Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5W8_LEIMU

TriTrypDb:

LmxM.34.0880

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5W8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.495
CLV_C14_Caspase3-7	241	245	PF00656	0.755
CLV_C14_Caspase3-7	92	96	PF00656	0.538
CLV_NRD_NRD_1	107	109	PF00675	0.492
CLV_NRD_NRD_1	116	118	PF00675	0.580
CLV_NRD_NRD_1	126	128	PF00675	0.486
CLV_NRD_NRD_1	302	304	PF00675	0.610
CLV_NRD_NRD_1	378	380	PF00675	0.585
CLV_NRD_NRD_1	442	444	PF00675	0.670
CLV_NRD_NRD_1	509	511	PF00675	0.572
CLV_PCSK_FUR_1	386	390	PF00082	0.499
CLV_PCSK_FUR_1	448	452	PF00082	0.679
CLV_PCSK_FUR_1	505	509	PF00082	0.623
CLV_PCSK_KEX2_1	107	109	PF00082	0.505
CLV_PCSK_KEX2_1	126	128	PF00082	0.608
CLV_PCSK_KEX2_1	148	150	PF00082	0.558
CLV_PCSK_KEX2_1	301	303	PF00082	0.575
CLV_PCSK_KEX2_1	378	380	PF00082	0.555
CLV_PCSK_KEX2_1	388	390	PF00082	0.448
CLV_PCSK_KEX2_1	442	444	PF00082	0.664
CLV_PCSK_KEX2_1	447	449	PF00082	0.620
CLV_PCSK_KEX2_1	450	452	PF00082	0.607
CLV_PCSK_KEX2_1	507	509	PF00082	0.575
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.558
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.609
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.504
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.702
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.697
CLV_PCSK_PC7_1	443	449	PF00082	0.704
CLV_PCSK_PC7_1	505	511	PF00082	0.670
CLV_PCSK_SKI1_1	100	104	PF00082	0.496
CLV_PCSK_SKI1_1	107	111	PF00082	0.473
CLV_PCSK_SKI1_1	358	362	PF00082	0.456
CLV_PCSK_SKI1_1	42	46	PF00082	0.640
CLV_PCSK_SKI1_1	486	490	PF00082	0.697
CLV_PCSK_SKI1_1	501	505	PF00082	0.575
DEG_APCC_DBOX_1	13	21	PF00400	0.562
DEG_APCC_DBOX_1	139	147	PF00400	0.575
DEG_APCC_DBOX_1	377	385	PF00400	0.585
DEG_SPOP_SBC_1	5	9	PF00917	0.603
DOC_CYCLIN_RxL_1	355	363	PF00134	0.564
DOC_MAPK_gen_1	12	20	PF00069	0.514
DOC_MAPK_gen_1	126	133	PF00069	0.583
DOC_MAPK_gen_1	45	55	PF00069	0.546
DOC_MAPK_MEF2A_6	126	133	PF00069	0.583
DOC_MAPK_MEF2A_6	48	57	PF00069	0.569
DOC_MAPK_NFAT4_5	126	134	PF00069	0.549
DOC_MAPK_RevD_3	289	302	PF00069	0.579
DOC_PP4_FxxP_1	489	492	PF00568	0.631
DOC_USP7_MATH_1	132	136	PF00917	0.517
DOC_USP7_MATH_1	167	171	PF00917	0.743
DOC_USP7_MATH_1	231	235	PF00917	0.584
DOC_USP7_MATH_1	332	336	PF00917	0.720
DOC_USP7_MATH_1	452	456	PF00917	0.697
DOC_USP7_MATH_1	6	10	PF00917	0.538
DOC_USP7_MATH_1	98	102	PF00917	0.592
DOC_WW_Pin1_4	225	230	PF00397	0.657
DOC_WW_Pin1_4	462	467	PF00397	0.673
LIG_14-3-3_CanoR_1	378	382	PF00244	0.541
LIG_14-3-3_CanoR_1	442	446	PF00244	0.643
LIG_14-3-3_CanoR_1	451	461	PF00244	0.575
LIG_14-3-3_CanoR_1	54	60	PF00244	0.526
LIG_14-3-3_CterR_2	516	519	PF00244	0.678
LIG_Actin_WH2_2	363	380	PF00022	0.509
LIG_BRCT_BRCA1_1	362	366	PF00533	0.499
LIG_CtBP_PxDLS_1	290	294	PF00389	0.601
LIG_DLG_GKlike_1	65	72	PF00625	0.652
LIG_FHA_1	275	281	PF00498	0.555
LIG_FHA_1	5	11	PF00498	0.595
LIG_FHA_1	68	74	PF00498	0.635
LIG_FHA_2	191	197	PF00498	0.577
LIG_FHA_2	239	245	PF00498	0.773
LIG_FHA_2	247	253	PF00498	0.796
LIG_FHA_2	277	283	PF00498	0.597
LIG_FHA_2	307	313	PF00498	0.600
LIG_FHA_2	389	395	PF00498	0.615
LIG_FHA_2	495	501	PF00498	0.679
LIG_FHA_2	6	12	PF00498	0.504
LIG_FHA_2	62	68	PF00498	0.655
LIG_LIR_Gen_1	125	136	PF02991	0.487
