LeishMANIAdb
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RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
RRM domain-containing protein
Gene product:
Nucleoporin NUP65, putative
Species:
Leishmania mexicana
UniProt:
E9B5U4_LEIMU
TriTrypDb:
LmxM.34.0630
Length:
597

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

E9B5U4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5U4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 31 35 PF00656 0.541
CLV_NRD_NRD_1 12 14 PF00675 0.694
CLV_NRD_NRD_1 16 18 PF00675 0.744
CLV_NRD_NRD_1 411 413 PF00675 0.554
CLV_NRD_NRD_1 446 448 PF00675 0.441
CLV_PCSK_FUR_1 13 17 PF00082 0.698
CLV_PCSK_KEX2_1 12 14 PF00082 0.694
CLV_PCSK_KEX2_1 15 17 PF00082 0.739
CLV_PCSK_KEX2_1 411 413 PF00082 0.554
CLV_PCSK_KEX2_1 446 448 PF00082 0.444
CLV_PCSK_PC7_1 12 18 PF00082 0.755
CLV_PCSK_PC7_1 407 413 PF00082 0.500
CLV_PCSK_PC7_1 442 448 PF00082 0.444
CLV_PCSK_SKI1_1 198 202 PF00082 0.631
CLV_PCSK_SKI1_1 41 45 PF00082 0.674
CLV_PCSK_SKI1_1 502 506 PF00082 0.482
DEG_APCC_DBOX_1 562 570 PF00400 0.665
DEG_Nend_Nbox_1 1 3 PF02207 0.432
DEG_SPOP_SBC_1 142 146 PF00917 0.446
DEG_SPOP_SBC_1 231 235 PF00917 0.443
DEG_SPOP_SBC_1 361 365 PF00917 0.425
DOC_CYCLIN_RxL_1 193 202 PF00134 0.373
DOC_CYCLIN_RxL_1 376 387 PF00134 0.209
DOC_CYCLIN_yCln2_LP_2 374 380 PF00134 0.318
DOC_MAPK_gen_1 172 181 PF00069 0.514
DOC_MAPK_gen_1 502 510 PF00069 0.662
DOC_MAPK_MEF2A_6 125 132 PF00069 0.260
DOC_MAPK_MEF2A_6 172 181 PF00069 0.451
DOC_MAPK_MEF2A_6 563 570 PF00069 0.637
DOC_MAPK_MEF2A_6 580 588 PF00069 0.281
DOC_PP1_SILK_1 37 42 PF00149 0.523
DOC_PP2B_LxvP_1 431 434 PF13499 0.697
DOC_PP4_FxxP_1 132 135 PF00568 0.300
DOC_PP4_FxxP_1 358 361 PF00568 0.441
DOC_SPAK_OSR1_1 379 383 PF12202 0.403
DOC_USP7_MATH_1 156 160 PF00917 0.473
DOC_USP7_MATH_1 164 168 PF00917 0.466
DOC_USP7_MATH_1 215 219 PF00917 0.521
DOC_USP7_MATH_1 231 235 PF00917 0.477
DOC_USP7_MATH_1 243 247 PF00917 0.494
DOC_USP7_MATH_1 285 289 PF00917 0.489
DOC_USP7_MATH_1 294 298 PF00917 0.512
DOC_USP7_MATH_1 314 318 PF00917 0.483
DOC_USP7_MATH_1 35 39 PF00917 0.479
DOC_USP7_MATH_1 361 365 PF00917 0.425
DOC_USP7_MATH_1 397 401 PF00917 0.695
DOC_USP7_MATH_1 497 501 PF00917 0.578
DOC_USP7_MATH_1 67 71 PF00917 0.523
DOC_USP7_MATH_2 461 467 PF00917 0.625
DOC_WW_Pin1_4 131 136 PF00397 0.279
