Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5W7_LEIMU

TriTrypDb:

LmxM.34.0870

Length:

923

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0070209	ASTRA complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9B5W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5W7

Function

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006278	RNA-templated DNA biosynthetic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006996	organelle organization	4	1
GO:0007004	telomere maintenance via telomerase	7	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010833	telomere maintenance via telomere lengthening	6	1
GO:0016043	cellular component organization	3	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0031647	regulation of protein stability	3	1
GO:0032200	telomere organization	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050821	protein stabilization	4	1
GO:0051276	chromosome organization	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0071897	DNA biosynthetic process	5	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0031072	heat shock protein binding	3	1
GO:0042162	telomeric DNA binding	6	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0051879	Hsp90 protein binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.559
CLV_MEL_PAP_1	458	464	PF00089	0.742
CLV_NRD_NRD_1	171	173	PF00675	0.491
CLV_NRD_NRD_1	180	182	PF00675	0.431
CLV_NRD_NRD_1	221	223	PF00675	0.672
CLV_NRD_NRD_1	708	710	PF00675	0.656
CLV_NRD_NRD_1	722	724	PF00675	0.520
CLV_NRD_NRD_1	819	821	PF00675	0.423
CLV_NRD_NRD_1	843	845	PF00675	0.577
CLV_PCSK_KEX2_1	171	173	PF00082	0.485
CLV_PCSK_KEX2_1	180	182	PF00082	0.431
CLV_PCSK_KEX2_1	221	223	PF00082	0.624
CLV_PCSK_KEX2_1	242	244	PF00082	0.544
CLV_PCSK_KEX2_1	722	724	PF00082	0.617
CLV_PCSK_KEX2_1	843	845	PF00082	0.577
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.544
CLV_PCSK_SKI1_1	115	119	PF00082	0.562
CLV_PCSK_SKI1_1	156	160	PF00082	0.508
CLV_PCSK_SKI1_1	187	191	PF00082	0.480
CLV_PCSK_SKI1_1	297	301	PF00082	0.428
CLV_PCSK_SKI1_1	9	13	PF00082	0.426
CLV_Separin_Metazoa	829	833	PF03568	0.361
DEG_APCC_DBOX_1	296	304	PF00400	0.396
DEG_APCC_DBOX_1	8	16	PF00400	0.562
DEG_MDM2_SWIB_1	863	871	PF02201	0.470
DEG_SCF_FBW7_1	65	72	PF00400	0.242
DOC_CKS1_1	258	263	PF01111	0.417
DOC_CKS1_1	772	777	PF01111	0.481
DOC_CYCLIN_RxL_1	181	193	PF00134	0.547
DOC_CYCLIN_RxL_1	853	864	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	345	351	PF00134	0.473
DOC_CYCLIN_yCln2_LP_2	630	636	PF00134	0.540
DOC_MAPK_DCC_7	832	842	PF00069	0.506
