SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5V3_LEIMU

TriTrypDb:

LmxM.34.0730

Length:

733

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	6
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B5V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5V3

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	561	565	PF00656	0.652
CLV_NRD_NRD_1	139	141	PF00675	0.451
CLV_NRD_NRD_1	2	4	PF00675	0.457
CLV_NRD_NRD_1	202	204	PF00675	0.454
CLV_NRD_NRD_1	223	225	PF00675	0.462
CLV_NRD_NRD_1	240	242	PF00675	0.447
CLV_NRD_NRD_1	322	324	PF00675	0.330
CLV_NRD_NRD_1	435	437	PF00675	0.247
CLV_NRD_NRD_1	648	650	PF00675	0.464
CLV_NRD_NRD_1	690	692	PF00675	0.623
CLV_NRD_NRD_1	694	696	PF00675	0.601
CLV_NRD_NRD_1	93	95	PF00675	0.557
CLV_PCSK_FUR_1	203	207	PF00082	0.436
CLV_PCSK_FUR_1	646	650	PF00082	0.461
CLV_PCSK_KEX2_1	139	141	PF00082	0.451
CLV_PCSK_KEX2_1	2	4	PF00082	0.457
CLV_PCSK_KEX2_1	202	204	PF00082	0.454
CLV_PCSK_KEX2_1	205	207	PF00082	0.454
CLV_PCSK_KEX2_1	322	324	PF00082	0.330
CLV_PCSK_KEX2_1	648	650	PF00082	0.503
CLV_PCSK_KEX2_1	690	692	PF00082	0.623
CLV_PCSK_KEX2_1	694	696	PF00082	0.601
CLV_PCSK_KEX2_1	92	94	PF00082	0.540
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.434
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.540
CLV_PCSK_PC7_1	690	696	PF00082	0.622
CLV_PCSK_PC7_1	89	95	PF00082	0.486
CLV_PCSK_SKI1_1	202	206	PF00082	0.451
CLV_PCSK_SKI1_1	316	320	PF00082	0.247
CLV_PCSK_SKI1_1	323	327	PF00082	0.255
CLV_PCSK_SKI1_1	648	652	PF00082	0.618
DEG_APCC_DBOX_1	694	702	PF00400	0.448
DEG_Nend_UBRbox_1	1	4	PF02207	0.668
DEG_SCF_TRCP1_1	502	508	PF00400	0.579
DEG_SPOP_SBC_1	388	392	PF00917	0.456
DEG_SPOP_SBC_1	49	53	PF00917	0.724
DOC_CYCLIN_RxL_1	2	12	PF00134	0.629
DOC_CYCLIN_yClb3_PxF_3	217	225	PF00134	0.666
DOC_MAPK_DCC_7	406	415	PF00069	0.467
DOC_MAPK_gen_1	181	190	PF00069	0.710
DOC_MAPK_gen_1	2	10	PF00069	0.663
DOC_MAPK_gen_1	202	212	PF00069	0.653
DOC_MAPK_gen_1	224	231	PF00069	0.682
DOC_MAPK_gen_1	322	333	PF00069	0.497
DOC_MAPK_gen_1	621	631	PF00069	0.479
DOC_MAPK_gen_1	690	698	PF00069	0.424
DOC_MAPK_gen_1	89	99	PF00069	0.723
DOC_MAPK_MEF2A_6	205	214	PF00069	0.693
DOC_MAPK_MEF2A_6	625	633	PF00069	0.469
DOC_MAPK_MEF2A_6	74	82	PF00069	0.744
DOC_MAPK_RevD_3	678	692	PF00069	0.417
