Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5X4_LEIMU

TriTrypDb:

LmxM.34.0940

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9B5X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5X4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	203	205	PF00675	0.398
CLV_NRD_NRD_1	68	70	PF00675	0.541
CLV_PCSK_KEX2_1	202	204	PF00082	0.415
CLV_PCSK_KEX2_1	68	70	PF00082	0.541
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.459
CLV_PCSK_SKI1_1	180	184	PF00082	0.436
DEG_Nend_Nbox_1	1	3	PF02207	0.729
DEG_SPOP_SBC_1	17	21	PF00917	0.679
DOC_USP7_MATH_1	17	21	PF00917	0.679
DOC_USP7_MATH_1	33	37	PF00917	0.725
DOC_USP7_MATH_1	51	55	PF00917	0.695
DOC_USP7_MATH_2	77	83	PF00917	0.757
DOC_USP7_UBL2_3	180	184	PF12436	0.662
DOC_USP7_UBL2_3	91	95	PF12436	0.738
DOC_WW_Pin1_4	153	158	PF00397	0.682
DOC_WW_Pin1_4	161	166	PF00397	0.689
LIG_14-3-3_CanoR_1	144	150	PF00244	0.694
LIG_14-3-3_CanoR_1	34	39	PF00244	0.628
LIG_BRCT_BRCA1_1	81	85	PF00533	0.709
LIG_FHA_1	19	25	PF00498	0.681
LIG_FHA_1	62	68	PF00498	0.730
LIG_FHA_1	91	97	PF00498	0.733
LIG_FHA_2	10	16	PF00498	0.623
LIG_FHA_2	183	189	PF00498	0.646
LIG_FHA_2	196	202	PF00498	0.662
LIG_HCF-1_HBM_1	114	117	PF13415	0.563
LIG_LIR_Gen_1	86	96	PF02991	0.670
LIG_LIR_Nem_3	86	92	PF02991	0.676
LIG_LYPXL_yS_3	194	197	PF13949	0.704
LIG_MAD2	181	189	PF02301	0.718
LIG_Pex14_2	85	89	PF04695	0.681
LIG_SH2_NCK_1	113	117	PF00017	0.717
LIG_SH2_SRC	113	116	PF00017	0.564
LIG_SH2_STAP1	178	182	PF00017	0.689
LIG_SH2_STAT5	149	152	PF00017	0.695
LIG_SH2_STAT5	30	33	PF00017	0.631
LIG_SH3_3	159	165	PF00018	0.702
LIG_SUMO_SIM_par_1	195	201	PF11976	0.669
LIG_TRAF2_1	198	201	PF00917	0.691
LIG_ULM_U2AF65_1	202	208	PF00076	0.661
MOD_CDK_SPxxK_3	161	168	PF00069	0.687
MOD_CK1_1	148	154	PF00069	0.687
MOD_CK1_1	18	24	PF00069	0.644
MOD_CK1_1	36	42	PF00069	0.699
MOD_CK1_1	53	59	PF00069	0.722
MOD_CK1_1	9	15	PF00069	0.700
MOD_CK2_1	182	188	PF00069	0.648
MOD_CK2_1	195	201	PF00069	0.664
MOD_CK2_1	9	15	PF00069	0.625
MOD_GlcNHglycan	213	216	PF01048	0.485
MOD_GlcNHglycan	42	45	PF01048	0.487
MOD_GlcNHglycan	53	56	PF01048	0.382
MOD_GlcNHglycan	8	11	PF01048	0.494
MOD_GlcNHglycan	81	84	PF01048	0.492
MOD_GSK3_1	16	23	PF00069	0.658
MOD_GSK3_1	36	43	PF00069	0.762
MOD_GSK3_1	50	57	PF00069	0.678
MOD_NEK2_1	1	6	PF00069	0.665
MOD_NEK2_1	16	21	PF00069	0.664
MOD_NEK2_1	219	224	PF00069	0.459
MOD_PIKK_1	61	67	PF00454	0.635
MOD_PKA_2	33	39	PF00069	0.705
MOD_PKA_2	61	67	PF00069	0.721
MOD_Plk_1	85	91	PF00069	0.680
MOD_Plk_4	26	32	PF00069	0.678
MOD_ProDKin_1	153	159	PF00069	0.680
MOD_ProDKin_1	161	167	PF00069	0.687
TRG_ENDOCYTIC_2	193	196	PF00928	0.680
TRG_ER_diArg_1	203	205	PF00400	0.597
TRG_ER_diArg_1	67	69	PF00400	0.707
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.713

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIS0	Leptomonas seymouri	65%	100%
A0A0S4IWD5	Bodo saltans	36%	100%
A0A1X0NKL7	Trypanosomatidae	51%	100%
A0A3S7X940	Leishmania donovani	87%	94%
A4HMC5	Leishmania braziliensis	77%	100%
A4IAZ1	Leishmania infantum	87%	94%
C9ZNI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AER9	Leishmania major	96%	100%