DOC_MAPK_gen_1	171	179	PF00069	0.454
DOC_MAPK_gen_1	43	52	PF00069	0.565
DOC_MAPK_gen_1	620	629	PF00069	0.382
DOC_MAPK_gen_1	709	715	PF00069	0.735
DOC_MAPK_HePTP_8	617	629	PF00069	0.493
DOC_MAPK_MEF2A_6	45	54	PF00069	0.523
DOC_MAPK_MEF2A_6	620	629	PF00069	0.398
DOC_MAPK_RevD_3	165	181	PF00069	0.524
DOC_PP1_RVXF_1	857	864	PF00149	0.539
DOC_PP2B_LxvP_1	630	633	PF13499	0.541
DOC_USP7_MATH_1	223	227	PF00917	0.535
DOC_USP7_MATH_1	361	365	PF00917	0.646
DOC_USP7_MATH_1	433	437	PF00917	0.659
DOC_USP7_MATH_1	511	515	PF00917	0.747
DOC_USP7_MATH_1	559	563	PF00917	0.468
DOC_USP7_MATH_1	823	827	PF00917	0.490
DOC_USP7_MATH_1	895	899	PF00917	0.480
DOC_USP7_UBL2_3	327	331	PF12436	0.535
DOC_WW_Pin1_4	257	262	PF00397	0.406
DOC_WW_Pin1_4	357	362	PF00397	0.320
DOC_WW_Pin1_4	545	550	PF00397	0.601
DOC_WW_Pin1_4	65	70	PF00397	0.432
DOC_WW_Pin1_4	771	776	PF00397	0.487
LIG_14-3-3_CanoR_1	115	120	PF00244	0.601
LIG_14-3-3_CanoR_1	171	179	PF00244	0.543
LIG_14-3-3_CanoR_1	231	236	PF00244	0.507
LIG_14-3-3_CanoR_1	289	296	PF00244	0.474
LIG_14-3-3_CanoR_1	461	466	PF00244	0.664
LIG_14-3-3_CanoR_1	482	490	PF00244	0.583
LIG_14-3-3_CanoR_1	565	574	PF00244	0.498
LIG_14-3-3_CanoR_1	709	715	PF00244	0.509
LIG_Actin_WH2_2	155	173	PF00022	0.535
LIG_AP2alpha_1	366	370	PF02296	0.586
LIG_BRCT_BRCA1_1	321	325	PF00533	0.517
LIG_BRCT_BRCA1_1	567	571	PF00533	0.555
LIG_BRCT_BRCA1_1	579	583	PF00533	0.521
LIG_BRCT_BRCA1_1	859	863	PF00533	0.453
LIG_BRCT_BRCA1_2	321	327	PF00533	0.540
LIG_BRCT_BRCA1_2	567	573	PF00533	0.567
LIG_BRCT_BRCA1_2	859	865	PF00533	0.561
LIG_CaM_IQ_9	234	249	PF13499	0.258
LIG_eIF4E_1	651	657	PF01652	0.518
LIG_EVH1_1	697	701	PF00568	0.615
LIG_FHA_1	131	137	PF00498	0.478
LIG_FHA_1	153	159	PF00498	0.474
LIG_FHA_1	274	280	PF00498	0.456
LIG_FHA_1	289	295	PF00498	0.484
LIG_FHA_1	377	383	PF00498	0.565
LIG_FHA_1	401	407	PF00498	0.432
LIG_FHA_1	65	71	PF00498	0.417
LIG_FHA_1	652	658	PF00498	0.541
LIG_FHA_1	700	706	PF00498	0.592
LIG_FHA_1	709	715	PF00498	0.609
LIG_FHA_1	889	895	PF00498	0.517
LIG_FHA_2	312	318	PF00498	0.518
LIG_FHA_2	333	339	PF00498	0.534
LIG_FHA_2	358	364	PF00498	0.331
LIG_FHA_2	519	525	PF00498	0.571
LIG_FHA_2	686	692	PF00498	0.570
LIG_FHA_2	875	881	PF00498	0.516
LIG_LIR_Gen_1	124	135	PF02991	0.501
LIG_LIR_Gen_1	234	244	PF02991	0.474
LIG_LIR_Gen_1	3	12	PF02991	0.524
LIG_LIR_Gen_1	319	325	PF02991	0.463
LIG_LIR_Gen_1	537	545	PF02991	0.445
LIG_LIR_Gen_1	568	578	PF02991	0.521
LIG_LIR_Gen_1	580	589	PF02991	0.582
LIG_LIR_Gen_1	590	601	PF02991	0.269
LIG_LIR_Gen_1	762	772	PF02991	0.461
LIG_LIR_Gen_1	801	810	PF02991	0.454
