LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B5W9_LEIMU
TriTrypDb:
LmxM.34.0890
Length:
165

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B5W9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5W9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 146 148 PF00675 0.522
CLV_PCSK_KEX2_1 146 148 PF00082 0.522
DEG_Nend_Nbox_1 1 3 PF02207 0.785
DEG_SPOP_SBC_1 77 81 PF00917 0.714
DEG_SPOP_SBC_1 83 87 PF00917 0.735
DOC_CYCLIN_yCln2_LP_2 47 53 PF00134 0.591
DOC_PP2B_LxvP_1 111 114 PF13499 0.651
DOC_USP7_MATH_1 24 28 PF00917 0.684
DOC_USP7_MATH_1 83 87 PF00917 0.720
DOC_USP7_UBL2_3 159 163 PF12436 0.689
DOC_USP7_UBL2_3 6 10 PF12436 0.701
DOC_WW_Pin1_4 4 9 PF00397 0.698
DOC_WW_Pin1_4 46 51 PF00397 0.590
DOC_WW_Pin1_4 85 90 PF00397 0.757
LIG_14-3-3_CanoR_1 146 152 PF00244 0.602
LIG_LIR_Gen_1 107 115 PF02991 0.652
LIG_LIR_Nem_3 107 113 PF02991 0.585
LIG_LIR_Nem_3 27 32 PF02991 0.579
LIG_SH2_CRK 69 73 PF00017 0.645
LIG_SH2_STAP1 119 123 PF00017 0.505
LIG_SH3_3 86 92 PF00018 0.777
LIG_SUMO_SIM_anti_2 135 141 PF11976 0.402
MOD_CDK_SPxK_1 4 10 PF00069 0.662
MOD_CK1_1 35 41 PF00069 0.677
MOD_CK1_1 4 10 PF00069 0.758
MOD_CK1_1 76 82 PF00069 0.729
MOD_CK1_1 85 91 PF00069 0.683
MOD_GlcNHglycan 100 103 PF01048 0.614
MOD_GlcNHglycan 75 78 PF01048 0.658
MOD_GSK3_1 72 79 PF00069 0.635
MOD_GSK3_1 94 101 PF00069 0.703
MOD_N-GLC_1 35 40 PF02516 0.552
MOD_NEK2_1 1 6 PF00069 0.781
MOD_NEK2_1 51 56 PF00069 0.601
MOD_NEK2_1 72 77 PF00069 0.632
MOD_PIKK_1 145 151 PF00454 0.640
MOD_PKA_2 145 151 PF00069 0.713
MOD_Plk_1 129 135 PF00069 0.558
MOD_Plk_1 35 41 PF00069 0.571
MOD_Plk_4 153 159 PF00069 0.730
MOD_Plk_4 35 41 PF00069 0.680
MOD_ProDKin_1 4 10 PF00069 0.700
MOD_ProDKin_1 46 52 PF00069 0.593
MOD_ProDKin_1 85 91 PF00069 0.753
MOD_SUMO_rev_2 27 32 PF00179 0.687
MOD_SUMO_rev_2 97 102 PF00179 0.752
TRG_ENDOCYTIC_2 69 72 PF00928 0.642

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3P8 Leptomonas seymouri 62% 93%
A0A1X0NIU2 Trypanosomatidae 35% 100%
A0A3R7KNC4 Trypanosoma rangeli 35% 96%
A0A3S7X8W7 Leishmania donovani 91% 100%
A4HMC0 Leishmania braziliensis 81% 100%
A4IAY6 Leishmania infantum 90% 100%
C9ZNI3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9AER4 Leishmania major 92% 100%
V5D1X1 Trypanosoma cruzi 37% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS