Glycerophosphocholine acyltransferase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2838), putative

Species:

Leishmania mexicana

UniProt:

E9B5W5_LEIMU

TriTrypDb:

LmxM.34.0850

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9B5W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5W5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	7
GO:0008654	phospholipid biosynthetic process	5	7
GO:0009058	biosynthetic process	2	7
GO:0009987	cellular process	1	7
GO:0019637	organophosphate metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006656	phosphatidylcholine biosynthetic process	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046470	phosphatidylcholine metabolic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.576
CLV_NRD_NRD_1	110	112	PF00675	0.679
CLV_NRD_NRD_1	216	218	PF00675	0.439
CLV_NRD_NRD_1	320	322	PF00675	0.457
CLV_NRD_NRD_1	350	352	PF00675	0.408
CLV_NRD_NRD_1	354	356	PF00675	0.414
CLV_NRD_NRD_1	418	420	PF00675	0.502
CLV_PCSK_KEX2_1	110	112	PF00082	0.679
CLV_PCSK_KEX2_1	216	218	PF00082	0.447
CLV_PCSK_KEX2_1	320	322	PF00082	0.457
CLV_PCSK_KEX2_1	350	352	PF00082	0.408
CLV_PCSK_KEX2_1	354	356	PF00082	0.414
CLV_PCSK_KEX2_1	360	362	PF00082	0.431
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.503
CLV_PCSK_PC7_1	350	356	PF00082	0.315
CLV_PCSK_SKI1_1	101	105	PF00082	0.684
CLV_PCSK_SKI1_1	180	184	PF00082	0.394
CLV_PCSK_SKI1_1	210	214	PF00082	0.386
CLV_PCSK_SKI1_1	321	325	PF00082	0.447
CLV_PCSK_SKI1_1	361	365	PF00082	0.495
CLV_PCSK_SKI1_1	420	424	PF00082	0.376
CLV_PCSK_SKI1_1	425	429	PF00082	0.356
DOC_CYCLIN_yCln2_LP_2	386	392	PF00134	0.596
DOC_MAPK_gen_1	124	133	PF00069	0.503
DOC_MAPK_gen_1	367	375	PF00069	0.657
DOC_MAPK_MEF2A_6	127	135	PF00069	0.491
DOC_PP1_RVXF_1	328	334	PF00149	0.653
DOC_PP2B_LxvP_1	117	120	PF13499	0.532
DOC_PP2B_PxIxI_1	457	463	PF00149	0.397
DOC_USP7_MATH_1	263	267	PF00917	0.683
DOC_USP7_MATH_1	390	394	PF00917	0.757
DOC_USP7_UBL2_3	360	364	PF12436	0.638
DOC_USP7_UBL2_3	494	498	PF12436	0.693
DOC_WW_Pin1_4	104	109	PF00397	0.450
DOC_WW_Pin1_4	385	390	PF00397	0.626
DOC_WW_Pin1_4	397	402	PF00397	0.713
LIG_14-3-3_CanoR_1	190	198	PF00244	0.572
LIG_14-3-3_CanoR_1	210	219	PF00244	0.450
LIG_14-3-3_CanoR_1	279	285	PF00244	0.793
LIG_14-3-3_CanoR_1	320	326	PF00244	0.588
LIG_14-3-3_CanoR_1	404	409	PF00244	0.625
LIG_14-3-3_CanoR_1	434	440	PF00244	0.608
LIG_Actin_WH2_2	281	298	PF00022	0.764
