Putative aspartate aminotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aspartate aminotransferase, putative

Species:

Leishmania mexicana

UniProt:

E9B5W2_LEIMU

TriTrypDb:

LmxM.34.0820

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5W2

PDB structure(s): 4h51_A , 4h51_B

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	13
GO:0006520	amino acid metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009987	cellular process	1	13
GO:0019752	carboxylic acid metabolic process	5	13
GO:0043436	oxoacid metabolic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044281	small molecule metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	5	13
GO:0005488	binding	1	13
GO:0008483	transaminase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016769	transferase activity, transferring nitrogenous groups	3	13
GO:0019842	vitamin binding	3	13
GO:0030170	pyridoxal phosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0070279	vitamin B6 binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.327
CLV_C14_Caspase3-7	401	405	PF00656	0.428
CLV_NRD_NRD_1	244	246	PF00675	0.450
CLV_NRD_NRD_1	314	316	PF00675	0.372
CLV_NRD_NRD_1	333	335	PF00675	0.409
CLV_NRD_NRD_1	410	412	PF00675	0.425
CLV_NRD_NRD_1	59	61	PF00675	0.345
CLV_PCSK_KEX2_1	244	246	PF00082	0.447
CLV_PCSK_KEX2_1	278	280	PF00082	0.327
CLV_PCSK_KEX2_1	29	31	PF00082	0.466
CLV_PCSK_KEX2_1	333	335	PF00082	0.384
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.327
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.466
CLV_PCSK_PC7_1	240	246	PF00082	0.447
CLV_PCSK_SKI1_1	119	123	PF00082	0.377
CLV_PCSK_SKI1_1	174	178	PF00082	0.445
CLV_Separin_Metazoa	339	343	PF03568	0.377
DEG_SPOP_SBC_1	6	10	PF00917	0.484
DOC_CKS1_1	343	348	PF01111	0.345
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.281
DOC_MAPK_gen_1	244	251	PF00069	0.447
DOC_MAPK_gen_1	35	43	PF00069	0.377
DOC_MAPK_gen_1	57	67	PF00069	0.378
DOC_MAPK_MEF2A_6	244	251	PF00069	0.402
DOC_MAPK_MEF2A_6	265	273	PF00069	0.377
DOC_MAPK_MEF2A_6	60	69	PF00069	0.377
DOC_PP2B_LxvP_1	177	180	PF13499	0.327
DOC_USP7_MATH_1	180	184	PF00917	0.296
DOC_USP7_MATH_1	228	232	PF00917	0.287
DOC_USP7_UBL2_3	274	278	PF12436	0.377
DOC_WW_Pin1_4	127	132	PF00397	0.340
DOC_WW_Pin1_4	342	347	PF00397	0.296
LIG_14-3-3_CanoR_1	328	333	PF00244	0.402
LIG_APCC_ABBA_1	259	264	PF00400	0.296
LIG_APCC_ABBAyCdc20_2	333	339	PF00400	0.447
LIG_BIR_II_1	1	5	PF00653	0.576
LIG_FHA_1	109	115	PF00498	0.304
LIG_FHA_1	162	168	PF00498	0.347
LIG_FHA_1	266	272	PF00498	0.452
LIG_FHA_1	94	100	PF00498	0.432
LIG_FHA_2	193	199	PF00498	0.296
LIG_FHA_2	333	339	PF00498	0.432
LIG_FHA_2	399	405	PF00498	0.431
LIG_FHA_2	6	12	PF00498	0.506
LIG_LIR_Apic_2	293	297	PF02991	0.431
LIG_LIR_Gen_1	10	21	PF02991	0.482
LIG_LIR_Gen_1	202	212	PF02991	0.325
LIG_LIR_Gen_1	335	343	PF02991	0.374
