Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear transmembrane protein, putative

Species:

Leishmania mexicana

UniProt:

E9B5W4_LEIMU

TriTrypDb:

LmxM.34.0840

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0031090	organelle membrane	3	1
GO:0031965	nuclear membrane	4	1

Expansion

Sequence features

E9B5W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5W4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.420
CLV_NRD_NRD_1	339	341	PF00675	0.651
CLV_PCSK_KEX2_1	167	169	PF00082	0.420
CLV_PCSK_KEX2_1	338	340	PF00082	0.662
CLV_PCSK_SKI1_1	14	18	PF00082	0.402
CLV_PCSK_SKI1_1	156	160	PF00082	0.523
CLV_PCSK_SKI1_1	186	190	PF00082	0.509
CLV_PCSK_SKI1_1	234	238	PF00082	0.467
CLV_PCSK_SKI1_1	255	259	PF00082	0.424
CLV_PCSK_SKI1_1	49	53	PF00082	0.542
CLV_PCSK_SKI1_1	81	85	PF00082	0.527
DEG_COP1_1	393	400	PF00400	0.496
DEG_Nend_UBRbox_2	1	3	PF02207	0.529
DEG_SPOP_SBC_1	106	110	PF00917	0.661
DOC_CKS1_1	121	126	PF01111	0.633
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.411
DOC_PP2B_LxvP_1	26	29	PF13499	0.474
DOC_PP2B_LxvP_1	275	278	PF13499	0.513
DOC_PP4_FxxP_1	83	86	PF00568	0.701
DOC_USP7_MATH_1	111	115	PF00917	0.655
DOC_USP7_MATH_1	127	131	PF00917	0.761
DOC_USP7_MATH_1	188	192	PF00917	0.698
DOC_USP7_MATH_1	294	298	PF00917	0.527
DOC_USP7_MATH_1	341	345	PF00917	0.476
DOC_USP7_MATH_1	373	377	PF00917	0.709
DOC_USP7_MATH_1	378	382	PF00917	0.489
DOC_USP7_MATH_1	383	387	PF00917	0.411
DOC_USP7_MATH_1	77	81	PF00917	0.652
DOC_WW_Pin1_4	107	112	PF00397	0.767
DOC_WW_Pin1_4	120	125	PF00397	0.778
DOC_WW_Pin1_4	128	133	PF00397	0.801
DOC_WW_Pin1_4	290	295	PF00397	0.500
DOC_WW_Pin1_4	323	328	PF00397	0.503
DOC_WW_Pin1_4	57	62	PF00397	0.726
DOC_WW_Pin1_4	82	87	PF00397	0.774
LIG_14-3-3_CanoR_1	113	122	PF00244	0.708
LIG_14-3-3_CanoR_1	156	163	PF00244	0.724
LIG_14-3-3_CanoR_1	262	272	PF00244	0.466
LIG_14-3-3_CterR_2	421	424	PF00244	0.540
LIG_BRCT_BRCA1_1	174	178	PF00533	0.723
LIG_BRCT_BRCA1_1	79	83	PF00533	0.708
LIG_Clathr_ClatBox_1	389	393	PF01394	0.513
LIG_FHA_1	101	107	PF00498	0.635
LIG_FHA_1	2	8	PF00498	0.466
LIG_FHA_1	264	270	PF00498	0.494
LIG_FHA_1	312	318	PF00498	0.377
LIG_FHA_1	324	330	PF00498	0.509
LIG_FHA_1	346	352	PF00498	0.511
LIG_FHA_1	377	383	PF00498	0.411
LIG_FHA_1	399	405	PF00498	0.246
LIG_GBD_Chelix_1	309	317	PF00786	0.751
LIG_GBD_Chelix_1	384	392	PF00786	0.402
LIG_LIR_Apic_2	229	235	PF02991	0.705
LIG_LIR_Apic_2	80	86	PF02991	0.703
LIG_LIR_Gen_1	216	226	PF02991	0.695
LIG_LIR_Gen_1	266	276	PF02991	0.513
LIG_LIR_Gen_1	355	363	PF02991	0.346
LIG_LIR_Gen_1	386	395	PF02991	0.513
LIG_LIR_Nem_3	216	221	PF02991	0.725
LIG_LIR_Nem_3	266	271	PF02991	0.443
LIG_LIR_Nem_3	355	359	PF02991	0.346
LIG_LIR_Nem_3	386	390	PF02991	0.513
LIG_LIR_Nem_3	95	99	PF02991	0.711
LIG_Pex14_2	96	100	PF04695	0.759
LIG_SH2_CRK	218	222	PF00017	0.769
LIG_SH2_CRK	356	360	PF00017	0.222
LIG_SH2_PTP2	232	235	PF00017	0.645
LIG_SH2_SRC	195	198	PF00017	0.692
LIG_SH2_STAP1	19	23	PF00017	0.402
LIG_SH2_STAP1	280	284	PF00017	0.499
LIG_SH2_STAP1	31	35	PF00017	0.402
LIG_SH2_STAT5	195	198	PF00017	0.732
LIG_SH2_STAT5	209	212	PF00017	0.710