DOC_PIKK_1	666	673	PF02985	0.419
DOC_PP2B_LxvP_1	231	234	PF13499	0.706
DOC_USP7_MATH_1	143	147	PF00917	0.823
DOC_USP7_MATH_1	388	392	PF00917	0.540
DOC_USP7_MATH_1	40	44	PF00917	0.718
DOC_USP7_MATH_1	481	485	PF00917	0.681
DOC_USP7_MATH_1	56	60	PF00917	0.770
DOC_USP7_MATH_1	662	666	PF00917	0.446
DOC_USP7_MATH_1	72	76	PF00917	0.645
DOC_USP7_MATH_2	29	35	PF00917	0.705
DOC_USP7_UBL2_3	205	209	PF12436	0.698
DOC_WW_Pin1_4	195	200	PF00397	0.689
DOC_WW_Pin1_4	21	26	PF00397	0.816
DOC_WW_Pin1_4	241	246	PF00397	0.677
DOC_WW_Pin1_4	29	34	PF00397	0.735
DOC_WW_Pin1_4	613	618	PF00397	0.658
LIG_14-3-3_CanoR_1	139	147	PF00244	0.736
LIG_14-3-3_CanoR_1	19	25	PF00244	0.721
LIG_14-3-3_CanoR_1	287	291	PF00244	0.650
LIG_14-3-3_CanoR_1	3	9	PF00244	0.693
LIG_14-3-3_CanoR_1	553	560	PF00244	0.523
LIG_14-3-3_CanoR_1	83	91	PF00244	0.690
LIG_Actin_WH2_2	635	653	PF00022	0.384
LIG_APCC_ABBA_1	249	254	PF00400	0.701
LIG_BIR_III_4	397	401	PF00653	0.502
LIG_BRCT_BRCA1_1	197	201	PF00533	0.731
LIG_CaM_IQ_9	330	345	PF13499	0.530
LIG_FHA_1	261	267	PF00498	0.695
LIG_FHA_1	319	325	PF00498	0.447
LIG_FHA_1	327	333	PF00498	0.447
LIG_FHA_1	352	358	PF00498	0.530
LIG_FHA_1	390	396	PF00498	0.474
LIG_FHA_1	455	461	PF00498	0.451
LIG_FHA_1	5	11	PF00498	0.656
LIG_FHA_2	102	108	PF00498	0.769
LIG_FHA_2	123	129	PF00498	0.746
LIG_FHA_2	147	153	PF00498	0.640
LIG_FHA_2	478	484	PF00498	0.706
LIG_FHA_2	559	565	PF00498	0.656
LIG_FHA_2	83	89	PF00498	0.748
LIG_Integrin_isoDGR_2	298	300	PF01839	0.493
LIG_KLC1_Yacidic_2	470	474	PF13176	0.560
LIG_LIR_Apic_2	587	591	PF02991	0.528
LIG_LIR_Gen_1	457	466	PF02991	0.515
LIG_LIR_Gen_1	555	565	PF02991	0.506
LIG_LIR_Gen_1	620	631	PF02991	0.572
LIG_LIR_Gen_1	655	664	PF02991	0.400
LIG_LIR_Nem_3	198	204	PF02991	0.668
LIG_LIR_Nem_3	216	222	PF02991	0.584
LIG_LIR_Nem_3	280	284	PF02991	0.651
LIG_LIR_Nem_3	555	560	PF02991	0.610
LIG_LIR_Nem_3	620	626	PF02991	0.628
LIG_LIR_Nem_3	655	661	PF02991	0.420
LIG_LIR_Nem_3	70	76	PF02991	0.659
LIG_LYPXL_S_1	76	80	PF13949	0.526
LIG_LYPXL_yS_3	77	80	PF13949	0.661
LIG_NRP_CendR_1	730	733	PF00754	0.670
LIG_PTB_Apo_2	452	459	PF02174	0.409
LIG_PTB_Apo_2	594	601	PF02174	0.519
LIG_PTB_Phospho_1	452	458	PF10480	0.409
LIG_PTB_Phospho_1	594	600	PF10480	0.520
