Putative proteasome activator protein pa26

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome activator protein pa26, putative

Species:

Leishmania mexicana

UniProt:

E9B5V5_LEIMU

TriTrypDb:

LmxM.34.0750

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0008537	proteasome activator complex	2	11
GO:0032991	protein-containing complex	1	11

Expansion

Sequence features

E9B5V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5V5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	4	6	PF00082	0.457
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.446
CLV_PCSK_SKI1_1	5	9	PF00082	0.453
DOC_CYCLIN_yCln2_LP_2	51	57	PF00134	0.627
DOC_MAPK_MEF2A_6	100	109	PF00069	0.518
DOC_MAPK_MEF2A_6	171	179	PF00069	0.588
DOC_USP7_MATH_1	151	155	PF00917	0.541
DOC_USP7_MATH_1	173	177	PF00917	0.585
DOC_USP7_MATH_1	38	42	PF00917	0.544
DOC_USP7_UBL2_3	158	162	PF12436	0.520
LIG_14-3-3_CanoR_1	221	229	PF00244	0.691
LIG_Actin_WH2_2	102	117	PF00022	0.604
LIG_Clathr_ClatBox_1	189	193	PF01394	0.466
LIG_FHA_1	60	66	PF00498	0.629
LIG_FHA_2	13	19	PF00498	0.509
LIG_PCNA_yPIPBox_3	110	123	PF02747	0.549
LIG_PCNA_yPIPBox_3	72	82	PF02747	0.426
LIG_SH2_STAP1	210	214	PF00017	0.454
LIG_SH2_STAP1	55	59	PF00017	0.612
LIG_SH2_STAT5	148	151	PF00017	0.450
LIG_SH2_STAT5	55	58	PF00017	0.516
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.555
LIG_UBA3_1	116	123	PF00899	0.515
LIG_WRC_WIRS_1	203	208	PF05994	0.539
MOD_CK1_1	222	228	PF00069	0.695
MOD_CK2_1	12	18	PF00069	0.464
MOD_CK2_1	31	37	PF00069	0.399
MOD_CK2_1	67	73	PF00069	0.618
MOD_GlcNHglycan	128	131	PF01048	0.631
MOD_GlcNHglycan	171	174	PF01048	0.647
MOD_GlcNHglycan	193	197	PF01048	0.500
MOD_GSK3_1	14	21	PF00069	0.465
MOD_GSK3_1	169	176	PF00069	0.560
MOD_GSK3_1	194	201	PF00069	0.465
MOD_GSK3_1	27	34	PF00069	0.412
MOD_GSK3_1	59	66	PF00069	0.585
MOD_N-GLC_1	222	227	PF02516	0.738
MOD_NEK2_1	124	129	PF00069	0.697
MOD_NEK2_1	192	197	PF00069	0.541
MOD_NEK2_2	84	89	PF00069	0.604
MOD_PIKK_1	194	200	PF00454	0.487
MOD_PKA_2	12	18	PF00069	0.418
MOD_PKA_2	151	157	PF00069	0.489
MOD_PKA_2	38	44	PF00069	0.536
MOD_Plk_1	18	24	PF00069	0.517
MOD_Plk_2-3	14	20	PF00069	0.498
MOD_Plk_4	109	115	PF00069	0.492
MOD_Plk_4	173	179	PF00069	0.514
MOD_Plk_4	63	69	PF00069	0.548
MOD_SUMO_for_1	99	102	PF00179	0.531
MOD_SUMO_rev_2	118	125	PF00179	0.572
MOD_SUMO_rev_2	154	160	PF00179	0.505
MOD_SUMO_rev_2	164	170	PF00179	0.728

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3A8	Leptomonas seymouri	72%	100%
A0A0S4JD53	Bodo saltans	36%	100%
A0A1X0NKN6	Trypanosomatidae	45%	92%
A0A3Q8IHQ9	Leishmania donovani	95%	100%
A0A3R7MG26	Trypanosoma rangeli	49%	99%
A4HMA7	Leishmania braziliensis	85%	100%
A4IAX3	Leishmania infantum	95%	100%
D0A282	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AEQ0	Leishmania major	94%	100%