LIG_SH2_STAT5	232	235	PF00017	0.700
LIG_SH2_STAT5	319	322	PF00017	0.472
LIG_SH3_3	121	127	PF00018	0.829
LIG_SH3_3	199	205	PF00018	0.608
LIG_SH3_3	58	64	PF00018	0.684
LIG_SUMO_SIM_anti_2	381	386	PF11976	0.411
LIG_SUMO_SIM_anti_2	4	11	PF11976	0.325
LIG_SUMO_SIM_par_1	386	394	PF11976	0.416
LIG_SUMO_SIM_par_1	408	413	PF11976	0.249
LIG_TRAF2_1	149	152	PF00917	0.815
LIG_TRAF2_1	213	216	PF00917	0.705
LIG_TRAF2_1	236	239	PF00917	0.688
LIG_TRAF2_2	124	129	PF00917	0.628
LIG_TRFH_1	33	37	PF08558	0.622
LIG_WRC_WIRS_1	384	389	PF05994	0.513
MOD_CDC14_SPxK_1	110	113	PF00782	0.613
MOD_CDK_SPxK_1	107	113	PF00069	0.611
MOD_CK1_1	114	120	PF00069	0.746
MOD_CK1_1	137	143	PF00069	0.836
MOD_CK1_1	180	186	PF00069	0.778
MOD_CK1_1	283	289	PF00069	0.488
MOD_CK1_1	322	328	PF00069	0.500
MOD_CK1_1	376	382	PF00069	0.465
MOD_CK1_1	85	91	PF00069	0.739
MOD_CK2_1	210	216	PF00069	0.713
MOD_GlcNHglycan	136	139	PF01048	0.632
MOD_GlcNHglycan	163	166	PF01048	0.551
MOD_GlcNHglycan	174	177	PF01048	0.506
MOD_GlcNHglycan	190	193	PF01048	0.495
MOD_GlcNHglycan	331	334	PF01048	0.592
MOD_GlcNHglycan	393	396	PF01048	0.411
MOD_GlcNHglycan	75	78	PF01048	0.569
MOD_GSK3_1	100	107	PF00069	0.766
MOD_GSK3_1	137	144	PF00069	0.720
MOD_GSK3_1	177	184	PF00069	0.778
MOD_GSK3_1	220	227	PF00069	0.695
MOD_GSK3_1	290	297	PF00069	0.508
MOD_GSK3_1	319	326	PF00069	0.569
MOD_GSK3_1	329	336	PF00069	0.510
MOD_GSK3_1	341	348	PF00069	0.381
MOD_GSK3_1	69	76	PF00069	0.696
MOD_GSK3_1	85	92	PF00069	0.708
MOD_N-GLC_1	221	226	PF02516	0.553
MOD_NEK2_1	100	105	PF00069	0.605
MOD_NEK2_1	141	146	PF00069	0.715
MOD_NEK2_1	210	215	PF00069	0.715
MOD_NEK2_1	312	317	PF00069	0.551
MOD_NEK2_1	334	339	PF00069	0.588
MOD_NEK2_1	366	371	PF00069	0.433
MOD_NEK2_1	68	73	PF00069	0.661
MOD_NEK2_2	398	403	PF00069	0.228
MOD_OFUCOSY	364	370	PF10250	0.411
MOD_PIKK_1	156	162	PF00454	0.777
MOD_PIKK_1	203	209	PF00454	0.704
MOD_PIKK_1	89	95	PF00454	0.713
MOD_PKA_2	114	120	PF00069	0.773
MOD_PKA_2	172	178	PF00069	0.721
MOD_PKA_2	322	328	PF00069	0.577
MOD_PKA_2	373	379	PF00069	0.546
MOD_PKA_2	73	79	PF00069	0.730
MOD_Plk_1	181	187	PF00069	0.712
MOD_Plk_1	224	230	PF00069	0.651
MOD_Plk_1	341	347	PF00069	0.513
MOD_Plk_1	398	404	PF00069	0.211
MOD_Plk_1	69	75	PF00069	0.767
MOD_Plk_4	341	347	PF00069	0.445
MOD_Plk_4	355	361	PF00069	0.405
MOD_Plk_4	383	389	PF00069	0.513
MOD_Plk_4	410	416	PF00069	0.332
MOD_Plk_4	92	98	PF00069	0.742
MOD_ProDKin_1	107	113	PF00069	0.770
MOD_ProDKin_1	120	126	PF00069	0.779
MOD_ProDKin_1	128	134	PF00069	0.800
MOD_ProDKin_1	290	296	PF00069	0.499
MOD_ProDKin_1	323	329	PF00069	0.505
MOD_ProDKin_1	57	63	PF00069	0.727
MOD_ProDKin_1	82	88	PF00069	0.773
MOD_SUMO_rev_2	293	303	PF00179	0.405
TRG_ENDOCYTIC_2	218	221	PF00928	0.728
TRG_ENDOCYTIC_2	356	359	PF00928	0.513
TRG_ER_diArg_1	166	168	PF00400	0.734
TRG_ER_diArg_1	170	173	PF00400	0.746
TRG_ER_diArg_1	252	255	PF00400	0.623
TRG_ER_diArg_1	338	340	PF00400	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHG2	Leptomonas seymouri	46%	99%
A0A3Q8IP51	Leishmania donovani	87%	100%
A4HMB5	Leishmania braziliensis	68%	96%
A4IAY1	Leishmania infantum	87%	100%
E9AEQ9	Leishmania major	88%	100%