LIG_SH2_CRK	281	285	PF00017	0.728
LIG_SH2_CRK	623	627	PF00017	0.602
LIG_SH2_CRK	73	77	PF00017	0.714
LIG_SH2_NCK_1	623	627	PF00017	0.615
LIG_SH2_PTP2	588	591	PF00017	0.514
LIG_SH2_SRC	588	591	PF00017	0.514
LIG_SH2_STAP1	658	662	PF00017	0.367
LIG_SH2_STAT5	370	373	PF00017	0.550
LIG_SH2_STAT5	441	444	PF00017	0.483
LIG_SH2_STAT5	472	475	PF00017	0.550
LIG_SH2_STAT5	568	571	PF00017	0.476
LIG_SH2_STAT5	588	591	PF00017	0.405
LIG_SH2_STAT5	600	603	PF00017	0.493
LIG_SH3_1	242	248	PF00018	0.675
LIG_SH3_3	188	194	PF00018	0.655
LIG_SH3_3	211	217	PF00018	0.652
LIG_SH3_3	242	248	PF00018	0.749
LIG_SH3_5	215	219	PF00018	0.685
LIG_SUMO_SIM_anti_2	328	336	PF11976	0.447
LIG_SUMO_SIM_par_1	420	426	PF11976	0.544
LIG_SUMO_SIM_par_1	5	12	PF11976	0.628
LIG_SUMO_SIM_par_1	632	637	PF11976	0.400
LIG_TRAF2_1	233	236	PF00917	0.647
LIG_TRAF2_1	484	487	PF00917	0.694
LIG_TRAF2_1	580	583	PF00917	0.581
LIG_TRAF2_1	665	668	PF00917	0.396
LIG_TRAF2_1	85	88	PF00917	0.810
LIG_TRAF2_1	98	101	PF00917	0.618
LIG_UBA3_1	721	730	PF00899	0.332
LIG_WRC_WIRS_1	219	224	PF05994	0.730
LIG_WRC_WIRS_1	424	429	PF05994	0.447
MOD_CDC14_SPxK_1	32	35	PF00782	0.787
MOD_CDK_SPxK_1	29	35	PF00069	0.751
MOD_CDK_SPxxK_3	195	202	PF00069	0.688
MOD_CK1_1	146	152	PF00069	0.753
MOD_CK1_1	390	396	PF00069	0.415
MOD_CK1_1	43	49	PF00069	0.648
MOD_CK1_1	431	437	PF00069	0.538
MOD_CK1_1	503	509	PF00069	0.618
MOD_CK1_1	51	57	PF00069	0.629
MOD_CK1_1	59	65	PF00069	0.739
MOD_CK2_1	101	107	PF00069	0.775
MOD_CK2_1	122	128	PF00069	0.690
MOD_CK2_1	269	275	PF00069	0.709
MOD_CK2_1	379	385	PF00069	0.465
MOD_CK2_1	429	435	PF00069	0.490
MOD_CK2_1	477	483	PF00069	0.656
MOD_CK2_1	662	668	PF00069	0.417
MOD_CK2_1	82	88	PF00069	0.754
MOD_GlcNHglycan	113	118	PF01048	0.536
MOD_GlcNHglycan	499	505	PF01048	0.421
MOD_GlcNHglycan	54	57	PF01048	0.544
MOD_GlcNHglycan	554	557	PF01048	0.382
MOD_GlcNHglycan	58	61	PF01048	0.545
MOD_GSK3_1	138	145	PF00069	0.769
MOD_GSK3_1	29	36	PF00069	0.780
MOD_GSK3_1	307	314	PF00069	0.546
MOD_GSK3_1	374	381	PF00069	0.457
MOD_GSK3_1	477	484	PF00069	0.694
MOD_GSK3_1	48	55	PF00069	0.777
MOD_GSK3_1	500	507	PF00069	0.662
MOD_GSK3_1	56	63	PF00069	0.757
MOD_N-GLC_1	448	453	PF02516	0.260
MOD_N-GLC_1	454	459	PF02516	0.252
MOD_NEK2_1	268	273	PF00069	0.738
MOD_NEK2_1	311	316	PF00069	0.563