LIG_LIR_Gen_1	907	916	PF02991	0.542
LIG_LIR_Nem_3	124	130	PF02991	0.407
LIG_LIR_Nem_3	197	202	PF02991	0.437
LIG_LIR_Nem_3	234	240	PF02991	0.461
LIG_LIR_Nem_3	3	7	PF02991	0.514
LIG_LIR_Nem_3	319	324	PF02991	0.468
LIG_LIR_Nem_3	474	480	PF02991	0.598
LIG_LIR_Nem_3	537	542	PF02991	0.431
LIG_LIR_Nem_3	568	574	PF02991	0.536
LIG_LIR_Nem_3	58	64	PF02991	0.595
LIG_LIR_Nem_3	580	586	PF02991	0.557
LIG_LIR_Nem_3	590	596	PF02991	0.284
LIG_LIR_Nem_3	646	651	PF02991	0.475
LIG_LIR_Nem_3	762	767	PF02991	0.464
LIG_LIR_Nem_3	783	789	PF02991	0.483
LIG_LIR_Nem_3	801	807	PF02991	0.307
LIG_LIR_Nem_3	833	837	PF02991	0.489
LIG_LIR_Nem_3	857	861	PF02991	0.532
LIG_LIR_Nem_3	907	913	PF02991	0.542
LIG_LYPXL_S_1	696	700	PF13949	0.568
LIG_LYPXL_yS_3	697	700	PF13949	0.567
LIG_NRBOX	164	170	PF00104	0.462
LIG_PCNA_yPIPBox_3	231	240	PF02747	0.521
LIG_Pex14_2	195	199	PF04695	0.495
LIG_Pex14_2	321	325	PF04695	0.406
LIG_Pex14_2	366	370	PF04695	0.586
LIG_Pex14_2	751	755	PF04695	0.493
LIG_Pex14_2	804	808	PF04695	0.505
LIG_Pex14_2	863	867	PF04695	0.405
LIG_PTB_Apo_2	268	275	PF02174	0.472
LIG_REV1ctd_RIR_1	477	486	PF16727	0.634
LIG_SH2_CRK	351	355	PF00017	0.480
LIG_SH2_CRK	401	405	PF00017	0.543
LIG_SH2_CRK	539	543	PF00017	0.432
LIG_SH2_CRK	621	625	PF00017	0.487
LIG_SH2_CRK	740	744	PF00017	0.485
LIG_SH2_CRK	858	862	PF00017	0.553
LIG_SH2_CRK	910	914	PF00017	0.549
LIG_SH2_GRB2like	740	743	PF00017	0.607
LIG_SH2_STAP1	275	279	PF00017	0.334
LIG_SH2_STAP1	351	355	PF00017	0.480
LIG_SH2_STAP1	401	405	PF00017	0.543
LIG_SH2_STAP1	438	442	PF00017	0.725
LIG_SH2_STAP1	57	61	PF00017	0.335
LIG_SH2_STAP1	740	744	PF00017	0.505
LIG_SH2_STAP1	910	914	PF00017	0.549
LIG_SH2_STAT5	138	141	PF00017	0.532
LIG_SH2_STAT5	188	191	PF00017	0.561
LIG_SH2_STAT5	275	278	PF00017	0.397
LIG_SH2_STAT5	520	523	PF00017	0.554
LIG_SH2_STAT5	64	67	PF00017	0.289
LIG_SH2_STAT5	773	776	PF00017	0.440
LIG_SH3_1	695	701	PF00018	0.605
LIG_SH3_3	19	25	PF00018	0.668
LIG_SH3_3	467	473	PF00018	0.579
LIG_SH3_3	593	599	PF00018	0.447
LIG_SH3_3	626	632	PF00018	0.482
LIG_SH3_3	695	701	PF00018	0.619
LIG_SH3_3	769	775	PF00018	0.445
LIG_SH3_3	98	104	PF00018	0.496
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.273
LIG_SUMO_SIM_anti_2	527	534	PF11976	0.456
LIG_SUMO_SIM_anti_2	592	598	PF11976	0.380
LIG_SUMO_SIM_anti_2	626	631	PF11976	0.370
LIG_SUMO_SIM_anti_2	826	833	PF11976	0.476
LIG_SUMO_SIM_anti_2	869	875	PF11976	0.474
LIG_SUMO_SIM_par_1	600	605	PF11976	0.496
LIG_SUMO_SIM_par_1	891	898	PF11976	0.430
LIG_TRAF2_1	473	476	PF00917	0.728
LIG_TYR_ITIM	349	354	PF00017	0.372
LIG_TYR_ITIM	619	624	PF00017	0.423
