Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5X3_LEIMU

TriTrypDb:

LmxM.34.0930

Length:

168

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9B5X3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5X3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.345
CLV_NRD_NRD_1	135	137	PF00675	0.383
CLV_NRD_NRD_1	45	47	PF00675	0.470
CLV_NRD_NRD_1	90	92	PF00675	0.337
CLV_PCSK_FUR_1	133	137	PF00082	0.309
CLV_PCSK_KEX2_1	134	136	PF00082	0.379
CLV_PCSK_KEX2_1	45	47	PF00082	0.470
CLV_PCSK_KEX2_1	90	92	PF00082	0.337
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.441
CLV_PCSK_PC7_1	131	137	PF00082	0.385
CLV_PCSK_PC7_1	41	47	PF00082	0.321
CLV_PCSK_SKI1_1	145	149	PF00082	0.290
CLV_Separin_Metazoa	87	91	PF03568	0.571
DOC_MAPK_MEF2A_6	145	153	PF00069	0.465
DOC_USP7_MATH_1	13	17	PF00917	0.608
DOC_USP7_MATH_1	20	24	PF00917	0.739
DOC_USP7_UBL2_3	114	118	PF12436	0.639
DOC_WW_Pin1_4	120	125	PF00397	0.566
DOC_WW_Pin1_4	21	26	PF00397	0.739
DOC_WW_Pin1_4	91	96	PF00397	0.614
LIG_14-3-3_CanoR_1	90	94	PF00244	0.612
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BRCT_BRCA1_1	155	159	PF00533	0.352
LIG_FHA_1	144	150	PF00498	0.526
LIG_FHA_2	53	59	PF00498	0.672
LIG_LIR_Gen_1	158	167	PF02991	0.209
LIG_LIR_Nem_3	142	147	PF02991	0.600
LIG_LIR_Nem_3	158	164	PF02991	0.312
LIG_LIR_Nem_3	96	101	PF02991	0.556
LIG_REV1ctd_RIR_1	164	168	PF16727	0.490
LIG_SH2_CRK	144	148	PF00017	0.374
LIG_SH2_STAT3	66	69	PF00017	0.579
LIG_SUMO_SIM_anti_2	146	152	PF11976	0.289
LIG_SUMO_SIM_anti_2	85	90	PF11976	0.637
LIG_TRAF2_1	55	58	PF00917	0.578
LIG_UBA3_1	160	168	PF00899	0.343
MOD_CK1_1	16	22	PF00069	0.733
MOD_CK1_1	68	74	PF00069	0.578
MOD_CK1_1	94	100	PF00069	0.535
MOD_CK2_1	120	126	PF00069	0.606
MOD_CK2_1	52	58	PF00069	0.572
MOD_CK2_1	94	100	PF00069	0.642
MOD_DYRK1A_RPxSP_1	91	95	PF00069	0.613
MOD_GlcNHglycan	15	18	PF01048	0.438
MOD_GlcNHglycan	20	23	PF01048	0.475
MOD_GSK3_1	155	162	PF00069	0.192
MOD_GSK3_1	16	23	PF00069	0.750
MOD_GSK3_1	89	96	PF00069	0.538
MOD_NEK2_1	159	164	PF00069	0.372
MOD_NEK2_1	89	94	PF00069	0.629
MOD_PIKK_1	52	58	PF00454	0.628
MOD_PIKK_1	65	71	PF00454	0.612
MOD_PKA_2	89	95	PF00069	0.612
MOD_Plk_4	143	149	PF00069	0.487
MOD_ProDKin_1	120	126	PF00069	0.566
MOD_ProDKin_1	21	27	PF00069	0.741
MOD_ProDKin_1	91	97	PF00069	0.611
MOD_SUMO_for_1	113	116	PF00179	0.602
MOD_SUMO_rev_2	115	120	PF00179	0.683
TRG_ENDOCYTIC_2	144	147	PF00928	0.553
TRG_ER_diArg_1	130	133	PF00400	0.517
TRG_ER_diArg_1	44	46	PF00400	0.570
TRG_ER_diArg_1	89	91	PF00400	0.535
TRG_NLS_MonoCore_2	132	137	PF00514	0.621
TRG_NLS_MonoExtN_4	131	138	PF00514	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT3	Leptomonas seymouri	66%	78%
A0A0S4IZW1	Bodo saltans	27%	100%
A0A3Q8IV31	Leishmania donovani	89%	99%
A0A3R7JZ23	Trypanosoma rangeli	37%	90%
A4HMC4	Leishmania braziliensis	77%	100%
A4IAZ0	Leishmania infantum	89%	99%
C9ZNI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	80%
E9AER8	Leishmania major	91%	100%