MOD_NEK2_1	428	433	PF00069	0.474
MOD_NEK2_1	448	453	PF00069	0.478
MOD_NEK2_1	50	55	PF00069	0.603
MOD_NEK2_1	82	87	PF00069	0.733
MOD_NEK2_2	72	77	PF00069	0.704
MOD_PIKK_1	14	20	PF00454	0.590
MOD_PIKK_1	527	533	PF00454	0.700
MOD_PIKK_1	83	89	PF00454	0.748
MOD_PKA_1	2	8	PF00069	0.655
MOD_PKA_2	138	144	PF00069	0.753
MOD_PKA_2	2	8	PF00069	0.601
MOD_PKA_2	286	292	PF00069	0.704
MOD_PKA_2	477	483	PF00069	0.684
MOD_PKA_2	552	558	PF00069	0.669
MOD_PKA_2	82	88	PF00069	0.718
MOD_Plk_1	268	274	PF00069	0.708
MOD_Plk_1	40	46	PF00069	0.660
MOD_Plk_1	429	435	PF00069	0.456
MOD_Plk_1	448	454	PF00069	0.461
MOD_Plk_1	474	480	PF00069	0.492
MOD_Plk_2-3	269	275	PF00069	0.709
MOD_Plk_4	326	332	PF00069	0.490
MOD_Plk_4	379	385	PF00069	0.447
MOD_Plk_4	423	429	PF00069	0.447
MOD_Plk_4	490	496	PF00069	0.741
MOD_Plk_4	634	640	PF00069	0.379
MOD_ProDKin_1	195	201	PF00069	0.688
MOD_ProDKin_1	21	27	PF00069	0.815
MOD_ProDKin_1	241	247	PF00069	0.676
MOD_ProDKin_1	29	35	PF00069	0.736
MOD_ProDKin_1	613	619	PF00069	0.664
MOD_SUMO_for_1	210	213	PF00179	0.703
MOD_SUMO_for_1	325	328	PF00179	0.502
MOD_SUMO_for_1	342	345	PF00179	0.465
MOD_SUMO_rev_2	430	439	PF00179	0.515
MOD_SUMO_rev_2	616	624	PF00179	0.618
TRG_DiLeu_BaEn_2	164	170	PF01217	0.592
TRG_ENDOCYTIC_2	219	222	PF00928	0.659
TRG_ENDOCYTIC_2	281	284	PF00928	0.714
TRG_ENDOCYTIC_2	458	461	PF00928	0.447
TRG_ENDOCYTIC_2	557	560	PF00928	0.633
TRG_ENDOCYTIC_2	623	626	PF00928	0.581
TRG_ENDOCYTIC_2	658	661	PF00928	0.421
TRG_ENDOCYTIC_2	73	76	PF00928	0.657
TRG_ENDOCYTIC_2	77	80	PF00928	0.652
TRG_ER_diArg_1	1	3	PF00400	0.674
TRG_ER_diArg_1	201	203	PF00400	0.644
TRG_ER_diArg_1	322	324	PF00400	0.530
TRG_ER_diArg_1	645	648	PF00400	0.418
TRG_ER_diArg_1	673	676	PF00400	0.399
TRG_ER_diArg_1	694	696	PF00400	0.420
TRG_NLS_MonoExtC_3	690	695	PF00514	0.397
TRG_NLS_MonoExtN_4	690	695	PF00514	0.395
TRG_NLS_MonoExtN_4	89	96	PF00514	0.742
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D5	Leptomonas seymouri	61%	99%
A0A0S4JG56	Bodo saltans	46%	100%
A0A3S5H7Y5	Leishmania donovani	91%	100%
A4HMA5	Leishmania braziliensis	79%	98%
A4IAX0	Leishmania infantum	91%	100%
D0A284	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AEP8	Leishmania major	90%	99%
V5B354	Trypanosoma cruzi	53%	100%