DOC_WW_Pin1_4 21 26 PF00397 0.573
DOC_WW_Pin1_4 227 232 PF00397 0.515
DOC_WW_Pin1_4 362 367 PF00397 0.469
DOC_WW_Pin1_4 420 425 PF00397 0.703
DOC_WW_Pin1_4 429 434 PF00397 0.721
DOC_WW_Pin1_4 457 462 PF00397 0.585
LIG_14-3-3_CanoR_1 143 148 PF00244 0.449
LIG_14-3-3_CanoR_1 208 214 PF00244 0.461
LIG_14-3-3_CanoR_1 232 236 PF00244 0.536
LIG_14-3-3_CanoR_1 276 281 PF00244 0.515
LIG_14-3-3_CanoR_1 291 297 PF00244 0.439
LIG_14-3-3_CanoR_1 349 355 PF00244 0.426
LIG_14-3-3_CanoR_1 446 450 PF00244 0.633
LIG_14-3-3_CanoR_1 580 585 PF00244 0.403
LIG_14-3-3_CanoR_1 82 91 PF00244 0.267
LIG_Actin_WH2_2 434 452 PF00022 0.572
LIG_APCC_ABBAyCdc20_2 185 191 PF00400 0.427
LIG_BRCT_BRCA1_1 145 149 PF00533 0.440
LIG_BRCT_BRCA1_1 355 359 PF00533 0.435
LIG_eIF4E_1 376 382 PF01652 0.209
LIG_eIF4E_1 581 587 PF01652 0.318
LIG_FHA_1 34 40 PF00498 0.526
LIG_FHA_1 350 356 PF00498 0.475
LIG_FHA_1 426 432 PF00498 0.709
LIG_FHA_1 85 91 PF00498 0.340
LIG_FHA_2 122 128 PF00498 0.312
LIG_FHA_2 153 159 PF00498 0.457
LIG_FHA_2 250 256 PF00498 0.498
LIG_FHA_2 281 287 PF00498 0.525
LIG_FHA_2 3 9 PF00498 0.442
LIG_FHA_2 550 556 PF00498 0.631
LIG_FHA_2 71 77 PF00498 0.522
LIG_IBAR_NPY_1 494 496 PF08397 0.638
LIG_LIR_Apic_2 356 361 PF02991 0.436
LIG_LIR_Gen_1 126 136 PF02991 0.279
LIG_LIR_Gen_1 367 378 PF02991 0.403
LIG_LIR_Gen_1 387 397 PF02991 0.235
LIG_LIR_Gen_1 460 470 PF02991 0.570
LIG_LIR_Gen_1 488 497 PF02991 0.600
LIG_LIR_Gen_1 585 594 PF02991 0.348
LIG_LIR_Gen_1 70 80 PF02991 0.522
LIG_LIR_Gen_1 86 96 PF02991 0.234
LIG_LIR_Nem_3 104 109 PF02991 0.191
LIG_LIR_Nem_3 126 132 PF02991 0.279
LIG_LIR_Nem_3 319 325 PF02991 0.543
LIG_LIR_Nem_3 367 373 PF02991 0.444
LIG_LIR_Nem_3 387 392 PF02991 0.193
LIG_LIR_Nem_3 463 467 PF02991 0.558
LIG_LIR_Nem_3 488 492 PF02991 0.590
LIG_LIR_Nem_3 535 540 PF02991 0.668
LIG_LIR_Nem_3 585 590 PF02991 0.348
LIG_LIR_Nem_3 70 75 PF02991 0.547
LIG_LIR_Nem_3 86 91 PF02991 0.234
LIG_MLH1_MIPbox_1 355 359 PF16413 0.435
LIG_PCNA_yPIPBox_3 74 84 PF02747 0.472
LIG_Pex14_1 577 581 PF04695 0.318
LIG_SH2_CRK 470 474 PF00017 0.578
LIG_SH2_CRK 581 585 PF00017 0.318
LIG_SH2_STAP1 147 151 PF00017 0.372
LIG_SH2_STAT3 496 499 PF00017 0.665
LIG_SH2_STAT5 105 108 PF00017 0.346
LIG_SH2_STAT5 109 112 PF00017 0.316
LIG_SH2_STAT5 129 132 PF00017 0.312