LIG_LIR_Nem_3	10	16	PF02991	0.460
LIG_LIR_Nem_3	156	160	PF02991	0.356
LIG_LIR_Nem_3	202	207	PF02991	0.309
LIG_LIR_Nem_3	221	227	PF02991	0.213
LIG_LIR_Nem_3	335	340	PF02991	0.344
LIG_LIR_Nem_3	360	364	PF02991	0.323
LIG_LIR_Nem_3	74	78	PF02991	0.379
LIG_LIR_Nem_3	79	84	PF02991	0.338
LIG_NRBOX	268	274	PF00104	0.377
LIG_PCNA_PIPBox_1	355	364	PF02747	0.309
LIG_PCNA_yPIPBox_3	348	362	PF02747	0.300
LIG_Pex14_1	139	143	PF04695	0.321
LIG_SH2_CRK	143	147	PF00017	0.327
LIG_SH2_CRK	294	298	PF00017	0.309
LIG_SH2_NCK_1	294	298	PF00017	0.309
LIG_SH2_SRC	75	78	PF00017	0.402
LIG_SH2_STAP1	237	241	PF00017	0.345
LIG_SH2_STAP1	262	266	PF00017	0.315
LIG_SH2_STAP1	337	341	PF00017	0.377
LIG_SH2_STAT5	133	136	PF00017	0.297
LIG_SH2_STAT5	294	297	PF00017	0.377
LIG_SH2_STAT5	371	374	PF00017	0.447
LIG_SH2_STAT5	75	78	PF00017	0.346
LIG_SH2_STAT6	80	84	PF00017	0.447
LIG_SH3_3	134	140	PF00018	0.357
LIG_SUMO_SIM_anti_2	268	273	PF11976	0.377
LIG_SUMO_SIM_par_1	101	107	PF11976	0.391
LIG_SUMO_SIM_par_1	95	100	PF11976	0.487
LIG_TRAF2_1	199	202	PF00917	0.450
LIG_TYR_ITIM	71	76	PF00017	0.381
LIG_UBA3_1	24	29	PF00899	0.495
LIG_UBA3_1	358	366	PF00899	0.369
LIG_WRC_WIRS_1	358	363	PF05994	0.447
MOD_CDK_SPxK_1	342	348	PF00069	0.189
MOD_CK1_1	231	237	PF00069	0.327
MOD_CK2_1	307	313	PF00069	0.325
MOD_CK2_1	5	11	PF00069	0.549
MOD_GlcNHglycan	108	111	PF01048	0.330
MOD_GlcNHglycan	221	224	PF01048	0.330
MOD_GlcNHglycan	228	231	PF01048	0.352
MOD_GlcNHglycan	321	325	PF01048	0.410
MOD_GlcNHglycan	381	384	PF01048	0.365
MOD_GlcNHglycan	78	81	PF01048	0.425
MOD_GSK3_1	104	111	PF00069	0.309
MOD_GSK3_1	281	288	PF00069	0.389
MOD_GSK3_1	328	335	PF00069	0.456
MOD_NEK2_1	108	113	PF00069	0.325
MOD_NEK2_1	219	224	PF00069	0.333
MOD_NEK2_1	251	256	PF00069	0.347
MOD_NEK2_1	307	312	PF00069	0.348
MOD_NEK2_1	332	337	PF00069	0.432
MOD_NEK2_1	398	403	PF00069	0.508
MOD_NEK2_2	180	185	PF00069	0.447
MOD_PIKK_1	197	203	PF00454	0.377
MOD_PKA_2	332	338	PF00069	0.455
MOD_Plk_1	320	326	PF00069	0.467
MOD_Plk_2-3	281	287	PF00069	0.377
MOD_Plk_4	141	147	PF00069	0.314
MOD_Plk_4	180	186	PF00069	0.325
MOD_Plk_4	206	212	PF00069	0.327
MOD_Plk_4	267	273	PF00069	0.345
MOD_Plk_4	281	287	PF00069	0.345
MOD_ProDKin_1	127	133	PF00069	0.340
MOD_ProDKin_1	342	348	PF00069	0.296
MOD_SUMO_rev_2	275	285	PF00179	0.356
TRG_DiLeu_BaEn_1	206	211	PF01217	0.410
TRG_DiLeu_BaEn_1	98	103	PF01217	0.302
TRG_ENDOCYTIC_2	143	146	PF00928	0.315
TRG_ENDOCYTIC_2	337	340	PF00928	0.345
TRG_ENDOCYTIC_2	73	76	PF00928	0.303
TRG_ENDOCYTIC_2	81	84	PF00928	0.283
TRG_ER_diArg_1	332	334	PF00400	0.406
TRG_NES_CRM1_1	355	367	PF08389	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0F7CUE9	Hapsidospora irregularis	33%	100%
A0A0N0P7Z5	Leptomonas seymouri	36%	94%
A0A0N1PAS7	Leptomonas seymouri	69%	100%
A0A0S4IPP7	Bodo saltans	40%	100%
A0A0S4JFW4	Bodo saltans	50%	100%
A0A1X0NIT8	Trypanosomatidae	53%	100%
