Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5V2_LEIMU

TriTrypDb:

LmxM.34.0720

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5V2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	237	239	PF00675	0.649
CLV_NRD_NRD_1	314	316	PF00675	0.708
CLV_NRD_NRD_1	326	328	PF00675	0.565
CLV_NRD_NRD_1	391	393	PF00675	0.648
CLV_NRD_NRD_1	447	449	PF00675	0.601
CLV_NRD_NRD_1	460	462	PF00675	0.648
CLV_PCSK_FUR_1	389	393	PF00082	0.649
CLV_PCSK_KEX2_1	237	239	PF00082	0.649
CLV_PCSK_KEX2_1	314	316	PF00082	0.708
CLV_PCSK_KEX2_1	326	328	PF00082	0.447
CLV_PCSK_KEX2_1	391	393	PF00082	0.648
CLV_PCSK_KEX2_1	447	449	PF00082	0.629
CLV_PCSK_KEX2_1	460	462	PF00082	0.646
CLV_PCSK_SKI1_1	187	191	PF00082	0.641
CLV_PCSK_SKI1_1	195	199	PF00082	0.577
CLV_PCSK_SKI1_1	416	420	PF00082	0.570
CLV_PCSK_SKI1_1	92	96	PF00082	0.457
CLV_Separin_Metazoa	257	261	PF03568	0.568
DEG_APCC_DBOX_1	108	116	PF00400	0.559
DEG_APCC_DBOX_1	91	99	PF00400	0.510
DEG_Nend_Nbox_1	1	3	PF02207	0.555
DEG_SPOP_SBC_1	304	308	PF00917	0.495
DOC_CKS1_1	428	433	PF01111	0.665
DOC_MAPK_FxFP_2	281	284	PF00069	0.424
DOC_MAPK_gen_1	109	117	PF00069	0.547
DOC_MAPK_gen_1	90	98	PF00069	0.568
DOC_MAPK_HePTP_8	176	188	PF00069	0.502
DOC_MAPK_MEF2A_6	153	161	PF00069	0.442
DOC_MAPK_MEF2A_6	179	188	PF00069	0.499
DOC_MAPK_MEF2A_6	90	98	PF00069	0.561
DOC_PP1_RVXF_1	445	452	PF00149	0.603
DOC_PP1_RVXF_1	79	85	PF00149	0.535
DOC_PP2B_LxvP_1	190	193	PF13499	0.468
DOC_PP2B_LxvP_1	96	99	PF13499	0.580
DOC_PP4_FxxP_1	281	284	PF00568	0.591
DOC_USP7_MATH_1	298	302	PF00917	0.696
DOC_USP7_MATH_1	340	344	PF00917	0.664
DOC_USP7_MATH_1	358	362	PF00917	0.472
DOC_USP7_MATH_1	407	411	PF00917	0.668
DOC_USP7_MATH_1	459	463	PF00917	0.668
DOC_USP7_MATH_1	496	500	PF00917	0.677
DOC_USP7_MATH_1	56	60	PF00917	0.602
DOC_USP7_MATH_1	62	66	PF00917	0.641
DOC_USP7_MATH_1	70	74	PF00917	0.499
DOC_WW_Pin1_4	153	158	PF00397	0.568
DOC_WW_Pin1_4	427	432	PF00397	0.591
LIG_14-3-3_CanoR_1	140	148	PF00244	0.485
LIG_14-3-3_CanoR_1	210	216	PF00244	0.636
LIG_14-3-3_CanoR_1	237	243	PF00244	0.659
LIG_14-3-3_CanoR_1	326	334	PF00244	0.600
LIG_14-3-3_CanoR_1	460	470	PF00244	0.670
LIG_BRCT_BRCA1_1	141	145	PF00533	0.562
LIG_BRCT_BRCA1_1	279	283	PF00533	0.515
LIG_deltaCOP1_diTrp_1	167	171	PF00928	0.391
LIG_deltaCOP1_diTrp_1	436	443	PF00928	0.626
LIG_FHA_1	176	182	PF00498	0.465
LIG_FHA_1	216	222	PF00498	0.529
LIG_FHA_1	251	257	PF00498	0.379
LIG_FHA_1	350	356	PF00498	0.739
LIG_FHA_2	102	108	PF00498	0.513
LIG_FHA_2	189	195	PF00498	0.624