LIG_LIR_Gen_1	76	83	PF02991	0.586
LIG_LIR_Nem_3	125	131	PF02991	0.488
LIG_LIR_Nem_3	76	80	PF02991	0.616
LIG_NBox_RRM_1	397	407	PF00076	0.622
LIG_NRBOX	216	222	PF00104	0.561
LIG_SH2_CRK	128	132	PF00017	0.581
LIG_SH2_CRK	77	81	PF00017	0.660
LIG_SH2_SRC	319	322	PF00017	0.607
LIG_SH2_STAP1	319	323	PF00017	0.660
LIG_SH2_STAT3	266	269	PF00017	0.634
LIG_SH2_STAT5	266	269	PF00017	0.545
LIG_SH2_STAT5	272	275	PF00017	0.641
LIG_SH2_STAT5	474	477	PF00017	0.635
LIG_SH3_3	346	352	PF00018	0.676
LIG_SH3_3	463	469	PF00018	0.665
LIG_SUMO_SIM_anti_2	215	223	PF11976	0.488
LIG_SUMO_SIM_par_1	215	223	PF11976	0.670
LIG_TRAF2_1	406	409	PF00917	0.542
LIG_TRAF2_1	430	433	PF00917	0.700
LIG_WW_3	483	487	PF00397	0.571
MOD_CK1_1	219	225	PF00069	0.677
MOD_CK1_1	465	471	PF00069	0.733
MOD_CK2_1	132	138	PF00069	0.555
MOD_CK2_1	190	196	PF00069	0.522
MOD_CK2_1	227	233	PF00069	0.686
MOD_CK2_1	246	252	PF00069	0.787
MOD_CK2_1	276	282	PF00069	0.552
MOD_CK2_1	306	312	PF00069	0.496
MOD_CK2_1	332	338	PF00069	0.539
MOD_CK2_1	427	433	PF00069	0.701
MOD_CK2_1	443	449	PF00069	0.454
MOD_CK2_1	494	500	PF00069	0.581
MOD_Cter_Amidation	505	508	PF01082	0.667
MOD_GlcNHglycan	320	324	PF01048	0.633
MOD_GlcNHglycan	428	432	PF01048	0.666
MOD_GSK3_1	175	182	PF00069	0.634
MOD_GSK3_1	219	226	PF00069	0.648
MOD_GSK3_1	227	234	PF00069	0.768
MOD_GSK3_1	276	283	PF00069	0.608
MOD_GSK3_1	332	339	PF00069	0.641
MOD_GSK3_1	57	64	PF00069	0.637
MOD_N-GLC_1	120	125	PF02516	0.617
MOD_N-GLC_1	175	180	PF02516	0.628
MOD_N-GLC_1	306	311	PF02516	0.441
MOD_N-GLC_2	348	350	PF02516	0.617
MOD_NEK2_1	131	136	PF00069	0.578
MOD_NEK2_1	438	443	PF00069	0.739
MOD_PIKK_1	184	190	PF00454	0.458
MOD_PIKK_1	336	342	PF00454	0.494
MOD_PKA_1	388	394	PF00069	0.614
MOD_PKA_2	280	286	PF00069	0.666
MOD_PKA_2	377	383	PF00069	0.526
MOD_PKA_2	388	394	PF00069	0.499
MOD_PKA_2	438	444	PF00069	0.767
MOD_Plk_1	175	181	PF00069	0.593
MOD_Plk_1	232	238	PF00069	0.659
MOD_Plk_1	319	325	PF00069	0.683
MOD_Plk_1	408	414	PF00069	0.554
MOD_Plk_1	65	71	PF00069	0.528
MOD_Plk_1	75	81	PF00069	0.599
MOD_Plk_2-3	306	312	PF00069	0.552
MOD_Plk_4	190	196	PF00069	0.594
MOD_Plk_4	213	219	PF00069	0.565
MOD_Plk_4	232	238	PF00069	0.729
MOD_Plk_4	293	299	PF00069	0.389
MOD_Plk_4	388	394	PF00069	0.622
MOD_ProDKin_1	225	231	PF00069	0.655
MOD_ProDKin_1	462	468	PF00069	0.665
MOD_SUMO_for_1	342	345	PF00179	0.721
MOD_SUMO_for_1	387	390	PF00179	0.611
MOD_SUMO_rev_2	257	264	PF00179	0.551
MOD_SUMO_rev_2	29	34	PF00179	0.561
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.328
TRG_ENDOCYTIC_2	128	131	PF00928	0.535
TRG_ENDOCYTIC_2	476	479	PF00928	0.569
TRG_ENDOCYTIC_2	77	80	PF00928	0.624
TRG_ER_diArg_1	107	109	PF00400	0.454
TRG_ER_diArg_1	126	128	PF00400	0.579
TRG_ER_diArg_1	377	379	PF00400	0.614
TRG_ER_diArg_1	504	507	PF00400	0.615
TRG_ER_diArg_1	508	510	PF00400	0.569
TRG_NLS_MonoExtC_3	300	306	PF00514	0.562
TRG_NLS_MonoExtN_4	299	305	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0N1	Leptomonas seymouri	53%	90%
A0A1X0NJ03	Trypanosomatidae	29%	89%
A0A3S7X8Y2	Leishmania donovani	90%	100%
A0A422NI80	Trypanosoma rangeli	31%	92%
A4HMB9	Leishmania braziliensis	81%	100%
A4IAY5	Leishmania infantum	90%	100%
C9ZNI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	89%
E9AER3	Leishmania major	89%	100%