A0A1X0NJG0	Trypanosomatidae	38%	99%
A0A1X0NJN9	Trypanosomatidae	55%	100%
A0A1X0NKG0	Trypanosomatidae	37%	99%
A0A3Q8IG20	Leishmania donovani	93%	100%
A0A3R7MWM6	Trypanosoma rangeli	38%	99%
A0A3S7WY33	Leishmania donovani	34%	96%
A0A422NI78	Trypanosoma rangeli	55%	99%
A4HD93	Leishmania braziliensis	35%	100%
A4HMB3	Leishmania braziliensis	84%	100%
A5A6K8	Pan troglodytes	45%	100%
D0A277	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D0A706	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	99%
E9AH48	Leishmania infantum	34%	96%
E9AWM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
O42652	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
O85746	Klebsiella pneumoniae	32%	100%
O94320	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	94%
P00503	Sus scrofa	45%	100%
P00504	Gallus gallus	45%	100%
P00505	Homo sapiens	44%	96%
P00506	Sus scrofa	43%	96%
P00507	Rattus norvegicus	43%	96%
P00508	Gallus gallus	42%	97%
P00509	Escherichia coli (strain K12)	39%	100%
P04693	Escherichia coli (strain K12)	34%	100%
P05201	Mus musculus	46%	100%
P05202	Mus musculus	44%	96%
P08906	Equus caballus	43%	100%
P08907	Equus caballus	43%	100%
P12344	Bos taurus	44%	96%
P12345	Oryctolagus cuniculus	44%	96%
P13221	Rattus norvegicus	47%	100%
P17174	Homo sapiens	45%	100%
P23542	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	99%
P26563	Lupinus angustifolius	43%	91%
P28011	Medicago sativa	46%	99%
P28734	Daucus carota	48%	100%
P33097	Bos taurus	45%	100%
P37833	Oryza sativa subsp. japonica	47%	100%
P43336	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	37%	100%
P44425	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	37%	100%
P46248	Arabidopsis thaliana	42%	91%
P46643	Arabidopsis thaliana	42%	96%
P46644	Arabidopsis thaliana	46%	92%
P46645	Arabidopsis thaliana	45%	100%
P46646	Arabidopsis thaliana	43%	100%
P58661	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	40%	100%
P72173	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	36%	100%
P74861	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	35%	100%
P95468	Paracoccus denitrificans	38%	100%
Q01802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	91%
Q02636	Rhizobium meliloti (strain 1021)	37%	100%
Q22067	Caenorhabditis elegans	40%	100%
Q28F67	Xenopus tropicalis	43%	96%
Q2PD92	Leishmania infantum	93%	100%
Q2T9S8	Bos taurus	30%	100%
Q4FX34	Leishmania major	93%	100%
Q4QAU4	Leishmania major	35%	100%
Q4R559	Macaca fascicularis	43%	96%
Q4R5L1	Macaca fascicularis	44%	100%
Q54SF7	Dictyostelium discoideum	48%	94%
Q55F21	Dictyostelium discoideum	41%	97%
Q56114	Salmonella typhi	40%	100%
Q5R691	Pongo abelii	45%	100%
Q5REB0	Pongo abelii	43%	96%
Q7SYK7	Danio rerio	42%	96%
Q7TSV6	Mus musculus	27%	100%
Q8NHS2	Homo sapiens	29%	98%
V5BSS0	Trypanosoma cruzi	55%	100%
V5BVY2	Trypanosoma cruzi	39%	99%