LIG_APCC_ABBA_1	427	432	PF00400	0.684
LIG_BRCT_BRCA1_1	156	160	PF00533	0.363
LIG_BRCT_BRCA1_1	455	459	PF00533	0.436
LIG_FHA_1	301	307	PF00498	0.742
LIG_FHA_1	442	448	PF00498	0.558
LIG_FHA_2	148	154	PF00498	0.430
LIG_FHA_2	343	349	PF00498	0.599
LIG_FHA_2	379	385	PF00498	0.736
LIG_IRF3_LxIS_1	131	136	PF10401	0.423
LIG_LIR_Apic_2	97	102	PF02991	0.578
LIG_LIR_Gen_1	112	122	PF02991	0.502
LIG_LIR_Gen_1	136	145	PF02991	0.463
LIG_LIR_Gen_1	156	166	PF02991	0.419
LIG_LIR_Gen_1	187	196	PF02991	0.562
LIG_LIR_Gen_1	282	290	PF02991	0.770
LIG_LIR_Gen_1	35	44	PF02991	0.411
LIG_LIR_Gen_1	456	467	PF02991	0.450
LIG_LIR_Nem_3	112	117	PF02991	0.482
LIG_LIR_Nem_3	125	131	PF02991	0.391
LIG_LIR_Nem_3	136	140	PF02991	0.454
LIG_LIR_Nem_3	156	161	PF02991	0.389
LIG_LIR_Nem_3	168	172	PF02991	0.333
LIG_LIR_Nem_3	18	24	PF02991	0.411
LIG_LIR_Nem_3	192	198	PF02991	0.599
LIG_LIR_Nem_3	282	288	PF02991	0.779
LIG_LIR_Nem_3	324	328	PF02991	0.567
LIG_LIR_Nem_3	35	39	PF02991	0.411
LIG_LIR_Nem_3	454	460	PF02991	0.454
LIG_LIR_Nem_3	97	103	PF02991	0.535
LIG_LYPXL_yS_3	457	460	PF13949	0.411
LIG_PCNA_yPIPBox_3	236	246	PF02747	0.710
LIG_PCNA_yPIPBox_3	41	51	PF02747	0.513
LIG_Pex14_1	339	343	PF04695	0.583
LIG_Pex14_1	74	78	PF04695	0.511
LIG_Pex14_2	158	162	PF04695	0.411
LIG_Pex14_2	342	346	PF04695	0.597
LIG_Pex14_2	426	430	PF04695	0.606
LIG_SH2_CRK	285	289	PF00017	0.680
LIG_SH2_CRK	312	316	PF00017	0.708
LIG_SH2_CRK	325	329	PF00017	0.495
LIG_SH2_GRB2like	228	231	PF00017	0.646
LIG_SH2_NCK_1	228	232	PF00017	0.698
LIG_SH2_SRC	132	135	PF00017	0.480
LIG_SH2_SRC	228	231	PF00017	0.702
LIG_SH2_SRC	9	12	PF00017	0.222
LIG_SH2_STAT3	24	27	PF00017	0.619
LIG_SH2_STAT5	132	135	PF00017	0.450
LIG_SH2_STAT5	144	147	PF00017	0.353
LIG_SH2_STAT5	195	198	PF00017	0.565
LIG_SH2_STAT5	31	34	PF00017	0.511
LIG_SH2_STAT5	36	39	PF00017	0.336
LIG_SH2_STAT5	9	12	PF00017	0.411
LIG_SH3_3	128	134	PF00018	0.485
LIG_TYR_ITIM	29	34	PF00017	0.530
LIG_TYR_ITIM	323	328	PF00017	0.577
LIG_UBA3_1	13	20	PF00899	0.404
LIG_UBA3_1	48	56	PF00899	0.487
LIG_WRC_WIRS_1	155	160	PF05994	0.419
LIG_WRC_WIRS_1	185	190	PF05994	0.546
LIG_WRC_WIRS_1	343	348	PF05994	0.595
MOD_CDK_SPxK_1	104	110	PF00069	0.488
MOD_CDK_SPxxK_3	104	111	PF00069	0.475
MOD_CDK_SPxxK_3	397	404	PF00069	0.680
MOD_CK1_1	283	289	PF00069	0.747
MOD_CK2_1	147	153	PF00069	0.435
MOD_CK2_1	342	348	PF00069	0.596
MOD_CK2_1	374	380	PF00069	0.666
MOD_CK2_1	397	403	PF00069	0.685