LIG_SH2_STAT5 472 475 PF00017 0.613
LIG_SH2_STAT5 72 75 PF00017 0.528
LIG_SH3_1 471 477 PF00018 0.572
LIG_SH3_2 170 175 PF14604 0.499
LIG_SH3_2 430 435 PF14604 0.700
LIG_SH3_3 167 173 PF00018 0.543
LIG_SH3_3 19 25 PF00018 0.489
LIG_SH3_3 260 266 PF00018 0.518
LIG_SH3_3 275 281 PF00018 0.518
LIG_SH3_3 427 433 PF00018 0.699
LIG_SH3_3 471 477 PF00018 0.572
LIG_SUMO_SIM_par_1 380 385 PF11976 0.321
LIG_SUMO_SIM_par_1 97 104 PF11976 0.279
LIG_TYR_ITIM 468 473 PF00017 0.566
LIG_WRC_WIRS_1 464 469 PF05994 0.620
LIG_WW_3 172 176 PF00397 0.484
LIG_WW_3 432 436 PF00397 0.695
MOD_CDC14_SPxK_1 432 435 PF00782 0.695
MOD_CDK_SPK_2 227 232 PF00069 0.478
MOD_CDK_SPxK_1 429 435 PF00069 0.701
MOD_CDK_SPxxK_3 362 369 PF00069 0.471
MOD_CK1_1 119 125 PF00069 0.334
MOD_CK1_1 145 151 PF00069 0.439
MOD_CK1_1 159 165 PF00069 0.437
MOD_CK1_1 230 236 PF00069 0.645
MOD_CK1_1 238 244 PF00069 0.518
MOD_CK1_1 279 285 PF00069 0.511
MOD_CK1_1 297 303 PF00069 0.466
MOD_CK1_1 305 311 PF00069 0.554
MOD_CK1_1 334 340 PF00069 0.428
MOD_CK1_1 364 370 PF00069 0.429
MOD_CK1_1 582 588 PF00069 0.332
MOD_CK1_1 70 76 PF00069 0.502
MOD_CK2_1 121 127 PF00069 0.238
MOD_CK2_1 152 158 PF00069 0.451
MOD_CK2_1 280 286 PF00069 0.518
MOD_CK2_1 457 463 PF00069 0.579
MOD_CK2_1 549 555 PF00069 0.634
MOD_CK2_1 70 76 PF00069 0.531
MOD_CMANNOS 386 389 PF00535 0.403
MOD_DYRK1A_RPxSP_1 232 236 PF00069 0.434
MOD_GlcNHglycan 166 169 PF01048 0.722
MOD_GlcNHglycan 240 244 PF01048 0.853
MOD_GlcNHglycan 272 275 PF01048 0.764
MOD_GlcNHglycan 296 299 PF01048 0.718
MOD_GlcNHglycan 304 307 PF01048 0.694
MOD_GlcNHglycan 31 34 PF01048 0.709
MOD_GlcNHglycan 316 319 PF01048 0.781
MOD_GlcNHglycan 366 369 PF01048 0.622
MOD_GlcNHglycan 399 402 PF01048 0.472
MOD_GlcNHglycan 457 460 PF01048 0.390
MOD_GlcNHglycan 515 518 PF01048 0.479
MOD_GlcNHglycan 54 57 PF01048 0.690
MOD_GlcNHglycan 91 94 PF01048 0.540
MOD_GSK3_1 116 123 PF00069 0.319
MOD_GSK3_1 141 148 PF00069 0.374
MOD_GSK3_1 152 159 PF00069 0.434
MOD_GSK3_1 223 230 PF00069 0.545
MOD_GSK3_1 231 238 PF00069 0.493
MOD_GSK3_1 239 246 PF00069 0.464
MOD_GSK3_1 270 277 PF00069 0.545
MOD_GSK3_1 280 287 PF00069 0.478
MOD_GSK3_1 29 36 PF00069 0.484
MOD_GSK3_1 302 309 PF00069 0.519
MOD_GSK3_1 336 343 PF00069 0.494
MOD_GSK3_1 349 356 PF00069 0.399
MOD_GSK3_1 360 367 PF00069 0.410
