524
MOD_GlcNHglycan	443	446	PF01048	0.581
MOD_GlcNHglycan	459	462	PF01048	0.588
MOD_GlcNHglycan	471	474	PF01048	0.663
MOD_GlcNHglycan	478	481	PF01048	0.526
MOD_GlcNHglycan	509	512	PF01048	0.606
MOD_GlcNHglycan	588	591	PF01048	0.509
MOD_GlcNHglycan	593	596	PF01048	0.534
MOD_GlcNHglycan	618	621	PF01048	0.539
MOD_GlcNHglycan	770	773	PF01048	0.300
MOD_GlcNHglycan	776	779	PF01048	0.476
MOD_GlcNHglycan	95	98	PF01048	0.400
MOD_GSK3_1	146	153	PF00069	0.731
MOD_GSK3_1	165	172	PF00069	0.771
MOD_GSK3_1	202	209	PF00069	0.584
MOD_GSK3_1	239	246	PF00069	0.674
MOD_GSK3_1	253	260	PF00069	0.527
MOD_GSK3_1	292	299	PF00069	0.659
MOD_GSK3_1	300	307	PF00069	0.669
MOD_GSK3_1	355	362	PF00069	0.498
MOD_GSK3_1	410	417	PF00069	0.546
MOD_GSK3_1	469	476	PF00069	0.666
MOD_GSK3_1	542	549	PF00069	0.429
MOD_GSK3_1	616	623	PF00069	0.563
MOD_GSK3_1	679	686	PF00069	0.436
MOD_GSK3_1	710	717	PF00069	0.581
MOD_GSK3_1	730	737	PF00069	0.790
MOD_GSK3_1	786	793	PF00069	0.423
MOD_LATS_1	601	607	PF00433	0.433
MOD_N-GLC_1	620	625	PF02516	0.582
MOD_N-GLC_1	684	689	PF02516	0.660
MOD_NEK2_1	164	169	PF00069	0.659
MOD_NEK2_1	2	7	PF00069	0.511
MOD_NEK2_1	47	52	PF00069	0.364
MOD_NEK2_1	557	562	PF00069	0.383
MOD_NEK2_1	604	609	PF00069	0.662
MOD_NEK2_1	647	652	PF00069	0.493
MOD_NEK2_2	786	791	PF00069	0.409
MOD_PIKK_1	141	147	PF00454	0.718
MOD_PIKK_1	244	250	PF00454	0.719
MOD_PKA_1	104	110	PF00069	0.609
MOD_PKA_1	11	17	PF00069	0.543
MOD_PKA_2	11	17	PF00069	0.518
MOD_PKA_2	299	305	PF00069	0.748
MOD_PKA_2	324	330	PF00069	0.573
MOD_PKA_2	515	521	PF00069	0.496
MOD_PKA_2	586	592	PF00069	0.600
MOD_PKA_2	602	608	PF00069	0.633
MOD_PKA_2	61	67	PF00069	0.374
MOD_PKA_2	650	656	PF00069	0.379
MOD_PKA_2	93	99	PF00069	0.533
MOD_Plk_1	220	226	PF00069	0.400
MOD_Plk_4	159	165	PF00069	0.734
MOD_Plk_4	546	552	PF00069	0.349
MOD_Plk_4	786	792	PF00069	0.415
MOD_ProDKin_1	147	153	PF00069	0.631
MOD_ProDKin_1	193	199	PF00069	0.659
MOD_ProDKin_1	202	208	PF00069	0.669
MOD_ProDKin_1	23	29	PF00069	0.473
MOD_ProDKin_1	272	278	PF00069	0.479
MOD_ProDKin_1	338	344	PF00069	0.515
MOD_ProDKin_1	410	416	PF00069	0.496
MOD_ProDKin_1	420	426	PF00069	0.558
MOD_ProDKin_1	474	480	PF00069	0.598
MOD_ProDKin_1	491	497	PF00069	0.643
MOD_ProDKin_1	634	640	PF00069	0.620
MOD_SUMO_rev_2	209	216	PF00179	0.565
MOD_SUMO_rev_2	233	242	PF00179	0.464
MOD_SUMO_rev_2	336	342	PF00179	0.537
MOD_SUMO_rev_2	370	378	PF00179	0.558
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.368
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.533
TRG_DiLeu_BaLyEn_6	643	648	PF01217	0.511
TRG_ENDOCYTIC_2	54	57	PF00928	0.374
TRG_ENDOCYTIC_2	758	761	PF00928	0.336
TRG_ENDOCYTIC_2	82	85	PF00928	0.330
TRG_ER_diArg_1	134	136	PF00400	0.590
TRG_ER_diArg_1	188	190	PF00400	0.425
TRG_ER_diArg_1	312	314	PF00400	0.441
TRG_ER_diArg_1	578	581	PF00400	0.540
TRG_ER_diArg_1	9	12	PF00400	0.471
TRG_Pf-PMV_PEXEL_1	657	662	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q0	Leptomonas seymouri	47%	96%
A0A1X0NJG4	Trypanosomatidae	27%	97%
A0A3S7X8V4	Leishmania donovani	88%	100%
A0A422N118	Trypanosoma rangeli	31%	100%
A4HMC7	Leishmania braziliensis	73%	99%
A4IAZ3	Leishmania infantum	88%	100%
E9AES1	Leishmania major	89%	100%
V5B090	Trypanosoma cruzi	30%	100%