MOD_Cter_Amidation	417	420	PF01082	0.507
MOD_GlcNHglycan	120	123	PF01048	0.536
MOD_GlcNHglycan	213	216	PF01048	0.391
MOD_GlcNHglycan	265	268	PF01048	0.481
MOD_GlcNHglycan	376	379	PF01048	0.492
MOD_GlcNHglycan	468	471	PF01048	0.572
MOD_GlcNHglycan	65	68	PF01048	0.652
MOD_GSK3_1	265	272	PF00069	0.713
MOD_GSK3_1	279	286	PF00069	0.668
MOD_GSK3_1	374	381	PF00069	0.681
MOD_N-GLC_1	229	234	PF02516	0.442
MOD_N-GLC_1	238	243	PF02516	0.367
MOD_N-GLC_1	80	85	PF02516	0.701
MOD_NEK2_1	160	165	PF00069	0.506
MOD_NEK2_1	211	216	PF00069	0.674
MOD_NEK2_1	238	243	PF00069	0.665
MOD_NEK2_1	280	285	PF00069	0.766
MOD_NEK2_1	295	300	PF00069	0.577
MOD_NEK2_1	342	347	PF00069	0.594
MOD_NEK2_1	39	44	PF00069	0.513
MOD_NEK2_1	441	446	PF00069	0.535
MOD_NEK2_1	451	456	PF00069	0.403
MOD_NEK2_1	499	504	PF00069	0.661
MOD_NEK2_1	85	90	PF00069	0.534
MOD_PIKK_1	295	301	PF00454	0.751
MOD_PIKK_1	441	447	PF00454	0.558
MOD_PKA_1	110	116	PF00069	0.472
MOD_PKA_2	110	116	PF00069	0.475
MOD_PKA_2	189	195	PF00069	0.546
MOD_PKA_2	295	301	PF00069	0.751
MOD_PKA_2	403	409	PF00069	0.643
MOD_Plk_1	238	244	PF00069	0.654
MOD_Plk_2-3	218	224	PF00069	0.651
MOD_Plk_4	154	160	PF00069	0.419
MOD_Plk_4	202	208	PF00069	0.602
MOD_Plk_4	248	254	PF00069	0.673
MOD_Plk_4	280	286	PF00069	0.741
MOD_Plk_4	39	45	PF00069	0.436
MOD_Plk_4	435	441	PF00069	0.610
MOD_ProDKin_1	104	110	PF00069	0.451
MOD_ProDKin_1	385	391	PF00069	0.623
MOD_ProDKin_1	397	403	PF00069	0.711
MOD_SUMO_for_1	363	366	PF00179	0.693
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.525
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.507
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.799
TRG_ENDOCYTIC_2	132	135	PF00928	0.407
TRG_ENDOCYTIC_2	195	198	PF00928	0.565
TRG_ENDOCYTIC_2	228	231	PF00928	0.702
TRG_ENDOCYTIC_2	285	288	PF00928	0.720
TRG_ENDOCYTIC_2	31	34	PF00928	0.565
TRG_ENDOCYTIC_2	312	315	PF00928	0.693
TRG_ENDOCYTIC_2	325	328	PF00928	0.506
TRG_ENDOCYTIC_2	343	346	PF00928	0.581
TRG_ENDOCYTIC_2	36	39	PF00928	0.451
TRG_ENDOCYTIC_2	408	411	PF00928	0.595
TRG_ENDOCYTIC_2	457	460	PF00928	0.411
TRG_ER_diArg_1	109	111	PF00400	0.476
TRG_ER_diArg_1	319	321	PF00400	0.652
TRG_ER_diArg_1	349	351	PF00400	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X8X9	Leishmania donovani	94%	96%
A0A422NIA4	Trypanosoma rangeli	43%	93%
A4HMB6	Leishmania braziliensis	82%	100%
A4IAY2	Leishmania infantum	94%	96%
E9AER0	Leishmania major	93%	100%