MOD_GSK3_1 425 432 PF00069 0.740
MOD_N-GLC_1 164 169 PF02516 0.624
MOD_N-GLC_1 306 311 PF02516 0.622
MOD_NEK2_1 118 123 PF00069 0.341
MOD_NEK2_1 239 244 PF00069 0.527
MOD_NEK2_1 292 297 PF00069 0.552
MOD_NEK2_1 336 341 PF00069 0.502
MOD_NEK2_1 384 389 PF00069 0.403
MOD_NEK2_1 445 450 PF00069 0.666
MOD_NEK2_1 504 509 PF00069 0.624
MOD_NEK2_1 83 88 PF00069 0.448
MOD_NEK2_2 156 161 PF00069 0.478
MOD_NEK2_2 331 336 PF00069 0.380
MOD_NEK2_2 497 502 PF00069 0.623
MOD_PIKK_1 425 431 PF00454 0.750
MOD_PIKK_1 532 538 PF00454 0.629
MOD_PIKK_1 67 73 PF00454 0.493
MOD_PKA_2 142 148 PF00069 0.442
MOD_PKA_2 231 237 PF00069 0.554
MOD_PKA_2 243 249 PF00069 0.483
MOD_PKA_2 270 276 PF00069 0.574
MOD_PKA_2 445 451 PF00069 0.697
MOD_PKA_2 549 555 PF00069 0.731
MOD_PKA_2 579 585 PF00069 0.403
MOD_PKB_1 511 519 PF00069 0.642
MOD_Plk_1 532 538 PF00069 0.666
MOD_Plk_4 331 337 PF00069 0.389
MOD_Plk_4 35 41 PF00069 0.524
MOD_Plk_4 350 356 PF00069 0.498
MOD_Plk_4 463 469 PF00069 0.581
MOD_Plk_4 504 510 PF00069 0.626
MOD_Plk_4 582 588 PF00069 0.318
MOD_Plk_4 84 90 PF00069 0.264
MOD_ProDKin_1 131 137 PF00069 0.279
MOD_ProDKin_1 21 27 PF00069 0.573
MOD_ProDKin_1 227 233 PF00069 0.516
MOD_ProDKin_1 362 368 PF00069 0.460
MOD_ProDKin_1 420 426 PF00069 0.702
MOD_ProDKin_1 429 435 PF00069 0.721
MOD_ProDKin_1 457 463 PF00069 0.579
TRG_DiLeu_BaEn_1 565 570 PF01217 0.638
TRG_DiLeu_BaEn_2 462 468 PF01217 0.560
TRG_DiLeu_BaLyEn_6 260 265 PF01217 0.518
TRG_ENDOCYTIC_2 129 132 PF00928 0.236
TRG_ENDOCYTIC_2 375 378 PF00928 0.318
TRG_ENDOCYTIC_2 464 467 PF00928 0.560
TRG_ENDOCYTIC_2 470 473 PF00928 0.580
TRG_ENDOCYTIC_2 581 584 PF00928 0.318
TRG_ENDOCYTIC_2 72 75 PF00928 0.528
TRG_ER_diArg_1 12 15 PF00400 0.501
TRG_ER_diArg_1 205 208 PF00400 0.511
TRG_ER_diArg_1 266 269 PF00400 0.499
TRG_ER_diArg_1 289 292 PF00400 0.415
TRG_ER_diArg_1 445 447 PF00400 0.693
TRG_ER_diArg_1 510 513 PF00400 0.616
TRG_Pf-PMV_PEXEL_1 198 202 PF00026 0.619
TRG_Pf-PMV_PEXEL_1 435 439 PF00026 0.485
TRG_Pf-PMV_PEXEL_1 502 506 PF00026 0.482

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HRZ6 Leptomonas seymouri 48% 100%
A0A3S7X8T0 Leishmania donovani 90% 100%
A4HM96 Leishmania braziliensis 79% 100%
A4IAW0 Leishmania infantum 90% 100%
E9AEN8 Leishmania major 88% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS