Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B5U3_LEIMU

TriTrypDb:

LmxM.34.0620

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B5U3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5U3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.570
CLV_C14_Caspase3-7	163	167	PF00656	0.637
CLV_C14_Caspase3-7	249	253	PF00656	0.552
CLV_C14_Caspase3-7	368	372	PF00656	0.539
CLV_NRD_NRD_1	199	201	PF00675	0.709
CLV_NRD_NRD_1	22	24	PF00675	0.484
CLV_NRD_NRD_1	29	31	PF00675	0.453
CLV_NRD_NRD_1	56	58	PF00675	0.692
CLV_PCSK_KEX2_1	101	103	PF00082	0.597
CLV_PCSK_KEX2_1	199	201	PF00082	0.693
CLV_PCSK_KEX2_1	22	24	PF00082	0.484
CLV_PCSK_KEX2_1	28	30	PF00082	0.463
CLV_PCSK_KEX2_1	56	58	PF00082	0.692
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.597
CLV_PCSK_PC7_1	97	103	PF00082	0.596
CLV_PCSK_SKI1_1	200	204	PF00082	0.785
CLV_PCSK_SKI1_1	254	258	PF00082	0.635
CLV_PCSK_SKI1_1	30	34	PF00082	0.346
CLV_PCSK_SKI1_1	64	68	PF00082	0.778
DEG_APCC_DBOX_1	130	138	PF00400	0.565
DEG_APCC_DBOX_1	63	71	PF00400	0.575
DEG_MDM2_SWIB_1	34	42	PF02201	0.411
DEG_SIAH_1	339	347	PF03145	0.600
DOC_CYCLIN_yCln2_LP_2	356	362	PF00134	0.580
DOC_MAPK_gen_1	173	182	PF00069	0.611
DOC_PP2B_LxvP_1	69	72	PF13499	0.574
DOC_PP4_FxxP_1	138	141	PF00568	0.510
DOC_PP4_FxxP_1	46	49	PF00568	0.411
DOC_USP7_MATH_1	17	21	PF00917	0.582
DOC_USP7_MATH_1	256	260	PF00917	0.361
DOC_WW_Pin1_4	303	308	PF00397	0.536
DOC_WW_Pin1_4	349	354	PF00397	0.531
LIG_14-3-3_CanoR_1	173	178	PF00244	0.548
LIG_14-3-3_CanoR_1	254	261	PF00244	0.493
LIG_14-3-3_CanoR_1	298	302	PF00244	0.596
LIG_14-3-3_CanoR_1	89	94	PF00244	0.520
LIG_Actin_WH2_2	6	24	PF00022	0.541
LIG_CaM_IQ_9	74	90	PF13499	0.495
LIG_Clathr_ClatBox_1	354	358	PF01394	0.521
LIG_FHA_1	214	220	PF00498	0.480
LIG_FHA_1	22	28	PF00498	0.715
LIG_FHA_1	255	261	PF00498	0.504
LIG_FHA_1	71	77	PF00498	0.542
LIG_FHA_2	130	136	PF00498	0.522
LIG_FHA_2	174	180	PF00498	0.543
LIG_FHA_2	317	323	PF00498	0.507
LIG_FHA_2	366	372	PF00498	0.498
LIG_LIR_Apic_2	135	141	PF02991	0.579
LIG_LIR_Apic_2	44	49	PF02991	0.411
LIG_NRBOX	260	266	PF00104	0.560
LIG_Pex14_2	120	124	PF04695	0.481
LIG_Pex14_2	34	38	PF04695	0.411
LIG_SH2_CRK	52	56	PF00017	0.458
LIG_SH2_SRC	125	128	PF00017	0.563
LIG_SH2_STAT5	125	128	PF00017	0.535
LIG_SH2_STAT5	142	145	PF00017	0.560
LIG_SH2_STAT5	328	331	PF00017	0.450
LIG_SH2_STAT5	35	38	PF00017	0.385