LIG_TYR_ITIM	856	861	PF00017	0.562
LIG_UBA3_1	158	163	PF00899	0.517
LIG_UBA3_1	178	187	PF00899	0.207
LIG_UBA3_1	235	242	PF00899	0.495
LIG_UBA3_1	353	359	PF00899	0.461
LIG_UBA3_1	616	622	PF00899	0.320
LIG_WRC_WIRS_1	512	517	PF05994	0.605
MOD_CK1_1	18	24	PF00069	0.469
MOD_CK1_1	216	222	PF00069	0.657
MOD_CK1_1	252	258	PF00069	0.547
MOD_CK1_1	443	449	PF00069	0.671
MOD_CK1_1	483	489	PF00069	0.572
MOD_CK1_1	530	536	PF00069	0.529
MOD_CK1_1	676	682	PF00069	0.688
MOD_CK1_1	708	714	PF00069	0.554
MOD_CK1_1	781	787	PF00069	0.479
MOD_CK2_1	311	317	PF00069	0.476
MOD_CK2_1	357	363	PF00069	0.326
MOD_CK2_1	461	467	PF00069	0.705
MOD_CK2_1	518	524	PF00069	0.560
MOD_CK2_1	531	537	PF00069	0.446
MOD_CK2_1	665	671	PF00069	0.424
MOD_CK2_1	685	691	PF00069	0.727
MOD_CK2_1	823	829	PF00069	0.472
MOD_CK2_1	866	872	PF00069	0.535
MOD_CK2_1	99	105	PF00069	0.443
MOD_CMANNOS	229	232	PF00535	0.407
MOD_GlcNHglycan	251	254	PF01048	0.527
MOD_GlcNHglycan	321	324	PF01048	0.539
MOD_GlcNHglycan	335	338	PF01048	0.462
MOD_GlcNHglycan	407	410	PF01048	0.598
MOD_GlcNHglycan	561	564	PF01048	0.423
MOD_GlcNHglycan	675	678	PF01048	0.714
MOD_GlcNHglycan	82	86	PF01048	0.648
MOD_GlcNHglycan	868	871	PF01048	0.531
MOD_GSK3_1	333	340	PF00069	0.501
MOD_GSK3_1	357	364	PF00069	0.473
MOD_GSK3_1	527	534	PF00069	0.456
MOD_GSK3_1	65	72	PF00069	0.491
MOD_GSK3_1	673	680	PF00069	0.633
MOD_GSK3_1	699	706	PF00069	0.614
MOD_GSK3_1	709	716	PF00069	0.608
MOD_GSK3_1	77	84	PF00069	0.510
MOD_GSK3_1	857	864	PF00069	0.488
MOD_N-GLC_1	115	120	PF02516	0.595
MOD_N-GLC_1	419	424	PF02516	0.548
MOD_N-GLC_1	732	737	PF02516	0.726
MOD_N-GLC_1	815	820	PF02516	0.461
MOD_N-GLC_2	146	148	PF02516	0.438
MOD_NEK2_1	121	126	PF00069	0.467
MOD_NEK2_1	130	135	PF00069	0.357
MOD_NEK2_1	137	142	PF00069	0.338
MOD_NEK2_1	15	20	PF00069	0.595
MOD_NEK2_1	207	212	PF00069	0.478
MOD_NEK2_1	382	387	PF00069	0.578
MOD_NEK2_1	460	465	PF00069	0.740
MOD_NEK2_1	480	485	PF00069	0.426
MOD_NEK2_1	665	670	PF00069	0.515
MOD_NEK2_1	705	710	PF00069	0.431
MOD_NEK2_1	861	866	PF00069	0.452
MOD_NEK2_1	874	879	PF00069	0.544
MOD_NEK2_1	99	104	PF00069	0.394
MOD_NEK2_2	213	218	PF00069	0.668
MOD_NEK2_2	400	405	PF00069	0.421
MOD_NEK2_2	815	820	PF00069	0.461
MOD_NEK2_2	895	900	PF00069	0.509
MOD_PIKK_1	109	115	PF00454	0.546
MOD_PIKK_1	216	222	PF00454	0.705
MOD_PIKK_1	433	439	PF00454	0.703
MOD_PIKK_1	443	449	PF00454	0.622
MOD_PIKK_1	665	671	PF00454	0.466
MOD_PK_1	709	715	PF00069	0.703
MOD_PKA_1	709	715	PF00069	0.735
MOD_PKA_2	15	21	PF00069	0.576
MOD_PKA_2	288	294	PF00069	0.483
MOD_PKA_2	311	317	PF00069	0.525