LIG_FHA_2	306	312	PF00498	0.586
LIG_FHA_2	336	342	PF00498	0.756
LIG_FHA_2	391	397	PF00498	0.588
LIG_FHA_2	473	479	PF00498	0.727
LIG_FHA_2	75	81	PF00498	0.500
LIG_LIR_Apic_2	279	284	PF02991	0.658
LIG_LIR_Apic_2	292	298	PF02991	0.625
LIG_LIR_Apic_2	361	367	PF02991	0.648
LIG_LIR_Gen_1	209	217	PF02991	0.514
LIG_LIR_Gen_1	395	406	PF02991	0.595
LIG_LIR_Nem_3	142	148	PF02991	0.477
LIG_LIR_Nem_3	209	215	PF02991	0.548
LIG_LIR_Nem_3	280	286	PF02991	0.416
LIG_LIR_Nem_3	311	316	PF02991	0.626
LIG_LIR_Nem_3	343	349	PF02991	0.645
LIG_LIR_Nem_3	362	368	PF02991	0.605
LIG_LIR_Nem_3	395	401	PF02991	0.595
LIG_LYPXL_yS_3	346	349	PF13949	0.744
LIG_PDZ_Class_1	496	501	PF00595	0.669
LIG_Pex14_1	451	455	PF04695	0.653
LIG_SH2_CRK	398	402	PF00017	0.633
LIG_SH2_CRK	44	48	PF00017	0.445
LIG_SH2_NCK_1	398	402	PF00017	0.633
LIG_SH2_NCK_1	479	483	PF00017	0.703
LIG_SH2_PTP2	212	215	PF00017	0.642
LIG_SH2_PTP2	365	368	PF00017	0.660
LIG_SH2_SRC	309	312	PF00017	0.705
LIG_SH2_SRC	365	368	PF00017	0.660
LIG_SH2_SRC	37	40	PF00017	0.500
LIG_SH2_SRC	378	381	PF00017	0.673
LIG_SH2_STAP1	305	309	PF00017	0.606
LIG_SH2_STAP1	479	483	PF00017	0.658
LIG_SH2_STAT3	16	19	PF00017	0.511
LIG_SH2_STAT5	148	151	PF00017	0.411
LIG_SH2_STAT5	16	19	PF00017	0.465
LIG_SH2_STAT5	212	215	PF00017	0.588
LIG_SH2_STAT5	305	308	PF00017	0.643
LIG_SH2_STAT5	365	368	PF00017	0.620
LIG_SH2_STAT5	378	381	PF00017	0.651
LIG_SH3_3	12	18	PF00018	0.532
LIG_SH3_3	151	157	PF00018	0.480
LIG_SH3_3	227	233	PF00018	0.577
LIG_TRAF2_1	393	396	PF00917	0.660
LIG_TYR_ITIM	344	349	PF00017	0.667
LIG_TYR_ITIM	35	40	PF00017	0.385
MOD_CDK_SPxK_1	427	433	PF00069	0.668
MOD_CDK_SPxxK_3	153	160	PF00069	0.497
MOD_CK1_1	175	181	PF00069	0.468
MOD_CK1_1	279	285	PF00069	0.640
MOD_CK1_1	325	331	PF00069	0.609
MOD_CK1_1	350	356	PF00069	0.695
MOD_CK1_1	411	417	PF00069	0.669
MOD_CK1_1	462	468	PF00069	0.739
MOD_CK1_1	472	478	PF00069	0.725
MOD_CK1_1	60	66	PF00069	0.642
MOD_CK2_1	113	119	PF00069	0.506
MOD_CK2_1	305	311	PF00069	0.648
MOD_CK2_1	350	356	PF00069	0.669
MOD_CK2_1	390	396	PF00069	0.631
MOD_CK2_1	472	478	PF00069	0.653
MOD_CK2_1	74	80	PF00069	0.549
MOD_CMANNOS	168	171	PF00535	0.286
MOD_DYRK1A_RPxSP_1	153	157	PF00069	0.563
MOD_GlcNHglycan	129	132	PF01048	0.679
MOD_GlcNHglycan	141	144	PF01048	0.353
MOD_GlcNHglycan	163	167	PF01048	0.605
MOD_GlcNHglycan	201	204	PF01048	0.505
MOD_GlcNHglycan	298	301	PF01048	0.684
MOD_GlcNHglycan	370	373	PF01048	0.632
MOD_GlcNHglycan	410	413	PF01048	0.652
MOD_GlcNHglycan	471	474	PF01048	0.661