LIG_SH3_2	188	193	PF14604	0.521
LIG_SH3_3	150	156	PF00018	0.557
LIG_SH3_3	185	191	PF00018	0.495
LIG_SH3_3	234	240	PF00018	0.614
LIG_SH3_3	334	340	PF00018	0.523
LIG_SUMO_SIM_par_1	39	44	PF11976	0.227
LIG_SUMO_SIM_par_1	72	77	PF11976	0.569
LIG_TRAF2_1	221	224	PF00917	0.526
LIG_TRAF2_1	277	280	PF00917	0.577
LIG_TRAF2_1	319	322	PF00917	0.598
LIG_TRFH_1	124	128	PF08558	0.499
LIG_TYR_ITIM	2	7	PF00017	0.665
LIG_UBA3_1	264	273	PF00899	0.508
MOD_CK1_1	129	135	PF00069	0.497
MOD_CK1_1	227	233	PF00069	0.528
MOD_CK1_1	300	306	PF00069	0.408
MOD_CK1_1	365	371	PF00069	0.559
MOD_CK2_1	173	179	PF00069	0.617
MOD_CK2_1	272	278	PF00069	0.526
MOD_CK2_1	316	322	PF00069	0.511
MOD_CK2_1	59	65	PF00069	0.513
MOD_GlcNHglycan	347	350	PF01048	0.801
MOD_GSK3_1	17	24	PF00069	0.603
MOD_GSK3_1	293	300	PF00069	0.581
MOD_GSK3_1	345	352	PF00069	0.569
MOD_GSK3_1	70	77	PF00069	0.510
MOD_NEK2_1	21	26	PF00069	0.551
MOD_NEK2_1	222	227	PF00069	0.591
MOD_NEK2_1	266	271	PF00069	0.514
MOD_NEK2_1	293	298	PF00069	0.541
MOD_NEK2_1	301	306	PF00069	0.523
MOD_NEK2_1	362	367	PF00069	0.488
MOD_PIKK_1	224	230	PF00454	0.534
MOD_PIKK_1	363	369	PF00454	0.528
MOD_PIKK_1	74	80	PF00454	0.489
MOD_PKA_1	22	28	PF00069	0.619
MOD_PKA_2	21	27	PF00069	0.679
MOD_PKA_2	297	303	PF00069	0.560
MOD_PKB_1	173	181	PF00069	0.535
MOD_PKB_1	57	65	PF00069	0.514
MOD_PKB_1	89	97	PF00069	0.483
MOD_Plk_1	74	80	PF00069	0.501
MOD_Plk_4	256	262	PF00069	0.410
MOD_Plk_4	3	9	PF00069	0.664
MOD_Plk_4	41	47	PF00069	0.411
MOD_ProDKin_1	303	309	PF00069	0.537
MOD_ProDKin_1	349	355	PF00069	0.531
TRG_DiLeu_BaEn_1	214	219	PF01217	0.576
TRG_DiLeu_BaEn_1	65	70	PF01217	0.579
TRG_ENDOCYTIC_2	328	331	PF00928	0.487
TRG_ENDOCYTIC_2	4	7	PF00928	0.620
TRG_ENDOCYTIC_2	52	55	PF00928	0.469
TRG_ER_diArg_1	131	134	PF00400	0.564
TRG_ER_diArg_1	172	175	PF00400	0.636
TRG_ER_diArg_1	198	200	PF00400	0.514
TRG_ER_diArg_1	21	23	PF00400	0.711
TRG_ER_diArg_1	27	30	PF00400	0.646
TRG_ER_diArg_1	55	57	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.811
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.748
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.649
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGT9	Leptomonas seymouri	40%	100%
A0A3Q8IEV9	Leishmania donovani	89%	99%
A4HM95	Leishmania braziliensis	77%	100%
A4IAV9	Leishmania infantum	89%	97%
E9AEN7	Leishmania major	86%	100%