Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5W6_LEIMU

TriTrypDb:

LmxM.34.0860

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5W6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006400	tRNA modification	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	3
GO:0009055	electron transfer activity	3	3
GO:0016491	oxidoreductase activity	2	3
GO:0020037	heme binding	4	3
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046906	tetrapyrrole binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.727
CLV_C14_Caspase3-7	218	222	PF00656	0.793
CLV_C14_Caspase3-7	4	8	PF00656	0.767
CLV_C14_Caspase3-7	74	78	PF00656	0.727
CLV_C14_Caspase3-7	85	89	PF00656	0.562
CLV_NRD_NRD_1	153	155	PF00675	0.683
CLV_NRD_NRD_1	159	161	PF00675	0.703
CLV_NRD_NRD_1	277	279	PF00675	0.671
CLV_NRD_NRD_1	317	319	PF00675	0.671
CLV_NRD_NRD_1	388	390	PF00675	0.588
CLV_NRD_NRD_1	393	395	PF00675	0.554
CLV_PCSK_FUR_1	150	154	PF00082	0.761
CLV_PCSK_FUR_1	315	319	PF00082	0.748
CLV_PCSK_KEX2_1	123	125	PF00082	0.757
CLV_PCSK_KEX2_1	150	152	PF00082	0.669
CLV_PCSK_KEX2_1	153	155	PF00082	0.651
CLV_PCSK_KEX2_1	159	161	PF00082	0.703
CLV_PCSK_KEX2_1	2	4	PF00082	0.770
CLV_PCSK_KEX2_1	317	319	PF00082	0.671
CLV_PCSK_KEX2_1	388	390	PF00082	0.605
CLV_PCSK_KEX2_1	393	395	PF00082	0.577
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.785
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.770
CLV_PCSK_PC7_1	389	395	PF00082	0.514
CLV_PCSK_SKI1_1	19	23	PF00082	0.708
CLV_PCSK_SKI1_1	250	254	PF00082	0.520
CLV_PCSK_SKI1_1	278	282	PF00082	0.629
CLV_PCSK_SKI1_1	388	392	PF00082	0.714
DEG_Nend_UBRbox_1	1	4	PF02207	0.749
DEG_SCF_FBW7_2	53	58	PF00400	0.369
DEG_SPOP_SBC_1	214	218	PF00917	0.760
DOC_CYCLIN_RxL_1	13	25	PF00134	0.462
DOC_CYCLIN_RxL_1	275	282	PF00134	0.578
DOC_MAPK_gen_1	14	22	PF00069	0.636
DOC_MAPK_gen_1	278	285	PF00069	0.672
DOC_MAPK_gen_1	315	325	PF00069	0.673
DOC_MAPK_gen_1	41	50	PF00069	0.523
DOC_MAPK_MEF2A_6	172	179	PF00069	0.470
DOC_MAPK_MEF2A_6	278	285	PF00069	0.639
DOC_MAPK_MEF2A_6	318	327	PF00069	0.599
DOC_MAPK_NFAT4_5	172	180	PF00069	0.584
DOC_MAPK_NFAT4_5	278	286	PF00069	0.641
DOC_PP2B_LxvP_1	177	180	PF13499	0.574
DOC_SPAK_OSR1_1	354	358	PF12202	0.549
DOC_USP7_MATH_1	107	111	PF00917	0.513
DOC_USP7_MATH_1	213	217	PF00917	0.750
DOC_USP7_MATH_1	232	236	PF00917	0.366
DOC_USP7_MATH_1	307	311	PF00917	0.764
DOC_USP7_MATH_1	316	320	PF00917	0.721
DOC_USP7_MATH_1	341	345	PF00917	0.665
DOC_USP7_MATH_1	359	363	PF00917	0.448
DOC_USP7_MATH_1	79	83	PF00917	0.762
DOC_USP7_MATH_1	92	96	PF00917	0.578
DOC_WW_Pin1_4	133	138	PF00397	0.817
DOC_WW_Pin1_4	153	158	PF00397	0.739
DOC_WW_Pin1_4	412	417	PF00397	0.682
DOC_WW_Pin1_4	51	56	PF00397	0.411
LIG_14-3-3_CanoR_1	118	125	PF00244	0.732
LIG_14-3-3_CanoR_1	159	167	PF00244	0.647
LIG_14-3-3_CanoR_1	236	242	PF00244	0.618
LIG_14-3-3_CanoR_1	278	284	PF00244	0.590
LIG_14-3-3_CanoR_1	315	321	PF00244	0.649
LIG_14-3-3_CanoR_1	388	396	PF00244	0.676
LIG_BIR_III_2	221	225	PF00653	0.666
LIG_BIR_III_4	77	81	PF00653	0.736
LIG_BRCT_BRCA1_1	160	164	PF00533	0.663
LIG_BRCT_BRCA1_1	281	285	PF00533	0.605
LIG_FHA_1	225	231	PF00498	0.614
LIG_FHA_1	236	242	PF00498	0.532
LIG_FHA_1	320	326	PF00498	0.722
LIG_FHA_1	345	351	PF00498	0.579
LIG_FHA_1	370	376	PF00498	0.623
LIG_FHA_1	52	58	PF00498	0.627
LIG_FHA_2	197	203	PF00498	0.638
LIG_FHA_2	216	222	PF00498	0.784
LIG_FHA_2	267	273	PF00498	0.580