MOD_PKA_2	460	466	PF00069	0.613
MOD_PKA_2	481	487	PF00069	0.720
MOD_PKA_2	587	593	PF00069	0.559
MOD_PKA_2	708	714	PF00069	0.581
MOD_PKB_1	575	583	PF00069	0.543
MOD_Plk_1	115	121	PF00069	0.572
MOD_Plk_1	223	229	PF00069	0.507
MOD_Plk_1	337	343	PF00069	0.450
MOD_Plk_1	419	425	PF00069	0.502
MOD_Plk_1	815	821	PF00069	0.566
MOD_Plk_2-3	3	9	PF00069	0.489
MOD_Plk_2-3	685	691	PF00069	0.559
MOD_Plk_4	115	121	PF00069	0.554
MOD_Plk_4	130	136	PF00069	0.338
MOD_Plk_4	157	163	PF00069	0.395
MOD_Plk_4	224	230	PF00069	0.482
MOD_Plk_4	231	237	PF00069	0.406
MOD_Plk_4	400	406	PF00069	0.406
MOD_Plk_4	461	467	PF00069	0.737
MOD_Plk_4	527	533	PF00069	0.500
MOD_Plk_4	589	595	PF00069	0.476
MOD_Plk_4	597	603	PF00069	0.437
MOD_Plk_4	709	715	PF00069	0.636
MOD_Plk_4	781	787	PF00069	0.394
MOD_Plk_4	823	829	PF00069	0.427
MOD_Plk_4	83	89	PF00069	0.571
MOD_Plk_4	908	914	PF00069	0.575
MOD_ProDKin_1	257	263	PF00069	0.409
MOD_ProDKin_1	357	363	PF00069	0.326
MOD_ProDKin_1	545	551	PF00069	0.595
MOD_ProDKin_1	65	71	PF00069	0.428
MOD_ProDKin_1	771	777	PF00069	0.482
MOD_SUMO_for_1	429	432	PF00179	0.498
MOD_SUMO_rev_2	149	158	PF00179	0.557
MOD_SUMO_rev_2	241	249	PF00179	0.529
MOD_SUMO_rev_2	712	721	PF00179	0.664
TRG_DiLeu_BaEn_1	154	159	PF01217	0.364
TRG_DiLeu_BaEn_2	328	334	PF01217	0.547
TRG_DiLeu_BaEn_2	588	594	PF01217	0.289
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.472
TRG_DiLeu_BaLyEn_6	411	416	PF01217	0.617
TRG_ENDOCYTIC_2	351	354	PF00928	0.379
TRG_ENDOCYTIC_2	401	404	PF00928	0.546
TRG_ENDOCYTIC_2	477	480	PF00928	0.720
TRG_ENDOCYTIC_2	539	542	PF00928	0.425
TRG_ENDOCYTIC_2	621	624	PF00928	0.399
TRG_ENDOCYTIC_2	697	700	PF00928	0.567
TRG_ENDOCYTIC_2	740	743	PF00928	0.506
TRG_ENDOCYTIC_2	858	861	PF00928	0.556
TRG_ENDOCYTIC_2	910	913	PF00928	0.550
TRG_ER_diArg_1	170	172	PF00400	0.441
TRG_ER_diArg_1	179	181	PF00400	0.431
TRG_ER_diArg_1	574	577	PF00400	0.577
TRG_ER_diArg_1	722	724	PF00400	0.617
TRG_ER_diArg_1	734	737	PF00400	0.585
TRG_ER_diArg_1	842	844	PF00400	0.513
TRG_NES_CRM1_1	35	48	PF08389	0.458
TRG_NES_CRM1_1	494	509	PF08389	0.683
TRG_Pf-PMV_PEXEL_1	565	569	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	900	905	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P438	Leptomonas seymouri	52%	100%
A0A1X0NJ45	Trypanosomatidae	31%	95%
A0A3Q8ILW9	Leishmania donovani	91%	100%
A0A3R7MMH0	Trypanosoma rangeli	32%	95%
A4HMB8	Leishmania braziliensis	78%	100%
A4IAY4	Leishmania infantum	91%	100%
C9ZNI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	96%
E9AER2	Leishmania major	92%	100%
V5BAN0	Trypanosoma cruzi	31%	94%