MOD_GlcNHglycan	480	483	PF01048	0.589
MOD_GlcNHglycan	498	501	PF01048	0.422
MOD_GlcNHglycan	64	67	PF01048	0.620
MOD_GlcNHglycan	71	75	PF01048	0.550
MOD_GSK3_1	113	120	PF00069	0.493
MOD_GSK3_1	127	134	PF00069	0.643
MOD_GSK3_1	135	142	PF00069	0.444
MOD_GSK3_1	211	218	PF00069	0.616
MOD_GSK3_1	390	397	PF00069	0.739
MOD_GSK3_1	407	414	PF00069	0.529
MOD_GSK3_1	416	423	PF00069	0.696
MOD_GSK3_1	491	498	PF00069	0.627
MOD_GSK3_1	56	63	PF00069	0.576
MOD_GSK3_1	70	77	PF00069	0.622
MOD_LATS_1	236	242	PF00433	0.410
MOD_N-GLC_1	198	203	PF02516	0.586
MOD_N-GLC_1	215	220	PF02516	0.546
MOD_NEK2_1	133	138	PF00069	0.521
MOD_NEK2_1	139	144	PF00069	0.456
MOD_NEK2_1	172	177	PF00069	0.506
MOD_NEK2_1	198	203	PF00069	0.443
MOD_NEK2_1	215	220	PF00069	0.601
MOD_NEK2_1	265	270	PF00069	0.679
MOD_NEK2_1	349	354	PF00069	0.559
MOD_NEK2_2	250	255	PF00069	0.517
MOD_OFUCOSY	248	254	PF10250	0.416
MOD_PIKK_1	133	139	PF00454	0.546
MOD_PIKK_1	238	244	PF00454	0.478
MOD_PIKK_1	350	356	PF00454	0.655
MOD_PIKK_1	484	490	PF00454	0.667
MOD_PKA_1	460	466	PF00069	0.719
MOD_PKA_2	139	145	PF00069	0.492
MOD_PKA_2	236	242	PF00069	0.410
MOD_PKA_2	322	328	PF00069	0.640
MOD_PKA_2	390	396	PF00069	0.607
MOD_PKA_2	459	465	PF00069	0.679
MOD_PKB_1	392	400	PF00069	0.705
MOD_Plk_1	215	221	PF00069	0.587
MOD_Plk_1	340	346	PF00069	0.694
MOD_Plk_1	394	400	PF00069	0.701
MOD_Plk_1	420	426	PF00069	0.715
MOD_Plk_1	70	76	PF00069	0.540
MOD_Plk_4	113	119	PF00069	0.527
MOD_ProDKin_1	153	159	PF00069	0.569
MOD_ProDKin_1	427	433	PF00069	0.585
MOD_SUMO_rev_2	182	189	PF00179	0.618
TRG_DiLeu_BaEn_1	185	190	PF01217	0.611
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.466
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.498
TRG_ENDOCYTIC_2	12	15	PF00928	0.507
TRG_ENDOCYTIC_2	212	215	PF00928	0.587
TRG_ENDOCYTIC_2	346	349	PF00928	0.642
TRG_ENDOCYTIC_2	365	368	PF00928	0.660
TRG_ENDOCYTIC_2	37	40	PF00928	0.446
TRG_ENDOCYTIC_2	398	401	PF00928	0.584
TRG_ENDOCYTIC_2	44	47	PF00928	0.400
TRG_ER_diArg_1	286	289	PF00400	0.597
TRG_ER_diArg_1	313	315	PF00400	0.686
TRG_ER_diArg_1	388	391	PF00400	0.670
TRG_ER_diArg_1	447	449	PF00400	0.628
TRG_ER_diArg_1	459	461	PF00400	0.645
TRG_NES_CRM1_1	107	119	PF08389	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S8	Leptomonas seymouri	39%	97%
A0A0S4JCU2	Bodo saltans	21%	100%
A0A3S7X8U0	Leishmania donovani	87%	100%
A4HMA4	Leishmania braziliensis	72%	100%
A4IAW9	Leishmania infantum	87%	100%
E9AEP7	Leishmania major	88%	100%
V5DJL7	Trypanosoma cruzi	28%	100%