LIG_FHA_2	331	337	PF00498	0.580
LIG_LIR_Apic_2	161	166	PF02991	0.645
LIG_LIR_Gen_1	239	249	PF02991	0.526
LIG_LIR_Nem_3	161	167	PF02991	0.635
LIG_LIR_Nem_3	239	245	PF02991	0.478
LIG_NRBOX	276	282	PF00104	0.585
LIG_NRBOX	97	103	PF00104	0.686
LIG_PALB2_WD40_1	159	167	PF16756	0.660
LIG_Pex14_2	253	257	PF04695	0.562
LIG_PTB_Apo_2	6	13	PF02174	0.490
LIG_SH2_STAT5	174	177	PF00017	0.500
LIG_SH2_STAT5	49	52	PF00017	0.522
LIG_SH3_3	183	189	PF00018	0.604
LIG_SH3_3	226	232	PF00018	0.584
LIG_SH3_3	265	271	PF00018	0.524
LIG_SH3_3	355	361	PF00018	0.546
LIG_SH3_3	88	94	PF00018	0.757
LIG_TRAF2_1	36	39	PF00917	0.556
LIG_TRFH_1	257	261	PF08558	0.488
MOD_CDK_SPK_2	412	417	PF00069	0.682
MOD_CDK_SPxK_1	153	159	PF00069	0.738
MOD_CDK_SPxxK_3	153	160	PF00069	0.734
MOD_CK1_1	235	241	PF00069	0.578
MOD_CK1_1	319	325	PF00069	0.680
MOD_CK1_1	344	350	PF00069	0.578
MOD_CK1_1	362	368	PF00069	0.509
MOD_CK1_1	415	421	PF00069	0.592
MOD_CK1_1	51	57	PF00069	0.631
MOD_CK1_1	67	73	PF00069	0.736
MOD_CK1_1	97	103	PF00069	0.558
MOD_CK2_1	196	202	PF00069	0.719
MOD_CK2_1	213	219	PF00069	0.710
MOD_CK2_1	266	272	PF00069	0.587
MOD_CK2_1	330	336	PF00069	0.585
MOD_GlcNHglycan	207	210	PF01048	0.704
MOD_GlcNHglycan	343	346	PF01048	0.578
MOD_GlcNHglycan	73	76	PF01048	0.805
MOD_GlcNHglycan	94	97	PF01048	0.749
MOD_GSK3_1	107	114	PF00069	0.597
MOD_GSK3_1	141	148	PF00069	0.781
MOD_GSK3_1	178	185	PF00069	0.566
MOD_GSK3_1	192	199	PF00069	0.559
MOD_GSK3_1	262	269	PF00069	0.561
MOD_GSK3_1	365	372	PF00069	0.684
MOD_GSK3_1	388	395	PF00069	0.633
MOD_GSK3_1	415	422	PF00069	0.579
MOD_GSK3_1	64	71	PF00069	0.500
MOD_GSK3_1	92	99	PF00069	0.657
MOD_N-GLC_1	119	124	PF02516	0.733
MOD_N-GLC_1	182	187	PF02516	0.663
MOD_N-GLC_1	290	295	PF02516	0.428
MOD_N-GLC_1	330	335	PF02516	0.566
MOD_NEK2_1	1	6	PF00069	0.776
MOD_NEK2_1	119	124	PF00069	0.785
MOD_NEK2_1	205	210	PF00069	0.755
MOD_NEK2_1	289	294	PF00069	0.523
MOD_NEK2_1	30	35	PF00069	0.529
MOD_NEK2_1	325	330	PF00069	0.646
MOD_NEK2_1	406	411	PF00069	0.653
MOD_NEK2_1	48	53	PF00069	0.544
MOD_NEK2_1	64	69	PF00069	0.593
MOD_NEK2_2	316	321	PF00069	0.744
MOD_PKA_1	388	394	PF00069	0.654
MOD_PKA_2	158	164	PF00069	0.687
MOD_PKA_2	235	241	PF00069	0.619
MOD_PKA_2	316	322	PF00069	0.656
MOD_PKA_2	388	394	PF00069	0.654
MOD_PKA_2	68	74	PF00069	0.472
MOD_PKA_2	80	86	PF00069	0.803
MOD_Plk_1	182	188	PF00069	0.643
MOD_Plk_1	290	296	PF00069	0.723
MOD_Plk_1	330	336	PF00069	0.710
MOD_Plk_1	369	375	PF00069	0.592
MOD_Plk_1	87	93	PF00069	0.747
MOD_Plk_4	224	230	PF00069	0.571
MOD_Plk_4	97	103	PF00069	0.526
MOD_ProDKin_1	133	139	PF00069	0.817
MOD_ProDKin_1	153	159	PF00069	0.738
MOD_ProDKin_1	412	418	PF00069	0.679
MOD_ProDKin_1	51	57	PF00069	0.406
MOD_SUMO_for_1	416	419	PF00179	0.680
TRG_ENDOCYTIC_2	174	177	PF00928	0.511
TRG_ER_diArg_1	150	153	PF00400	0.664
TRG_ER_diArg_1	315	318	PF00400	0.687
TRG_ER_diArg_1	388	390	PF00400	0.597
TRG_NLS_MonoCore_2	122	127	PF00514	0.769
TRG_NLS_MonoExtC_3	122	128	PF00514	0.779

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGK4	Leptomonas seymouri	67%	100%
A0A0S4J2S0	Bodo saltans	27%	100%
A0A1X0NJH1	Trypanosomatidae	37%	100%
A0A3Q8IHS0	Leishmania donovani	91%	100%
A0A3R7NE95	Trypanosoma rangeli	42%	100%
A4HMB7	Leishmania braziliensis	78%	99%
A4IAY3	Leishmania infantum	91%	100%
D0A272	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AER1	Leishmania major	92%	100%